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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1999 1
2000 1
2001 22
2002 64
2003 42
2004 61
2005 53
2006 67
2007 86
2008 99
2009 101
2010 110
2011 119
2012 141
2013 119
2014 106
2015 141
2016 131
2017 117
2018 84
2019 34
2020 1
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1,539 results
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Page 1
The nuclear pore complex: understanding its function through structural insight.
Beck M and Hurt E. Nat Rev Mol Cell Biol 2017 - Review. PMID 27999437
Nuclear pore complexes (NPCs) fuse the inner and outer nuclear membranes to form channels across the nuclear envelope. They are large macromolecular assemblies with a complex composition and diverse functions. ...
Nuclear pore complexes (NPCs) fuse the inner and outer nuclear membranes to form channels across the nuclear env
Integrative structure and functional anatomy of a nuclear pore complex.
Kim SJ, et al. Nature 2018. PMID 29539637 Free PMC article.
These cables also tie together all other elements of the nuclear pore complex, including membrane-interacting regions, outer rings and RNA-processing platforms. ...This integrative structure enables us to rationalize the architecture, transport mechanism and evolutionary origins of the nuclear pore complex....
These cables also tie together all other elements of the nuclear pore complex, including membrane-interacting regions, …
Moonlighting nuclear pore proteins: tissue-specific nucleoporin function in health and disease.
Jühlen R and Fahrenkrog B. Histochem Cell Biol 2018 - Review. PMID 30361777
The nuclear pore complex is the main transportation hub for exchange between the cytoplasm and the nucleus. It is built from nucleoporins that form distinct subcomplexes to establish this huge protein complex in the nuclear envelope. ...On the other hand, nucleoporins forming the scaffold structure of the nuclear pore complex are eminently mutation-prone. These novel and exciting associations between nucleoporins and human diseases emphasize the need to shed light on these unanticipated tissue-specific roles of nucleoporins that may go well beyond their role in nucleocytoplasmic transport. ...
The nuclear pore complex is the main transportation hub for exchange between the cytoplasm and the nucleus. It is built …
The nuclear pore complex--structure and function at a glance.
Kabachinski G and Schwartz TU. J Cell Sci 2015 - Review. PMID 26046137 Free PMC article.
Nuclear pore complexes (NPCs) are indispensable for cell function and are at the center of several human diseases. NPCs provide access to the nucleus and regulate the transport of proteins and RNA across the nuclear envelope. ...Our aim is to provide a general overview on what we currently know about the nuclear pore and point out directions of research this area is heading to....
Nuclear pore complexes (NPCs) are indispensable for cell function and are at the center of several human diseases. NPCs provid
The roles of the nuclear pore complex in cellular dysfunction, aging and disease.
Sakuma S and D'Angelo MA. Semin Cell Dev Biol 2017 - Review. PMID 28506892 Free PMC article.
The study of the Nuclear Pore Complex (NPC), the proteins that compose it (nucleoporins), and the nucleocytoplasmic transport that it controls have revealed an unexpected layer to pathogenic disease onset and progression. ...
The study of the Nuclear Pore Complex (NPC), the proteins that compose it (nucleoporins), and the nucleocytoplas …
Mechanisms of nuclear pore complex assembly - two different ways of building one molecular machine.
Otsuka S and Ellenberg J. FEBS Lett 2018 - Review. PMID 29119545 Free PMC article.
The nuclear pore complex (NPC) mediates all macromolecular transport across the nuclear envelope. In higher eukaryotes that have an open mitosis, NPCs assemble at two points in the cell cycle: during nuclear assembly in late mitosis and during nuclear growth in interphase. ...We furthermore integrate understanding of NPC assembly with the mechanisms for rapid nuclear growth in embryos and, finally, speculate on the evolutionary origin of the NPC implied by the presence of two distinct assembly mechanisms....
The nuclear pore complex (NPC) mediates all macromolecular transport across the nuclear envelope. In higher euka …
Mutant Huntingtin Disrupts the Nuclear Pore Complex.
Grima JC, et al. Neuron 2017. PMID 28384479 Free PMC article.
Nucleocytoplasmic transport, the trafficking of macromolecules between the nucleus and cytoplasm, is tightly regulated by nuclear pore complexes (NPCs) made up of nucleoporins (NUPs). ...HD repeat-associated non-ATG (RAN) translation proteins also disrupted nucleocytoplasmic transport. Additionally, overexpression of NUPs and treatment with drugs that prevent aberrant NUP biology also mitigated this transport defect and neurotoxicity, providing future novel therapy targets....
Nucleocytoplasmic transport, the trafficking of macromolecules between the nucleus and cytoplasm, is tightly regulated by nuclear
Structural dynamics of the nuclear pore complex.
Sakiyama Y, et al. Semin Cell Dev Biol 2017 - Review. PMID 28579449
Nuclear pore complexes (NPCs) are the sole conduits that facilitate macromolecular exchange between the nucleus and cytosol. ...Moreover, we postulate that structural flexibility might resonate throughout the NPC framework from the cytoplasmic filaments to the nuclear basket....
Nuclear pore complexes (NPCs) are the sole conduits that facilitate macromolecular exchange between the nucleus and cytosol. .
The functional versatility of the nuclear pore complex proteins.
Hezwani M and Fahrenkrog B. Semin Cell Dev Biol 2017 - Review. PMID 28506894
Over the past few decades, it is increasingly evident that nucleoporins are multi-functional proteins that are not only pivotal for the formation of the nuclear pore complex. ...
Over the past few decades, it is increasingly evident that nucleoporins are multi-functional proteins that are not only pivotal for t …
Nuclear pore proteins and the control of genome functions.
Ibarra A and Hetzer MW. Genes Dev 2015 - Review. PMID 25691464 Free PMC article.
Nuclear pore complexes (NPCs) are composed of several copies of ∼30 different proteins called nucleoporins (Nups). NPCs penetrate the nuclear envelope (NE) and regulate the nucleocytoplasmic trafficking of macromolecules. ...Here we discuss genome-related functions of Nups and their impact on essential DNA metabolism processes such as transcription, chromosome duplication, and segregation....
Nuclear pore complexes (NPCs) are composed of several copies of ∼30 different proteins called nucleoporins (Nups). NPCs
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