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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1965 2
1966 10
1967 18
1968 21
1969 25
1970 19
1971 28
1972 35
1973 47
1974 75
1975 57
1976 51
1977 97
1978 120
1979 157
1980 180
1981 197
1982 217
1983 262
1984 379
1985 399
1986 425
1987 521
1988 524
1989 577
1990 716
1991 755
1992 689
1993 812
1994 716
1995 693
1996 720
1997 694
1998 607
1999 574
2000 614
2001 577
2002 590
2003 523
2004 480
2005 484
2006 493
2007 504
2008 522
2009 539
2010 523
2011 549
2012 556
2013 526
2014 531
2015 532
2016 482
2017 457
2018 427
2019 202
2020 1
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20,382 results
Results by year
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Page 1
Neutrophil chemotaxis.
Petri B and Sanz MJ. Cell Tissue Res 2018 - Review. PMID 29350282
Neutrophils are the primary cells recruited to inflamed sites during an innate immune response to tissue damage and/or infection. ...Neutrophil chemoattractants exert their effects through interaction with heptahelical G protein-coupled receptors (GPCRs) expressed on cell surfaces and the chemotactic response is mainly regulated by the Rho family of GTPases. ...
Neutrophils are the primary cells recruited to inflamed sites during an innate immune response to tissue damage and/or infection. ...
Gasdermin D Exerts Anti-inflammatory Effects by Promoting Neutrophil Death.
Kambara H, et al. Cell Rep 2018. PMID 29539421 Free PMC article.
It was mediated by a neutrophil-specific serine protease, neutrophil elastase (ELANE), released from cytoplasmic granules into the cytosol in aging neutrophils. ...Thus, GSDMD is pleiotropic, exerting both pro- and anti-inflammatory effects that make it a potential target for antibacterial and anti-inflammatory therapies....
It was mediated by a neutrophil-specific serine protease, neutrophil elastase (ELANE), released from cytoplasmic granules into …
Exploring inflammatory disease drug effects on neutrophil function.
Wu X, et al. Analyst 2014. PMID 24946254 Free PMC article.
Neutrophils are critical inflammatory cells; thus, it is important to characterize the effects of drugs on neutrophil function in the context of inflammatory diseases. ...This study provides mechanistic insight into the drug effects on neutrophil function, facilitating comparison of current and potential pharmaceutical approaches....
Neutrophils are critical inflammatory cells; thus, it is important to characterize the effects of drugs on neutrophil f
Simplified Human Neutrophil Extracellular Traps (NETs) Isolation and Handling.
Najmeh S, et al. J Vis Exp 2015. PMID 25938591 Free PMC article.
Neutrophil Extracellular Traps (NETs) have been recently identified as part of the neutrophil's antimicrobial armamentarium. ...This enables an assessment of their biologic properties in the absence of the potential confounding effects of neutrophils themselves. ...
Neutrophil Extracellular Traps (NETs) have been recently identified as part of the neutrophil's antimicrobial armamentarium. .
IN VITRO EFFECTS OF A COMMERCIAL HERBAL MEDICINE USED AS AFRICAN TRADITIONAL MEDICINE ON HUMAN NEUTROPHILS.
Mothibe ME, et al. Afr J Tradit Complement Altern Med 2017. PMID 28480416 Free PMC article.
RESULTS: The HM had variable stimulatory and inhibitory effects on the luminescence activity of healthy isolated and non-isolated human neutrophils. ...The in vitro inhibitory and stimulatory effects on neutrophils which are furthermore time-based, suggest variable effects on the immune system, which may be beneficial as well as risky. ...
RESULTS: The HM had variable stimulatory and inhibitory effects on the luminescence activity of healthy isolated and non-isolated hum …
Effects of fucoidans and heparin on reactions of neutrophils induced by IL-8 and C5a.
Liewert I, et al. Carbohydr Polym 2017. PMID 28363573
In this study, two fucoidans from Saccharina latissima and Fucus vesiculosus, and unfractionated heparin (UFH) were examined for their binding properties to IL-8 and C5a and their effects on IL-8- and C5a-induced reactions of polymorphonuclear neutrophils (PMN). ...Whereas UFH displayed only moderate effects, the fucoidans concentration-dependently reduced the IL-8- and C5a-induced intracellular calcium release, Erk1/2 phosphorylation and chemotaxis of PMN. ...
In this study, two fucoidans from Saccharina latissima and Fucus vesiculosus, and unfractionated heparin (UFH) were examined for their bindi …
Tamoxifen induces apoptotic neutrophil efferocytosis in horses.
Olave C, et al. Vet Res Commun 2018. PMID 29297134
Tamoxifen (TX) is a non-steroidal estrogen receptor modulator with effects on cell growth and survival. Previous studies showed that TX treatment in horses with induced acute pulmonary inflammation promoted early apoptosis of blood and BALF neutrophils, reduction of BALF neutrophils, and improvement in animals' clinical status. ...In conclusion, these results confirm that tamoxifen has a direct effect on equine peripheral blood neutrophils, through stimulation of the engulfment of apoptotic neutrophils by alveolar macrophages....
Tamoxifen (TX) is a non-steroidal estrogen receptor modulator with effects on cell growth and survival. Previous studies showed that …
Modulation of innate immunity by cyclosporine A
Liddicoat AM and Lavelle EC. Biochem Pharmacol 2019 - Review. PMID 30880061
However, cyclosporine A also impacts on innate immune cells including dendritic cells, macrophages and neutrophils. In dendritic cells, which are essential for T cell priming, cyclosporine A can modulate both expression of surface molecules that engage with T cells and cytokine secretion, leading to altered induction of T cell responses. In macrophages and neutrophils, which play key antimicrobial roles, cyclosporine A reduces the production of cytokines that can play protective roles against pathogens. ...
However, cyclosporine A also impacts on innate immune cells including dendritic cells, macrophages and neutrophils. In dendritic cell …
Adsorbed plasma proteins modulate the effects of single-walled carbon nanotubes on neutrophils in blood.
Vlasova II, et al. Nanomedicine 2016. PMID 27015767
In blood samples, all plasma proteins mitigated damage of neutrophils observed just after blood exposure to PEG-SWCNTs, while only treatment of PEG-SWCNTs with IgG resulted in dose- and time-dependent enhancement of CNT-induced neutrophil activation and in potentiation of oxidative stress. Our study demonstrates the ability of adsorbed plasma proteins to influence neutrophil response caused by PEG-SWCNTs in whole blood....
In blood samples, all plasma proteins mitigated damage of neutrophils observed just after blood exposure to PEG-SWCNTs, while only tr …
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