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1996 1
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1998 15
1999 27
2000 28
2001 42
2002 54
2003 58
2004 73
2005 118
2006 140
2007 115
2008 131
2009 132
2010 130
2011 152
2012 166
2013 169
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2018 109
2019 51
2020 0
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1,982 results
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Page 1
Renal Drug Transporters and Drug Interactions
Ivanyuk A, et al. Clin Pharmacokinet 2017 - Review. PMID 28210973
Organic anions tend to be secreted by the transport proteins OAT1, OAT3 and OATP4C1 on the basolateral side of tubular cells, and multidrug resistance protein (MRP) 2, MRP4, OATP1A2 and breast cancer resistance protein (BCRP) on the apical side. Organic cations are secreted by organic cation transporter (OCT) 2 on the basolateral side, and multidrug and toxic compound extrusion (MATE) proteins MATE1, MATE2/2-K, P-glycoprotein, organic cation and carnitine transporter (OCTN) 1 and OCTN2 on the apical side. ...
Organic anions tend to be secreted by the transport proteins OAT1, OAT3 and OATP4C1 on the basolateral side of tubular
Carnitine transport and fatty acid oxidation.
Longo N, et al. Biochim Biophys Acta 2016 - Review. PMID 26828774 Free PMC article.
Carnitine is accumulated by the cells and retained by kidneys using OCTN2, a high affinity organic cation transporter specific for carnitine. ...
Carnitine is accumulated by the cells and retained by kidneys using OCTN2, a high affinity organic cation transporter specific …
Apical Shear Stress Enhanced Organic Cation Transport in Human OCT2/MATE1-Transfected Madin-Darby Canine Kidney Cells Involves Ciliary Sensing.
Jayagopal A, et al. J Pharmacol Exp Ther 2019. PMID 30910922 Free article.
In this study, we investigated the role of shear stress on active transport of 4-(4-(dimethylamino)styryl)-N-methylpyridinium iodide (ASP+) by Madin-Darby canine kidney cells exogenously expressing the human organic cation transporters organic cation transporter 2 (OCT2) and multidrug and toxin extrusion protein 1 (MATE1). ...These results indicate that shear stress affects active transport of organic cations in renal tubular epithelial cells in a cilia-dependent manner....
In this study, we investigated the role of shear stress on active transport of 4-(4-(dimethylamino)styryl)-N-methylpyridinium iodide …
Role of organic cation transporters in drug-drug interaction.
Koepsell H. Expert Opin Drug Metab Toxicol 2015 - Review. PMID 26206523
INTRODUCTION: Organic cation transporters OCT1, OCT2 and OCT3 expressed in the small intestine, liver, brain and other organs play important roles in absorption, excretion and distribution of cationic drugs. ...AREAS COVERED: Current knowledge about structure, polyspecific cation binding and transport of OCTs is summarized. Tissue distributions of OCT1-3 and their presumed physiological roles in the small intestine, liver, kidney and brain are reported, and drugs that are transported by human OCT1-3 are listed. ...
INTRODUCTION: Organic cation transporters OCT1, OCT2 and OCT3 expressed in the small intestine, liver, brain and other organs …
Unstirred Water Layers and the Kinetics of Organic Cation Transport.
Shibayama T, et al. Pharm Res 2015. PMID 25791216 Free PMC article.
PURPOSE: Unstirred water layers (UWLs) present an unavoidable complication to the measurement of transport kinetics in cultured cells, and the high rates of transport achieved by overexpressing heterologous transporters exacerbate the UWL effect. ...Several methods were used to manipulate maximal transport rates. RESULTS: Vigorous stirring stimulated uptake of OCT2-mediated transport by decreasing apparent Kt (Ktapp) values. ...
PURPOSE: Unstirred water layers (UWLs) present an unavoidable complication to the measurement of transport kinetics in cultured cells …
Multiple organic cation transporters contribute to the renal transport of sulpiride.
Li L, et al. Biopharm Drug Dispos 2017. PMID 28926871
The results demonstrated that sulpiride was a substrate of human carnitine/organic cation transporter 1 (hOCTN1) and 2 (hOCTN2), human organic cation transporter 2 (hOCT2), human multidrug and toxin efflux extrusion protein 1 (hMATE1) and 2-K (hMATE2-K). ...
The results demonstrated that sulpiride was a substrate of human carnitine/organic cation transporter 1 (hOCTN1) and 2 (hOCTN2 …
Renal vectorial transport of berberine mediated by organic cation transporter 2 (OCT2) and multidrug and toxin extrusion proteins 1 (MATE1) in rats.
Shi R, et al. Biopharm Drug Dispos 2018. PMID 29065218
However, the transporter-mediated renal transport of berberine remains largely unclear. This study aimed to investigate the renal transport mechanism of berberine using transfected cells, kidney slices and animal experiments. ...Both OCT2 and MATE1 mediate the renal vectorial transport of berberine....
However, the transporter-mediated renal transport of berberine remains largely unclear. This study aimed to investigate the renal …
Memantine transport by a proton-coupled organic cation antiporter in hCMEC/D3 cells, an in vitro human blood-brain barrier model.
Higuchi K, et al. Drug Metab Pharmacokinet 2015. PMID 25857234
The aim of this study is to characterize memantine transport at the blood-brain barrier (BBB) using hCMEC/D3 cells, a human BBB model. ...Thus, proton-coupled organic cation antiporter(s) appears to be involved in the transport of memantine in hCMEC/D3 cells, at least in part. ...
The aim of this study is to characterize memantine transport at the blood-brain barrier (BBB) using hCMEC/D3 cells, a human BBB model …
Interplay of the Organic Cation Transporters OCT1 and OCT2 with the Apically Localized Export Protein MATE1 for the Polarized Transport of Trospium.
Deutsch B, et al. Mol Pharm 2019. PMID 30656943
Chemically, it is an organic cation, and it is a substrate of the uptake transporters OCT1 and OCT2 as well as for the export proteins MATE1 and MATE2-K as determined in uptake studies using HEK293 cells. ...We demonstrate that the transcellular, basal-to-apical transport of trospium is significantly higher in all cell lines compared to control cells over nearly the complete concentration range tested. ...
Chemically, it is an organic cation, and it is a substrate of the uptake transporters OCT1 and OCT2 as well as for the export …
Organic cation transporter 1 (OCT1) is involved in pentamidine transport at the human and mouse blood-brain barrier (BBB).
Sekhar GN, et al. PLoS One 2017. PMID 28362799 Free PMC article.
This study examined transporters involved in pentamidine transport at the human and mouse BBB using hCMEC/D3 and bEnd.3 cell lines, respectively. Results revealed that both cell lines expressed the organic cation transporters (OCT1, OCT2 and OCT3), however, P-gp was only expressed in hCMEC/D3 cells. ...
This study examined transporters involved in pentamidine transport at the human and mouse BBB using hCMEC/D3 and bEnd.3 cell lines, r …
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