"Osteoarthritis Initiative" - Search Results

Year	Number of Results
2003	1
2004	3
2005	1
2006	1
2007	4
2008	10
2009	20
2010	32
2011	39
2012	44
2013	62
2014	57
2015	85
2016	89
2017	112
2018	118
2019	105
2020	114
2021	107
2022	104
2023	118
2024	121
2025	121
2026	29

1

Femorotibial degeneration equilibrium analysis for objective and clinically interpretable knee osteoarthritis stratification.

Govindharaj I, Rajaram G, Ezhilarasan KK, Viswanath J. Govindharaj I, et al. J Orthop. 2026 Feb 24;75:290-304. doi: 10.1016/j.jor.2026.02.056. eCollection 2026 May. J Orthop. 2026. PMID: 41798627

The proposed method was evaluated using knee radiographs from the Osteoarthritis Initiative (OAI) dataset with expert Kellgren-Lawrence (KL) grading as the reference standard and was compared with joint space width measurement, texture-based analysis, shape deformat …

The proposed method was evaluated using knee radiographs from the Osteoarthritis Initiative (OAI) dataset with expert Kellgren …

2

Sex-related differences in femorotibial cartilage thickness: a matched pair analysis.

Spoelder N, Turmezei TD, Kessler DA, Mackay JW, Mastbergen SC, Karperien M, Jansen MP, Eckstein F. Spoelder N, et al. Ann Anat. 2026 Mar 5:152824. doi: 10.1016/j.aanat.2026.152824. Online ahead of print. Ann Anat. 2026. PMID: 41794304 Free article.

METHODS: Subjects without radiographic signs of knee OA were selected from the Osteoarthritis Initiative (OAI). Male-female pairs were matched (1:1) for age ( 5 years), BMI ( 2kg/m2), and height ( 1cm). ...

METHODS: Subjects without radiographic signs of knee OA were selected from the Osteoarthritis Initiative (OAI). Male-female pa …

3

Linking diabetes to worsening knee osteoarthritis symptoms and disability: evidence from the osteoarthritis initiative.

Alenazi AM, Alanazi SA, Alqthami AM, Alanazi MK, Alqahtani BA, Alhwoaimel NA, Alanazi AD, Almutairi SM, Alghamdi MS, Alshehri YS, Vennu V, Bindawas SM. Alenazi AM, et al. Front Med (Lausanne). 2026 Feb 18;13:1759342. doi: 10.3389/fmed.2026.1759342. eCollection 2026. Front Med (Lausanne). 2026. PMID: 41788697 Free PMC article.

METHODS: This was a secondary analysis using publicly available data from a longitudinal study design (Osteoarthritis Initiative). Data from 4,796 participants (45-79 years of age) were obtained, and only participants with grade 2 in either knee, using the Kellgren …

METHODS: This was a secondary analysis using publicly available data from a longitudinal study design (Osteoarthritis Initiative …

4

The associations between a diagnosis of early-stage knee osteoarthritis and the presence of MRI abnormalities in knees without radiographic osteoarthritis: data from 1,513 knees of the osteoarthritis initiative.

Drummen SJJ, Aitken D, Otahal P, Jones G, Bierma-Zeinstra SM, Runhaar J. Drummen SJJ, et al. Osteoarthritis Cartilage. 2026 Feb 28:S1063-4584(26)00684-9. doi: 10.1016/j.joca.2026.02.015. Online ahead of print. Osteoarthritis Cartilage. 2026. PMID: 41771368

METHODS: This study used cross-sectional Osteoarthritis Initiative (OAI) data from 1,500 knees without radiographic KOA (KL-grade <2) and with available MRI assessments, after excluding 13 knees with missing data. ...

METHODS: This study used cross-sectional Osteoarthritis Initiative (OAI) data from 1,500 knees without radiographic KOA (KL-gr …

5

Blanco FJ, Oreiro N, Vázquez-García J, Morano-Torres A, Relaño S, Martínez-Sotodosos L, Noriega-Cobo DM, Otero-Fariña F, Mosquera A, Fernández JL, Rego-Pérez I. Blanco FJ, et al. Antioxidants (Basel). 2026 Feb 21;15(2):266. doi: 10.3390/antiox15020266. Antioxidants (Basel). 2026. PMID: 41750646 Free PMC article.

We performed an exploratory analysis in Osteoarthritis Initiative (OAI) participants, combining nuclear genome-wide association, mitochondrial DNA (mtDNA) haplogroups, and leukocyte telomere length. ...

We performed an exploratory analysis in Osteoarthritis Initiative (OAI) participants, combining nuclear genome-wide associatio …

6

Cartilage thickness at the apex of femoral resections in kinematically aligned total knee arthroplasty is close to 2.5 millimeters.

Sandhar S, Nedopil AJ, Hull ML. Sandhar S, et al. J Exp Orthop. 2026 Feb 19;13(1):e70641. doi: 10.1002/jeo2.70641. eCollection 2026 Jan. J Exp Orthop. 2026. PMID: 41727955 Free PMC article.

METHODS: MR images from 100 knees without evidence of OA were accessed in the Osteoarthritis Initiative (OAI) database. After aligning images in kinematic planes, the apices of the distal and posterior femoral resections were identified, and the apex cartilage thick …

METHODS: MR images from 100 knees without evidence of OA were accessed in the Osteoarthritis Initiative (OAI) database. After …

7

Feasibility and predictive value of proposed early endpoints for randomized controlled trials in knee osteoarthritis.

Collins JE, Mesenbrink P, Dunn R, Deveza LA, Zhu Z, Zimmerman A, Kwoh CK, Kraus VB, Hunter DJ. Collins JE, et al. Osteoarthritis Cartilage. 2026 Feb 20:S1063-4584(26)00655-2. doi: 10.1016/j.joca.2026.02.001. Online ahead of print. Osteoarthritis Cartilage. 2026. PMID: 41724426

DESIGN: We selected knees from the Osteoarthritis Initiative meeting typical RCT inclusion criteria, including pain and radiographic OA. ...

DESIGN: We selected knees from the Osteoarthritis Initiative meeting typical RCT inclusion criteria, including pain and radiog …

8

Novel algorithm for knee localization and diagnosis and grading of knee osteoarthritis based on a priori information: data from OAI.

Deng C, Peng C, Sun Y, Wang G, Liu J, Liu X. Deng C, et al. BMC Med Imaging. 2026 Feb 17. doi: 10.1186/s12880-026-02235-0. Online ahead of print. BMC Med Imaging. 2026. PMID: 41703497 Free article.

METHODS: All X-rays were obtained from the Osteoarthritis Initiative (OAI). We comprehensively consider the a priori information of knee data, redesign the KOA assessment process, and propose the Anchor-free Knee Probability Calculation Net (AKPCNet) knee joint regi …

METHODS: All X-rays were obtained from the Osteoarthritis Initiative (OAI). We comprehensively consider the a priori informati …

9

Temporal Patterns of Wearable Accelerometer-Measured Physical Activity and Symptom Worsening in Knee Osteoarthritis: A 2-Year Longitudinal Study from the Osteoarthritis Initiative.

Kushioka J, Sun R, Smuck M. Kushioka J, et al. Sensors (Basel). 2026 Feb 3;26(3):982. doi: 10.3390/s26030982. Sensors (Basel). 2026. PMID: 41682497 Free PMC article.

Using data from 782 participants in the Osteoarthritis Initiative accelerometer sub-study, PA was tracked with hip-worn ActiGraphs. ...

Using data from 782 participants in the Osteoarthritis Initiative accelerometer sub-study, PA was tracked with hip-worn ActiGr …

10

Comment on "Relationship of strength training lifetime exposure with functional outcomes and mobility over 4 years: Data from the Osteoarthritis Initiative".

Zhu J, Li L, Feng J, Mou L. Zhu J, et al. J Sport Health Sci. 2026 Feb 10:101129. doi: 10.1016/j.jshs.2026.101129. Online ahead of print. J Sport Health Sci. 2026. PMID: 41679472 Free article. No abstract available.

11

The interaction between knee osteoarthritis and multimorbidity with fall risk: A longitudinal study using data from the osteoarthritis initiative.

Alenazi AM. Alenazi AM. Clin Rehabil. 2026 Feb 12:2692155261420780. doi: 10.1177/02692155261420780. Online ahead of print. Clin Rehabil. 2026. PMID: 41678400

ObjectiveTo examine the interaction between baseline Multiple Long-term Conditions (multimorbidity) and baseline knee osteoarthritis with longitudinal fall risk and fall counts.DesignA longitudinal study using publicly available data from the osteoarthritis initiative …

ObjectiveTo examine the interaction between baseline Multiple Long-term Conditions (multimorbidity) and baseline knee osteoarthritis with lo …

12

Predicting total knee replacement in knee osteoarthritis using a machine learning-guided approach in patients of the Osteoarthritis Initiative (OAI).

Blanco FJ, Oreiro N, Vázquez-García J, Morano-Torres A, Balboa-Barreiro V, Rodríguez-Valle I, Relaño S, Veronese N, de Andrés MC, Rego-Pérez I. Blanco FJ, et al. RMD Open. 2026 Feb 10;12(1):e006476. doi: 10.1136/rmdopen-2025-006476. RMD Open. 2026. PMID: 41667218 Free PMC article.

OBJECTIVE: To develop a pragmatic model to predict total knee replacement (TKR) in knee osteoarthritis using non-imaging clinical, genetic and lifestyle data with machine learning (ML)-guided feature selection. METHODS: We analysed 3790 Osteoarthritis Initiative par …

OBJECTIVE: To develop a pragmatic model to predict total knee replacement (TKR) in knee osteoarthritis using non-imaging clinical, genetic a …

13

Performance of an Artificial Intelligence-Based Software for Automated Kellgren-Lawrence Grading of Knee Osteoarthritis: A Multicenter Cohort Study.

Choi BS, Hong SH, Lee HJ, Kim SH. Choi BS, et al. J Arthroplasty. 2026 Feb 4:S0883-5403(26)00104-X. doi: 10.1016/j.arth.2026.01.078. Online ahead of print. J Arthroplasty. 2026. PMID: 41651085

The AI software was trained exclusively on public United States datasets (Osteoarthritis Initiative and the Multicenter Osteoarthritis Study) and validated on this separate Korean dataset. ...

The AI software was trained exclusively on public United States datasets (Osteoarthritis Initiative and the Multicenter Osteoa …

14

DeciViT-Knee 2025 as Precision Fuzzy Techniques of Decision Trees and VIT in Analysis of Knee Osteoarthritis.

Moghe S, Jindal L. Moghe S, et al. J Vis Exp. 2026 Jan 13;(227). doi: 10.3791/69411. J Vis Exp. 2026. PMID: 41628110

Then, it gets radiographic and MRI datasets from the Osteoarthritis Initiative (OAI) and the Multicenter Osteoarthritis Study (MOST). Before the fine-tuned ViT-B/16 model processes the data to obtain 768-dimensional image embeddings, it is curated through contrast e …

Then, it gets radiographic and MRI datasets from the Osteoarthritis Initiative (OAI) and the Multicenter Osteoarthritis Study …

15

Predicting Long-Term Pain Resilience in Knee Osteoarthritis: An Osteoarthritis Initiative Nomogram.

Alkhatatbeh A, Alkhatatbeh T, Chen J, Chen H, Xu J, Hu J. Alkhatatbeh A, et al. Bioengineering (Basel). 2026 Jan 14;13(1):96. doi: 10.3390/bioengineering13010096. Bioengineering (Basel). 2026. PMID: 41596027 Free PMC article.

Knee osteoarthritis prognostic tools often target structural progression or surgery and require imaging or biomarker inputs that are not routinely available. Using Osteoarthritis Initiative data, we developed a fully clinical nomogram to estimate both the probabilit …

Knee osteoarthritis prognostic tools often target structural progression or surgery and require imaging or biomarker inputs that are not rou …

16

The Link Between Depression, Analgesia Usage and Function in Osteoarthritis: A Propensity Score-Matched Analysis from the Osteoarthritis Initiative Cohort.

Gill SS, Jones GG, Cobb JP, Alagha MA. Gill SS, et al. Bioengineering (Basel). 2026 Jan 6;13(1):63. doi: 10.3390/bioengineering13010063. Bioengineering (Basel). 2026. PMID: 41595995 Free PMC article.

This study aimed to assess if DSs influence analgesic use and functional outcomes in knee OA. Using data from the Osteoarthritis Initiative (n = 3680), we used a Machine Learning (ML)-based Gradient Boosting Machine (GBM) model to perform propensity score matching, …

This study aimed to assess if DSs influence analgesic use and functional outcomes in knee OA. Using data from the Osteoarthritis I …

17

Knee muscle strength as a mediator of sex differences in incident knee osteoarthritis.

Li X, Wu Z, Zhang Y, Zeng C, Lei G, Wei J, Li J, Xiao Y. Li X, et al. Arthritis Res Ther. 2026 Jan 24;28(1):46. doi: 10.1186/s13075-026-03745-6. Arthritis Res Ther. 2026. PMID: 41580764 Free PMC article.

METHODS: This cohort study utilized data from the Osteoarthritis Initiative, a longitudinal prospective study of participants aged 45-79 years. ...

METHODS: This cohort study utilized data from the Osteoarthritis Initiative, a longitudinal prospective study of participants …

18

Clinical validation of fully automated (peri-)articular tissue analysis for assessing osteoarthritis progression: A narrative review.

Wirth W, Eder J. Wirth W, et al. Osteoarthr Cartil Open. 2025 Dec 12;8(1):100719. doi: 10.1016/j.ocarto.2025.100719. eCollection 2026 Mar. Osteoarthr Cartil Open. 2025. PMID: 41550414 Free PMC article. Review.

Most of the studies were based on DL methods and relied on data from the Osteoarthritis Initiative (OAI). The included studies reported similar or greater sensitivity to change and similar discriminative power for detecting differences in change between clinically d …

Most of the studies were based on DL methods and relied on data from the Osteoarthritis Initiative (OAI). The included studies …

19

Magnetic resonance imaging-defined knee osteoarthritis rarely occurs without cartilage damage.

Chang AH, Sharma L, Roemer FW, Almagor O, Lee J, Guermazi A. Chang AH, et al. Osteoarthr Cartil Open. 2025 Dec 16;8(1):100733. doi: 10.1016/j.ocarto.2025.100733. eCollection 2026 Mar. Osteoarthr Cartil Open. 2025. PMID: 41536419 Free PMC article.

