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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1946 2
1947 4
1950 4
1951 4
1953 3
1954 1
1955 7
1956 1
1957 4
1958 4
1959 5
1960 8
1961 4
1962 4
1963 5
1964 11
1965 17
1966 11
1967 25
1968 20
1969 30
1970 19
1971 23
1972 33
1973 32
1974 38
1975 32
1976 33
1977 20
1978 28
1979 39
1980 29
1981 25
1982 31
1983 20
1984 20
1985 32
1986 55
1987 112
1988 188
1989 267
1990 375
1991 621
1992 929
1993 1411
1994 2130
1995 2580
1996 2710
1997 3159
1998 3196
1999 3414
2000 3565
2001 3611
2002 3729
2003 3746
2004 3779
2005 4069
2006 4083
2007 4132
2008 4108
2009 3941
2010 4022
2011 4047
2012 4084
2013 4079
2014 3848
2015 3671
2016 3460
2017 3350
2018 2987
2019 1491
2020 23
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87,795 results
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Page 1
Nitric oxide maintains endothelial redox homeostasis through PKM2 inhibition.
Siragusa M, et al. EMBO J 2019. PMID 31328803 Free PMC article.
Decreased nitric oxide (NO) bioavailability and oxidative stress are hallmarks of endothelial dysfunction and cardiovascular diseases. ...
Decreased nitric oxide (NO) bioavailability and oxidative stress are hallmarks of endothelial dysfunction and cardiovascular d …
Postoperative Inhaled Nitric Oxide Does Not Decrease Length of Stay in Pediatric Cardiac Surgery Admissions.
Wong J, et al. Pediatr Cardiol 2019. PMID 31446473
Of these, 726 (1.8%) received inhaled nitric oxide. Regression analyses demonstrated that inhaled nitric oxide was independently associated with increased length of stay, billed charges, and inpatient mortality. ...Of these, 195 (11.6%) received inhaled nitric oxide. Regression analyses demonstrated that inhaled nitric oxide was independently associated with a significant increase in length of stay and billed charges. ...
Of these, 726 (1.8%) received inhaled nitric oxide. Regression analyses demonstrated that inhaled nitric oxide w …
Modulation of Nitric Oxide Synthases by Oxidized LDLs: Role in Vascular Inflammation and Atherosclerosis Development.
Gliozzi M, et al. Int J Mol Sci 2019 - Review. PMID 31277498 Free PMC article.
The maintenance of physiological levels of nitric oxide (NO) produced by eNOS represents a key element for vascular endothelial homeostasis. ...
The maintenance of physiological levels of nitric oxide (NO) produced by eNOS represents a key element for vascular endothelia …
Endothelial Nitric Oxide Level as a Predictor of Coronary Complexity in Patients With Unstable Angina Pectoris.
Acara AC and Bolatkale M. Am J Med Sci 2019. PMID 31000423
RESULTS: The mean nitric oxide levels in the unstable angina pectoris group were lower than in the control group (P < 0.001). ...CONCLUSIONS: Nitric oxide may be considered as a novel biomarker in the prediction of coronary complexity in patients with unstable angina pectoris....

RESULTS: The mean nitric oxide levels in the unstable angina pectoris group were lower than in the control group (P < 0.001

Regulation of boar sperm functionality by the nitric oxide synthase/nitric oxide system.
Staicu FD, et al. J Assist Reprod Genet 2019. PMID 31325069 Free PMC article.
PURPOSE: Nitric oxide (NO) is a free radical synthesized mainly by nitric oxide synthases (NOSs). NO regulates many aspects in sperm physiology in different species. ...
PURPOSE: Nitric oxide (NO) is a free radical synthesized mainly by nitric oxide synthases (NOSs). NO regulates m …
Comparison of exhaled nitric oxide levels in pediatric patients with allergic rhinitis.
Sapsaprang S, et al. Int J Pediatr Otorhinolaryngol 2019. PMID 31369971
CONCLUSIONS: Exhaled nitric oxide may be elevated in children with AR that do not have concomitant asthma. This suggests exhaled nitric oxide may show utility as a parameter to monitor the severity of allergic rhinitis and to monitor the efficacy of the treatment. Physicians should consider comorbid AR when utilizing exhaled nitric oxide as a monitoring parameter in the treatment of asthma....
CONCLUSIONS: Exhaled nitric oxide may be elevated in children with AR that do not have concomitant asthma. This suggests exhal …
Structural insights into the mechanism of human soluble guanylate cyclase
Kang Y, et al. Nature 2019. PMID 31514202
Soluble guanylate cyclase (sGC) is the primary sensor of nitric oxide. It has a central role in nitric oxide signalling and has been implicated in many essential physiological processes and disease conditions. The binding of nitric oxide boosts the enzymatic activity of sGC. However, the mechanism by which nitric oxide activates the enzyme is unclear. ...
Soluble guanylate cyclase (sGC) is the primary sensor of nitric oxide. It has a central role in nitric oxide sig …
The Role of Nitric Oxide, ADMA, and Homocysteine in The Etiopathogenesis of Preeclampsia-Review.
Dymara-Konopka W and Laskowska M. Int J Mol Sci 2019 - Review. PMID 31195628 Free PMC article.
In this review, we will present the latest findings on the role of nitric oxide, asymmetric dimethylarginine (ADMA), and homocysteine in the etiopathogenesis of preeclampsia and their possible clinical implications....
In this review, we will present the latest findings on the role of nitric oxide, asymmetric dimethylarginine (ADMA), and homoc …
Supplementary Nitric Oxide Donors and Exercise as Potential Means to Improve Vascular Health in People with Type 1 Diabetes: Yes to NO?
McCarthy O, et al. Nutrients 2019 - Review. PMID 31336832 Free PMC article.
Vascular dysfunction has been shown at the level of the endothelial layers and failure to maintain a continuous pool of circulating nitric oxide (NO) has been implicated in the progression of poor vascular health. Biochemically, NO can be produced via two distinct yet inter-related pathways that involve an upregulation in the enzymatic activity of nitric oxide synthase (NOS). ...
Vascular dysfunction has been shown at the level of the endothelial layers and failure to maintain a continuous pool of circulating nitri
The Role of Metabolic Flexibility in the Regulation of the DNA Damage Response by Nitric Oxide.
Oleson BJ, et al. Mol Cell Biol 2019. PMID 31235477 Free PMC article.
In this report, we show that nitric oxide suppresses DNA damage response (DDR) signaling in the pancreatic β-cell line INS 832/13 and rat islets by inhibiting intermediary metabolism. Nitric oxide is known to inhibit complex IV of the electron transport chain and aconitase of the Krebs cycle. Non-β cells compensate by increasing glycolytic metabolism to maintain ATP levels; however, β cells lack this metabolic flexibility, resulting in a nitric oxide-dependent decrease in ATP and NAD(+) Like nitric oxide, mitochondrial toxins inhibit DDR signaling in β cells by a mechanism that is associated with a decrease in ATP. ...
In this report, we show that nitric oxide suppresses DNA damage response (DDR) signaling in the pancreatic β-cell line INS 832 …
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