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Year Number of Results
2003 1
2004 11
2005 11
2006 11
2007 19
2008 8
2009 12
2010 16
2011 19
2012 14
2013 15
2014 23
2015 20
2016 22
2017 15
2018 14
2019 2
2020 0
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195 results
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Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation.
Visnes T, et al. Science 2018. PMID 30442810 Free PMC article.
Because 8-oxoguanine DNA glycosylase 1 (OGG1) binds 8-oxoG and because Ogg1-deficient mice are resistant to acute and systemic inflammation, we hypothesized that OGG1 inhibition may represent a strategy for the prevention and treatment of inflammation. We developed TH5487, a selective active-site inhibitor of OGG1, which hampers OGG1 binding to and repair of 8-oxoG and which is well tolerated by mice. ...
Because 8-oxoguanine DNA glycosylase 1 (OGG1) binds 8-oxoG and because Ogg1-deficient mice are resistant to acute and systemic …
The DNA Repair Protein OGG1 Protects Against Obesity by Altering Mitochondrial Energetics in White Adipose Tissue.
Komakula SSB, et al. Sci Rep 2018. PMID 30291284 Free PMC article.
Here, we demonstrate that transgenic targeting of OGG1 to mitochondria confers significant protection from diet-induced obesity, insulin resistance, and adipose tissue inflammation. ...These data demonstrate a critical role for a DNA repair protein in modulating mitochondrial energetics and whole-body energy balance....
Here, we demonstrate that transgenic targeting of OGG1 to mitochondria confers significant protection from diet-induced obesit …
Ogg1-Dependent DNA Repair Regulates NLRP3 Inflammasome and Prevents Atherosclerosis.
Tumurkhuu G, et al. Circ Res 2016. PMID 27384322 Free PMC article.
Finally, we found that proatherogenic miR-33 can directly inhibit human OGG1 expression and indirectly suppress both mouse and human OGG1 via AMP-activated protein kinase. CONCLUSIONS: OGG1 plays a protective role in atherogenesis by preventing excessive inflammasome activation. Our study provides insight into a new target for therapeutic intervention based on a link between oxidative mtDNA damage, OGG1, and atherosclerosis via NLRP3 inflammasome....
Finally, we found that proatherogenic miR-33 can directly inhibit human OGG1 expression and indirectly suppress both mouse and human …
Defective Base Excision Repair of Oxidative DNA Damage in Vascular Smooth Muscle Cells Promotes Atherosclerosis
Shah A, et al. Circulation 2018. PMID 29643057 Free PMC article.
RESULTS: Human plaque VSMCs showed defective nuclear 8oxoG repair, associated with reduced acetylation of OGG1. OGG1 was a key regulatory enzyme of 8oxoG repair in VSMCs, and its acetylation was crucial to its repair function through regulation of protein stability and expression. p300 and sirtuin 1 were identified as the OGG1 acetyltransferase and deacetylase regulators, respectively, and both proteins interacted with OGG1 and regulated OGG1 acetylation at endogenous levels. ...We generated mice that express VSMC-restricted OGG1 or an acetylation defective version (SM22α-OGG1 and SM22α-OGG1(K-R) mice) and crossed them with ApoE(-/-) mice. ...
RESULTS: Human plaque VSMCs showed defective nuclear 8oxoG repair, associated with reduced acetylation of OGG1. OGG1 was a key …
OGG1-initiated base excision repair exacerbates oxidative stress-induced parthanatos.
Wang R, et al. Cell Death Dis 2018. PMID 29795387 Free PMC article.
The most common oxidation product of DNA is base lesion 8-oxo-7,8-dihydroguanine (8-oxoG), which is repaired by 8-oxoG glycosylase1 (OGG1)-initiated baseexcision repair (BER) pathway (OGG1-BER); however, the role of OGG1-BER in oxidative stress-induced cell death is poorly investigated. ...To test, wild type, knockout, siRNA-depleted MEFs and neuroblastoma cells, or those expressing repair-deficient OGG1 mutants were oxidatively stressed and the role of OGG1 was examined. ...