METHODS: We analyzed baseline data from participants without definite radiographic TFOA [Kellgren-Lawrence (KL) grade <2 in both knees] in the Osteoarthritis Initiative (OAI) and Multicenter Osteoarthritis Study (MOST) cohorts. OAI knees were scored using the MRI …

METHODS: We analyzed baseline data from participants without definite radiographic TFOA [Kellgren-Lawrence (KL) grade <2 in both knees] i …

20

The Relation of Within-Day Physical Activity Patterns with All-Cause Mortality in Adults with Knee Osteoarthritis: Findings from the Osteoarthritis Initiative.

Liles SC, Cleveland RJ, Jakiela JT, Copson J, Tore NG, Golightly YM, Werner DM, White DK. Liles SC, et al. Arthritis Care Res (Hoboken). 2025 Dec 22. doi: 10.1002/acr.70024. Online ahead of print. Arthritis Care Res (Hoboken). 2025. PMID: 41431139

METHODS: We performed a secondary analysis of the Osteoarthritis Initiative (NCT00080171). Our exposure was within-day patterns of physical activity using a Multidimensional (14-hour) Multilevel (4-day) Functional Principal Component Analysis to analyze acceleromete …

METHODS: We performed a secondary analysis of the Osteoarthritis Initiative (NCT00080171). Our exposure was within-day pattern …

21

Per- and Polyfluoroalkyl Substances and Hand Osteoarthritis: Data From the Osteoarthritis Initiative.

Driban JB, Rokoff LB, Lu B, McAlindon TE, Eaton CB, Roberts MB, Mathes D, Lestician C, Xu ZC, Fan ZT, O'Leary SP, Haugen IK, Sellam J, Courties A, Fleisch AF. Driban JB, et al. Arthritis Rheumatol. 2025 Dec 22:10.1002/art.70026. doi: 10.1002/art.70026. Online ahead of print. Arthritis Rheumatol. 2025. PMID: 41429602 Free PMC article.

METHODS: Among a case-cohort sample from the Osteoarthritis Initiative (n = 1,878), we examined associations of eight PFAS in serum with odds of developing over the subsequent 4 years (1) symptomatic HOA and (2) an increased number of joints with radiographic osteoa …

METHODS: Among a case-cohort sample from the Osteoarthritis Initiative (n = 1,878), we examined associations of eight PFAS in …

22

Reframing early-stage symptomatic knee osteoarthritis (EsSKOA): A strategic lens for trial design.

Mahmoudian A, King LK, Liew JW, Wang Q, Berenbaum F, Das S, Ding C, Emery CA, Filbay SR, Hochberg MC, Ishijima M, Kloppenburg M, Lane NE, Losina E, Mobasheri A, Thomas Appleton C, Englund M, Stefan Lohmander L, Runhaar J, Turkiewicz A, Hawker GA, Neogi T, Haugen IK; OARSI Early-stage Symptomatic Knee Osteoarthritis Initiative. Mahmoudian A, et al. Osteoarthritis Cartilage. 2025 Dec 20:S1063-4584(25)01279-8. doi: 10.1016/j.joca.2025.12.016. Online ahead of print. Osteoarthritis Cartilage. 2025. PMID: 41429384 No abstract available.

23

Metabolomic Signatures of Dietary Patterns and Incident Radiographic Knee Osteoarthritis: A Case-Cohort Study From the Osteoarthritis Initiative.

Xu S, Driban JB, Prakash PS, McAlindon TE, Eaton CB, Lu B. Xu S, et al. J Rheumatol. 2026 Jan 15:jrheum.2025-0830. doi: 10.3899/jrheum.2025-0830. Online ahead of print. J Rheumatol. 2026. PMID: 41397862 Free PMC article.

METHODS: This case-cohort study included 603 participants from the Osteoarthritis Initiative, comprising 237 incident radiographic knee OA cases and 366 noncases during a 6-year follow-up. ...

METHODS: This case-cohort study included 603 participants from the Osteoarthritis Initiative, comprising 237 incident radiogra …

24

Rethinking the role of cartilage loss: the influence of intra- and extra-articular factors on symptoms in advanced knee osteoarthritis.

Bianco Prevot L, Bensa A, Randelli PS, Filardo G. Bianco Prevot L, et al. Bone Jt Open. 2025 Dec 16;6(12):1611-1618. doi: 10.1302/2633-1462.612.BJO-2025-0036.R1. Bone Jt Open. 2025. PMID: 41397409 Free PMC article.

METHODS: Subjects were selected from the Osteoarthritis Initiative database based on the criteria: Kellgren-Lawrence (KL) grades 3 to 4 and baseline clinical and MRI data. ...

METHODS: Subjects were selected from the Osteoarthritis Initiative database based on the criteria: Kellgren-Lawrence (KL) grad …

25

Enhancing total knee replacement prediction: a longitudinal joint space radiomic model integrated with clinical symptoms.

Wang T, Liu H, Rong H, Liu Z, Cao P, Li J, Chen T, Wang Y, Zhao W, Chen L, Chen L, Liao R, Liu S, Ruan G, Zhang Y, Wang X, Dang Q, Wang Q, Zhang M, Bai Q, Akbar A, Tack A, Hunter D, Ding C, Li S. Wang T, et al. Int J Surg. 2025 Dec 11. doi: 10.1097/JS9.0000000000004427. Online ahead of print. Int J Surg. 2025. PMID: 41376347

METHODS: We selected 442 knees with symptomatic knee OA but without TKR at baseline from the Osteoarthritis Initiative cohort. There were 1227 knee MRIs included during 4-year follow-up. ...

METHODS: We selected 442 knees with symptomatic knee OA but without TKR at baseline from the Osteoarthritis Initiative cohort. …

26

Thigh Muscle Changes in the ACL-Deficient Knee: A 4-Year Longitudinal MRI Study of 1,207 Patients.

Alzobi O, Mohajer B, Fleuriscar J, Demehri S, Zikria BA. Alzobi O, et al. J Bone Joint Surg Am. 2026 Feb 4;108(3):219-226. doi: 10.2106/JBJS.25.00641. Epub 2025 Dec 10. J Bone Joint Surg Am. 2026. PMID: 41370366

METHODS: The present cohort study utilized Osteoarthritis Initiative data to assess longitudinal thigh muscle changes in individuals with ACL tears confirmed on magnetic resonance imaging (MRI) and no history of reconstruction. ...Strength was assessed with use of s …

METHODS: The present cohort study utilized Osteoarthritis Initiative data to assess longitudinal thigh muscle changes in indiv …

27

Deep learning-derived orthogonal minimum joint space width improves radiographic assessment of knee osteoarthritis severity and progression.

Lee DW, Song DS, Lee YS, Choi JY, Ro DH. Lee DW, et al. Knee Surg Sports Traumatol Arthrosc. 2025 Dec 10. doi: 10.1002/ksa.70227. Online ahead of print. Knee Surg Sports Traumatol Arthrosc. 2025. PMID: 41368950

METHODS: A total of 15,313 knee radiographs from the Osteoarthritis Initiative (OAI), spanning baseline to 72-month follow-up, were analysed in this retrospective cohort study. ...

METHODS: A total of 15,313 knee radiographs from the Osteoarthritis Initiative (OAI), spanning baseline to 72-month follow-up, …

28

Impact of stair climbing volume on patellofemoral cartilage: a dose-response analysis from the osteoarthritis initiative reveals elevated risk at middle levels.

Yang Y, Zhao Z, Zhang H, Zhou F, Liu X. Yang Y, et al. Front Med (Lausanne). 2025 Nov 24;12:1699297. doi: 10.3389/fmed.2025.1699297. eCollection 2025. Front Med (Lausanne). 2025. PMID: 41368303 Free PMC article.

OBJECTIVE: To evaluate the impact of stair climbing volume on cartilage degeneration in the patellofemoral joint, with a particular focus on the medial/lateral patellar and trochlear regions. METHODS: Utilizing data from the osteoarthritis initiative (OAI) cohort, w …

OBJECTIVE: To evaluate the impact of stair climbing volume on cartilage degeneration in the patellofemoral joint, with a particular focus on …

29

Progression and influencing factors of knee osteoarthritis based on a multi-state Markov model: Data from OAI.

Nuer A, Yang Y, Sun B, Wang Y, Xiao W, Wang L, Wang S, Lu W. Nuer A, et al. Osteoarthr Cartil Open. 2025 Nov 13;8(1):100703. doi: 10.1016/j.ocarto.2025.100703. eCollection 2026 Mar. Osteoarthr Cartil Open. 2025. PMID: 41362328 Free PMC article.

METHODS: Participants aged 45-79 years from the Osteoarthritis Initiative (OAI) were analyzed over eight years, classifying KOA states as normal, early-KOA, radiographic KOA (rKOA), and end-stage KOA (es-KOA) using Kellgren-Lawrence (K-L) grades, symptoms, and patie …

METHODS: Participants aged 45-79 years from the Osteoarthritis Initiative (OAI) were analyzed over eight years, classifying KO …

30

Observations of early structural changes over 6 years on magnetic resonance imaging in knees without radiographic osteoarthritis.

Magnusson K, Turkiewicz A, Paemre J, Mahmoudian A, Englund M. Magnusson K, et al. Osteoarthritis Cartilage. 2025 Dec 6:S1063-4584(25)01242-7. doi: 10.1016/j.joca.2025.12.003. Online ahead of print. Osteoarthritis Cartilage. 2025. PMID: 41360180 Free article.

DESIGN: In 340 individuals from the Osteoarthritis Initiative aged 45-55 years (51% women) with 430 knees at risk for OA and 250 not at risk, we assessed MRI scans of both knees using the MRI OA Knee Score system. ...

DESIGN: In 340 individuals from the Osteoarthritis Initiative aged 45-55 years (51% women) with 430 knees at risk for OA and 2 …

31

Combining Machine-Learning Assessment of Multiple MRI Pathologies and Clinical Phenotypes for Predicting Joint Replacement in Knee Osteoarthritis: Data From the Osteoarthritis Initiative.

D'Assignies G, Demanse D, Saxer F, Laurent D, Zille P, Vesoul T, Cordelle P, Herpe G, Conaghan PG, Schieker M. D'Assignies G, et al. Cartilage. 2025 Dec 5:19476035251395177. doi: 10.1177/19476035251395177. Online ahead of print. Cartilage. 2025. PMID: 41351291 Free PMC article.

This study evaluated their prevalence within pre-defined clinical phenotypes and their predictive value for knee replacement (KR).DesignBaseline MRIs (n = 8,667) from the Osteoarthritis Initiative were analyzed using a machine-learning (ML) algorithm. The presence o …

This study evaluated their prevalence within pre-defined clinical phenotypes and their predictive value for knee replacement (KR).DesignBase …

32

The association between anserine bursa pain and fall susceptibility: a prospective analysis of the osteoarthritis initiative.

Wang F, Xiao J, Song Z, Zhang C, Zhu Z. Wang F, et al. Front Aging. 2025 Nov 19;6:1666627. doi: 10.3389/fragi.2025.1666627. eCollection 2025. Front Aging. 2025. PMID: 41346375 Free PMC article.

METHOD: The study utilized 2-year follow-up data derived from the Osteoarthritis Initiative cohort, a comprehensive multicenter observational investigation. ...

METHOD: The study utilized 2-year follow-up data derived from the Osteoarthritis Initiative cohort, a comprehensive multicente …

33

Physical Activity and 4-Year Radiographic Medial Joint Space Loss in Knee Osteoarthritis: A Joint Model Analysis.

Cai Q, Peng H, Duong V, Oo WM, Gao Y, Feng Y, Zhang C, Arbeeva L, White DK, Hunter DJ, Fu K. Cai Q, et al. J Bone Joint Surg Am. 2025 Dec 3. doi: 10.2106/JBJS.25.00656. Online ahead of print. J Bone Joint Surg Am. 2025. PMID: 41337563

METHODS: We analyzed 1,806 participants from the Osteoarthritis Initiative. PA was measured with the Physical Activity Scale for the Elderly (PASE) and was categorized as low, moderate, or high. ...

METHODS: We analyzed 1,806 participants from the Osteoarthritis Initiative. PA was measured with the Physical Activity Scale f …

34

EFRNet: A Deep Hybrid Model for End-to-End Knee Osteoarthritis Detection and Progression Assessment.

Kumar A, Ranjan R, Srivastava S. Kumar A, et al. Annu Int Conf IEEE Eng Med Biol Soc. 2025 Jul;2025:1-6. doi: 10.1109/EMBC58623.2025.11252719. Annu Int Conf IEEE Eng Med Biol Soc. 2025. PMID: 41337410

To evaluate the effectiveness of the proposed method, publicly available KOA image data from the Osteoarthritis Initiative has been collected. The efficacy of the proposed model is comprehensively evaluated utilizing various metrics. ...

To evaluate the effectiveness of the proposed method, publicly available KOA image data from the Osteoarthritis Initiative has …

35

The state of the Osteoarthritis Initiative (OAI): Entering a new era.

Driban JB, Patarini JC, Liu SH, McAlindon TE, Lapane KL, Lemon SC, Zai AH, Nevitt MC, Hochberg MC, Cauley JA, Eaton CB, Rubin S, Schneider E, Lo GH. Driban JB, et al. Semin Arthritis Rheum. 2025 Dec;75:152887. doi: 10.1016/j.semarthrit.2025.152887. Epub 2025 Nov 22. Semin Arthritis Rheum. 2025. PMID: 41308296 Free PMC article. Review. No abstract available.

36

Medial plica is associated with progression of medial meniscus extrusion in middle-aged persons with Kellgren-Lawrence grade 0: data from the osteoarthritis initiative.

Hada S, Kaneko H, Aoki T, Nojiri S, Englund M, Ishijima M. Hada S, et al. J Orthop Surg Res. 2025 Nov 24;20(1):1030. doi: 10.1186/s13018-025-06472-x. J Orthop Surg Res. 2025. PMID: 41286955 Free PMC article.

METHODS: A total of 340 subjects with tibiofemoral Kellgren-Lawrence (K/L) grade 0 from the Osteoarthritis Initiative were included. We evaluated magnetic resonance imaging (MRI) data (right knee) at baseline and six years later. ...

METHODS: A total of 340 subjects with tibiofemoral Kellgren-Lawrence (K/L) grade 0 from the Osteoarthritis Initiative were inc …

37

Gardening/yardwork over a lifetime is associated with less symptomatic knee osteoarthritis: data from the Osteoarthritis Initiative.

Lo GH, Tran ST, Patarini JC, Lee JC, McAlindon TE, Kriska AM, Rockette-Wagner B, Eaton CB, Hochberg MC, Kwoh CK, Nevitt MC, Driban JB. Lo GH, et al. Clin Rheumatol. 2026 Feb;45(2):1523-1532. doi: 10.1007/s10067-025-07762-9. Epub 2025 Nov 21. Clin Rheumatol. 2026. PMID: 41272337

We aimed to evaluate the relationship of gardening/yardwork with the prevalence of symptomatic knee osteoarthritis in the Osteoarthritis Initiative (OAI), a community-based cohort not recruited based on gardening/yardwork status. ...

