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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1962 1
1963 3
1964 1
1967 1
1970 2
1971 3
1974 3
1976 1
1977 2
1978 6
1979 1
1980 4
1981 4
1982 8
1983 12
1984 7
1985 10
1986 3
1987 5
1988 6
1989 10
1990 3
1991 7
1992 11
1993 6
1994 11
1995 13
1996 21
1997 30
1998 47
1999 34
2000 49
2001 19
2002 20
2003 22
2004 22
2005 18
2006 19
2007 12
2008 26
2009 19
2010 16
2011 26
2012 23
2013 22
2014 13
2015 20
2016 32
2017 14
2018 17
2019 32
2020 18
2021 9
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684 results
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Page 1
[Development of innovative T-cell immunotherapy for hematological malignancies].
Ochi T. Ochi T. Rinsho Ketsueki. 2019;60(7):824-833. doi: 10.11406/rinketsu.60.824. Rinsho Ketsueki. 2019. PMID: 31391373 Review. Japanese.
With the emergence of cancer immunotherapy, T cells have played important roles in inducing antitumor responses. Many types of antitumor receptors, which possess tumor-binding sites and T-cell activation sites, have been developed. For example, genetically engineere …
With the emergence of cancer immunotherapy, T cells have played important roles in inducing antitumor responses. Many types of antitu …
Gene Modification and Immunological Analyses for the Development of Immunotherapy Utilizing T Cells Redirected with Antigen-Specific Receptors.
Ochi T, Maruta M, Hirano N. Ochi T, et al. Methods Mol Biol. 2019;2048:27-39. doi: 10.1007/978-1-4939-9728-2_3. Methods Mol Biol. 2019. PMID: 31396926
To achieve this, it is important to establish the ways (1) to generate optimal viral particle for T-cell transduction, (2) to transduce antitumor receptors into T cells and expand redirected T cells efficiently, and (3) to assess the functionality of antigen- …
To achieve this, it is important to establish the ways (1) to generate optimal viral particle for T-cell transduction, (2) to transdu …
Application of adoptive T-cell therapy using tumor antigen-specific T-cell receptor gene transfer for the treatment of human leukemia.
Ochi T, Fujiwara H, Yasukawa M. Ochi T, et al. J Biomed Biotechnol. 2010;2010:521248. doi: 10.1155/2010/521248. Epub 2010 May 5. J Biomed Biotechnol. 2010. PMID: 20454585 Free PMC article. Review.
Beginning with the identification of cancer antigens, followed by the clinical application of anti-cancer peptide vaccination, it has now been proven that adoptive T-cell therapy (ACT) using cancer antigen-specific T cells is the most effective option. ...Currently, …
Beginning with the identification of cancer antigens, followed by the clinical application of anti-cancer peptide vaccination, it has now be …
Requisite considerations for successful adoptive immunotherapy with engineered T-lymphocytes using tumor antigen-specific T-cell receptor gene transfer.
Ochi T, Fujiwara H, Yasukawa M. Ochi T, et al. Expert Opin Biol Ther. 2011 Jun;11(6):699-713. doi: 10.1517/14712598.2011.566853. Epub 2011 Mar 18. Expert Opin Biol Ther. 2011. PMID: 21413911 Review.
INTRODUCTION: Although engineered T-cell-based antitumor immunotherapy using tumor-antigen-specific T-cell receptor (TCR) gene transfer is undoubtedly a promising strategy, a number of studies have revealed that it has several drawbacks. ...Readers will be able to r …
INTRODUCTION: Although engineered T-cell-based antitumor immunotherapy using tumor-antigen-specific T-cell receptor (TCR) gene …
Novel immunotherapy for adult T-cell leukemia/lymphoma: Targeting aurora kinase A.
Casey NP, Fujiwara H, Ochi T, Yasukawa M. Casey NP, et al. Oncoimmunology. 2016 Oct 7;5(11):e1239006. doi: 10.1080/2162402X.2016.1239006. eCollection 2016. Oncoimmunology. 2016. PMID: 27999761 Free PMC article.
Adult T-cell leukemia/lymphoma is caused by infection with HTLV-1, following a long latent period. Immunotherapy targeting Aurora kinase A, a tumor-associated antigen over-expressed in adult T-cell leukemia/lymphoma, holds great therapeutic potential. We review the …
Adult T-cell leukemia/lymphoma is caused by infection with HTLV-1, following a long latent period. Immunotherapy targeting Aurora kin …
Novel adoptive T-cell immunotherapy using a WT1-specific TCR vector encoding silencers for endogenous TCRs shows marked antileukemia reactivity and safety.
Ochi T, Fujiwara H, Okamoto S, An J, Nagai K, Shirakata T, Mineno J, Kuzushima K, Shiku H, Yasukawa M. Ochi T, et al. Blood. 2011 Aug 11;118(6):1495-503. doi: 10.1182/blood-2011-02-337089. Epub 2011 Jun 14. Blood. 2011. PMID: 21673345 Free article.
Adoptive T-cell therapy for malignancies using redirected T cells genetically engineered by tumor antigen-specific T-cell receptor (TCR) gene transfer is associated with mispairing between introduced and endogenous TCR chains with unknown specificity. ...WT1- …
Adoptive T-cell therapy for malignancies using redirected T cells genetically engineered by tumor antigen-specific T-ce …
Perspectives on protein crystallisation.
Ochi T, Bolanos-Garcia VM, Stojanoff V, Moreno A. Ochi T, et al. Prog Biophys Mol Biol. 2009 Nov;101(1-3):56-63. doi: 10.1016/j.pbiomolbio.2009.12.001. Epub 2009 Dec 11. Prog Biophys Mol Biol. 2009. PMID: 20005246 Review.
Optimization of T-cell Reactivity by Exploiting TCR Chain Centricity for the Purpose of Safe and Effective Antitumor TCR Gene Therapy.
Ochi T, Nakatsugawa M, Chamoto K, Tanaka S, Yamashita Y, Guo T, Fujiwara H, Yasukawa M, Butler MO, Hirano N. Ochi T, et al. Cancer Immunol Res. 2015 Sep;3(9):1070-81. doi: 10.1158/2326-6066.CIR-14-0222. Epub 2015 May 5. Cancer Immunol Res. 2015. PMID: 25943533 Free PMC article.
Adoptive transfer of T cells redirected by a high-affinity antitumor T-cell receptor (TCR) is a promising treatment modality for cancer patients. ...However, it is still mandatory to carefully monitor for possible harmful toxicities caused by adoptive transfer of …
Adoptive transfer of T cells redirected by a high-affinity antitumor T-cell receptor (TCR) is a promising treatment modality f …
684 results
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