The most common oxidation product of DNA is base lesion 8-oxo-7,8-dihydroguanine (8-oxoG), which is repaired by 8-oxoG glycosylase1 (OGG1
Enhanced mitochondrial DNA repair of the common disease-associated variant, Ser326Cys, of hOGG1 through small molecule intervention
Baptiste BA, et al. Free Radic Biol Med 2018. PMID 29879444 Free PMC article.
Individuals homozygous for the less active OGG1 allele, Ser326Cys, have increased risk of several cancers. Here, small molecule enhancers of OGG1 were identified and tested for their ability to stimulate DNA repair and protect cells from the environmental hazard paraquat (PQ). ...These data demonstrate that small molecules can stimulate OGG1 activity with consequent cellular protection. Thus, OGG1-activating compounds may be useful in select humans to mitigate the deleterious effects of environmental oxidants and mutagens....
Individuals homozygous for the less active OGG1 allele, Ser326Cys, have increased risk of several cancers. Here, small molecule enhan …
OGG1 regulates the level of symmetric dimethylation of histone H4 arginine-3 by interacting with PRMT5.
Zhou X, et al. Mol Cell Probes 2018. PMID 29409673
In this study, we focused on the roles of OGG1 in histone modification. First, to study the effects of OGG1 on histone modification, the protein levels of symmetric dimethylation of histone H4 arginine-3 (H4R3me2s) were determined by western blot analysis following the knockdown or overexpression of OGG1. ...Knockdown of OGG1 by siRNA led to a decrease in H4R3me2s, while overexpression of OGG1 increased the level of H4R3me2s. OGG1 also interacted with PRMT5 and histone H4, and the interaction between PRMT5 and histone H4 was reduced in MEF Ogg(-/-) cells. ...
In this study, we focused on the roles of OGG1 in histone modification. First, to study the effects of OGG1 on histone modific …
Quantifying Activity for Repair of the DNA Lesion 8-Oxoguanine by Oxoguanine Glycosylase 1 (OGG1) in Mouse Adult and Fetal Brain Nuclear Extracts Using Biotin-Labeled DNA.
Bhatia S and Wells PG. Methods Mol Biol 2019. PMID 31069685
Measurement of the activity of OGG1 can be useful in elucidating mechanisms and complements measurements of 8-oxoG levels in tissues of interest. ...Briefly, a synthetic duplex containing the 8-oxoG residue in one of the nucleotides (49-mer), labeled with biotin at the 3'-end, is incubated with protein extract from the tissue of interest containing OGG1, which cleaves the 8-oxoG residue producing a cleavage product of ~27-mer. ...
Measurement of the activity of OGG1 can be useful in elucidating mechanisms and complements measurements of 8-oxoG levels in tissues …
8-oxoguanine DNA glycosylase (Ogg1) controls hepatic gluconeogenesis.
Scheffler K, et al. DNA Repair (Amst) 2018. PMID 29207315
Mitochondrial DNA (mtDNA) resides in close proximity to metabolic reactions, and is maintained by the 8-oxoguanine DNA glycosylase (Ogg1) and other members of the base excision repair pathway. ...Interestingly, these phenotypes were absent in ogg1(-/-) mice during fasting. Gene expression and functional analyses suggest that the diabetogenic phenotype in the ogg1(-/-) mice is due to a failure to suppress gluconeogensis in the fed state. ...
Mitochondrial DNA (mtDNA) resides in close proximity to metabolic reactions, and is maintained by the 8-oxoguanine DNA glycosylase (Ogg1
Metabolism and DNA repair shape a specific modification pattern in mitochondrial DNA
Pawar T, et al. Mitochondrion 2018. PMID 28893634
Two mouse mutants with a metabolic phenotype were compared to wild-type (WT) mice: the ogg1(-/-) mouse that lacks the 8-oxoguanine DNA glycosylase (OGG1), and the alkbh7(-/-) mouse missing the ALKBH7 protein that has been implicated in fatty acid oxidation. ...Our results show that mtDNA is dynamically modified with metabolic activity and imply a novel synergy between metabolism and mtDNA repair proteins....
Two mouse mutants with a metabolic phenotype were compared to wild-type (WT) mice: the ogg1(-/-) mouse that lacks the 8-oxoguanine DN …
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