We aimed to evaluate the relationship of gardening/yardwork with the prevalence of symptomatic knee osteoarthritis in the Osteoarthritis …

38

Relationship of strength training lifetime exposure with functional outcomes and mobility over 4 years: Data from the Osteoarthritis Initiative.

Kiehl D, Thompson Z, Johnson AJ, Sibille KT, Vincent KR, Vincent HK. Kiehl D, et al. J Sport Health Sci. 2025 Nov 14:101102. doi: 10.1016/j.jshs.2025.101102. Online ahead of print. J Sport Health Sci. 2025. PMID: 41242429 Free article.

BACKGROUND: This study compared knee osteoarthritis (OA) outcomes specific to pain, physical function, and quality of life in later life based on strength training (ST) participation over a lifetime. METHODS: Participants from the Osteoarthritis Initiative (n = 3192 …

BACKGROUND: This study compared knee osteoarthritis (OA) outcomes specific to pain, physical function, and quality of life in later life bas …

39

Deep contrastive learning improves identification of early-stage knee osteoarthritis across multicohort X-ray datasets.

Jia L, Du G, Fan Z, Li X, Liu H, Zhang J, Li D, Yan L, Jiu J, Li R, Li S, Yang Y, Liu H, Ren Y, Liu X, Li JJ, Zhang Y, Lin J, Wang B. Jia L, et al. Knee Surg Sports Traumatol Arthrosc. 2026 Jan;34(1):362-369. doi: 10.1002/ksa.70191. Epub 2025 Nov 14. Knee Surg Sports Traumatol Arthrosc. 2026. PMID: 41235478

METHODS: Weight-bearing anteroposterior knee radiographs were obtained from three datasets: the osteoarthritis initiative (OAI), Wuchuan and Shunyi. The OAI dataset included baseline, 72-month, and 96-month follow-up images, while the Wuchuan and Shunyi datasets wer …

METHODS: Weight-bearing anteroposterior knee radiographs were obtained from three datasets: the osteoarthritis initiative (OAI …

40

Validity of Substantial Clinical Benefit Estimates in Knee Arthroplasty Is Weak Based on Comparisons to a Gold Standard of Meaningful Improvement.

Riddle DL, Dumenci L. Riddle DL, et al. J Arthroplasty. 2025 Nov 11:S0883-5403(25)01434-2. doi: 10.1016/j.arth.2025.11.009. Online ahead of print. J Arthroplasty. 2025. PMID: 41232850

METHODS: There were two datasets, the Knee Arthroplasty pain coping Skills Training (KASTPain) no-effect randomized clinical trial and the Osteoarthritis Initiative (OAI) data on patients who had a knee arthroplasty. Both studies captured preoperative and multiple p …

METHODS: There were two datasets, the Knee Arthroplasty pain coping Skills Training (KASTPain) no-effect randomized clinical trial and the …

41

Replacing Stationary and Physical Activity Time Is Associated With 2-Year Improvements in Clinical Outcomes in Individuals With Varying Knee Osteoarthritis Severity.

Halliwell C, Budarick A, O'Brien M, Moyer R. Halliwell C, et al. J Aging Phys Act. 2025 Nov 13:1-10. doi: 10.1123/japa.2024-0383. Online ahead of print. J Aging Phys Act. 2025. PMID: 41232521

Device-based stationary and physical activities were monitored using accelerometry within the Osteoarthritis Initiative cohort (n = 848). All analyses were completed separately for mild-to-moderate (Kellgren-Lawrence grade = 1-2) and severe (Kellgren-Lawrence grade …

Device-based stationary and physical activities were monitored using accelerometry within the Osteoarthritis Initiative cohort …

42

Association of blood pressure with knee pain progression over 4 years in middle-aged and elderly individuals with or at risks for osteoarthritis: data from the Osteoarthritis Initiative.

Fu L, Du G, Liu Y. Fu L, et al. Clin Rheumatol. 2026 Jan;45(1):429-440. doi: 10.1007/s10067-025-07802-4. Epub 2025 Nov 12. Clin Rheumatol. 2026. PMID: 41225241

METHOD: This retrospective, multicenter, cohort study utilized a total of 2906 subjects (61.7% female, aged 45-79 years) from the Osteoarthritis Initiative. Blood pressure parameters included diastolic blood pressure, systolic blood pressure, pulse pressure (PP), an …

METHOD: This retrospective, multicenter, cohort study utilized a total of 2906 subjects (61.7% female, aged 45-79 years) from the Osteoar …

43

Health State Utility Values Associated with Knee Osteoarthritis: A Vignette-Based Approach.

Ramos-Goñi JM, Janssen MF, Perez-Nieves M, Rivero-Arias O, Gonsahn-Bollie S, Boye KS. Ramos-Goñi JM, et al. Patient Prefer Adherence. 2025 Nov 6;19:3469-3482. doi: 10.2147/PPA.S555596. eCollection 2025. Patient Prefer Adherence. 2025. PMID: 41221306 Free PMC article.

PATIENTS AND METHODS: Six different health state vignettes were developed using best practices and real-world data from the Osteoarthritis Initiative (OAI) database that included the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) instrument. …

PATIENTS AND METHODS: Six different health state vignettes were developed using best practices and real-world data from the Osteoarthriti …

44

Interobserver reliability of Coronal Plane Alignment of the Knee (CPAK) phenotype classification : external validation using data from the Osteoarthritis Initiative.

Wynell-Mayow W, Hall TAG, Singh A, van Arkel RJ, Jones GG. Wynell-Mayow W, et al. Bone Jt Open. 2025 Nov 11;6(11):1425-1435. doi: 10.1302/2633-1462.611.BJO-2025-0153.R1. Bone Jt Open. 2025. PMID: 41213302 Free PMC article.

METHODS: Two readers labelled 75 long-leg radiographs (LLRs) from the Osteoarthritis Initiative database for analyses of CPAK inter-reader reproducibility. A single reader then labelled and classified phenotypes for an aggregate total of 1,128 LLRs. ...

METHODS: Two readers labelled 75 long-leg radiographs (LLRs) from the Osteoarthritis Initiative database for analyses of CPAK …

45

Development and validation of a deep learning model for automatic severity grading of hip osteoarthritis: a multi-center study.

Xu S, Guo C, Zuo J, Yang M, Chen B, Li S, Xiao J, Tang X, Qin Y. Xu S, et al. Ann Med. 2025 Dec;57(1):2584361. doi: 10.1080/07853890.2025.2584361. Epub 2025 Nov 9. Ann Med. 2025. PMID: 41208350 Free PMC article.

METHODS: We retrospectively collected 20,745 hip radiographs from two Chinese hospitals for model development, 1,928 radiographs from a third hospital for external validation, and 1,249 hips from the Osteoarthritis Initiative (OAI) dataset. A ResNet-50 network with …

METHODS: We retrospectively collected 20,745 hip radiographs from two Chinese hospitals for model development, 1,928 radiographs from a thir …

46

Total knee radiomic feature atlas derived from magnetic resonance imaging segmentation: Insights into osteoarthritis incidence predictors.

Mu L, Fu J, Li M, Liu H, Dong D, Gong J, Jiang Y, Huai X, Xu P, Zhang H. Mu L, et al. Eur J Radiol. 2026 Jan;194:112480. doi: 10.1016/j.ejrad.2025.112480. Epub 2025 Oct 22. Eur J Radiol. 2026. PMID: 41187641

This article investigates KOA risk predictors using the Radkneeatlas, a total knee radiomic feature atlas derived from the segmentation of 29 knee structures on magnetic resonance imaging (MRI). METHODS: The study included Osteoarthritis Initiative (OAI) participant …

This article investigates KOA risk predictors using the Radkneeatlas, a total knee radiomic feature atlas derived from the segmentation of 2 …

47

An MRI-based radiomics framework for early identification and progression stratification in knee osteoarthritis: data from the osteoarthritis initiative.

Fu J, Mu L, Dong D, Li M, Miao Z, Huai X, Zheng Y, Zhang H. Fu J, et al. BMC Musculoskelet Disord. 2025 Oct 31;26(1):1018. doi: 10.1186/s12891-025-09234-2. BMC Musculoskelet Disord. 2025. PMID: 41174627 Free PMC article.

MATERIALS AND METHODS: The study analyzed 456 participants without radiographic OA (Kellgren-Lawrence [KL] 0-1) at baseline were selected from the Osteoarthritis Initiative (OAI) and randomly divided into training and testing cohorts (7:3). ...

MATERIALS AND METHODS: The study analyzed 456 participants without radiographic OA (Kellgren-Lawrence [KL] 0-1) at baseline were selected fr …

48

Association between knee stiffness and MRI-detected lesions: data from the osteoarthritis initiative (OAI).

Kong H, Gao J, Lin J, Liu Q, Zhang Y. Kong H, et al. BMC Musculoskelet Disord. 2025 Oct 28;26(1):1006. doi: 10.1186/s12891-025-09242-2. BMC Musculoskelet Disord. 2025. PMID: 41152777 Free PMC article.

METHODS: A within-person knee-matched case-control study was performed. We included participants from the Osteoarthritis Initiative (OAI) whose stiffness score differed by 1 point between their knees, as assessed by the Western Ontario and McMasters Universities O …

METHODS: A within-person knee-matched case-control study was performed. We included participants from the Osteoarthritis Initiativ …

49

Self-reported physical activity and risk of primary knee replacement for osteoarthritis: a competing risks cohort analysis.

Peng H, Cai Q, Liu D, Duong V, Oo WM, Zhang C, Hunter DJ, Zheng Y, Fu K. Peng H, et al. BMC Musculoskelet Disord. 2025 Oct 27;26(1):1000. doi: 10.1186/s12891-025-09254-y. BMC Musculoskelet Disord. 2025. PMID: 41146133 Free PMC article.

BACKGROUND: Whether baseline self-reported physical activity (PA) is associated with the risk of primary knee replacement (KR) for osteoarthritis (OA) remains uncertain, particularly across radiographic severity. METHODS: In 2,534 Osteoarthritis Initiative (OAI) par …

BACKGROUND: Whether baseline self-reported physical activity (PA) is associated with the risk of primary knee replacement (KR) for osteoarth …

50

Baseline loss of knee extension is associated with regional MRI progression in knee osteoarthritis: a retrospective longitudinal cohort study-data from the osteoarthritis initiative.

Chan Chun Kong D, Conaghan PG, Campbell TM. Chan Chun Kong D, et al. Rheumatol Int. 2025 Oct 23;45(11):257. doi: 10.1007/s00296-025-06008-w. Rheumatol Int. 2025. PMID: 41128850

A retrospective cohort analysis was conducted using data from 1018 participants (1131 knees) from an Osteoarthritis Initiative (OAI) sub-cohort. Baseline KE was measured using a goniometer. Structural changes were assessed annually over four years using the MRI Oste …

A retrospective cohort analysis was conducted using data from 1018 participants (1131 knees) from an Osteoarthritis Initiative …

51

Peripheral blood DNA methylation changes are predictive of incident radiographic osteoarthritis development: Data and biospecimens from the osteoarthritis initiative.

Brawner CM, Dyson G, Barrett M, Hanebutt N, Szymczak A, Mehta-D'souza P, Jeffries MA. Brawner CM, et al. Osteoarthr Cartil Open. 2025 Sep 30;7(4):100692. doi: 10.1016/j.ocarto.2025.100692. eCollection 2025 Dec. Osteoarthr Cartil Open. 2025. PMID: 41127556 Free PMC article.

52

Association between constant and intermittent knee pain and T2 values and cartilage thickness: data from the osteoarthritis initiative.

Löffler MT, Joseph GB, Lynch JA, Lane NE, Pedoia V, Majumdar S, Nevitt M, McCulloch C, Link TM. Löffler MT, et al. Arthritis Res Ther. 2025 Oct 22;27(1):196. doi: 10.1186/s13075-025-03667-9. Arthritis Res Ther. 2025. PMID: 41126321 Free PMC article.

BACKGROUND: We investigated whether cartilage composition and thickness and its change over time were associated with future intermittent and constant knee pain. METHODS: Osteoarthritis Initiative participants with 3T MRI scans from baseline to 36-month visits were …

BACKGROUND: We investigated whether cartilage composition and thickness and its change over time were associated with future intermittent an …

53

Simplifying Knee OA Prognosis: A Deep Learning Approach Using Radiographs and Minimal Clinical Inputs.

Wang CT, Chang KT, Lai F, Pao JL, Lin SM, Chang CH. Wang CT, et al. Diagnostics (Basel). 2025 Oct 9;15(19):2543. doi: 10.3390/diagnostics15192543. Diagnostics (Basel). 2025. PMID: 41095764 Free PMC article.

Design: A vision transformer-based model was trained using 5565 knee radiographs as baseline images from the osteoarthritis initiative (OAI), including 578 testing images. Each knee had a corresponding Kellgren and Lawrence (KL) stage after 48 months of follow-up. . …

Design: A vision transformer-based model was trained using 5565 knee radiographs as baseline images from the osteoarthritis initia …

54

Development and validation of a generalisable survival model to predict osteoarthritis progression.

Li HHT, Chan LC, Chan PK, Wen C. Li HHT, et al. Osteoarthr Cartil Open. 2025 Sep 25;7(4):100688. doi: 10.1016/j.ocarto.2025.100688. eCollection 2025 Dec. Osteoarthr Cartil Open. 2025. PMID: 41089820 Free PMC article.

METHOD: A DeepSurv model was trained on the Osteoarthritis Initiative (OAI) dataset with baseline clinical variables, including age, sex, BMI, comorbidities, smoking status, prior knee injury and surgery, pain medication use, use of walking aids, and activity level …

METHOD: A DeepSurv model was trained on the Osteoarthritis Initiative (OAI) dataset with baseline clinical variables, includin …

55

Association of different pain patterns with physical function in participants with knee osteoarthritis: data from the osteoarthritis initiative.

Li S, Li G, Zou J, Gong Z, He Z, Zhao Y, Fan T, Fan W, Zhang Z, Zheng M, Huang G, Zeng Q. Li S, et al. J Orthop Surg Res. 2025 Oct 8;20(1):877. doi: 10.1186/s13018-025-06146-8. J Orthop Surg Res. 2025. PMID: 41063240 Free PMC article.

