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Year Number of Results
2002 2
2004 4
2006 1
2007 5
2008 4
2009 4
2010 5
2011 3
2012 8
2013 4
2014 1
2015 1
2016 4
2017 2
2020 0
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Page 1
Carnitine transport and fatty acid oxidation.
Longo N, et al. Biochim Biophys Acta 2016 - Review. PMID 26828774 Free PMC article.
Carnitine is accumulated by the cells and retained by kidneys using OCTN2, a high affinity organic cation transporter specific for carnitine. ...Primary carnitine deficiency can be suspected from the clinical presentation or identified by low levels of free carnitine (C0) in the newborn screening. ...
Carnitine is accumulated by the cells and retained by kidneys using OCTN2, a high affinity organic cation transporter specific …
Primary Carnitine Deficiency and Newborn Screening for Disorders of the Carnitine Cycle.
Longo N. Ann Nutr Metab 2016 - Review. PMID 27931018 Free article.
Defects in carnitine transport such as those caused by defective activity of the OCTN2 transporter encoded by the SLC22A5 gene result in primary carnitine deficiency, and newborn screening programmes can identify patients at risk for this condition before irreversible damage. Initial biochemical diagnosis can be confirmed through molecular testing, although direct study of carnitine transport in fibroblasts is very useful to confirm or exclude primary carnitine deficiency in individuals with genetic variations of unknown clinical significance or who continue to have low levels of carnitine despite negative molecular analyses. ...
Defects in carnitine transport such as those caused by defective activity of the OCTN2 transporter encoded by the SLC22A5 gene result …
The impact of Organic Anion-Transporting Polypeptides (OATPs) on disposition and toxicity of antitumor drugs: Insights from knockout and humanized mice.
Durmus S, et al. Drug Resist Updat 2016 - Review. PMID 27449599
It is now widely accepted that organic anion-transporting polypeptides (OATPs), especially members of the OATP1A/1B family, can have a major impact on the disposition and elimination of a variety of endogenous molecules and drugs. ...We further discuss recent work on OATP-mediated drug-drug interactions in these mouse models, as well as on the role of OATP1A/1B proteins in the phenomenon of hepatocyte hopping, an efficient and flexible way of liver detoxification for both endogenous and exogenous substrates. ...
It is now widely accepted that organic anion-transporting polypeptides (OATPs), especially members of the OATP1A/1B family, can have …
Renal organic cation and nucleoside transport.
Chen R, et al. Biochem Pharmacol 2002. PMID 12123738
We previously reported that the rat organic cation transporter rOCT1 could transport the nucleoside analog deoxytubercidin (dTub) (Chen R, Nelson JA. ...We also reported that although rOCT2 is similar to rOCT1, it does not transport dTub at pH 7.4. In this study, we measured the K(m) and V(max) values of dTub(+) uptake at a reduced pH (pH 5.4) for both rOCT1 and rOCT2. ...
We previously reported that the rat organic cation transporter rOCT1 could transport the nucleoside analog deoxytuberci …
Mitigation of acute kidney injury by cell-cycle inhibitors that suppress both CDK4/6 and OCT2 functions
Pabla N, et al. Proc Natl Acad Sci U S A 2015. PMID 25848011 Free PMC article.
Of additional significance, these compounds were found to be potent inhibitors of organic cation transporter 2 (OCT2), which contributes to the cellular accumulation of cisplatin and subsequent kidney injury. ...
Of additional significance, these compounds were found to be potent inhibitors of organic cation transporter 2 (OCT2), which c …
Histopathologic abnormalities of the lymphoreticular tissues in organic cation transporter 2 deficiency: evidence for impaired B cell maturation.
Komlósi K, et al. J Pediatr 2007. PMID 17188629
Immunohistology of lymphoreticular tissues of a fatal case of organic cation transporter 2 deficiency revealed inhibited proliferation with increased apoptosis in the germinal centers, resulting in "burned out" follicles. ...Defective humoral immune response might explain the recurrent infections in untreated organic cation transporter 2 deficiency....
Immunohistology of lymphoreticular tissues of a fatal case of organic cation transporter 2 deficiency revealed inhibite …
Renoprotective Effects of Metformin are Independent of Organic Cation Transporters 1 &2 and AMP-activated Protein Kinase in the Kidney.
Christensen M, et al. Sci Rep 2016. PMID 27782167 Free PMC article.
Hepatic metformin uptake depends on the expression of organic cation transporters (OCTs). To test whether the effects of metformin in the kidney are dependent on these transporters, we tested metformin treatment in OCT1/2(-/-) mice. ...
Hepatic metformin uptake depends on the expression of organic cation transporters (OCTs). To test whether the effects of metfo …
Oxaliplatin-induced neurotoxicity is dependent on the organic cation transporter OCT2.
Sprowl JA, et al. Proc Natl Acad Sci U S A 2013. PMID 23776246 Free PMC article.
We found that the organic cation transporter 2 (OCT2) is expressed on dorsal root ganglia cells within the nervous system where oxaliplatin is known to accumulate. ...
We found that the organic cation transporter 2 (OCT2) is expressed on dorsal root ganglia cells within the nervous system wher …
Coexistence of passive and proton antiporter-mediated processes in nicotine transport at the mouse blood-brain barrier.
Cisternino S, et al. AAPS J 2013. PMID 23212563 Free PMC article.
Recently, it has been shown that nicotine interacts with some organic cation transporters (OCT), but their influence at the BBB has not yet been assessed in vivo. ...At its usual micromolar concentrations in the plasma, most (79%) of the net transport of nicotine at the BBB was carrier-mediated, while passive diffusion accounted for 21%. ...
Recently, it has been shown that nicotine interacts with some organic cation transporters (OCT), but their influence at the BB …
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