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Year Number of Results
1960 1
1982 1
1983 3
1984 19
1985 46
1986 127
1987 173
1988 175
1989 160
1990 156
1991 174
1992 176
1993 140
1994 151
1995 163
1996 159
1997 180
1998 163
1999 213
2000 207
2001 251
2002 224
2003 248
2004 237
2005 259
2006 298
2007 263
2008 245
2009 255
2010 242
2011 260
2012 284
2013 158
2014 99
2015 89
2016 100
2017 92
2018 82
2019 37
2020 1
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5,988 results
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Page 1
Fluoroquinolone-Associated Tendinopathy: Does Levofloxacin Pose the Greatest Risk?
Bidell MR and Lodise TP. Pharmacotherapy 2016 - Review. PMID 27138564
Although tendinopathy is considered a fluoroquinolone class-wide toxicity, data from in vitro studies, animal studies, patient-level analyses, and large national and international surveillance reports suggest that levofloxacin, as well as its parent compound ofloxacin, possess higher propensities to cause tendon damage relative to other fluoroquinolones. Risk with ofloxacin and levofloxacin appears to be exposure dependent, with higher doses and longer durations being most commonly associated with tendinopathy. ...
Although tendinopathy is considered a fluoroquinolone class-wide toxicity, data from in vitro studies, animal studies, patient-level analyse …
Pharmacokinetic study of ofloxacin enantiomers in Pagrosomus major by chiral HPLC.
Nie J, et al. Biomed Chromatogr 2016. PMID 26179954
However, the apparent volume of distribution and total body clearance of (S)-(-)-ofloxacin were greater than those of (R)-(+)-ofloxacin. The ratio of the (S)-(-)- to (R)-(+)-ofloxacin plasma concentration was always <1.0. Together, these data suggest that (S)-(-)-ofloxacin was preferentially excreted and (R)-(+)-ofloxacin was preferentially absorbed. ...
However, the apparent volume of distribution and total body clearance of (S)-(-)-ofloxacin were greater than those of (R)-(+)-oflo
Limited Effect of Later-Generation Fluoroquinolones in the Treatment of Ofloxacin-Resistant and Moxifloxacin-Susceptible Multidrug-Resistant Tuberculosis.
Lee H, et al. Antimicrob Agents Chemother 2018. PMID 29203478 Free PMC article.
Overall, 171 patients (82%) had ofloxacin-susceptible, moxifloxacin-susceptible MDR-TB (ofloxacin-susceptible group), and 37 (18%) had ofloxacin-resistant, moxifloxacin-susceptible MDR-TB (ofloxacin-resistant group). ...Favorable outcomes were more frequently achieved for the ofloxacin-susceptible group than for the ofloxacin-resistant group (91% [156/171] versus 57% [21/37], respectively [P < 0.001]). ...
Overall, 171 patients (82%) had ofloxacin-susceptible, moxifloxacin-susceptible MDR-TB (ofloxacin-susceptible group), and 37 ( …
Degradation of Ofloxacin by Perylene Diimide Supramolecular Nanofiber Sunlight-Driven Photocatalysis.
Chen P, et al. Environ Sci Technol 2019. PMID 30604606
Reactive species, namely, h(+), (1)O(2), and O(2)(•-), comprised the primary photocatalytic mechanisms for ofloxacin degradation. Frontier electron density calculations and mass spectrometry were used to verify the major degradation pathways of ofloxacin by the PDI-sunlight photocatalytic system and identify the transformation products of ofloxacin, respectively. ...
Reactive species, namely, h(+), (1)O(2), and O(2)(•-), comprised the primary photocatalytic mechanisms for ofloxacin degradation. Fro …
Enantioselective degradation of ofloxacin and levofloxacin by the bacterial strains Labrys portucalensis F11 and Rhodococcus sp. FP1.
Maia AS, et al. Ecotoxicol Environ Saf 2018. PMID 29510309
Enrichment of the (R)-enantiomer was observed in FP1 and F11 cultures supplied with ofloxacin. Racemization was observed in the biodegradation of the pure (S)-ofloxacin (levofloxacin) by strain F11, which was confirmed by liquid chromatography - exact mass spectrometry. ...This is the first time that enantioselective biodegradation of ofloxacin and levofloxacin by single bacteria is reported....