METHODS: 412 participants with radiological KOA were included from the Osteoarthritis Initiative (OAI). Pain severity and four pain patterns were assessed, including intermittent, constant, weight-bearing, and non-weight-bearing pain patterns. ...

METHODS: 412 participants with radiological KOA were included from the Osteoarthritis Initiative (OAI). Pain severity and four …

56

Limited effects of non-steroidal anti-inflammatory drugs (NSAIDs) on imaging outcomes in osteoarthritis: observational data from the osteoarthritis initiative (OAI).

Kreutzinger V, Ziegeler K, Luitjens J, Joseph GB, Lynch J, Lane NE, McCulloch CE, Nevitt M, Link TM. Kreutzinger V, et al. BMC Musculoskelet Disord. 2025 Oct 8;26(1):939. doi: 10.1186/s12891-025-09172-z. BMC Musculoskelet Disord. 2025. PMID: 41063134 Free PMC article.

METHODS: Applying a new user design to identify treatment effects in observational data, we selected participants from the Osteoarthritis Initiative (OAI) who were prescribed regular, oral NSAID medication between baseline and 48 months follow-up and who had availab …

METHODS: Applying a new user design to identify treatment effects in observational data, we selected participants from the Osteoarthritis …

57

Association of Frailty With Risk of Osteoarthritis Development, Progression, and Worse Clinical Outcomes in Older Adults.

Waghorn J, Maxwell SP, Rayner SE, Moyer R, Rockwood K, Theou O, Rizkallah M, Legge A, O'Brien MW. Waghorn J, et al. J Rheumatol. 2026 Mar 1;53(3):314-321. doi: 10.3899/jrheum.2025-0578. J Rheumatol. 2026. PMID: 41033828

METHODS: A frailty index score was calculated for 4753 participants (58.53% female; mean age 61.2 years, 95% CI 60.94-61.46) from the Osteoarthritis Initiative (OAI), broken into control, incidence, and progression groups. Longitudinal OAI outcomes including inciden …

METHODS: A frailty index score was calculated for 4753 participants (58.53% female; mean age 61.2 years, 95% CI 60.94-61.46) from the Ost …

58

Localizing Knee Pain via Explainable Bayesian Generative Models and Counterfactual MRI: Data from the Osteoarthritis Initiative.

Chuang TY, Lian PH, Kuo YC, Chang GH. Chuang TY, et al. J Imaging Inform Med. 2025 Sep 24. doi: 10.1007/s10278-025-01678-1. Online ahead of print. J Imaging Inform Med. 2025. PMID: 40993478

We trained and validated this framework on 2148 knee pairs obtained from a multicenter study of the Osteoarthritis Initiative (OAI), achieving high anatomical specificity in terms of identifying pain-relevant features such as patellar effusions and bone marrow lesio …

We trained and validated this framework on 2148 knee pairs obtained from a multicenter study of the Osteoarthritis Initiative …

59

Association between body weight fluctuation and progression of radiographic knee osteoarthritis: a longitudinal cohort study.

Fu K, Oo WM, Pelletier JP, Martel-Pelletier J, Feng Y, Zhang C, Cai Q, Ding C, Cicuttini F, Hunter DJ. Fu K, et al. RMD Open. 2025 Sep 21;11(3):e005890. doi: 10.1136/rmdopen-2025-005890. RMD Open. 2025. PMID: 40983395 Free PMC article.

DESIGN: We conducted a longitudinal study using data from the Osteoarthritis Initiative. We analysed body weight variability through metrics of average successive variability (ASV), and residual ASV from baseline to 48 months. ...

DESIGN: We conducted a longitudinal study using data from the Osteoarthritis Initiative. We analysed body weight variability t …

60

Meniscal degeneration among knees without radiographic osteoarthritis correlates with changes in disease activity and subsequent cumulative damage: Data from the Osteoarthritis Initiative.

Harvey JT, McAlindon TE, Baek J, MacKay J, Zhang M, Lo GH, Liu SH, Eaton CB, Harkey MS, Patarini JC, Driban JB. Harvey JT, et al. Osteoarthr Imaging. 2025 Jun;5(2):100264. doi: 10.1016/j.ostima.2025.100264. Epub 2025 Mar 23. Osteoarthr Imaging. 2025. PMID: 40964513 Free article.

DESIGN: This analysis involved 225 participants from the Osteoarthritis Initiative with intact menisci (defined as normal or meniscal degeneration without tear) on MRI and no radiographic knee osteoarthritis at baseline. ...

DESIGN: This analysis involved 225 participants from the Osteoarthritis Initiative with intact menisci (defined as normal or m …

61

MRI versus radiography as eligibility screening tool for knee osteoarthritis clinical trials: Data from the osteoarthritis initiative.

Guermazi A, Roemer FW, Ashbeck EL, Lynch J, Kwoh CK, Jarraya M. Guermazi A, et al. Semin Arthritis Rheum. 2025 Oct;74:152818. doi: 10.1016/j.semarthrit.2025.152818. Epub 2025 Aug 28. Semin Arthritis Rheum. 2025. PMID: 40913839

METHODS: We selected participants from the baseline visit of the Osteoarthritis Initiative that met radiographic structural and clinical eligibility criteria for a DMOAD clinical trial: Radiographic OA (Kellgren-Lawrence grade 2 or 3 with medial minimum joint space …

METHODS: We selected participants from the baseline visit of the Osteoarthritis Initiative that met radiographic structural an …

62

Mediating role of effusion-synovitis in knee pain worsening following quadriceps weakness: data from the osteoarthritis initiative.

Gong Z, Ao D, Li T, Li L. Gong Z, et al. BMC Musculoskelet Disord. 2025 Sep 2;26(1):847. doi: 10.1186/s12891-025-09113-w. BMC Musculoskelet Disord. 2025. PMID: 40898245 Free PMC article.

This study aimed to assess the impact of alterations in the effusion-synovitis, a special kind of nociceptive structure, on changes in knee pain associated with quadriceps weakness. METHODS: Based on the osteoarthritis initiative cohort, knees with comprehensive rec …

This study aimed to assess the impact of alterations in the effusion-synovitis, a special kind of nociceptive structure, on changes in knee …

63

Comparative Evaluation of Deep Learning and Foundation Model Embeddings for Osteoarthritis Feature Classification in Knee Radiographs.

Chavoshi M, Trivedi H, Newsome J, Mansuri A, Li F, Dapamede T, Khosravi B, Gichoya J. Chavoshi M, et al. J Imaging Inform Med. 2025 Sep 2. doi: 10.1007/s10278-025-01636-x. Online ahead of print. J Imaging Inform Med. 2025. PMID: 40897834

We analyzed 44,985 knee radiographs from the Osteoarthritis Initiative dataset. Two convolutional neural network models (ResNet18 and ConvNeXt-Small) were trained to classify osteophytes, joint space narrowing, subchondral sclerosis, and Kellgren-Lawrence grades (KL …

We analyzed 44,985 knee radiographs from the Osteoarthritis Initiative dataset. Two convolutional neural network models (ResNe …

64

A Deep Learning Tool for Hip Minimum Joint Space Width Calculation on Antero-posterior Pelvis Radiographs.

Bukowiec LG, Kanabar A, Girod MM, Saniei S, Mulford KL, Taunton MJ, Sierra RJ, Sierra SV, Wyles CC. Bukowiec LG, et al. J Arthroplasty. 2025 Aug 21:S0883-5403(25)01028-9. doi: 10.1016/j.arth.2025.08.023. Online ahead of print. J Arthroplasty. 2025. PMID: 40848813

External validation was performed on 75 images from the Osteoarthritis Initiative. Algorithm performance was measured by calculating the mean absolute error and constructing a Bland-Altman plot. ...In 70% of cases, the algorithm's mJSW measurements were less than on …

External validation was performed on 75 images from the Osteoarthritis Initiative. Algorithm performance was measured by calcu …

65

Comparison between coronal FLASH and sagittal double echo steady state MRI in detecting longitudinal cartilage thickness change by fully automated segmentation - Data from the FNIH biomarker cohort.

Eckstein F, Chaudhari AS, Hunter DJ, Wirth W. Eckstein F, et al. Osteoarthr Cartil Open. 2025 Aug 5;7(3):100657. doi: 10.1016/j.ocarto.2025.100657. eCollection 2025 Sep. Osteoarthr Cartil Open. 2025. PMID: 40822965 Free PMC article.

However, this finding was based on DESS MRI from the Osteoarthritis Initiative (OAI), whereas the vast majority of multicenter clinical trials rely on T1-weighted gradient echo (e.g. ...

However, this finding was based on DESS MRI from the Osteoarthritis Initiative (OAI), whereas the vast majority of multicenter …

66

Baseline Knee Osteoarthritis and Chronic Obstructive Pulmonary Disease as Predictors of Physical Activity Decline: A Five-Year Longitudinal Study in U.S. Adults Using the Disablement Process Framework.

Alhammad SA, Vennu V. Alhammad SA, et al. Healthcare (Basel). 2025 Aug 5;13(15):1902. doi: 10.3390/healthcare13151902. Healthcare (Basel). 2025. PMID: 40805935 Free PMC article.

Methods: We analyzed data from 855 adults aged 45 years enrolled in the Osteoarthritis Initiative (OAI). The participants were categorized into three baseline groups, control (n = 122), knee OA (n = 646), and COPD (n = 87), based on self-reports and prior clinical …

Methods: We analyzed data from 855 adults aged 45 years enrolled in the Osteoarthritis Initiative (OAI). The participants wer …

67

A virtual knee replacement (vKR) multi-component endpoint for knee osteoarthritis based on patient-reported PROs: Data from the Osteoarthritis Initiative.

Kwoh CK, Boudreau RM, Eckstein F, Roemer FW, Hannon MJ, Guermazi A, Hunter DJ. Kwoh CK, et al. Osteoarthritis Cartilage. 2025 Nov;33(11):1372-1381. doi: 10.1016/j.joca.2025.08.001. Epub 2025 Aug 6. Osteoarthritis Cartilage. 2025. PMID: 40780453 Free PMC article.

OBJECTIVE: To use patient-reported outcomes (PROs) and performance measures to develop a multi-component outcome (virtual knee replacement [vKR]) that predicts knee replacement (KR). METHODS: Osteoarthritis Initiative (OAI) participants with baseline radiographs, cl …

OBJECTIVE: To use patient-reported outcomes (PROs) and performance measures to develop a multi-component outcome (virtual knee replacement [ …

68

Effect of corticosteroids and hyaluronic acid injections on knee osteoarthritis trajectory.

Bensa A, Bianco Prevot L, Peretti GM, Filardo G. Bensa A, et al. J Exp Orthop. 2025 Aug 5;12(3):e70333. doi: 10.1002/jeo2.70333. eCollection 2025 Jul. J Exp Orthop. 2025. PMID: 40766808 Free PMC article.

METHODS: Patients were selected from the Osteoarthritis Initiative database, a prospective, multicentre, longitudinal, observational study, including 254 knees who received CS or HA injections. ...

METHODS: Patients were selected from the Osteoarthritis Initiative database, a prospective, multicentre, longitudinal, observa …

69

Frailty moderates the relation between moderate-to-vigorous physical activity & stationary time with knee osteoarthritis symptoms.

Rayner SE, Maxwell SP, Waghorn J, Moyer R, Rockwood K, Theou O, O'Brien MW. Rayner SE, et al. J Frailty Aging. 2025 Oct;14(5):100077. doi: 10.1016/j.tjfa.2025.100077. Epub 2025 Aug 5. J Frailty Aging. 2025. PMID: 40751915 Free PMC article.

DESIGN: This cohort observational study included participants (n = 1351; 728 females) from the Osteoarthritis Initiative, aged 45-79 (60 9) years. Hip-worn accelerometers were used to quantify free-living stationary time, light (LPA) and moderate-to-vigorous-physica …

DESIGN: This cohort observational study included participants (n = 1351; 728 females) from the Osteoarthritis Initiative, aged …

70

Synovitis mediates cartilage outcomes during weight-loss in knee osteoarthritis - 4-year follow-up data from the Osteoarthritis Initiative.

Kreutzinger V, Ziegeler K, Joseph GB, Lynch JA, Akkaya Z, Lane NE, McCulloch CE, Nevitt M, Link TM. Kreutzinger V, et al. Osteoarthr Cartil Open. 2025 Jul 17;7(3):100653. doi: 10.1016/j.ocarto.2025.100653. eCollection 2025 Sep. Osteoarthr Cartil Open. 2025. PMID: 40735540 Free PMC article.

METHOD: We analyzed right knees with baseline Kellgren & Lawrence grades 1-3 of 1153 obese and overweight participants of the Osteoarthritis Initiative (OAI) cohort with Whole Organ MRI Scores (WORMS) and semi-quantitative assessment of effusion synovitis and sy …

METHOD: We analyzed right knees with baseline Kellgren & Lawrence grades 1-3 of 1153 obese and overweight participants of the Osteoar …

71

Inter-Limb Strength Asymmetry and Risk of Total Knee Replacement: A Survival Analysis.

Halliwell C, Rayner S, Astephen Wilson J, Rutherford D, Feltmate B, Neyedli H, Moyer R. Halliwell C, et al. Am J Phys Med Rehabil. 2025 Dec 1;104(12):1133-1139. doi: 10.1097/PHM.0000000000002775. Epub 2025 Jul 4. Am J Phys Med Rehabil. 2025. PMID: 40720300

DESIGN: This longitudinal cohort study analyzed data from the Osteoarthritis Initiative, including 3860 individuals with or at risk for knee osteoarthritis. ...

DESIGN: This longitudinal cohort study analyzed data from the Osteoarthritis Initiative, including 3860 individuals with or at …

72

MR-Transformer: A Vision Transformer-based Deep Learning Model for Total Knee Replacement Prediction Using MRI.

Zhang C, Chen S, Cigdem O, Rajamohan HR, Cho K, Kijowski R, Deniz CM. Zhang C, et al. Radiol Artif Intell. 2025 Sep;7(5):e240373. doi: 10.1148/ryai.240373. Radiol Artif Intell. 2025. PMID: 40668131

Materials and Methods This retrospective study included 353 case-control matched pairs of coronal intermediate-weighted turbo spin-echo (COR-IW-TSE) and sagittal intermediate-weighted turbo spin-echo with fat suppression (SAG-IW-TSE-FS) knee MRI scans from the Osteoarthritis …

Materials and Methods This retrospective study included 353 case-control matched pairs of coronal intermediate-weighted turbo spin-echo (COR …

73

Cartilage lesions are not the main factor influencing pain and functional impairment in early knee osteoarthritis : a multivariate analysis on intra- and extra-articular factors affecting symptoms in over 200 knees.

