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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1946 8
1947 9
1948 14
1949 20
1950 17
1951 29
1952 29
1953 27
1954 42
1955 30
1956 33
1957 38
1958 67
1959 54
1960 44
1961 64
1962 67
1963 128
1964 202
1965 179
1966 190
1967 235
1968 275
1969 349
1970 389
1971 444
1972 515
1973 506
1974 565
1975 551
1976 537
1977 578
1978 731
1979 578
1980 634
1981 595
1982 635
1983 673
1984 687
1985 759
1986 742
1987 894
1988 1242
1989 1672
1990 2207
1991 2492
1992 2952
1993 3854
1994 4696
1995 5842
1996 6844
1997 8244
1998 9943
1999 11033
2000 12409
2001 13497
2002 13731
2003 14397
2004 15654
2005 16343
2006 17294
2007 17817
2008 18620
2009 19629
2010 20708
2011 22085
2012 23368
2013 24001
2014 24095
2015 24278
2016 23189
2017 22278
2018 21067
2019 9972
2020 180
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409,011 results
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Page 1
Dynamic regulation of nucleolar architecture
Németh A and Grummt I. Curr Opin Cell Biol 2018 - Review. PMID 29529563
The nucleolus is the largest nuclear sub-compartment in which the early steps of ribosome biogenesis take place. It also plays an essential role in the assembly and function of non-ribosomal ribonucleoprotein (RNP) complexes, controls cell cycle progression and senses environmental stress. The spatial organization and dynamics of nucleolar proteins and RNA is regulated at different structural levels, which finally determine nucleolar architecture. ...
The nucleolus is the largest nuclear sub-compartment in which the early steps of ribosome biogenesis take place. It also plays an ess …
Nuclear proteins as gene-transfer vectors.
Haberland A and Böttger M. Biotechnol Appl Biochem 2005 - Review. PMID 16171462
An interest in nuclear proteins as possible gene vectors arose as early as 1988. Nuclear proteins possess important features, such as DNA condensing capacity and the presence of NLSs (nuclear localization signals), which are thought to be perfect tools to combine cellular and nuclear uptake of DNA. ...In the pertinent published data, almost all nuclear proteins tested showed gene-transfer activity. The degree of activity of the individual nuclear proteins tested varied according to sequential and structural differences of the proteins, discriminating their DNA binding behaviour, but reported transfection efficiency differences are inconsistent. ...
An interest in nuclear proteins as possible gene vectors arose as early as 1988. Nuclear proteins possess import …
Rev7 dimerization is important for assembly and function of the Rev1/Polζ translesion synthesis complex
Rizzo AA, et al. Proc Natl Acad Sci U S A 2018. PMID 30111544 Free PMC article.
Rev7 interacts with Rev3 by a mechanism conserved among HORMA proteins, whereby an open-to-closed transition locks the ligand underneath the "safety belt" loop. Dimerization of HORMA proteins promotes binding and release of this ligand, as exemplified by the Rev7 homolog, Mad2. Here, we investigate the dimerization of Rev7 when bound to the two Rev7-binding motifs (RBMs) in Rev3 by combining in vitro analyses of Rev7 structure and interactions with a functional assay in a Rev7(-/-) cell line. ...
Rev7 interacts with Rev3 by a mechanism conserved among HORMA proteins, whereby an open-to-closed transition locks the ligand underne …
Small-molecule PROTAC degraders of the Bromodomain and Extra Terminal (BET) proteins - A review.
Yang CY, et al. Drug Discov Today Technol 2019 - Review. PMID 31200858
The BET proteins, comprised of BRD2, BRD3, BRD4 and the testis-specific BRDT protein, are epigenetic readers and master transcription coactivators. Extremely potent and efficacious small-molecule PROTAC degraders of the BET proteins, based on available, potent and selective BET inhibitors, have been reported. ...
The BET proteins, comprised of BRD2, BRD3, BRD4 and the testis-specific BRDT protein, are epigenetic readers and master transcription …
The Emerging Role of MORC Family Proteins in Cancer Development and Bone Homeostasis.
Hong G, et al. J Cell Physiol 2017 - Review. PMID 27791268
Microrchidia (MORC or MORC family CW-type zinc finger protein), a highly conserved nuclear protein superfamily, is an interesting new player in signaling-dependent chromatin remodeling and epigenetic regulation. ...Here we discuss recent research progress on the emerging role of MORC proteins in cancer development and bone metabolism. Unravelling the cellular and molecular mechanisms by which MORC proteins carry out their functions in a tissue specific manner are important subjects for future investigation. ...
Microrchidia (MORC or MORC family CW-type zinc finger protein), a highly conserved nuclear protein superfamily, is an interesting new …
Pellino1 regulates reversible ATM activation via NBS1 ubiquitination at DNA double-strand breaks
Ha GH, et al. Nat Commun 2019. PMID 30952868 Free PMC article.
They rely on highly coordinated processes including posttranslational modifications of proteins. Here we show that Pellino1 (Peli1) is a DSB-responsive ubiquitin ligase required for the accumulation of DNA damage response proteins and efficient homologous recombination (HR) repair. ...
They rely on highly coordinated processes including posttranslational modifications of proteins. Here we show that Pellino1 (Peli1) i …
409,011 results
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