Enrichment of the (R)-enantiomer was observed in FP1 and F11 cultures supplied with ofloxacin. Racemization was observed in the biode …
Clinical risk factors for Achilles tendinopathy: a systematic review
van der Vlist AC, et al. Br J Sports Med 2019. PMID 30718234 Free PMC article.
There is limited evidence for nine risk factors: (1) prior lower limb tendinopathy or fracture, (2) use of ofloxacin (quinolone) antibiotics, (3) an increased time between heart transplantation and initiation of quinolone treatment for infectious disease, (4) moderate alcohol use, (5) training during cold weather, (6) decreased isokinetic plantar flexor strength, (7) abnormal gait pattern with decreased forward progression of propulsion, (8) more lateral foot roll-over at the forefoot flat phase and (9) creatinine clearance of <60 mL/min in heart transplant patients. ...Clinicians may consider ofloxacin use, alcohol consumption and a reduced plantar flexor strength as modifiable risk factors when treating patients with Achilles tendinopathy. ...
There is limited evidence for nine risk factors: (1) prior lower limb tendinopathy or fracture, (2) use of ofloxacin (quinolone) anti …
Characterization of Ofloxacin Interaction with Mutated (A91V) Quinolone Resistance Determining Region of DNA Gyrase in Mycobacterium Leprae through Computational Simulation.
Nisha J and Shanthi V. Cell Biochem Biophys 2018. PMID 28822069
The GyrA protein of Mycobacterium leprae is the target of the antimycobacterial drug, Ofloxacin. In recent times, the GyrA mutation (A91V) has been found to be resistant to Ofloxacin. ...These structural insights will provide useful information for designing new drugs to target the Ofloxacin-resistant DNA gyrase....
The GyrA protein of Mycobacterium leprae is the target of the antimycobacterial drug, Ofloxacin. In recent times, the GyrA mutation ( …
Pregnancy outcomes in women reporting exposure to ofloxacin in early pregnancy.
Shin YJ, et al. J Obstet Gynaecol 2018. PMID 29565187
This study aimed to analyse perinatal outcomes in ofloxacin-exposed pregnancies. This prospective study was conducted on 143 singleton pregnancies between January 2001 and April 2014, after oral ofloxacin exposure in the first trimester. ...Ofloxacin has no significant effect on perinatal outcomes. Impact statement What is already known on this subject? Ofloxacin and other quinolones are avoided during pregnancy because of concerns about cartilage toxicity. ...
This study aimed to analyse perinatal outcomes in ofloxacin-exposed pregnancies. This prospective study was conducted on 143 singleto …
Timing of DNA damage responses impacts persistence to fluoroquinolones
Mok WWK and Brynildsen MP. Proc Natl Acad Sci U S A 2018. PMID 29915065 Free PMC article.
However, that model does not hold for nongrowing populations treated with ofloxacin, a fluoroquinolone, where antibiotic-induced damage is comparable between cells that live and those that die. To understand how those persisters achieve this feat, we employed a genetic system that uses orthogonal control of MazF and MazE, a toxin and its cognate antitoxin, to generate model persisters that are uniformly tolerant to ofloxacin. ...
However, that model does not hold for nongrowing populations treated with ofloxacin, a fluoroquinolone, where antibiotic-induced dama …
Ofloxacin loaded gellan/PVA nanofibers - Synthesis, characterization and evaluation of their gastroretentive/mucoadhesive drug delivery potential.
Vashisth P, et al. Mater Sci Eng C Mater Biol Appl 2017. PMID 27987752
Ofloxacin loaded gellan/poly vinyl alcohol (PVA) nanofibers were fabricated using a simple and versatile electrospinning technique. ...The antimicrobial activity of the ofloxacin loaded nanofibers was assessed in comparison to the pure ofloxacin by means of minimal inhibitory concentrations (MIC) against microbial strains of Enterococcus faecalis, Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa. ...
Ofloxacin loaded gellan/poly vinyl alcohol (PVA) nanofibers were fabricated using a simple and versatile electrospinning technique. .
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