Bianco Prevot L, Bensa A, Randelli PS, Filardo G. Bianco Prevot L, et al. Bone Jt Open. 2025 Jul 16;6(7):828-835. doi: 10.1302/2633-1462.67.BJO-2025-0010.R1. Bone Jt Open. 2025. PMID: 40665789 Free PMC article.

METHODS: The subjects were selected from the Osteoarthritis Initiative database according to the following inclusion criteria: Kellgren-Lawrence (KL) grade 0-1-2, MRI at baseline, and availability of cartilage-denuded subchondral bone values. ...

METHODS: The subjects were selected from the Osteoarthritis Initiative database according to the following inclusion criteria: …

74

Applying binary mixed model to predict knee osteoarthritis pain.

El-Zaatari H, Arbeeva L, Nelson AE. El-Zaatari H, et al. PLoS One. 2025 Jul 15;20(7):e0325678. doi: 10.1371/journal.pone.0325678. eCollection 2025. PLoS One. 2025. PMID: 40663584 Free PMC article.

Specifically, we utilized data from the baseline visit of the Osteoarthritis Initiative (OAI) and applied the Binary Mixed Models (BiMM) algorithm to predict two binary dependent variables. 1) presence of knee pain, stiffness or aching in the past 12 months and 2) p …

Specifically, we utilized data from the baseline visit of the Osteoarthritis Initiative (OAI) and applied the Binary Mixed Mod …

75

Depressive symptoms influence progression to total knee arthroplasty in patients with early knee osteoarthritis: Evidence from the Osteoarthritis Initiative database.

Bensa A, Bianco Prevot L, Piano A, Peretti GM, Filardo G. Bensa A, et al. J Exp Orthop. 2025 Jul 13;12(3):e70355. doi: 10.1002/jeo2.70355. eCollection 2025 Jul. J Exp Orthop. 2025. PMID: 40655255 Free PMC article.

METHODS: A total of 912 patients were selected from the Osteoarthritis Initiative (OAI) database. The data collected included demographic data, Kellgren-Lawrence (KL) OA grade, Visual analogue scale (VAS) for pain, Center for Epidemiologic Studies Depression Scale ( …

METHODS: A total of 912 patients were selected from the Osteoarthritis Initiative (OAI) database. The data collected included …

76

Changes to the Intercondylar Ligaments of the Knee in Different Stages of Osteoarthritis-A Retrospective Cross-Sectional Study.

Mandler E, Kainberger F, Hirtler L. Mandler E, et al. J Clin Med. 2025 Jun 25;14(13):4513. doi: 10.3390/jcm14134513. J Clin Med. 2025. PMID: 40648887 Free PMC article.

As not only the available intercondylar space directly influences the encased ligaments, but also the ligaments themselves may influence each other, the purpose of this study was to evaluate the influence of osteoarthritis on central ligament morphology. Methods: Imaging data fro …

As not only the available intercondylar space directly influences the encased ligaments, but also the ligaments themselves may influence eac …

77

Statistical shape modelling of the first carpometacarpal joint: A cross-sectional analysis of an osteoarthritis initiative cohort.

Shepherd J, Saunders FR, Narang Y, Hamlin K, Lawrie DFM, Winter B, Riemen AHK. Shepherd J, et al. Bone. 2025 Nov;200:117577. doi: 10.1016/j.bone.2025.117577. Epub 2025 Jul 6. Bone. 2025. PMID: 40628336

78

Confidence-Driven Deep Learning Framework for Early Detection of Knee Osteoarthritis.

Wang Z, Chetouani A, Chen YH, Ru Y, Chen F, Jarraya M, Bauer F, Zhang L, Hans D, Jennane R. Wang Z, et al. IEEE Trans Biomed Eng. 2026 Feb;73(2):530-541. doi: 10.1109/TBME.2025.3587003. IEEE Trans Biomed Eng. 2026. PMID: 40627470

Tailored loss functions are applied to improve model robustness and effectively handle uncertainty in annotations. Experimental results on the Osteoarthritis Initiative (OAI) dataset demonstrate that the proposed framework achieves competitive accuracy, sensitivity, …

Tailored loss functions are applied to improve model robustness and effectively handle uncertainty in annotations. Experimental results on t …

79

The influence of sex in diagnostic modelling of knee osteoarthritis.

McCabe PG, Lisboa P, Baltzopoulos B, Jarman I, Stamp K, Olier I. McCabe PG, et al. PLoS One. 2025 Jul 3;20(7):e0325681. doi: 10.1371/journal.pone.0325681. eCollection 2025. PLoS One. 2025. PMID: 40608746 Free PMC article.

OBJECTIVE: To compare diagnostic models for radiological KOA at KL2 + using sex-specific variables against a generic model with sex as an input. Data from the Osteoarthritis Initiative (OAI) was used for model development and optimisation. MATERIALS AND METHODS: Cur …

OBJECTIVE: To compare diagnostic models for radiological KOA at KL2 + using sex-specific variables against a generic model with sex as an in …

80

Identifying trajectories of joint space width loss among previously injured knees: Data from the Osteoarthritis Initiative.

Minnig MCC, Arbeeva L, Lund JL, Marshall SW, Nissman DB, Nelson AE, Golightly YM. Minnig MCC, et al. PLoS One. 2025 Jun 30;20(6):e0325822. doi: 10.1371/journal.pone.0325822. eCollection 2025. PLoS One. 2025. PMID: 40587450 Free PMC article.

To describe the relationship of trajectory groups with sociodemographic and clinical risk factors. METHODS: Using data from the Osteoarthritis Initiative, we identified right knees with a history of injury. We used group-based trajectory modeling to identify traject …

To describe the relationship of trajectory groups with sociodemographic and clinical risk factors. METHODS: Using data from the Osteoarth …

81

Association of Knee Pain Frequency and Severity with Quadriceps Strength but Not Rate of Decline Over Four Years.

Sherman DA, Neogi T, Hornsby S, Felson D, Lavalley M, Stefanik JJ; OAI investigators. Sherman DA, et al. ACR Open Rheumatol. 2025 Jul;7(7):e70067. doi: 10.1002/acr2.70067. ACR Open Rheumatol. 2025. PMID: 40586171 Free PMC article.

METHODS: We used baseline, two-year, and four-year quadriceps strength data from the Osteoarthritis Initiative to identify quadriceps strength trajectory groups using discrete mixture model clustering. ...

METHODS: We used baseline, two-year, and four-year quadriceps strength data from the Osteoarthritis Initiative to identify qua …

82

The relation between radiographic knee osteoarthritis severity and pain is stronger among more frail people.

Halliwell C, Rayner SE, Waghorn J, Feltmate B, Moyer R, O'Brien MW. Halliwell C, et al. Clin Rheumatol. 2025 Aug;44(8):3333-3340. doi: 10.1007/s10067-025-07546-1. Epub 2025 Jun 26. Clin Rheumatol. 2025. PMID: 40569498

METHOD: This cohort study included participants (n = 3,271; 58% female, 45-79 years) from the Osteoarthritis Initiative were included. Radiographic severity was assessed using the Kellgren-Lawrence Grade (KLG). ...

METHOD: This cohort study included participants (n = 3,271; 58% female, 45-79 years) from the Osteoarthritis Initiative were i …

83

Associations of Physical Activity, Sedentary Behaviour, Pain, Function and Quality of Life With Diabetes and Knee Osteoarthritis: Data From the Osteoarthritis Initiative.

Hart HF, White DK, Reichert SM, Stefanik JJ. Hart HF, et al. Musculoskeletal Care. 2025 Jun;23(2):e70128. doi: 10.1002/msc.70128. Musculoskeletal Care. 2025. PMID: 40495273 Free PMC article.

METHODS: Data on physical activity (light and moderate-vigorous physical activity minutes/day, steps/day, sedentary time percent of wear time), pain, physical function (Western Ontario and McMaster Index, walking speed during 20-m walk) and quality of life (SF-12) from the Ost …

METHODS: Data on physical activity (light and moderate-vigorous physical activity minutes/day, steps/day, sedentary time percent of wear tim …

84

The relation of activity patterns with incident slow gait speed over 4 years in adults with knee osteoarthritis: Data from the Osteoarthritis Initiative.

Tore NG, Liles S, Werner DM, Cleveland RJ, Bye TV, Golightly Y, Jakiela JT, White DK. Tore NG, et al. Osteoarthritis Cartilage. 2025 Sep;33(9):1121-1129. doi: 10.1016/j.joca.2025.06.002. Epub 2025 Jun 6. Osteoarthritis Cartilage. 2025. PMID: 40484272

OBJECTIVE: The purpose of this study was to describe activity patterns in adults with knee osteoarthritis (OA) and to examine the relation of patterns with incident slow gait speed over 4 years. DESIGN: Using data from the Osteoarthritis Initiative, we included adul …

OBJECTIVE: The purpose of this study was to describe activity patterns in adults with knee osteoarthritis (OA) and to examine the relation o …

85

Borderline acceleration in blood epigenetic age of unclear biological importance in knee osteoarthritis progression: Specimens and data from the Osteoarthritis Initiative and Johnston County Osteoarthritis Project.

Brawner CM, Sturdy C, Arbeeva L, Golightly YM, Nelson AE, Jeffries MA. Brawner CM, et al. Osteoarthritis Cartilage. 2026 Mar;34(3):372-379. doi: 10.1016/j.joca.2025.05.010. Epub 2025 Jun 4. Osteoarthritis Cartilage. 2026. PMID: 40480605

METHODS: Genome-wide baseline blood DNA methylation data from the Osteoarthritis Initiative (n = 554) and Johnston County Osteoarthritis Project (n = 128) were generated using Illumina MethylationEPICv1 arrays on baseline samples of OA progressors (radiographic and/ …

METHODS: Genome-wide baseline blood DNA methylation data from the Osteoarthritis Initiative (n = 554) and Johnston County Oste …

86

Ultra-processed food consumption is associated with knee osteoarthritis: Data from the Osteoarthritis Initiative.

Akkaya Z, Sims WM, Lynch JA, Löffler MT, Gassert F, Nevitt M, McCulloch CE, Lane NE, Pedoia V, Ziegeler K, Link TM, Joseph GB. Akkaya Z, et al. Osteoarthritis Cartilage. 2025 Sep;33(9):1130-1140. doi: 10.1016/j.joca.2025.05.011. Epub 2025 Jun 4. Osteoarthritis Cartilage. 2025. PMID: 40480603 Free article.

OBJECTIVE: To explore the relationship between ultra-processed food (UPF) intake and knee osteoarthritis (KOA)-related imaging and clinical outcomes in men and women. DESIGN: Osteoarthritis Initiative participants with sufficient dietary and sociodemographic data (n …

OBJECTIVE: To explore the relationship between ultra-processed food (UPF) intake and knee osteoarthritis (KOA)-related imaging and clinical …

87

Elucidating the initial symptoms and experiences of knee osteoarthritis: An international patient survey.

King LK, Mahmoudian A, Liew JW, Wang Q, Stanaitis I, Schiphof D, Callahan LF, Hunter DJ, Appleton CT, Turkiewicz A, Englund M, Lohmander LS, Haugen IK, Hawker GA, Neogi T, Runhaar J; OARSI Early-stage Symptomatic Knee Osteoarthritis Initiative. King LK, et al. Osteoarthritis Cartilage. 2025 Sep;33(9):1147-1152. doi: 10.1016/j.joca.2025.05.008. Epub 2025 May 26. Osteoarthritis Cartilage. 2025. PMID: 40436245 Free article.

88

Estimation of time-to-total knee replacement surgery with multimodal modeling and artificial intelligence.

Cigdem O, Hedayati E, Rajamohan HR, Cho K, Chang G, Kijowski R, Deniz CM. Cigdem O, et al. Comput Biol Med. 2025 Jul;193:110364. doi: 10.1016/j.compbiomed.2025.110364. Epub 2025 May 27. Comput Biol Med. 2025. PMID: 40435672

METHODS: A total of 547 subjects underwent TKR in the Osteoarthritis Initiative over nine years, and their longitudinal data was used for model training and testing. 518 and 164 subjects from Multi-Center Osteoarthritis Study and internal hospital data were used for …

METHODS: A total of 547 subjects underwent TKR in the Osteoarthritis Initiative over nine years, and their longitudinal data w …

89

Are Changes in Physical Activity, Pain, and Quality of Life in Patients with Knee Osteoarthritis After Exercise Therapy and Education Beyond Normal Fluctuations? A Comparative Study.

Rafiei M, Das S, Roos EM, Skou ST, Baumbach J, Baumbach L. Rafiei M, et al. J Clin Med. 2025 May 13;14(10):3406. doi: 10.3390/jcm14103406. J Clin Med. 2025. PMID: 40429401 Free PMC article.

Method: Patients with knee osteoarthritis participating in the Good Life with Osteoarthritis in Denmark (GLA:D( )) exercise therapy and education program (n = 7603) and participants from the Osteoarthritis Initiative (OAI) who received no specific treatment (n = 115 …

Method: Patients with knee osteoarthritis participating in the Good Life with Osteoarthritis in Denmark (GLA:D( )) exercise therapy and educ …

90

Intra-articular Knee Injections and Progression of Knee Osteoarthritis: Data from the Osteoarthritis Initiative.

Bharadwaj UU, Lynch JA, Joseph GB, Akkaya Z, Nevitt MC, Lane NE, McCulloch CE, Link TM. Bharadwaj UU, et al. Radiology. 2025 May;315(2):e233081. doi: 10.1148/radiol.233081. Radiology. 2025. PMID: 40423542

Materials and Methods This secondary analysis uses data from the Osteoarthritis Initiative (OAI), a multicenter, longitudinal, prospective study (February 2004 to January 2015). ...

Materials and Methods This secondary analysis uses data from the Osteoarthritis Initiative (OAI), a multicenter, longitudinal, …

91

OARSI initiative to develop classification criteria for early-stage symptomatic knee OA (EsSKOA): What conditions should be considered in the differential diagnosis of EsSKOA?

Hawker GA, King LK, Liew JW, Wang Q, Mahmoudian A, Jansen NEJ, Stanaitis I, Berenbaum F, Das S, Ding C, Emery CA, Filbay SR, Hochberg MC, Ishijima M, Kloppenburg M, Lane NE, Losina E, Mobasheri A, Runhaar J, Appleton CT, Turkiewicz A, Englund M, Lohmander LS, Haugen IK, Neogi T; OARSI Early-stage Symptomatic Knee Osteoarthritis Initiative. Hawker GA, et al. Osteoarthritis Cartilage. 2025 Sep;33(9):1141-1146. doi: 10.1016/j.joca.2025.05.005. Epub 2025 May 23. Osteoarthritis Cartilage. 2025. PMID: 40414550 Free article.

92

Thigh-muscle volume change in response to diet, exercise, and weight-loss in overweight and obese individuals-8-year follow-up data from the Osteoarthritis Initiative.

Ziegeler K, Kreutzinger V, Akkaya Z, Joseph GB, Lynch JA, Lane NE, McCulloch CE, Nevitt M, Link TM. Ziegeler K, et al. Skeletal Radiol. 2025 Dec;54(12):2651-2658. doi: 10.1007/s00256-025-04955-w. Epub 2025 May 24. Skeletal Radiol. 2025. PMID: 40411578

METHODS: Included in this longitudinal analysis of the Osteoarthritis Initiative were participants who had (a) stable weight (SW) (body mass index (BMI) 3%); (b) moderate weight loss (MWL) (5-10% BMI); (c) extensive weight loss (EWL) (> 10%) and available segme …

METHODS: Included in this longitudinal analysis of the Osteoarthritis Initiative were participants who had (a) stable weight ( …

93

Predicting Knee Osteoarthritis Severity from Radiographic Predictors: Data from the Osteoarthritis Initiative.

Nurmirinta TAT, Turunen MJ, Tohka J, Mononen ME, Liukkonen MK. Nurmirinta TAT, et al. Ann Biomed Eng. 2025 Aug;53(8):1852-1861. doi: 10.1007/s10439-025-03740-z. Epub 2025 May 9. Ann Biomed Eng. 2025. PMID: 40346351 Free PMC article.

94

Exploration of combined factors related to quality of life after knee replacement surgery.

Santoh K, Shigetoh H, Yamano H, Torizawa K, Takasaki H, Uritani D. Santoh K, et al. PLoS One. 2025 May 7;20(5):e0323007. doi: 10.1371/journal.pone.0323007. eCollection 2025. PLoS One. 2025. PMID: 40333812 Free PMC article.

In this study, we aimed to identify combined factors associated with lower postoperative quality of life (QOL) in knee replacement (KR) patients, utilising data from the Osteoarthritis Initiative (OAI) database. The data of 44 individuals from the OAI who underwent …

In this study, we aimed to identify combined factors associated with lower postoperative quality of life (QOL) in knee replacement (KR) pati …

95

Longitudinal Associations Between Baseline Sarcopenia and Knee Osteoarthritis Progression and Risk of Knee Replacement.

Wu T, Wang X, Cai Z, Cao P, Dang Q, Zhou W, Xie J, Chen J, Wang T, Tao G, Han W, Zhu Z, Wang J, Hunter DJ, Barazzoni R, Ding C, Li J. Wu T, et al. Arthritis Rheumatol. 2025 Oct;77(10):1362-1372. doi: 10.1002/art.43213. Epub 2025 Jun 19. Arthritis Rheumatol. 2025. PMID: 40325921

We aimed to examine the potential role of sarcopenia in KOA progression and subsequent knee replacement (KR). METHODS: Using data from the Osteoarthritis Initiative, baseline sarcopenia was first screened according to the EWGSOP2 algorithm using the SARC-F (Strength …

We aimed to examine the potential role of sarcopenia in KOA progression and subsequent knee replacement (KR). METHODS: Using data from the …

96

Association of single and multiple-site osteoarthritis with physical and mental health-related quality of life over an 8-year period in US adults: Findings from the osteoarthritis initiative.

Alenazi AM, Alghamdi MS, Alshehri MM, Alqahtani BA, Alanazi MF, Elnaggar RK, Alhowimel AS, Alhwoaimel NA, Alanazi AD, Almutairi SM, Alshehri YS, Vennu V, Alrawaili SM, Bindawas SM. Alenazi AM, et al. Medicine (Baltimore). 2025 May 2;104(18):e42335. doi: 10.1097/MD.0000000000042335. Medicine (Baltimore). 2025. PMID: 40324219 Free PMC article.

Data from 4796 participants aged between 45 and 79 years were acquired from the osteoarthritis initiative. Based on self-reported physician-diagnosed OA and grade 2 in either knee using Kellgren and Lawrence grade at baseline, participants were categorized into hi …

Data from 4796 participants aged between 45 and 79 years were acquired from the osteoarthritis initiative. Based on self-repor …

97

HCDPD: A Heterogeneous Causal Framework for Disease Pattern Detection in Medical Imaging.

Liu R, Shi C, Song R, Niethammer M, Li T, Zhu H. Liu R, et al. medRxiv [Preprint]. 2025 Apr 16:2025.04.15.25325904. doi: 10.1101/2025.04.15.25325904. medRxiv. 2025. PMID: 40321273 Free PMC article. Preprint.

Through the application of advanced Bayesian inference techniques, our method effectively estimates both direct and indirect causal effects within the HCDPD framework. We applied HCDPD to the Osteoarthritis Initiative (OAI) dataset, successfully identifying and deli …

Through the application of advanced Bayesian inference techniques, our method effectively estimates both direct and indirect causal effects …

98

A comparison of quantitative and semi-quantitative methods for assessing cartilage status and change over time; data from the osteoarthritis initiative.

Ray A, Brett AD, Dube B, Bowes MA, Rowbotham E, Conaghan PG. Ray A, et al. BMC Musculoskelet Disord. 2025 Apr 29;26(1):426. doi: 10.1186/s12891-025-08501-6. BMC Musculoskelet Disord. 2025. PMID: 40301834 Free PMC article.

99

Comprehensive comparative analysis of infrapatellar fat pad morphologies in a longitudinal knee osteoarthritis exploratory study: new insights into its role as an independent prognostic marker.

Pelletier JP, Paiement P, Abram F, Dorais M, Raynauld JP, Martel-Pelletier J. Pelletier JP, et al. Arthritis Res Ther. 2025 Apr 26;27(1):98. doi: 10.1186/s13075-025-03513-y. Arthritis Res Ther. 2025. PMID: 40287712 Free PMC article.

METHODS: This longitudinal study analyzed 1075 target knees (one knee per participant) from the Osteoarthritis Initiative (OAI) progression cohort. Structural changes include cartilage, bone marrow lesions (BMLs), and joint effusion volumes assessed using automated …

METHODS: This longitudinal study analyzed 1075 target knees (one knee per participant) from the Osteoarthritis Initiative (OAI …

100

The changes in 3D bone morphology mediate the association between meniscal extrusion and radiographic progression of osteoarthritis: data from the Osteoarthritis Initiative.

Deng C, Sun Y, Liu X. Deng C, et al. Quant Imaging Med Surg. 2025 Apr 1;15(4):2789-2801. doi: 10.21037/qims-24-1056. Epub 2025 Mar 25. Quant Imaging Med Surg. 2025. PMID: 40235799 Free PMC article.

METHODS: The participants in this study were drawn from the Osteoarthritis Initiative (OAI). The control group consisted of participants with an MME score <2 at baseline and 24 months, while the case group consisted of participants with an MME score 2 at baselin …

METHODS: The participants in this study were drawn from the Osteoarthritis Initiative (OAI). The control group consisted of pa …

101

A Progressive Risk Formulation for Enhanced Deep Learning based Total Knee Replacement Prediction in Knee Osteoarthritis.

Rajamohan HR, Kijowski R, Cho K, Deniz CM. Rajamohan HR, et al. ArXiv [Preprint]. 2025 Mar 28:arXiv:2406.10119v2. ArXiv. 2025. PMID: 40196144 Free PMC article. Preprint.

Knee radiographs and MRIs from the Osteoarthritis Initiative (OAI) and Multicenter Osteoarthritis Study (MOST) were used in this work and deep learning models were trained to predict TKR within 1, 2, and 4-year time periods. ...

Knee radiographs and MRIs from the Osteoarthritis Initiative (OAI) and Multicenter Osteoarthritis Study (MOST) were used in th …

102

Integration of longitudinal load-bearing tissue MRI radiomics and neural network to predict knee osteoarthritis incidence.

Chen T, Chen J, Liu H, Liu Z, Yu B, Wang Y, Zhao W, Peng Y, Li J, Yang Y, Wan H, Wang X, Zhang Z, Zhao D, Chen L, Chen L, Liao R, Liu S, Zeng G, Wen Z, Wang Y, Li X, Wang S, Miao H, Chen W, Zhu Y, Wang X, Ding C, Wang T, Li S, Zhang Y. Chen T, et al. J Orthop Translat. 2025 Mar 15;51:187-197. doi: 10.1016/j.jot.2025.01.007. eCollection 2025 Mar. J Orthop Translat. 2025. PMID: 40144553 Free PMC article.

METHODS: The 700 knees without radiographic KOA at baseline were included from Osteoarthritis Initiative cohort. We selected 2164 knee MRIs during 4-year follow-up. LBTC-RM, which integrated MRI features of meniscus, femur, tibia, femorotibial cartilage, and clinica …

METHODS: The 700 knees without radiographic KOA at baseline were included from Osteoarthritis Initiative cohort. We selected 2 …

103

Effects of total knee arthroplasty on symptoms, function and activity over 5 years in knee osteoarthritis: A propensity-score matched study.

Ge L, Wang J, Fang H, Wang Y, Shen Z, Cai G. Ge L, et al. J Exp Orthop. 2025 Mar 22;12(1):e70185. doi: 10.1002/jeo2.70185. eCollection 2025 Jan. J Exp Orthop. 2025. PMID: 40123679 Free PMC article.

PURPOSE: To evaluate the effects of total knee arthroplasty (TKA) on symptoms, function and activity over 5 years in knee osteoarthritis (KOA) patients. METHODS: Data were from the Osteoarthritis Initiative (OAI). Participants who conducted the first TKA from (not b …

PURPOSE: To evaluate the effects of total knee arthroplasty (TKA) on symptoms, function and activity over 5 years in knee osteoarthritis (KO …

104

Contralateral knee osteoarthritis severity relates to magnetic resonance imaging findings in knees with and without osteoarthritis: Data from the osteoarthritis initiative.

Driban JB, Baek J, Patarini JC, Kirillov E, Vo N, Richard MJ, Zhang M, Harkey MS, Lo GH, Liu SH, Eaton CB, MacKay J, Barbe MF, McAlindon TE. Driban JB, et al. Osteoarthr Cartil Open. 2025 Feb 17;7(2):100585. doi: 10.1016/j.ocarto.2025.100585. eCollection 2025 Jun. Osteoarthr Cartil Open. 2025. PMID: 40093663 Free PMC article.

OBJECTIVE: We explored whether a magnetic resonance imaging (MRI)-based composite score of bone marrow lesion and effusion-synovitis volumes related to contralateral knee osteoarthritis disease severity. DESIGN: Using data from the Osteoarthritis Initiative, we cond …

OBJECTIVE: We explored whether a magnetic resonance imaging (MRI)-based composite score of bone marrow lesion and effusion-synovitis volumes …

105

Weaker subchondral bone and thinner articular cartilage of the knee are associated with elevated baseline fracture risk independently of osteoarthritis risk factors.

Wong AKO, Pokhoy A, Naraghi AM, Mohankumar R. Wong AKO, et al. Arch Osteoporos. 2025 Mar 7;20(1):36. doi: 10.1007/s11657-025-01517-4. Arch Osteoporos. 2025. PMID: 40055244

METHODS: Male and female participants in the Osteoarthritis Initiative (OAI) at visit 5 (36 months) were evaluated for fracture risk using FRAX and categorized into low-, moderate-, or high-risk groups. ...

METHODS: Male and female participants in the Osteoarthritis Initiative (OAI) at visit 5 (36 months) were evaluated for fractur …

106

Kellgren-Lawrence grading of knee osteoarthritis using deep learning: Diagnostic performance with external dataset and comparison with four readers.

Vaattovaara E, Panfilov E, Tiulpin A, Niinimäki T, Niinimäki J, Saarakkala S, Nevalainen MT. Vaattovaara E, et al. Osteoarthr Cartil Open. 2025 Feb 7;7(2):100580. doi: 10.1016/j.ocarto.2025.100580. eCollection 2025 Jun. Osteoarthr Cartil Open. 2025. PMID: 40046240 Free PMC article.

The DL model was trained using all the CRs from Multicenter Osteoarthritis Study (MOST) and validated on Osteoarthritis Initiative (OAI) dataset and then tested on our external dataset. To assess the agreement between the graders, Cohen's quadratic kappa (k) with 95 …

The DL model was trained using all the CRs from Multicenter Osteoarthritis Study (MOST) and validated on Osteoarthritis Initiative …

107

End-to-End Prediction of Knee Osteoarthritis Progression With Multimodal Transformers.

Panfilov E, Saarakkala S, Nieminen MT, Tiulpin A. Panfilov E, et al. IEEE J Biomed Health Inform. 2025 Sep;29(9):6276-6286. doi: 10.1109/JBHI.2025.3536170. IEEE J Biomed Health Inform. 2025. PMID: 40031337

We analyzed its performance across different progression horizons - from short-term to long-term - using a large dataset (n = 3967/2421) from the Osteoarthritis Initiative. We show that structural knee MRI allows identifying radiographic KOA progressors on par with …

We analyzed its performance across different progression horizons - from short-term to long-term - using a large dataset (n = 3967/2421) fro …

108

Predicting joint space changes in knee osteoarthritis over 6 years: a combined model of TransUNet and XGBoost.

Guo J, Yan P, Luo H, Ma Y, Jiang Y, Ju C, Chen W, Liu M, Lv S, Qin Y. Guo J, et al. Quant Imaging Med Surg. 2025 Feb 1;15(2):1396-1410. doi: 10.21037/qims-24-1397. Epub 2025 Jan 8. Quant Imaging Med Surg. 2025. PMID: 39995733 Free PMC article.

METHODS: The data for this study was sourced from the Osteoarthritis Initiative database. We filtered knee X-ray images from 1,947 participants and tested six neural networks for segmentation to build an automatic JSW measurement model. ...

METHODS: The data for this study was sourced from the Osteoarthritis Initiative database. We filtered knee X-ray images from 1 …

109

Gender-differences in imaging phenotypes of osteoarthritis in the osteoarthritis initiative.

Kreutzinger V, Ziegeler K, Joseph GB, Lynch JA, Lane NE, McCulloch CE, Nevitt M, Link TM. Kreutzinger V, et al. Sci Rep. 2025 Feb 20;15(1):6219. doi: 10.1038/s41598-025-90782-x. Sci Rep. 2025. PMID: 39979538 Free PMC article.

Gender-specific differences in clinical OA manifestations have been identified, and this analysis aimed to assess whether these differences extend to imaging phenotypes.From the Osteoarthritis Initiative database 2523 participants (1409 women and 1114 men) with comp …

Gender-specific differences in clinical OA manifestations have been identified, and this analysis aimed to assess whether these differences …

110

MRI-based analysis of thigh intramuscular fat and its associations with age, sex, and BMI using data from the osteoarthritis initiative data.

Joseph GB, Akkaya Z, Sims WM, McCulloch CE, Nevitt MC, Lynch JA, Lane NE, Link TM. Joseph GB, et al. Sci Rep. 2025 Feb 20;15(1):6188. doi: 10.1038/s41598-024-75005-z. Sci Rep. 2025. PMID: 39979320 Free PMC article.

111

Symptoms predict total knee arthroplasty more than osteoarthritis severity: A multivariable analysis of more than 7500 knees.

Bianco Prevot L, Bensa A, Peretti G, Filardo G. Bianco Prevot L, et al. Knee Surg Sports Traumatol Arthrosc. 2025 Jun;33(6):2230-2236. doi: 10.1002/ksa.12623. Epub 2025 Feb 20. Knee Surg Sports Traumatol Arthrosc. 2025. PMID: 39976193

METHODS: A total of 7552 knees were selected from the Osteoarthritis Initiative (OAI) multicentre database. The data collected included demographic data, Kellgren-Lawrence (KL) grade, the presence of knee swelling, the frequency of swelling, visual analogue scale (V …

METHODS: A total of 7552 knees were selected from the Osteoarthritis Initiative (OAI) multicentre database. The data collected …

112

A longitudinal study of dietary inflammatory index and quality of life in people with osteoarthritis: data from the Osteoarthritis Initiative database.

Chen Z, Zhang H, Jin J, Su C, Chen H, Li B. Chen Z, et al. Sci Rep. 2025 Feb 19;15(1):6024. doi: 10.1038/s41598-025-86431-y. Sci Rep. 2025. PMID: 39971976 Free PMC article.

This study aims to investigate the relationship between DII and longitudinal trajectories of QoL, and the moderating effect of physical activity on this relationship in OA people. Data from the Osteoarthritis Initiative database includes baseline measurements and fo …

This study aims to investigate the relationship between DII and longitudinal trajectories of QoL, and the moderating effect of physical acti …

113

The Discordance Between Pain and Imaging in Knee Osteoarthritis.

Hill BG, Eble S, Moschetti WE, Schilling PL. Hill BG, et al. J Am Acad Orthop Surg. 2025 Feb 13;33(14):e786-e794. doi: 10.5435/JAAOS-D-24-00509. J Am Acad Orthop Surg. 2025. PMID: 39965186

We aimed to determine the degree to which commonly used structural features predict a patient's knee pain and symptoms. METHODS: Using Osteoarthritis Initiative data, a 10-year study of 4,796 patients with knee osteoarthritis (KOA), participants' KOA was characteriz …

We aimed to determine the degree to which commonly used structural features predict a patient's knee pain and symptoms. METHODS: Using Os …

114

Association Between Depressive Symptoms and Self-Reported Physical Activity in Persons With Knee Osteoarthritis.

Rathbun AM, Ryan AS, Shardell MD, Dong Y, Beamer BA, Luborsky M, Hochberg MC. Rathbun AM, et al. J Rheumatol. 2025 May 1;52(5):505-511. doi: 10.3899/jrheum.2024-0940. J Rheumatol. 2025. PMID: 39955095

The objective was to evaluate the longitudinal relationship between depressive symptoms and self-reported PA over time among persons with KOA. METHODS: The sample included Osteoarthritis Initiative participants (N = 2602) with radiographic disease (Kellgren-Lawrence …

The objective was to evaluate the longitudinal relationship between depressive symptoms and self-reported PA over time among persons with KO …

115

Association of radiographic structure deformity phenotypes of knee OA to clinical symptoms and risk for progression: Proposing a modification of Kellgren-Lawrence grade - Data from the Osteoarthritis Initiative and the MOST study.

Ko S, Choi Y, Han HS, Kim SH, Ro DH. Ko S, et al. Osteoarthr Cartil Open. 2025 Jan 9;7(1):100566. doi: 10.1016/j.ocarto.2025.100566. eCollection 2025 Mar. Osteoarthr Cartil Open. 2025. PMID: 39896932 Free PMC article.

116

Statin use and longitudinal bone marrow lesion burden: analysis of knees without osteoarthritis from the Osteoarthritis Initiative study.

Moradi K, Mohajer B, Guermazi A, Hadidchi R, Mohammadi S, Cao X, Wan M, Roemer FW, Demehri S. Moradi K, et al. Skeletal Radiol. 2025 Aug;54(8):1707-1714. doi: 10.1007/s00256-025-04878-6. Epub 2025 Jan 31. Skeletal Radiol. 2025. PMID: 39890641

We aimed to determine the association between statin use and longitudinal changes in magnetic resonance imaging (MRI)-based BML volume in participants without radiographic knee OA at baseline. METHODS: Using the Osteoarthritis Initiative (OAI) cohort, we classified …

We aimed to determine the association between statin use and longitudinal changes in magnetic resonance imaging (MRI)-based BML volume in pa …

117

Corrigendum to "Multi-centre modified Delphi exercise to identify candidate items for classifying early-stage symptomatic knee osteoarthritis" [Osteoarthritis Cartilage (2025) 155-165].

King LK, Liew JW, Mahmoudian A, Wang Q, Jansen NEJ, Stanaitis I, Hung V, Berenbaum F, Das S, Ding C, Emery CA, Filbay SR, Hochberg MC, Ishijima M, Kloppenburg M, Lane NE, Losina E, Mobasheri A, Turkiewicz A, Runhaar J, Haugen IK, Appleton CT, Lohmander LS, Englund M, Neogi T, Hawker GA; OARSI Early-stage Symptomatic Knee Osteoarthritis Initiative. King LK, et al. Osteoarthritis Cartilage. 2025 Apr;33(4):530-533. doi: 10.1016/j.joca.2025.01.002. Epub 2025 Jan 31. Osteoarthritis Cartilage. 2025. PMID: 39890093 Free article. No abstract available.

118

Morphological changes to the intercondylar space in different stages of osteoarthritis - A retrospective cross-sectional study.

Hirtler L, Schreiner M, Röhrich S, Kandathil SA, Kainberger F. Hirtler L, et al. Ann Anat. 2025 Apr;259:152388. doi: 10.1016/j.aanat.2025.152388. Epub 2025 Jan 28. Ann Anat. 2025. PMID: 39884442 Free article.

METHODS: Image data was retrieved from the Osteoarthritis Initiative. Patients were subdivided into five groups according to the severity of osteoarthritis following the Kellgren and Lawrence classification. 415 patients were selected randomly to ensure equally larg …

METHODS: Image data was retrieved from the Osteoarthritis Initiative. Patients were subdivided into five groups according to t …

119

Predicting rapid progression in knee osteoarthritis: a novel and interpretable automated machine learning approach, with specific focus on young patients and early disease.

Castagno S, Birch M, van der Schaar M, McCaskie A. Castagno S, et al. Ann Rheum Dis. 2025 Jan;84(1):124-135. doi: 10.1136/ard-2024-225872. Epub 2025 Jan 2. Ann Rheum Dis. 2025. PMID: 39874226 Free article.

Using two data sets within the OA Initiative-the Foundation for the National Institutes of Health OA Biomarker Consortium for training and hold-out validation, and the Pivotal Osteoarthritis Initiative MRI Analyses study for external validation-we employed two disti …

Using two data sets within the OA Initiative-the Foundation for the National Institutes of Health OA Biomarker Consortium for training and h …

120

Quantifying knee-adjacent subcutaneous fat in the entire OAI baseline dataset - Associations with cartilage MRI T₂, thickness and pain, independent of BMI.

Joseph GB, Liu F, Ziegeler K, Akkaya Z, Lynch JA, Pedoia V, Majumdar S, Lane NE, Nevitt MC, McCulloch CE, Link TM. Joseph GB, et al. Osteoarthritis Cartilage. 2025 Apr;33(4):482-490. doi: 10.1016/j.joca.2025.01.001. Epub 2025 Jan 27. Osteoarthritis Cartilage. 2025. PMID: 39864732 Free PMC article.

DESIGN: Baseline 3.0T MR images of the right knee from the entire Osteoarthritis Initiative cohort (n=4796) were used to quantify average values of kaSCF, cartilage thickness, and T(2) using deep learning algorithms. ...

DESIGN: Baseline 3.0T MR images of the right knee from the entire Osteoarthritis Initiative cohort (n=4796) were used to quant …

121

LMSST-GCN: Longitudinal MRI sub-structural texture guided graph convolution network for improved progression prediction of knee osteoarthritis.

Lv W, Peng J, Hu J, Lu Y, Zhou Z, Xu H, Xing K, Zhang X, Lu L. Lv W, et al. Comput Methods Programs Biomed. 2025 Apr;261:108600. doi: 10.1016/j.cmpb.2025.108600. Epub 2025 Jan 13. Comput Methods Programs Biomed. 2025. PMID: 39837061

METHODS: 600 KOA participants from the Osteoarthritis Initiative underwent 3 longitudinal MRI scans at baseline, 12 and 24 months. 3D nnU-net was adopted to segment 32 sub-structures of each knee on both IW and DESS sequences at each time point. 105 radiomics featur …

METHODS: 600 KOA participants from the Osteoarthritis Initiative underwent 3 longitudinal MRI scans at baseline, 12 and 24 mon …

122

Moderate-To-Vigorous Physical Activity Independent of Stationary Time Is Associated With Better Functional Outcomes Over Four-Years in Individuals With or at Risk of Knee Osteoarthritis.

Halliwell C, O'Brien M, Moyer R. Halliwell C, et al. Musculoskeletal Care. 2025 Mar;23(1):e70046. doi: 10.1002/msc.70046. Musculoskeletal Care. 2025. PMID: 39763150 Free PMC article.

METHODS: Data included 442 participants, with an average age of 66-years and 190-females from the Osteoarthritis Initiative who wore accelerometers to assess MVPA and stationary time. Participants were grouped into tertiles of MVPA and stationary time normalised to …

METHODS: Data included 442 participants, with an average age of 66-years and 190-females from the Osteoarthritis Initiative wh …

123

Association Between Average Daily Activity Counts and Knee Osteoarthritis Progression.

Tang X, Li D, Yao H, Chen X, Fan L, Hou Z. Tang X, et al. Am J Phys Med Rehabil. 2025 Jul 1;104(7):663-670. doi: 10.1097/PHM.0000000000002697. Epub 2025 Jan 3. Am J Phys Med Rehabil. 2025. PMID: 39750034

OBJECTIVE: The aim of the study was to explore the relationship between daily activity counts and knee osteoarthritis progression. DESIGN: A cohort study using Osteoarthritis Initiative data included 610 participants aged 45-79 yrs with knee osteoarthritis or at ris …

OBJECTIVE: The aim of the study was to explore the relationship between daily activity counts and knee osteoarthritis progression. DESIGN: A …

124

Estimating time-to-total knee replacement on radiographs and MRI: a multimodal approach using self-supervised deep learning.

Cigdem O, Chen S, Zhang C, Cho K, Kijowski R, Deniz CM. Cigdem O, et al. Radiol Adv. 2024 Nov 15;1(4):umae030. doi: 10.1093/radadv/umae030. eCollection 2022 Jan 1. Radiol Adv. 2024. PMID: 39744045 Free PMC article.

A survival analysis model for predicting time-to-TKR was developed using features from medical images and clinical measurements. METHODS: From the Osteoarthritis Initiative dataset, all knees with clinical variables, MRI scans, radiographs, and quantitative and semi …

A survival analysis model for predicting time-to-TKR was developed using features from medical images and clinical measurements. METHODS: Fr …

125

Knee osteoarthritis severity detection using deep inception transfer learning.

Sohail M, Azad MM, Kim HS. Sohail M, et al. Comput Biol Med. 2025 Mar;186:109641. doi: 10.1016/j.compbiomed.2024.109641. Epub 2024 Dec 31. Comput Biol Med. 2025. PMID: 39742824

This work proposes a transfer learning approach using an InceptionV3-based model fine-tuned on the Osteoarthritis Initiative dataset, and aims to enhance the identification of OA severity levels through dual-stage preprocessing and convolutional neural networks for …

This work proposes a transfer learning approach using an InceptionV3-based model fine-tuned on the Osteoarthritis Initiative d …

126

Individuals with Knee Osteoarthritis and Osteoporosis Represent a Distinctive Subgroup Whose Symptoms Originate from Differences in Subchondral Bone Rather than Cartilage.

Wong AKO, Naraghi AM, Probyn L. Wong AKO, et al. Calcif Tissue Int. 2024 Dec 14;116(1):5. doi: 10.1007/s00223-024-01315-z. Calcif Tissue Int. 2024. PMID: 39673599

To explore the hypothesis that knee osteoarthritis patients with osteoporosis represent a sub-cohort with different disease characteristics and origin of symptoms. Men and women in the Osteoarthritis Initiative (OAI) at visit 5 (36 months) were examined for osteopor …

To explore the hypothesis that knee osteoarthritis patients with osteoporosis represent a sub-cohort with different disease characteristics …

127

Effects of hypothetical low- versus moderate- to high-intensity weight management regimens on knee replacements.

Miki T, Cooray U, Kanai M, Hagiwara Y, Murakami M, Osaka K, Ikeda T. Miki T, et al. Am J Epidemiol. 2025 Oct 7;194(10):2829-2836. doi: 10.1093/aje/kwae446. Am J Epidemiol. 2025. PMID: 39673244

This study aimed to investigate the efficacy of a hypothetical biennial weight management regimen in reducing the necessity for knee replacement (KR) surgery among middle-aged and older adults with or at a higher risk for knee osteoarthritis (OA). Data were used from the Osteo …

This study aimed to investigate the efficacy of a hypothetical biennial weight management regimen in reducing the necessity for knee replace …

128

Multisite Pain Is Longitudinally Associated With an Increased Risk of Fall Among Older Adults With or at Risk of Knee Osteoarthritis: Data From the Osteoarthritis Initiative.

Alenazi AM. Alenazi AM. Am J Phys Med Rehabil. 2025 May 1;104(5):452-457. doi: 10.1097/PHM.0000000000002650. Epub 2024 Nov 20. Am J Phys Med Rehabil. 2025. PMID: 39642296

129

The association of vitamin D with knee osteoarthritis pain: an analysis from the Osteoarthritis Initiative database.

Zuo A, Jia Q, Zhang M, Zhou X, Li T, Wang L. Zuo A, et al. Sci Rep. 2024 Dec 4;14(1):30176. doi: 10.1038/s41598-024-81845-6. Sci Rep. 2024. PMID: 39632940 Free PMC article.

This study seeks to explore the association between serum Vitamin D levels and WOMAC pain scores, providing new insights into potential treatment strategies for KOA. Utilizing data from the Osteoarthritis Initiative (OAI) database, we conducted a cross-sectional ana …

This study seeks to explore the association between serum Vitamin D levels and WOMAC pain scores, providing new insights into potential trea …

130

MicroRNA signature for early prediction of knee osteoarthritis structural progression using integrated machine and deep learning approaches.

Jamshidi A, Espin-Garcia O, Wilson TG, Loveless I, Pelletier JP, Martel-Pelletier J, Ali SA. Jamshidi A, et al. Osteoarthritis Cartilage. 2025 Mar;33(3):330-340. doi: 10.1016/j.joca.2024.11.008. Epub 2024 Nov 29. Osteoarthritis Cartilage. 2025. PMID: 39617204 Free article.

METHODS: Baseline serum miRNAs from Osteoarthritis Initiative (OAI) participants were isolated and sequenced. Participants were categorized based on their likelihood of knee structural progression/non-progression using magnetic resonance imaging and X-ray data. ...

METHODS: Baseline serum miRNAs from Osteoarthritis Initiative (OAI) participants were isolated and sequenced. Participants wer …

131

Efficient development of subject-specific finite element knee models: Automated identification of soft-tissue attachments.

Malbouby V, Gibbons KD, Bursa N, Ivy AK, Fitzpatrick CK. Malbouby V, et al. J Biomech. 2025 Jan;178:112441. doi: 10.1016/j.jbiomech.2024.112441. Epub 2024 Nov 26. J Biomech. 2025. PMID: 39615057 Free PMC article.

Twelve knees were selected from the Osteoarthritis Initiative database and segmented to create 3D meshes of bone and cartilage. ...

Twelve knees were selected from the Osteoarthritis Initiative database and segmented to create 3D meshes of bone and cartilage …

132

Regression to the mean for physical function and quality of life in clinical trials for symptomatic knee osteoarthritis.

Englund M, Turkiewicz A. Englund M, et al. Osteoarthritis Cartilage. 2025 Mar;33(3):391-395. doi: 10.1016/j.joca.2024.11.006. Epub 2024 Nov 26. Osteoarthritis Cartilage. 2025. PMID: 39608563 Free article.

DESIGN: Longitudinal cohort study; we included participants of the Osteoarthritis Initiative who fulfilled typical inclusion criteria for enrolment in a trial. ...

DESIGN: Longitudinal cohort study; we included participants of the Osteoarthritis Initiative who fulfilled typical inclusion c …

133

Association of smoking with knee osteoarthritis structural defects and symptoms: an individual participant data meta-analysis.

Salis Z, Sainsbury A. Salis Z, et al. Sci Rep. 2024 Nov 22;14(1):29021. doi: 10.1038/s41598-024-80345-x. Sci Rep. 2024. PMID: 39578564 Free PMC article.

To address this limitation, we conducted an Individual Participant Data (IPD) meta-analysis using data from three large cohorts: the Osteoarthritis Initiative (OAI), the Multicenter Osteoarthritis Study (MOST), and the Cohort Hip and Cohort Knee (CHECK) study. ...

To address this limitation, we conducted an Individual Participant Data (IPD) meta-analysis using data from three large cohorts: the Oste …

134

Impact of knee geometry on joint contact mechanics after meniscectomy.

Deng R, Uzuner S, Li LP. Deng R, et al. Sci Rep. 2024 Nov 19;14(1):28595. doi: 10.1038/s41598-024-79662-y. Sci Rep. 2024. PMID: 39562771 Free PMC article.

135

Development of machine learning models for predicting depressive symptoms in knee osteoarthritis patients.

Li D, Lu H, Wu J, Chen H, Shen M, Tong B, Zeng W, Wang W, Shang S. Li D, et al. Sci Rep. 2024 Nov 19;14(1):28603. doi: 10.1038/s41598-024-79601-x. Sci Rep. 2024. PMID: 39562701 Free PMC article.

The China Health and Retirement Longitudinal Survey (CHARLS) data were used for model development and the Osteoarthritis Initiative (OAI) for external validation. 18 potential predictors were selected using LASSO regression. 4 machine learning models-logistic regres …

The China Health and Retirement Longitudinal Survey (CHARLS) data were used for model development and the Osteoarthritis Initiativ …

136

Machine learning-based prediction of contralateral knee osteoarthritis development using the Osteoarthritis Initiative and the Multicenter Osteoarthritis Study dataset.

Kim JS, Choi BS, Kim SE, Lee YS, Lee DW, Ro DH. Kim JS, et al. J Orthop Res. 2025 Mar;43(3):576-585. doi: 10.1002/jor.26018. Epub 2024 Nov 18. J Orthop Res. 2025. PMID: 39557015 Free article.

Data from 1353 unilateral KOA patients (900 from the Osteoarthritis Initiative [OAI] and 453 from the Multicenter Osteoarthritis Study [MOST]) over 4-5 years of follow-up were examined. ...

Data from 1353 unilateral KOA patients (900 from the Osteoarthritis Initiative [OAI] and 453 from the Multicenter Osteoarthrit …

137

Multi-centre modified Delphi exercise to identify candidate items for classifying early-stage symptomatic knee osteoarthritis.

King LK, Liew JW, Mahmoudian A, Wang Q, Jansen NEJ, Stanaitis I, Hung V, Berenbaum F, Das S, Ding C, Emery CA, Filbay SR, Hochberg MC, Ishijima M, Kloppenburg M, Lane NE, Losina E, Mobasheri A, Turkiewicz A, Runhaar J, Haugen IK, Appleton CT, Lohmander LS, Englund M, Neogi T, Hawker GA; OARSI Early-stage Symptomatic Knee Osteoarthritis Initiative. King LK, et al. Osteoarthritis Cartilage. 2025 Jan;33(1):155-165. doi: 10.1016/j.joca.2024.10.016. Epub 2024 Nov 8. Osteoarthritis Cartilage. 2025. PMID: 39521366 Free article.

138

Automated Diagnosis of Knee Osteoarthritis Using ResNet101 on a DEEP:PHI: Leveraging a No-Code AI Platform for Efficient and Accurate Medical Image Analysis.

Lee KH, Lee RW, Yun JS, Kim MS, Choi HS. Lee KH, et al. Diagnostics (Basel). 2024 Nov 1;14(21):2451. doi: 10.3390/diagnostics14212451. Diagnostics (Basel). 2024. PMID: 39518418 Free PMC article.

This study evaluates the efficacy of a deep learning model implemented through a no-code AI platform for diagnosing and grading knee OA from plain radiographs. Methods: We utilized the Osteoarthritis Initiative (OAI) dataset, comprising knee X-ray data from 1526 pat …

This study evaluates the efficacy of a deep learning model implemented through a no-code AI platform for diagnosing and grading knee OA from …

139

Osteoarthritis year in review 2024: Imaging.

Hayashi D, Roemer FW, Guermazi A. Hayashi D, et al. Osteoarthritis Cartilage. 2025 Jan;33(1):88-93. doi: 10.1016/j.joca.2024.10.009. Epub 2024 Oct 25. Osteoarthritis Cartilage. 2025. PMID: 39490728 Free article. Review.

There were several observational studies focusing on imaging of knee OA, such as the Multicenter Osteoarthritis Study, Rotterdam Study, Strontium ranelate efficacy in knee OA (SEKOIA) study, and the Osteoarthritis Initiative FNIH Biomarker study. Hip OA observationa …

There were several observational studies focusing on imaging of knee OA, such as the Multicenter Osteoarthritis Study, Rotterdam Study, Stro …

140

Understanding the role of machine learning in predicting progression of osteoarthritis.

Castagno S, Gompels B, Strangmark E, Robertson-Waters E, Birch M, van der Schaar M, McCaskie AW. Castagno S, et al. Bone Joint J. 2024 Nov 1;106-B(11):1216-1222. doi: 10.1302/0301-620X.106B11.BJJ-2024-0453.R1. Bone Joint J. 2024. PMID: 39481441

Most studies (85%) were published between 2020 and 2024, with 82% using publicly available datasets, primarily the Osteoarthritis Initiative. ML methods were predominantly supervised, with significant variability in the definitions of OA progression: most studies fo …

Most studies (85%) were published between 2020 and 2024, with 82% using publicly available datasets, primarily the Osteoarthritis …

141

Association of MRI-based knee osteoarthritis structural phenotypes with short-term structural progression and subsequent total knee replacement.

Liu Y, Xing Z, Wu B, Chen N, Wu T, Cai Z, Guo D, Tao G, Xie Z, Wu C, Cao P, Wang X, Li J. Liu Y, et al. J Orthop Surg Res. 2024 Oct 28;19(1):699. doi: 10.1186/s13018-024-05194-w. J Orthop Surg Res. 2024. PMID: 39468567 Free PMC article.

METHODS: A longitudinal study was conducted among participants with baseline Kellgren-Lawrence grade (KLG) 2 from the Osteoarthritis Initiative (OAI). The structural phenotypes at baseline were defined as subchondral bone, meniscus/cartilage and inflammatory pheno …

METHODS: A longitudinal study was conducted among participants with baseline Kellgren-Lawrence grade (KLG) 2 from the Osteoarthritis …

142

Improving Accuracy and Reproducibility of Cartilage T₂ Mapping in the OAI Dataset Through Extended Phase Graph Modeling.

Barbieri M, Gatti AA, Kogan F. Barbieri M, et al. J Magn Reson Imaging. 2025 May;61(5):2116-2127. doi: 10.1002/jmri.29646. Epub 2024 Oct 28. J Magn Reson Imaging. 2025. PMID: 39467097

BACKGROUND: The Osteoarthritis Initiative (OAI) collected extensive imaging data, including Multi-Echo Spin-Echo (MESE) sequences for measuring knee cartilage T(2) relaxation times. ...

BACKGROUND: The Osteoarthritis Initiative (OAI) collected extensive imaging data, including Multi-Echo Spin-Echo (MESE) sequen …

143

Fluctuation of Bone Marrow Lesions and Inflammatory MRI Markers over 2 Years and Concurrent Associations with Quantitative Cartilage Loss.

Roemer FW, Jansen MP, Maschek S, Mastbergen SC, Marijnissen AK, Wisser A, Heiss R, Weinans HH, Blanco FJ, Berenbaum F, Kloppenburg M, Haugen IK, Eckstein F, Hunter DJ, Guermazi A, Wirth W. Roemer FW, et al. Cartilage. 2025 Sep;16(3):308-321. doi: 10.1177/19476035241287694. Epub 2024 Oct 26. Cartilage. 2025. PMID: 39460605 Free PMC article.

ObjectiveTo assess whether change of semiquantitatively magnetic resonance imaging (MRI)-defined bone marrow lesions (BMLs) and inflammatory markers is associated with change in quantitatively-assessed cartilage loss in the femorotibial joint (FTJ) in knees with radiographic oste …

ObjectiveTo assess whether change of semiquantitatively magnetic resonance imaging (MRI)-defined bone marrow lesions (BMLs) and inflammatory …

144

Trajectories and Predictors of Weight-Bearing and Non-Weight-Bearing Pain in Knee Osteoarthritis: A 9-Year Follow-Up Study.

He ZJ, Wei JT, Jiang HM, Wang JY, Lai JY, Li SQ, Chen Z, Luo QL. He ZJ, et al. J Pain Res. 2024 Oct 16;17:3385-3395. doi: 10.2147/JPR.S480910. eCollection 2024. J Pain Res. 2024. PMID: 39429515 Free PMC article.

METHODS: We included 971 participants from the Osteoarthritis Initiative whose baseline magnetic resonance imaging data and 9-year follow-up data on pain were available. ...

METHODS: We included 971 participants from the Osteoarthritis Initiative whose baseline magnetic resonance imaging data and 9- …

145

Deep learning to combat knee osteoarthritis and severity assessment by using CNN-based classification.

Rani S, Memoria M, Almogren A, Bharany S, Joshi K, Altameem A, Rehman AU, Hamam H. Rani S, et al. BMC Musculoskelet Disord. 2024 Oct 16;25(1):817. doi: 10.1186/s12891-024-07942-9. BMC Musculoskelet Disord. 2024. PMID: 39415217 Free PMC article.

METHODS: To combat arthritis in the kneecap, this study employs a 12-layer Convolutional Neural Network (CNN) to reach deep learning capabilities. A collection of data from the Osteoarthritis Initiative (OAI) is used to classify KOA. Through the use of medical image …

METHODS: To combat arthritis in the kneecap, this study employs a 12-layer Convolutional Neural Network (CNN) to reach deep learning capabil …

146

Response to Letter to the Editor Commenting on: 'Inadequate Classification of Poor Response After Total Knee Arthroplasty: A Comparative Analysis of 15 Definitions Using Data From the Dutch Arthroplasty Register and the Osteoarthritis Initiative Database'.

Te Molder MEM, van den Ende CHM, Heesterbeek PJC. Te Molder MEM, et al. J Arthroplasty. 2024 Nov;39(11):e59. doi: 10.1016/j.arth.2024.06.046. J Arthroplasty. 2024. PMID: 39374990 No abstract available.

147

Letter to the Editor Commenting on "Inadequate Classification of Poor Response After Total Knee Arthroplasty: A Comparative Analysis of 15 Definitions Using Data From the Dutch Arthroplasty Register and the Osteoarthritis Initiative Database".

Riddle DL, Dumenci L. Riddle DL, et al. J Arthroplasty. 2024 Nov;39(11):e57-e58. doi: 10.1016/j.arth.2024.06.044. J Arthroplasty. 2024. PMID: 39374989 No abstract available.

148

Development of the machine learning model that is highly validated and easily applicable to predict radiographic knee osteoarthritis progression.

Lee DW, Han HS, Ro DH, Lee YS. Lee DW, et al. J Orthop Res. 2025 Jan;43(1):128-138. doi: 10.1002/jor.25982. Epub 2024 Oct 1. J Orthop Res. 2025. PMID: 39354808 Free article.

A retrospective analysis was conducted on prospectively collected data, using the Osteoarthritis Initiative data set (5966 knees) for model development and the Multicenter Osteoarthritis Study data set (3392 knees) for validation. ...

A retrospective analysis was conducted on prospectively collected data, using the Osteoarthritis Initiative data set (5966 kne …

149

Comment on 'Cachexia in Preclinical Rheumatoid Arthritis: Longitudinal Observational Study of Thigh Magnetic Resonance Imaging From Osteoarthritis Initiative Cohort' by Moradi Et Al.

Zhang L, Zhou X, