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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1952 1
1953 3
1954 13
1955 13
1956 29
1957 28
1958 26
1959 18
1960 12
1961 14
1962 23
1963 49
1964 86
1965 55
1966 52
1967 71
1968 101
1969 114
1970 67
1971 83
1972 89
1973 83
1974 104
1975 79
1976 56
1977 70
1978 48
1979 47
1980 43
1981 49
1982 54
1983 47
1984 50
1985 33
1986 31
1987 30
1988 37
1989 24
1990 33
1991 17
1992 26
1993 20
1994 28
1995 18
1996 17
1997 22
1998 17
1999 21
2000 14
2001 20
2002 30
2003 24
2004 27
2005 27
2006 29
2007 29
2008 34
2009 32
2010 29
2011 41
2012 37
2013 45
2014 40
2015 40
2016 35
2017 46
2018 49
2019 21
2020 0
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2,626 results
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Page 1
Updated Nitrofurantoin Recommendations in the Elderly: A Closer Look at the Evidence.
Hoang P and Salbu RL. Consult Pharm 2016 - Review. PMID 27412314
The American Geriatrics Society 2015 Beers Criteria Update Expert Panel has revised its recommendation to avoid use of nitrofurantoin in renal impairment from patients with a creatinine clearance (Clcr) of less than 60 mL/min to those with a Clcr of less than 30 mL/min, based on two retrospective studies that identified the safety and efficacy of nitrofurantoin in this population. ...The purpose of the manuscript is to provide readers with a brief review of updated evidence to confidently treat older patients with nitrofurantoin....
The American Geriatrics Society 2015 Beers Criteria Update Expert Panel has revised its recommendation to avoid use of nitrofurantoin
Effect of 5-Day Nitrofurantoin vs Single-Dose Fosfomycin on Clinical Resolution of Uncomplicated Lower Urinary Tract Infection in Women: A Randomized Clinical Trial.
Huttner A, et al. JAMA 2018 - Clinical Trial. PMID 29710295 Free PMC article.
IMPORTANCE: The use of nitrofurantoin and fosfomycin has increased since guidelines began recommending them as first-line therapy for lower urinary tract infection (UTI). OBJECTIVE: To compare the clinical and microbiologic efficacy of nitrofurantoin and fosfomycin in women with uncomplicated cystitis. ...
IMPORTANCE: The use of nitrofurantoin and fosfomycin has increased since guidelines began recommending them as first-line therapy for …
Nitrofurantoin's efficacy and safety as prophylaxis for urinary tract infections: a systematic review of the literature and meta-analysis of controlled trials.
Muller AE, et al. Clin Microbiol Infect 2017 - Review. PMID 27542332 Free article.
When compared with no prophylaxis, nitrofurantoin is effective in the prevention of UTI (risk ratio 0.38 in favour of nitrofurantoin, 95% CI 0.30-0.48). ...Cohort studies reported severe adverse effect frequencies of 0.02-1.5 per 1000 nitrofurantoin users. CONCLUSIONS: Nitrofurantoin is effective in the prevention of UTI. ...
When compared with no prophylaxis, nitrofurantoin is effective in the prevention of UTI (risk ratio 0.38 in favour of nitrofuranto
Nitrofurantoin revisited: a systematic review and meta-analysis of controlled trials.
Huttner A, et al. J Antimicrob Chemother 2015 - Review. PMID 26066581
We conducted a systematic review and meta-analysis to assess nitrofurantoin's efficacy and toxicity in the treatment of lower UTI. ...Acquisition of resistance to nitrofurantoin is still relatively rare. CONCLUSIONS: When given short term for lower UTI, nitrofurantoin has good clinical and microbiological efficacy; toxicity is mild and predominantly gastrointestinal....
We conducted a systematic review and meta-analysis to assess nitrofurantoin's efficacy and toxicity in the treatment of lower UTI. .. …
An update on the management of urinary tract infections in the era of antimicrobial resistance
Bader MS, et al. Postgrad Med 2017 - Review. PMID 27712137
The recommended first-line empiric therapies for acute uncomplicated bacterial cystitis in otherwise healthy adult nonpregnant females is a 5-day course of nitrofurantion or a 3-g single dose of fosfomycin tromethamine. ...Current treatment options for UTIs due to AmpC- β -lactamase-producing organisms include fosfomycin, nitrofurantion, fluoroquinolones, cefepime, piperacillin-tazobactam and carbapenems. ...
The recommended first-line empiric therapies for acute uncomplicated bacterial cystitis in otherwise healthy adult nonpregnant females is a …
Nitrofurantoin vs other prophylactic agents in reducing recurrent urinary tract infections in adult women: a systematic review and meta-analysis.
Price JR, et al. Am J Obstet Gynecol 2016 - Review. PMID 27457111
Randomized control trials of women with recurrent urinary tract infections comparing nitrofurantoin with any other treatment were included. ...CONCLUSION: Nitrofurantoin had similar efficacy but a greater risk of adverse events than other prophylactic treatments. Balancing the risks of adverse events, particularly gastrointestinal symptoms, with potential benefits of decreasing collateral ecological damage should be considered if selecting nitrofurantoin....
Randomized control trials of women with recurrent urinary tract infections comparing nitrofurantoin with any other treatment were inc …
Five-day nitrofurantoin is better than single-dose fosfomycin at resolving UTI symptoms.
[No authors listed] Drug Ther Bull 2018 - Clinical Trial. PMID 30297448
Review of: Huttner A et al Effect of 5-day nitrofurantoin vs single dose fosfomycin on clinical resolution of uncomplicated lower urinary tract infection in women. ...
Review of: Huttner A et al Effect of 5-day nitrofurantoin vs single dose fosfomycin on clinical resolution of uncomplicated lower uri …
Nitrofurantoin contraindication in patients with a creatinine clearance below 60 mL/min: looking for the evidence.
Oplinger M and Andrews CO. Ann Pharmacother 2013 - Review. PMID 23341159
OBJECTIVE: To investigate the evidence leading to nitrofurantoin contraindication in patients with a creatinine clearance (CrCl) below 60 mL/min. ...CONCLUSIONS: Data supporting the contraindication of nitrofurantoin for patients with a CrCl less than 60 mL/min are nonexistent. ...
OBJECTIVE: To investigate the evidence leading to nitrofurantoin contraindication in patients with a creatinine clearance (CrCl) belo …
Diagnosis and treatment of urinary tract infections across age groups
Chu CM and Lowder JL. Am J Obstet Gynecol 2018 - Review. PMID 29305250
Most uropathogens still display good sensitivity to nitrofurantoin. First-line treatments for urinary tract infection include nitrofurantoin, fosfomycin, and trimethoprim-sulfamethoxazole (when resistance levels are <20%). ...In pregnancy, beta-lactams, nitrofurantoin, fosfomycin, and trimethoprim-sulfamethoxazole can be appropriate treatments. Interpreting the probability of urinary tract infection based on symptoms and testing allows for greater accuracy in diagnosis of urinary tract infection, decreasing overtreatment and encouraging antimicrobial stewardship....
Most uropathogens still display good sensitivity to nitrofurantoin. First-line treatments for urinary tract infection include nitr
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