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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2001 2
2002 20
2003 30
2004 40
2005 57
2006 81
2007 80
2008 95
2009 88
2010 94
2011 118
2012 118
2013 113
2014 88
2015 98
2016 93
2017 85
2018 75
2019 36
2020 0
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1,217 results
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Page 1
Apical Shear Stress Enhanced Organic Cation Transport in Human OCT2/MATE1-Transfected Madin-Darby Canine Kidney Cells Involves Ciliary Sensing.
Jayagopal A, et al. J Pharmacol Exp Ther 2019. PMID 30910922 Free article.
In this study, we investigated the role of shear stress on active transport of 4-(4-(dimethylamino)styryl)-N-methylpyridinium iodide (ASP+) by Madin-Darby canine kidney cells exogenously expressing the human organic cation transporters organic cation transporter 2 (OCT2) and multidrug and toxin extrusion protein 1 (MATE1). ...These results indicate that shear stress affects active transport of organic cations in renal tubular epithelial cells in a cilia-dependent manner....
In this study, we investigated the role of shear stress on active transport of 4-(4-(dimethylamino)styryl)-N-methylpyridinium iodide …
Polyspecific organic cation transporters and their impact on drug intracellular levels and pharmacodynamics.
Wagner DJ, et al. Pharmacol Res 2016 - Review. PMID 27317943 Free PMC article.
This review focuses on polyspecific organic cation transporters, which include the organic cation transporters 1-3 (OCT1-3), the multidrug and toxin extrusion proteins 1-2 (MATE1-2) and the plasma membrane monoamine transporter (PMAT). Following an overview of the tissue distribution, transport mechanisms, and functional characteristics of these transporters, we highlight the studies demonstrating the ability of locally expressed OCTs to impact intracellular drug concentrations and directly influence their pharmacological and toxicological activities. ...
This review focuses on polyspecific organic cation transporters, which include the organic cation transporters 1 …
Organic cation transporter 1 (OCT1) is involved in pentamidine transport at the human and mouse blood-brain barrier (BBB).
Sekhar GN, et al. PLoS One 2017. PMID 28362799 Free PMC article.
This study examined transporters involved in pentamidine transport at the human and mouse BBB using hCMEC/D3 and bEnd.3 cell lines, respectively. Results revealed that both cell lines expressed the organic cation transporters (OCT1, OCT2 and OCT3), however, P-gp was only expressed in hCMEC/D3 cells. ...
This study examined transporters involved in pentamidine transport at the human and mouse BBB using hCMEC/D3 and bEnd.3 cell lines, r …
Purification and reconstitution of polyspecific H(+)/organic cation antiporter human MATE1.
Kawasaki T, et al. Biochim Biophys Acta Biomembr 2018. PMID 30028956 Free article.
Human MATE1 (multidrug and toxin extrusion 1, hMATE1) is a H(+)/organic cation (OC) exchanger responsible for the final step of toxic organic cation excretion in the kidney and liver. ...Furthermore, lipid-detergent micelle containing hMATE1 showed ∆pH-dependent TEA binding similar to transport. Mutated hMATE1 with replacement E273Q completely lacked these TEA binding and transport. ...
Human MATE1 (multidrug and toxin extrusion 1, hMATE1) is a H(+)/organic cation (OC) exchanger responsible for the final step o …
[Carnitine - mitochondria and beyond]
Nałęcz KA and Nałęcz MJ. Postepy Biochem 2016 - Review. PMID 28132459 Polish. Free article.
It enters the cell due to the activity of organic cation/carnitine transporter OCTN2 (SLC22A5), it can be as well transported by CT2 (SLC22A16) and a transporter of neutral and basic amino acids ATB(0, +) (SLC6A14). The hydroxyl group of carnitine is able to form esters with organic acids (xenobiotics, fatty acids) due to the activity of acylcarnitine transferases. ...
It enters the cell due to the activity of organic cation/carnitine transporter OCTN2 (SLC22A5), it can be as well transported …
Carnitine
Odle J, et al. Adv Nutr 2014. PMID 24829475 Free PMC article.
Functional transport of organic anions and cations in the murine mesonephros.
Lawrence ML, et al. Am J Physiol Renal Physiol 2018. PMID 29561184 Free article.
Early studies have suggested that the mesonephros in marsupials and some placental mammals may perform an excretory function, but these studies have not directly shown active transport of organic anions and cations. ...Here, we use live uptake and efflux assays in vitro to show that the murine mesonephros is able to transport organic anions and cations through specific transporters from early in its development. ...
Early studies have suggested that the mesonephros in marsupials and some placental mammals may perform an excretory function, but these stud …
Extraneuronal monoamine transporter and organic cation transporters 1 and 2: a review of transport efficiency.
Schömig E, et al. Handb Exp Pharmacol 2006 - Review. PMID 16722235
The organic cation transporters OCT1 and OCT2 are related to EMT. The three carriers share basic structural and functional characteristics. Hence, EMT, OCT1 and OCT2 constitute a group referred to as non-neuronal monoamine transporters or organic cation transporters. ...
The organic cation transporters OCT1 and OCT2 are related to EMT. The three carriers share basic structural and functional cha …
1,217 results
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