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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1987 3
1988 9
1989 9
1990 7
1991 10
1992 15
1993 22
1994 16
1995 21
1996 21
1997 36
1998 32
1999 32
2000 32
2001 46
2002 49
2003 52
2004 36
2005 54
2006 40
2007 41
2008 35
2009 38
2010 47
2011 22
2012 38
2013 35
2014 33
2015 31
2016 42
2017 41
2018 31
2019 6
2020 0
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908 results
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Page 1
Isavuconazole: A new broad-spectrum azole. Part 2: pharmacokinetics and clinical activity.
Ledoux MP, et al. J Mycol Med 2018 - Review. PMID 29551442
The most relevant pharmacokinetics features are water-solubility of the prodrug, rapid cleavage of the prodrug into active moiety and cleavage product by plasmatic esterases, high oral bioavailability of isavuconazole with an extensive penetration into most tissues and a good safety profile even in case of renal impairment. ...
The most relevant pharmacokinetics features are water-solubility of the prodrug, rapid cleavage of the prodrug into active moiety and …
The clinical pharmacokinetics of escitalopram.
Rao N. Clin Pharmacokinet 2007 - Review. PMID 17375980
Escitalopram and S-DCT exhibit linear and dose-proportional pharmacokinetics following single or multiple doses in the 10-30 mg/day dose range. ...The favourable pharmacokinetic profile of escitalopram suggests clinical utility in a broad range of patients....
Escitalopram and S-DCT exhibit linear and dose-proportional pharmacokinetics following single or multiple doses in the 10-30 mg/day d …
The use of aromatase inhibitors in boys with short stature: what to know before prescribing?
Linardi A, et al. Arch Endocrinol Metab 2017 - Review. PMID 28977209 Free article.
In this review, we describe the pharmacokinetic profile of both drugs, discussing possible drug interactions between ANZ and LTZ with other drugs. ...Therefore, it is important to understand the pharmacokinetics of AIs, recognizing and avoiding possible drug interactions and offering a safer prescription profile of this class of aromatase inhibitors. ...
In this review, we describe the pharmacokinetic profile of both drugs, discussing possible drug interactions between ANZ and LTZ with …
Anastrozole
Kelly CM and Buzdar AU. Expert Opin Drug Saf 2010 - Review. PMID 20923259
AREAS COVERED IN THIS REVIEW: This review discusses the mechanism of action of anastrozole; pharmacokinetic and pharmacodynamic characteristics; results of randomized controlled trials of anastrozole compared to tamoxifen in the adjuvant treatment of postmenopausal women with hormone receptor-positive breast cancer and the safety profile of anastrozole compared to tamoxifen. ...
AREAS COVERED IN THIS REVIEW: This review discusses the mechanism of action of anastrozole; pharmacokinetic and pharmacodynamic chara …
Escitalopram
Burke WJ. Expert Opin Investig Drugs 2002 - Review. PMID 12387707
Escitalopram has linear pharmacokinetics, so that plasma levels increase proportionately and predictably with increased doses and its half-life of 27 - 32 h is consistent with once-daily dosing. ...
Escitalopram has linear pharmacokinetics, so that plasma levels increase proportionately and predictably with increased doses and its …
Isavuconazole Kinetic Exploration for Clinical Practice
Darnaud L, et al. Drugs R D 2018. PMID 30306415 Free PMC article.
s population-pharmacokinetic model, it is possible to estimate a patient's most likely pharmacokinetic profile. If a patient's pharmacokinetic profile is close to the profiles reported by Desai et al., therapeutic drug monitoring is not required. ...CONCLUSIONS: Collecting one blood sample just before the first maintenance dose to make an early estimation of the patient's most likely pharmacokinetic profile is one method of identifying patients with outlier pharmacokinetic behavior....
s population-pharmacokinetic model, it is possible to estimate a patient's most likely pharmacokinetic profile. If a patient's …
Effects of psoralen on the pharmacokinetics of anastrozole in rats.
Zhang Y, et al. Pharm Biol 2018. PMID 30345900 Free PMC article.
OBJECTIVE: This study investigates the effects of psoralen on the pharmacokinetics of anastrozole in rats and its potential mechanism. MATERIALS AND METHODS: The pharmacokinetics of orally administered anastrozole (0.5 mg/kg) with (test group) or without (Control group) psoralen pretreatment (20 mg/kg/day for 10 days) in male Sprague-Dawley rats (six rats in each group) were investigated. ...
OBJECTIVE: This study investigates the effects of psoralen on the pharmacokinetics of anastrozole in rats and its potential mechanism …
Bioimaging predictors of rilpivirine biodistribution and antiretroviral activities
Ottemann BM, et al. Biomaterials 2018. PMID 30245386 Free PMC article.
However, novel ARV design has been slowed by prolonged pharmacokinetic testing requirements. To such ends, tri-modal theranostic nanoparticles were created with single-photon emission computed tomography (SPECT/CT), magnetic resonance imaging (MRI) and fluorescence capabilities to predict LASER ART biodistribution. ...
However, novel ARV design has been slowed by prolonged pharmacokinetic testing requirements. To such ends, tri-modal theranostic nano …
Pharmacokinetic evaluation of a transdermal anastrozole-in-adhesive formulation.
Regenthal R, et al. Drug Des Devel Ther 2018. PMID 30464397 Free PMC article.
CONCLUSION: These results provide the basis for establishing the transdermal application of anastrozole with improved pharmacokinetics and drug safety as novel therapeutic approach and promising option to treat human BC by decreasing the high burden of unwanted side effects....
CONCLUSION: These results provide the basis for establishing the transdermal application of anastrozole with improved pharmacokinetics
Comparative pharmacokinetics study of anastrozole after single administration and combination with celecoxib.
Sun X, et al. Xenobiotica 2018. PMID 28906164
Hence, this study was conducted to investigate the comparative pharmacokinetics of anastrozole after single administration and combination with celecoxib. 2. ...
Hence, this study was conducted to investigate the comparative pharmacokinetics of anastrozole after single administration and combin …
908 results
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