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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1947 1
1951 2
1952 10
1953 8
1955 3
1956 5
1957 5
1958 12
1959 6
1963 5
1964 9
1965 70
1966 181
1967 214
1968 184
1969 215
1970 184
1971 168
1972 224
1973 235
1974 272
1975 210
1976 237
1977 261
1978 272
1979 290
1980 326
1981 302
1982 360
1983 362
1984 367
1985 403
1986 431
1987 450
1988 444
1989 482
1990 632
1991 634
1992 811
1993 874
1994 867
1995 1020
1996 991
1997 1032
1998 1019
1999 1023
2000 1172
2001 1266
2002 1226
2003 1354
2004 1283
2005 1467
2006 1466
2007 1501
2008 1582
2009 1619
2010 1605
2011 1651
2012 1700
2013 1682
2014 1606
2015 1666
2016 1572
2017 1501
2018 1383
2019 572
2020 10
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41,551 results
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Page 1
Effects of Acute Alcohol Exposure on Layer 5 Pyramidal Neurons of Juvenile Mice.
Ferrini F, et al. Cell Mol Neurobiol 2018. PMID 29224183 Free article.
Yet, most of the basic neurobiological research on the acute effects of ethanol has been carried out on adult or early postnatal animals. ...After bath application of 50 mM ethanol to acute slices of the somatosensory cortex, no adverse effects were detected on cells survival, whereas the input resistance and firing rate of layer 5 neurons were significantly reduced. ...
Yet, most of the basic neurobiological research on the acute effects of ethanol has been carried out on adult or early postnatal anim …
Fremanezumab-A Humanized Monoclonal Anti-CGRP Antibody-Inhibits Thinly Myelinated (Aδ) But Not Unmyelinated (C) Meningeal Nociceptors
Melo-Carrillo A, et al. J Neurosci 2017. PMID 28972120 Free PMC article.
Fremanezumab pretreatment selectively inhibited the responsiveness of Aδ neurons, but not C-fiber neurons, as reflected in a decrease in the percentage of neurons that showed activation by cortical spreading depression. ...This is the first identification of an anti-migraine drug that appears to be selective for Aδ-fibers (peripherally) and HT neurons (centrally). ...
Fremanezumab pretreatment selectively inhibited the responsiveness of Aδ neurons, but not C-fiber neurons, as reflected in a d …
Visualizing Axonal Growth Cone Collapse and Early Amyloid β Effects in Cultured Mouse Neurons.
Kuboyama T. J Vis Exp 2018. PMID 30451220
To help identify the source, we propose a novel protocol that uses microscopy, gene transfection, and live cell imaging to investigate early changes caused by Aβ in axonal growth cones of cultured neurons. ...This protocol will be useful in studying the early effects of Aβ and may lead to more efficient and preventative AD treatment....
To help identify the source, we propose a novel protocol that uses microscopy, gene transfection, and live cell imaging to investigate early …
Effects of β(3)-adrenergic receptor stimulation on the resting holding current of medial prefrontal cortex pyramidal neurons in young rats.
Grzelka K, et al. Neurosci Lett 2019. PMID 30641111
Applications of the selective β(3)-adrenergic receptor agonists BRL 37344 and SR 58611 A evoked inward currents in the tested neurons. ...Thus, based on the results obtained here, functional β(3)-adrenergic receptors are expressed in layer V mPFC pyramidal neurons and their activation evokes inward currents....
Applications of the selective β(3)-adrenergic receptor agonists BRL 37344 and SR 58611 A evoked inward currents in the tested neurons
Adolescent exposure to Δ(9)-tetrahydrocannabinol alters the transcriptional trajectory and dendritic architecture of prefrontal pyramidal neurons.
Miller ML, et al. Mol Psychiatry 2019. PMID 30283037 Free PMC article.
Here, we investigated in a rat model the effects of adolescent exposure to Δ(9)-tetrahydrocannabinol (THC), a psychoactive component of cannabis, on the morphological architecture and transcriptional profile of layer III pyramidal neurons-using cell type- and layer-specific high-resolution microscopy, laser capture microdissection and next-generation RNA-sequencing. ...Overall, adolescent THC exposure altered the morphological and transcriptional trajectory of PFC pyramidal neurons, which could enhance vulnerability to psychiatric disorders....
Here, we investigated in a rat model the effects of adolescent exposure to Δ(9)-tetrahydrocannabinol (THC), a psychoactive component …
[Impact of opiates on dopaminergic neurons].
Kaufling J, et al. Med Sci (Paris) 2016 - Review. PMID 27406773 French. Free article.
Since the work of Johnson and North, it is known that opiates increase the activity of dopaminergic neurons by a GABA neuron-mediated desinhibition. ...Thus, the neuroanatomical location of the GABA neurons responsible for this desinhibition has been recently detailed: they belong to a brain structure in continuity with the posterior part of the ventral tegmental area and discovered this past decade. ...
Since the work of Johnson and North, it is known that opiates increase the activity of dopaminergic neurons by a GABA neuron-mediated …
Detection of 3,3'-Dichlorobiphenyl in Human Maternal Plasma and Its Effects on Axonal and Dendritic Growth in Primary Rat Neurons.
Sethi S, et al. Toxicol Sci 2017. PMID 28510766 Free PMC article.
To address this critical data gap, we measured PCB 11 levels in human maternal plasma and quantified the effects of PCB 11 and its major metabolites on morphometric parameters of neuronal connectivity in cultured primary neurons. ...Morphometric analyses of primary neuron-glia co-cultures dissociated from the neocortices or hippocampi of neonatal Sprague Dawley rats exposed to vehicle or concentrations ranging from 1 attamolar (aM) to 1 micromolar (µM) of PCB 11, OH-PCB 11, or PCB 11 sulfate indicated that PCB 11 and both metabolites significantly increased axonal and dendritic growth in cortical and hippocampal pyramidal neurons. ...
To address this critical data gap, we measured PCB 11 levels in human maternal plasma and quantified the effects of PCB 11 and its ma …
Dopamine and serotonin antagonists fail to alter the discriminative stimulus properties of ±methylenedioxymethamphetamine
Schenk S and Highgate Q. Behav Pharmacol 2019. PMID 30199389
Separate groups of rats were trained to discriminate AMPH (0.5 mg/kg) or MDMA (3.0 mg/kg) from saline using a food-reinforced drug-discrimination procedure. ...None of the 5HT antagonists altered the discriminative stimulus effects of either drug. The MDMA (3.0 mg/kg) stimulus comprises both a DAergic and 5HTergic response, and the results suggest that either one is sufficient, but not required, to maintain the stimulus effects....
Separate groups of rats were trained to discriminate AMPH (0.5 mg/kg) or MDMA (3.0 mg/kg) from saline using a food-reinforced drug-di …
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