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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2007 1
2009 5
2010 70
2011 221
2012 243
2013 285
2014 282
2015 284
2016 305
2017 328
2018 303
2019 114
2020 0
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2,118 results
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Neural stem/progenitor cells in Alzheimer's disease.
Tincer G, et al. Yale J Biol Med 2016 - Review. PMID 27505014 Free PMC article.
Another plausible therapeutic way that may complement the studies is to increase the survival of existing neurons by mobilizing the existing neural stem/progenitor cells (NSPCs) - i.e. ...In this review, we will discuss the use of stem cells in neurodegenerative diseases and in particular how NSPCs affect the AD pathology and how neurodegeneration affects NSPCs. ...
Another plausible therapeutic way that may complement the studies is to increase the survival of existing neurons by mobilizing the existing …
Canonical and noncanonical Wnt signaling in neural stem/progenitor cells.
Bengoa-Vergniory N and Kypta RM. Cell Mol Life Sci 2015 - Review. PMID 26306936 Free article.
Wnt signals in the developing and adult brain can drive neural stem cell self-renewal, expansion, asymmetric cell division, maturation and differentiation. ...Here, we review the roles played by Wnts in neural stem cells in the developing mouse brain, at neurogenic sites of the adult mouse and in neural stem cell culture models....
Wnt signals in the developing and adult brain can drive neural stem cell self-renewal, expansion, asymmetric cell division, ma …
Developmental Emergence of Adult Neural Stem Cells as Revealed by Single-Cell Transcriptional Profiling.
Yuzwa SA, et al. Cell Rep 2017. PMID 29281841 Free article.
Adult neural stem cells (NSCs) derive from embryonic precursors, but little is known about how or when this occurs. We have addressed this issue using single-cell RNA sequencing at multiple developmental time points to analyze the embryonic murine cortex, one source of adult forebrain NSCs. ...We define the initial emergence of RPs from neuroepithelial stem cells at E11.5. We show that, by E13.5, RPs express a transcriptional identity that is maintained and reinforced throughout their transition to a non-proliferative state between E15.5 and E17.5. ...
Adult neural stem cells (NSCs) derive from embryonic precursors, but little is known about how or when this occurs. We …
Single-cell transcriptome analyses reveal signals to activate dormant neural stem cells.
Luo Y, et al. Cell 2015. PMID 26000486 Free PMC article.
The scarcity of tissue-specific stem cells and the complexity of their surrounding environment have made molecular characterization of these cells particularly challenging. ...Administration of vascular endothelial growth factor (VEGF) activated CD133(+) ependymal neural stem cells (NSCs), lining not only the lateral but also the fourth ventricles and, together with basic fibroblast growth factor (bFGF), elicited subsequent neural lineage differentiation and migration. ...
The scarcity of tissue-specific stem cells and the complexity of their surrounding environment have made molecular characteriz …
IDH1R132H in Neural Stem Cells: Differentiation Impaired by Increased Apoptosis.
Rosiak K, et al. PLoS One 2016. PMID 27145078 Free PMC article.
METHODS: Neural stem cells were derived from human induced pluripotent stem cells following embryoid body formation. Neural stem cells transduced with mutant IDH1R132H, empty vector, non-transduced and overexpressing IDH1WT controls were differentiated into astrocytes and neurons in culture. ...High percentage of apoptotic cells was detected within IDH1R132H-positive neural stem cells population and their derivatives, if compared to normal neural stem cells and their derivatives. ...
METHODS: Neural stem cells were derived from human induced pluripotent stem cells following embryoid body …
Neural Stem Cells (NSCs) and Proteomics.
Shoemaker LD and Kornblum HI. Mol Cell Proteomics 2016 - Review. PMID 26494823 Free PMC article.
Neural stem cells (NSCs) can self-renew and give rise to the major cell types of the CNS. Studies of NSCs include the investigation of primary, CNS-derived cells as well as animal and human embryonic stem cell (ESC)-derived and induced pluripotent stem cell (iPSC)-derived sources. ...Proteomics studies of NSCs have the potential to delineate molecules and pathways critical for NSC biology and the means by which NSCs can participate in neural repair. ...
Neural stem cells (NSCs) can self-renew and give rise to the major cell types of the CNS. Studies of NSCs include the i
Maintaining multipotent trunk neural crest stem cells as self-renewing crestospheres.
Mohlin S, et al. Dev Biol 2019. PMID 30664880 Free PMC article.
Here we optimize culture conditions for maintenance of avian trunk crestospheres, comprised of both neural crest stem and progenitor cells. ...Taken together, this method enables long-term in vitro maintenance and manipulation of multipotent trunk neural crest cells in a premigratory stem or early progenitor state. ...
Here we optimize culture conditions for maintenance of avian trunk crestospheres, comprised of both neural crest stem and prog …
Long Neural Genes Harbor Recurrent DNA Break Clusters in Neural Stem/Progenitor Cells.
Wei PC, et al. Cell 2016. PMID 26871630 Free PMC article.
Repair of DNA double-strand breaks (DSBs) by non-homologous end joining is critical for neural development, and brain cells frequently contain somatic genomic variations that might involve DSB intermediates. We now use an unbiased, high-throughput approach to identify genomic regions harboring recurrent DSBs in primary neural stem/progenitor cells (NSPCs). ...
Repair of DNA double-strand breaks (DSBs) by non-homologous end joining is critical for neural development, and brain cells fr …
Hypothalamic regulation of regionally distinct adult neural stem cells and neurogenesis.
Paul A, et al. Science 2017. PMID 28619719
Neural stem cells (NSCs) in specialized niches in the adult mammalian brain generate neurons throughout life. NSCs in the adult mouse ventricular-subventricular zone (V-SVZ) exhibit a regional identity and, depending on their location, generate distinct olfactory bulb interneuron subtypes. ...Our findings reveal that neural circuitry, via mosaic innervation of the V-SVZ, can recruit distinct NSC pools, allowing on-demand neurogenesis in response to physiology and environmental signals....
Neural stem cells (NSCs) in specialized niches in the adult mammalian brain generate neurons throughout life. NSCs in t
Effects of aspirin and clopidogrel on neural stem cells.
Hwang M, et al. Cell Biol Toxicol 2018. PMID 28965180
We investigated the effects of aspirin and clopidogrel on neural stem cells (NSCs). NSCs were dissociated from fetal rat cortex and cultured with basic fibroblast growth factor and N2 medium. ...
We investigated the effects of aspirin and clopidogrel on neural stem cells (NSCs). NSCs were dissociated from fetal ra …
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