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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1988 17
1989 18
1990 19
1991 31
1992 29
1993 21
1994 23
1995 32
1996 32
1997 31
1998 18
1999 20
2000 33
2001 38
2002 34
2003 49
2004 41
2005 42
2006 44
2007 32
2008 40
2009 36
2010 35
2011 34
2012 53
2013 57
2014 53
2015 32
2016 27
2017 34
2018 35
2019 25
2020 0
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998 results
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Page 1
Fluoroquinolone-Associated Tendinopathy: Does Levofloxacin Pose the Greatest Risk?
Bidell MR and Lodise TP. Pharmacotherapy 2016 - Review. PMID 27138564
Due to the severity of these adverse events, a black box warning is included in the product labeling of all fluoroquinolones. ...Risk with ofloxacin and levofloxacin appears to be exposure dependent, with higher doses and longer durations being most commonly associated with tendinopathy. ...
Due to the severity of these adverse events, a black box warning is included in the product labeling of all fluoroquinolones. ...Risk …
Biomarker Effects in Carassius auratus Exposure to Ofloxacin, Sulfamethoxazole and Ibuprofen.
Yang X, et al. Int J Environ Res Public Health 2019. PMID 31075982 Free PMC article.
The combined effects of ofloxacin, sulfamethoxazole and ibuprofen were compared with their isolated effects on the three biomarkers, and the results indicated that exposure to ibuprofen and the mixture at environmentally relevant concentrations could trigger adverse impacts on Carassius auratus. ...Moreover, the present study showed that the effects of ofloxacin, sulfamethoxazole and ibuprofen might be additive on the physiological indices of Carassius auratus....
The combined effects of ofloxacin, sulfamethoxazole and ibuprofen were compared with their isolated effects on the thre …
A Multicenter, Randomized, Double-Blind, Phase 2 Study of the Efficacy and Safety of Plazomicin Compared with Levofloxacin in the Treatment of Complicated Urinary Tract Infection and Acute Pyelonephritis
Connolly LE, et al. Antimicrob Agents Chemother 2018 - Clinical Trial. PMID 29378708 Free PMC article.
Adverse events were reported in 31.8%, 35.1%, and 47.7% of the patients in the three groups, respectively. Serum creatinine values were generally stable over the course of the study. ...
Adverse events were reported in 31.8%, 35.1%, and 47.7% of the patients in the three groups, respectively. Serum creatinine values we
When antibiotics turn toxic
Marchant J. Nature 2018. PMID 29565407
Clinical risk factors for Achilles tendinopathy: a systematic review
van der Vlist AC, et al. Br J Sports Med 2019. PMID 30718234 Free PMC article.
There is limited evidence for nine risk factors: (1) prior lower limb tendinopathy or fracture, (2) use of ofloxacin (quinolone) antibiotics, (3) an increased time between heart transplantation and initiation of quinolone treatment for infectious disease, (4) moderate alcohol use, (5) training during cold weather, (6) decreased isokinetic plantar flexor strength, (7) abnormal gait pattern with decreased forward progression of propulsion, (8) more lateral foot roll-over at the forefoot flat phase and (9) creatinine clearance of <60 mL/min in heart transplant patients. ...Clinicians may consider ofloxacin use, alcohol consumption and a reduced plantar flexor strength as modifiable risk factors when treating patients with Achilles tendinopathy. ...
There is limited evidence for nine risk factors: (1) prior lower limb tendinopathy or fracture, (2) use of ofloxacin (quinolone) anti …
Levofloxacin
Norrby SR. Expert Opin Pharmacother 1999 - Review. PMID 11249554
Levofloxacin (DR-3355, Daiichi) is a new fluoroquinolone antibiotic which is the active isomer of ofloxacin (DL-8280, Daiichi). By removing the inactive isomer, the in vitro activity of levofloxacin is 8-128 times higher than that of ofloxacin. This means that bacterial species, which have borderline susceptibility to ofloxacin and other first generation fluoroquinolones (e.g., pneumococci and organisms causing atypical pneumonia), are considerably more sensitive to levofloxacin. ...
Levofloxacin (DR-3355, Daiichi) is a new fluoroquinolone antibiotic which is the active isomer of ofloxacin (DL-8280, Daiichi). By re …
Cardiac risks associated with antibiotics: azithromycin and levofloxacin
Lu ZK, et al. Expert Opin Drug Saf 2015 - Review. PMID 25494485 Free PMC article.
The adverse drug events associated with azithromycin and levofloxacin were considered rare. However, the US FDA released warnings regarding the possible risk of QT prolongation with azithromycin and levofloxacin. ...
The adverse drug events associated with azithromycin and levofloxacin were considered rare. However, the US FDA released warnings reg …
Safety profile of the fluoroquinolones: focus on levofloxacin
Liu HH. Drug Saf 2010 - Review. PMID 20397737
A literature search was performed of the MEDLINE database encompassing the dates 1980-2009, using as keywords the drug names levofloxacin and concurrently marketed fluoroquinolones combined with the words 'safety', 'adverse effect' or 'adverse drug reaction', or the name of the specific adverse effect. ...Furthermore, many of the fluoroquinolone-associated adverse effects and toxicities occur more frequently in patients with pre-existing risk factors, or in certain subpopulations. ...
A literature search was performed of the MEDLINE database encompassing the dates 1980-2009, using as keywords the drug names levofloxacin an …
998 results
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