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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1955 1
1958 1
1959 4
1960 3
1961 3
1962 1
1964 4
1965 22
1966 32
1967 48
1968 60
1969 77
1970 92
1971 107
1972 127
1973 138
1974 178
1975 154
1976 198
1977 229
1978 324
1979 246
1980 272
1981 257
1982 257
1983 276
1984 243
1985 269
1986 212
1987 272
1988 383
1989 514
1990 661
1991 949
1992 1327
1993 1898
1994 2251
1995 2780
1996 3364
1997 4210
1998 4675
1999 5160
2000 6086
2001 6965
2002 7358
2003 8016
2004 9093
2005 10107
2006 11359
2007 12016
2008 12888
2009 13928
2010 14782
2011 15899
2012 16982
2013 17500
2014 17026
2015 17128
2016 16581
2017 16062
2018 14975
2019 6813
2020 122
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256,111 results
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Page 1
Ki67, PCNA, and MCM proteins: Markers of proliferation in the diagnosis of breast cancer.
Juríková M, et al. Acta Histochem 2016 - Review. PMID 27246286
For example, Ki67, proliferating cell nuclear antigen (PCNA), and minichromosome maintenance (MCM) proteins are standard markers of proliferation that are commonly used to assess the growth fraction of a cell population. ...In contrast, PCNA and MCM proteins have been identified as important participants of DNA replication. All three proteins only manifest their expression during the cell division of normal and neoplastic cells. ...
For example, Ki67, proliferating cell nuclear antigen (PCNA), and minichromosome maintenance (MCM) proteins are standard marke …
Detection of Endogenous Nuclear Proteins in Plant Cells: Localizing Nuclear Matrix Constituent Proteins (NMCPs), the Plant Analogs of Lamins.
Ciska M and de la Espina SM. Methods Mol Biol 2017. PMID 28155164
In contrast, immunocytochemistry with specific antibodies represents a powerful tool for the localization of endogenous nuclear proteins at their "native" nuclear sub-compartments. ...Here we describe the application of this methodology to the localization of Nuclear Matrix Constituent Proteins (NMCP), the plant analogs of lamins, of the monocot Allium cepa, using antibodies raised against highly conserved regions of the proteins....
In contrast, immunocytochemistry with specific antibodies represents a powerful tool for the localization of endogenous nuclear pr
The Roles of MDM2 and MDMX in Cancer
Karni-Schmidt O, et al. Annu Rev Pathol 2016 - Review. PMID 27022975 Free PMC article.
These two proteins are best understood as negative regulators of the p53 tumor suppressor, although they may have additional p53-independent roles. ...Targeting the proteins themselves, or their regulators, may be a promising therapeutic approach to treating some forms of cancer....
These two proteins are best understood as negative regulators of the p53 tumor suppressor, although they may have additional p53-inde …
Nuclear envelopathies: a complex LINC between nuclear envelope and pathology.
Janin A, et al. Orphanet J Rare Dis 2017 - Review. PMID 28854936 Free PMC article.
These proteins can be part of the inner nuclear membrane (INM), such as emerin or SUN proteins, outer nuclear membrane (ONM), such as Nesprins, or the nuclear lamina, such as lamins A and C. ...For these reasons, the diagnosis and the identification of the molecular explanation of "nuclear envelopathies" is currently challenging.The aim of this review is to summarize the human diseases caused by mutations in genes coding for INM proteins, nuclear lamina, and ONM proteins, and to discuss their potential physiopathological mechanisms that could explain the large spectrum of observed symptoms....
These proteins can be part of the inner nuclear membrane (INM), such as emerin or SUN proteins, outer nuclear me …
The noncanonical NF-κB pathway
Sun SC. Immunol Rev 2012 - Review. PMID 22435551 Free PMC article.
The noncanonical nuclear factor-κB (NF-κB) signaling pathway mediates activation of the p52/RelB NF-κB complex and, thereby, regulates specific immunological processes. ...
The noncanonical nuclear factor-κB (NF-κB) signaling pathway mediates activation of the p52/RelB NF-κB complex and, thereby, regulate …
Biological function and histone recognition of family IV bromodomain-containing proteins.
Lloyd JT and Glass KC. J Cell Physiol 2018 - Review. PMID 28500727 Free PMC article.
Bromodomain proteins function as epigenetic readers that recognize acetylated histone tails to facilitate the transcription of target genes. ...The bromodomain-containing proteins in family IV include seven members (BRPF1, BRPF2, BRPF3, BRD7, BRD9, ATAD2, and ATAD2b). ...
Bromodomain proteins function as epigenetic readers that recognize acetylated histone tails to facilitate the transcription of target …
NLScore: a novel quantitative algorithm based on 3 dimensional structural determinants to predict the probability of nuclear localization in proteins containing classical nuclear localization signals.
Hari PS, et al. J Mol Model 2017. PMID 28791516
The presence of a nuclear localization signal (NLS) in proteins can be inferred by the presence of a stretch of basic amino acids (KRKK). ...Leave-one-out cross validation (LOOCV) showed that NLScore correctly predicted 78.6% and 81.6% of non-nuclear and nuclear proteins respectively. ...
The presence of a nuclear localization signal (NLS) in proteins can be inferred by the presence of a stretch of basic amino ac …
Bromodomain Histone Readers and Cancer
Jain AK and Barton MC. J Mol Biol 2017 - Review. PMID 27890782
Acetyl-lysine modifications create docking sites for bromodomains, which are structurally conserved modules present in transcription-associated proteins that are termed "reader" proteins. ...Many bromodomain-containing proteins are aberrantly expressed in diseases, as best studied in cancers, where bromodomain proteins impact the expression of oncogenes and anti-apoptotic proteins. ...
Acetyl-lysine modifications create docking sites for bromodomains, which are structurally conserved modules present in transcription-associa …
TIRR regulates 53BP1 by masking its histone methyl-lysine binding function
Drané P, et al. Nature 2017. PMID 28241136 Free PMC article.
Depletion of TIRR destabilizes 53BP1 in the nuclear-soluble fraction and alters the double-strand break-induced protein complex centring 53BP1. ...
Depletion of TIRR destabilizes 53BP1 in the nuclear-soluble fraction and alters the double-strand break-induced protein complex centr …
YEATS Domain-A Histone Acylation Reader in Health and Disease
Zhao D, et al. J Mol Biol 2017 - Review. PMID 28300602
Many of these PTMs are selectively recognized by dedicated effector proteins for normal cell growth and development, while dysregulation of these recognition events is often implicated in human diseases, notably cancer. ...
Many of these PTMs are selectively recognized by dedicated effector proteins for normal cell growth and development, while dysregulat …
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