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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1948 2
1950 1
1952 2
1955 1
1956 2
1958 4
1959 6
1960 4
1961 10
1962 1
1963 10
1964 15
1965 7
1966 2
1967 1
1968 2
1973 1
1974 2
1976 2
1978 1
1980 5
1981 3
1982 5
1983 12
1984 13
1985 29
1986 33
1987 177
1988 423
1989 552
1990 719
1991 888
1992 1133
1993 1584
1994 1717
1995 1961
1996 2196
1997 2650
1998 3024
1999 3310
2000 3796
2001 3842
2002 3786
2003 3702
2004 4007
2005 3820
2006 3333
2007 3305
2008 3416
2009 3462
2010 3490
2011 3745
2012 3763
2013 3739
2014 3823
2015 3744
2016 3112
2017 2908
2018 2701
2019 1142
2020 18
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82,996 results
Results by year
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Page 1
Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16.
Zhang X, et al. Nat Chem Biol 2019. PMID 31209349 Free PMC article.
Here, we use a chemical proteomic strategy that leverages broadly reactive, cysteine-directed electrophilic fragments coupled to selective ligands for intracellular proteins (for example, SLF for FKBP12, JQ1 for BRD4) to screen for heterobifunctional degrader compounds (or proteolysis targeting chimeras, PROTACs) that operate by covalent adduction of E3 ligases. This approach identified DCAF16-a poorly characterized substrate recognition component of CUL4-DDB1 E3 ubiquitin ligases-as a target of electrophilic PROTACs that promote the nuclear-restricted degradation of proteins. ...
Here, we use a chemical proteomic strategy that leverages broadly reactive, cysteine-directed electrophilic fragments coupled to selective l …
Functional Proteomics of Nuclear Proteins in Tetrahymena thermophila: A Review.
Saettone A, et al. Genes (Basel) 2019 - Review. PMID 31052454 Free PMC article.
Despite significant progress in elucidation of nuclear proteomes and interactomes of organisms such as yeast and mammalian systems, progress in other models has lagged. Protists, including the alveolate ciliate protozoa with Tetrahymena thermophila as one of the most studied members of this group, have a unique nuclear biology, and nuclear dimorphism, with structurally and functionally distinct nuclei in a common cytoplasm. ...
Despite significant progress in elucidation of nuclear proteomes and interactomes of organisms such as yeast and mammalian systems, p …
Constitutional abnormality of nuclear membrane proteins in small cell lung carcinoma.
Wang J, et al. Virchows Arch 2019. PMID 31201505
Nuclear membrane proteins reportedly play important roles in maintaining nuclear structures and coordinating cell activities. Studying profiles of nuclear membrane proteins may help us evaluate the biological and/or clinical nature of malignant tumors. ...
Nuclear membrane proteins reportedly play important roles in maintaining nuclear structures and coordinating cell activ
Nuclear hnRNPA2B1 initiates and amplifies the innate immune response to DNA viruses.
Wang L, et al. Science 2019. PMID 31320558
It is unclear, however, how nuclear pathogen-derived DNA triggers innate immune responses. We report that heterogeneous nuclear ribonucleoprotein A2B1 (hnRNPA2B1) recognizes pathogenic DNA and amplifies interferon-α/β (IFN-α/β) production. Upon DNA virus infection, nuclear-localized hnRNPA2B1 senses viral DNA, homodimerizes, and is then demethylated at arginine-226 by the arginine demethylase JMJD6. ...
It is unclear, however, how nuclear pathogen-derived DNA triggers innate immune responses. We report that heterogeneous nuclear
Brain Proteome of Drosophila melanogaster Is Enriched with Nuclear Proteins.
Kuznetsova KG, et al. Biochemistry (Mosc) 2019. PMID 30927528 Free article.
Fourteen of 24 identified proteins have been annotated as nuclear proteins. Comparison of three used datasets by label-free quantitation showed statistically significant enrichment of the brain proteome with nuclear proteins. Therefore, we recommend the use of isolated brain preparations in the studies of Drosophila nuclear proteins....
Fourteen of 24 identified proteins have been annotated as nuclear proteins. Comparison of three used datasets by label- …
Arabidopsis FLL2 promotes liquid-liquid phase separation of polyadenylation complexes
Fang X, et al. Nature 2019. PMID 31043738 Free PMC article.
An important component of cellular biochemistry is the concentration of proteins and nucleic acids in non-membranous compartments(1,2). ...These 3' RNA-processing components colocalized with FCA in the nuclear bodies in vivo, which indicates that FCA nuclear bodies compartmentalize 3'-end processing factors to enhance polyadenylation at specific sites. ...
An important component of cellular biochemistry is the concentration of proteins and nucleic acids in non-membranous compartments(1,2 …
m6A-induced lncRNA RP11 triggers the dissemination of colorectal cancer cells via upregulation of Zeb1
Wu Y, et al. Mol Cancer 2019. PMID 30979372 Free PMC article.
Mechanistically, the RP11/hnRNPA2B1/mRNA complex accelerated the mRNA degradation of two E3 ligases, Siah1 and Fbxo45, and subsequently prevented the proteasomal degradation of Zeb1. m(6)A methylation was involved in the upregulation of RP11 by increasing its nuclear accumulation. ...
Mechanistically, the RP11/hnRNPA2B1/mRNA complex accelerated the mRNA degradation of two E3 ligases, Siah1 and Fbxo45, and subsequently prev …
82,996 results
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