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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1971 1
1973 6
1974 19
1975 16
1976 17
1977 22
1978 9
1979 26
1980 50
1981 25
1982 34
1983 35
1984 46
1985 54
1986 60
1987 104
1988 70
1989 92
1990 122
1991 278
1992 225
1993 287
1994 287
1995 342
1996 301
1997 361
1998 282
1999 355
2000 361
2001 451
2002 341
2003 532
2004 510
2005 563
2006 506
2007 666
2008 604
2009 592
2010 583
2011 708
2012 715
2013 673
2014 793
2015 809
2016 684
2017 690
2018 725
2019 685
2020 47
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14,605 results
Results by year
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Page 1
Chemical modification of PS-ASO therapeutics reduces cellular protein-binding and improves the therapeutic index.
Shen W, De Hoyos CL, Migawa MT, Vickers TA, Sun H, Low A, Bell TA 3rd, Rahdar M, Mukhopadhyay S, Hart CE, Bell M, Riney S, Murray SF, Greenlee S, Crooke RM, Liang XH, Seth PP, Crooke ST. Shen W, et al. Nat Biotechnol. 2019 Jun;37(6):640-650. doi: 10.1038/s41587-019-0106-2. Epub 2019 Apr 29. Nat Biotechnol. 2019. PMID: 31036929
Aptamer chemistry.
Röthlisberger P, Hollenstein M. Röthlisberger P, et al. Adv Drug Deliv Rev. 2018 Sep;134:3-21. doi: 10.1016/j.addr.2018.04.007. Epub 2018 Apr 4. Adv Drug Deliv Rev. 2018. PMID: 29626546 Review.
Poly(oligonucleotide).
James CR, Rush AM, Insley T, Vuković L, Adamiak L, Král P, Gianneschi NC. James CR, et al. J Am Chem Soc. 2014 Aug 13;136(32):11216-9. doi: 10.1021/ja503142s. Epub 2014 Jul 31. J Am Chem Soc. 2014. PMID: 25077676 Free PMC article.
Modified oligonucleotides: synthesis and strategy for users.
Verma S, Eckstein F. Verma S, et al. Annu Rev Biochem. 1998;67:99-134. doi: 10.1146/annurev.biochem.67.1.99. Annu Rev Biochem. 1998. PMID: 9759484 Review.
Wavelength-selective uncaging of oligonucleotides.
Rodrigues-Correia A, Seyfried P, Heckel A. Rodrigues-Correia A, et al. Curr Protoc Nucleic Acid Chem. 2014 Jun 24;57:6.11.1-32. doi: 10.1002/0471142700.nc0611s57. Curr Protoc Nucleic Acid Chem. 2014. PMID: 24961722
Cooperative hybridization of oligonucleotides.
Zhang DY. Zhang DY. J Am Chem Soc. 2011 Feb 2;133(4):1077-86. doi: 10.1021/ja109089q. Epub 2010 Dec 17. J Am Chem Soc. 2011. PMID: 21166410
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