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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1995 8
1996 7
1997 12
1998 16
1999 32
2000 16
2001 23
2002 18
2003 24
2004 38
2005 21
2006 36
2007 39
2008 21
2009 30
2010 39
2011 33
2012 46
2013 50
2014 52
2015 64
2016 60
2017 56
2018 45
2019 20
2020 0
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715 results
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Page 1
Resveratrol, pterostilbene, and dementia
Lange KW and Li S. Biofactors 2018 - Review. PMID 29168580
Resveratrol is a natural phytoestrogen with neuroprotective properties. Polyphenolic compounds including resveratrol exert in vitro antioxidant, anti-inflammatory, and antiamyloid effects. ...The findings of available intervention trials of resveratrol in individuals with mild cognitive impairment or AD do not provide evidence of neuroprotective or therapeutic effects. ...
Resveratrol is a natural phytoestrogen with neuroprotective properties. Polyphenolic compounds including resveratrol exert in vitro a …
Mechanisms of Neuroprotection by Quercetin: Counteracting Oxidative Stress and More.
Costa LG, et al. Oxid Med Cell Longev 2016 - Review. PMID 26904161 Free PMC article.
Increasing interest has recently focused on determining whether several natural compounds, collectively referred to as nutraceuticals, may exert neuroprotective actions in the developing, adult, and aging nervous system. ...In addition, quercetin has been shown to activate sirtuins (SIRT1), to induce autophagy, and to act as a phytoestrogen, all mechanisms by which quercetin may provide its neuroprotection....
Increasing interest has recently focused on determining whether several natural compounds, collectively referred to as nutraceuticals, may e …
Neuroprotective properties of citicoline: facts, doubts and unresolved issues.
Grieb P. CNS Drugs 2014 - Review. PMID 24504829 Free PMC article.
Neuroprotective activity of citicoline has been repeatedly shown in preclinical models of brain ischaemia and trauma, but two recent, large, pivotal clinical trials have revealed no benefits in ischaemic stroke and traumatic brain injury. ...This paper critically discusses issues related to the clinical pharmacology of citicoline, including its pharmacokinetics/biotransformation and pharmacodynamics/mode of action. ...
Neuroprotective activity of citicoline has been repeatedly shown in preclinical models of brain ischaemia and trauma, but two recent,
Identification of dual Sigma1 receptor modulators/acetylcholinesterase inhibitors with antioxidant and neurotrophic properties, as neuroprotective agents.
Rui M, et al. Eur J Med Chem 2018. PMID 30223122
The compounds based on arylalkylaminoketone scaffold integrate the pharmacophoric elements of RRC-33, a S1R modulator developed by us, donepezil, a well-known AChE inhibitor, and curcumin, a natural antioxidant compound with neuroprotective properties. ...
The compounds based on arylalkylaminoketone scaffold integrate the pharmacophoric elements of RRC-33, a S1R modulator developed by us, donep …
Melatonin and the newborn brain
Colella M, et al. Early Hum Dev 2016 - Review. PMID 27616207
Among the candidate molecules, melatonin appears to be one of the most promising agents for its antioxidant and neuromodulatory action. ...This review recapitulates current basic research, safety and pharmacokinetic data and ongoing clinical trials on the use of melatonin as a neuroprotective agent in the newborn....
Among the candidate molecules, melatonin appears to be one of the most promising agents for its antioxidant and neuromodulatory actio …
A Mini Review on the Chemistry and Neuroprotective Effects of Silymarin.
Devi KP, et al. Curr Drug Targets 2017 - Review. PMID 28025940
OBJECTIVE: In this article we review the neuroprotective effects of silymarin against various neurological dysfunctions. RESULTS: The neuroprotective effects conferred by silymarin include modulation of various antioxidant mechanisms, and several kinases involved in cell signaling pathways, inhibition of the inflammatory response generated during neurodegeneration, neurotropic effects, regulation of neurotransmitters and inhibition of apoptosis. ...However, there is a growing need for improvements in the bioavailability of silymarin and related products, and more consistent and reliable human trials are required to accurately validate the neuroprotective efficacy of this natural compound. ...
OBJECTIVE: In this article we review the neuroprotective effects of silymarin against various neurological dysfunctions. RESULTS: The …
Neuroprotective agents for clinical trials in Parkinson's disease: a systematic assessment.
Ravina BM, et al. Neurology 2003 - Review. PMID 12707423
However, there have been relatively few clinical trials aimed at demonstrating neuroprotection. The authors sought to identify potential neuroprotective agents for testing in clinical trials. ...Agents were prioritized based on these criteria. RESULTS: The authors identified 59 potential neuroprotective compounds, proposed by 42 clinicians and scientists from 13 countries. ...
However, there have been relatively few clinical trials aimed at demonstrating neuroprotection. The authors sought to identify potent …
Toward the identification of neuroprotective agents: g-scale synthesis, pharmacokinetic evaluation and CNS distribution of (R)-RC-33, a promising SIGMA1 receptor agonist.
Marra A, et al. Future Med Chem 2016. PMID 26898712
RESULTS: Herein, we report the gram-scale synthesis, pharmacokinetic profile and CNS distribution of (R)-RC-33 in the mouse to determine the most suitable dosage schedule for in vivo administration. ...DISCUSSION: (R)-RC-33 shows a similar pharmacokinetic profile and a better CNS distribution when compared with PRE-084. CONCLUSION: (R)-RC-33 may be a promising candidate for in vivo studies in animal models of neurodegenerative diseases....
RESULTS: Herein, we report the gram-scale synthesis, pharmacokinetic profile and CNS distribution of (R)-RC-33 in the mouse to determ …
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