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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1967 1
1968 4
1969 9
1970 14
1971 18
1972 27
1973 29
1974 53
1975 63
1976 77
1977 109
1978 115
1979 127
1980 134
1981 170
1982 164
1983 200
1984 225
1985 237
1986 193
1987 219
1988 212
1989 264
1990 271
1991 310
1992 219
1993 250
1994 210
1995 197
1996 177
1997 198
1998 206
1999 193
2000 204
2001 219
2002 223
2003 186
2004 187
2005 217
2006 238
2007 246
2008 258
2009 307
2010 243
2011 319
2012 380
2013 458
2014 456
2015 460
2016 457
2017 428
2018 438
2019 198
2020 5
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10,325 results
Results by year
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Page 1
Neutrophil extracellular traps in immunity and disease.
Papayannopoulos V. Nat Rev Immunol 2018 - Review. PMID 28990587
Neutrophils are innate immune phagocytes that have a central role in immune defence. Our understanding of the role of neutrophils in pathogen clearance, immune regulation and disease pathology has advanced dramatically in recent years. Web-like chromatin structures known as neutrophil extracellular traps (NETs) have been at the forefront of this renewed interest in neutrophil biology. ...
Neutrophils are innate immune phagocytes that have a central role in immune defence. Our understanding of the role of neutrophils
Neutrophils in cancer: neutral no more.
Coffelt SB, et al. Nat Rev Cancer 2016 - Review. PMID 27282249
Neutrophils are indispensable antagonists of microbial infection and facilitators of wound healing. In the cancer setting, a newfound appreciation for neutrophils has come into view. The traditionally held belief that neutrophils are inert bystanders is being challenged by the recent literature. Emerging evidence indicates that tumours manipulate neutrophils, sometimes early in their differentiation process, to create diverse phenotypic and functional polarization states able to alter tumour behaviour. ...
Neutrophils are indispensable antagonists of microbial infection and facilitators of wound healing. In the cancer setting, a newfound
Neutrophils: New insights and open questions.
Ley K, et al. Sci Immunol 2018 - Review. PMID 30530726
Neutrophils take their cues directly from the infectious organism, from tissue macrophages and other elements of the immune system. Here, we review how neutrophils traffic to sites of infection or tissue injury, how they trap and kill bacteria, how they shape innate and adaptive immune responses, and the pathophysiology of monogenic neutrophil disorders....
Neutrophils take their cues directly from the infectious organism, from tissue macrophages and other elements of the immune system. H
Neutrophil plasticity in the tumor microenvironment.
Giese MA, et al. Blood 2019 - Review. PMID 30898857 Free PMC article.
Neutrophils display plasticity, with the ability to adapt their function in different inflammatory contexts. In the tumor microenvironment, neutrophils have varied functions and have been classified using different terms, including N1/N2 neutrophils, tumor-associated neutrophils, and polymorphonuclear neutrophil myeloid-derived suppressor cells (PMN-MDSCs). ...In this review, we will discuss neutrophil polarization and plasticity and the function of proinflammatory/anti-inflammatory and protumor/antitumor neutrophils in the tumor microenvironment. ...
Neutrophils display plasticity, with the ability to adapt their function in different inflammatory contexts. In the tumor microenviro
Heterogeneity of neutrophils.
Ng LG, et al. Nat Rev Immunol 2019 - Review. PMID 30816340
However, there are no established models that can be used to define the diversity of neutrophils, the most abundant myeloid cells. ...This perception is rapidly evolving as multiple phenotypic and functional variants of neutrophils have been found, both in homeostatic and disease conditions. ...
However, there are no established models that can be used to define the diversity of neutrophils, the most abundant myeloid cells. .. …
Neutrophils Kill Antibody-Opsonized Cancer Cells by Trogoptosis.
Matlung HL, et al. Cell Rep 2018. PMID 29949776 Free article.
However, the mechanism(s) by which neutrophils kill antibody-opsonized cancer cells has not been established. Here, we demonstrate that neutrophils can exert a mode of destruction of cancer cells, which involves antibody-mediated trogocytosis by neutrophils. ...Furthermore, this mode of destruction of antibody-opsonized cancer cells by neutrophils is potentiated by CD47-SIRPα checkpoint blockade. ...
However, the mechanism(s) by which neutrophils kill antibody-opsonized cancer cells has not been established. Here, we demonstrate th …
The enigmatic neutrophil: what we do not know.
Kubes P. Cell Tissue Res 2018 - Review. PMID 29404726
With this renewed interest in the neutrophil and its numerous new functions, it is worth examining not what we know but rather what we do not know and what still needs to be more thoroughly examined. In this review, consideration is given to such topics as neutrophil subtypes, neutrophil differentiation, neutrophil as a director of immunity, neutrophil residency and ultimately death of the neutrophil....
With this renewed interest in the neutrophil and its numerous new functions, it is worth examining not what we know but rather what w …
Understanding the Multifaceted Role of Neutrophils in Cancer and Autoimmune Diseases.
Wang X, et al. Front Immunol 2018 - Review. PMID 30473691 Free PMC article.
N1 and N2 neutrophils or high density neutrophils (HDNs) and low density neutrophils (LDNs) have been used to distinguish neutrophils subpopulations with pro- vs. anti-tumor activity, respectively. ...Given the heterogeneity and functional plasticity of neutrophils, it is necessary to understand the phenotypical and functional features of neutrophils in disease status. ...
N1 and N2 neutrophils or high density neutrophils (HDNs) and low density neutrophils (LDNs) have been used to distingui …
Neutrophil cell surface receptors and their intracellular signal transduction pathways.
Futosi K, et al. Int Immunopharmacol 2013 - Review. PMID 23994464 Free PMC article.
Neutrophils express a large number of cell surface receptors for the recognition of pathogen invasion and the inflammatory environment. ...This knowledge is crucial for understanding how neutrophils participate in antimicrobial host defense and inflammatory tissue damage and may also point to possible future targets of the pharmacological therapy of neutrophil-mediated autoimmune or inflammatory diseases....
Neutrophils express a large number of cell surface receptors for the recognition of pathogen invasion and the inflammatory environmen
Update on Neutrophil Function in Severe Inflammation.
Mortaz E, et al. Front Immunol 2018 - Review. PMID 30356867 Free PMC article.
However, neutrophils can play a dual role and besides their antimicrobial function, deregulation of neutrophils and their hyperactivity can lead to tissue damage in severe inflammation or trauma. Neutrophils also have an important role in the modulation of the immune system in response to severe injury and trauma. In this review we will provide an overview of the current understanding of neutrophil subpopulations and their function during and post-infection and discuss the possible mechanisms of immune modulation by neutrophils in severe inflammation....
However, neutrophils can play a dual role and besides their antimicrobial function, deregulation of neutrophils and their hype …
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