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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1952 8
1953 5
1954 19
1955 20
1956 7
1957 12
1958 5
1959 14
1960 11
1961 26
1962 13
1964 1
1965 20
1966 72
1967 88
1968 101
1969 134
1970 140
1971 198
1972 196
1973 197
1974 211
1975 139
1976 187
1977 190
1978 190
1979 192
1980 215
1981 213
1982 260
1983 255
1984 319
1985 357
1986 435
1987 428
1988 538
1989 657
1990 647
1991 661
1992 765
1993 831
1994 957
1995 1019
1996 1003
1997 1052
1998 1149
1999 1287
2000 1421
2001 1707
2002 1852
2003 1937
2004 2165
2005 2363
2006 2554
2007 2595
2008 2915
2009 3137
2010 3744
2011 3835
2012 4364
2013 4423
2014 3994
2015 4275
2016 4606
2017 4968
2018 4703
2019 1869
2020 18
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Search Results

71,300 results
Results by year
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Page 1
Neurodegenerative diseases.
Heemels MT. Nature 2016. PMID 27830810
Neurodegenerative diseases: expanding the prion concept.
Walker LC and Jucker M. Annu Rev Neurosci 2015 - Review. PMID 25840008 Free PMC article.
The prion paradigm has emerged as a unifying molecular principle for the pathogenesis of many age-related neurodegenerative diseases. ...As the concept has expanded to include other diseases, many of which are not infectious by any conventional definition, the designation of prions as infectious agents has become problematic. ...
The prion paradigm has emerged as a unifying molecular principle for the pathogenesis of many age-related neurodegenerative diseas
The role of extracellular vesicles in neurodegenerative diseases.
Quek C and Hill AF. Biochem Biophys Res Commun 2017 - Review. PMID 27659705
Of all neurodegenerative diseases, prion diseases are classified as the distinctive group owing to its transmissible and infectious nature of misfolded prion protein. ...Here we review the role of exosomes in prion diseases and other common neurodegenerative diseases, and discuss the potential of these vesicles for disease pathogenesis....
Of all neurodegenerative diseases, prion diseases are classified as the distinctive group owing to its transmissible an …
Novel Approaches for the Treatment of Alzheimer's and Parkinson's Disease
Van Bulck M, et al. Int J Mol Sci 2019 - Review. PMID 30743990 Free PMC article.
Neurodegenerative diseases, like in other age-related disorders, the progression of pathology begins many years before the onset of symptoms. Many efforts in this field have led to the conclusion that exits some similar events among these diseases that can explain why the aging brain is so vulnerable to suffer neurodegenerative diseases. ...
Neurodegenerative diseases, like in other age-related disorders, the progression of pathology begins many years before the ons
Autophagy Receptors and Neurodegenerative Diseases.
Deng Z, et al. Trends Cell Biol 2017 - Review. PMID 28169082
Growing evidence has linked the genetic variants of autophagy receptors to neurodegenerative diseases and multiple experimental systems have validated their roles in modulating the disease process. Here, we review the recent advances in understanding the physiology and pathophysiology of autophagy receptors in selective autophagy, and discuss their potentials as therapeutic targets for neurodegenerative diseases....
Growing evidence has linked the genetic variants of autophagy receptors to neurodegenerative diseases and multiple experimenta …
Epigenetics and DNA methylomic profiling in Alzheimer's disease and other neurodegenerative diseases.
Roubroeks JAY, et al. J Neurochem 2017 - Review. PMID 28805248 Free article.
Recent studies have suggested a role for epigenetic mechanisms in the complex etiology of various neurodegenerative diseases. ...We provide a brief overview of DNA modifications, followed by a summarization of studies of DNA modifications in Alzheimer's disease and other neurodegenerative diseases....
Recent studies have suggested a role for epigenetic mechanisms in the complex etiology of various neurodegenerative diseases. …
Mitophagy in neurodegenerative diseases.
Rodolfo C, et al. Neurochem Int 2018 - Review. PMID 28797885
Neurodegenerative diseases, such as Parkinson's disease (PD), Alzheimer's disease (AD), Huntington's disease (HD), and Amyotrophic Lateral Sclerosis (ALS), are a complex "family" of pathologies, characterised by the progressive loss of neurons and/or neuronal functions, leading to severe physical and cognitive inabilities in affected patients. ...Indeed, their impairment has been reported as associated with the development of these diseases. In this review, we focus on the role played by mitophagy, a specialised form of autophagy, in the onset and progression of major neurodegenerative diseases, as well as on possible therapeutic approaches involving mitophagy modulation....
Neurodegenerative diseases, such as Parkinson's disease (PD), Alzheimer's disease (AD), Huntington's disease (HD), and Amyotro
Mechanisms of selective autophagy and mitophagy: Implications for neurodegenerative diseases.
Chu CT. Neurobiol Dis 2019 - Review. PMID 30030024 Free PMC article.
Over the past 20 years, the concept of mammalian autophagy as a nonselective degradation system has been repudiated, due in part to important discoveries in neurodegenerative diseases, which opened the field of selective autophagy. ...This review summarizes key features of the major cargo recognition pathways for selective autophagy and mitophagy, highlighting their potential impact in the pathogenesis or amelioration of neurodegenerative diseases....
Over the past 20 years, the concept of mammalian autophagy as a nonselective degradation system has been repudiated, due in part to importan …
Proteopathic Strains and the Heterogeneity of Neurodegenerative Diseases.
Walker LC. Annu Rev Genet 2016 - Review. PMID 27893962 Free PMC article.
Most age-related neurodegenerative diseases are associated with the misfolding and aberrant accumulation of specific proteins in the nervous system. ...Insights into proteopathic strains gleaned from the classical prion diseases can be profitably incorporated into research on other neurodegenerative diseases. ...
Most age-related neurodegenerative diseases are associated with the misfolding and aberrant accumulation of specific proteins …
71,300 results
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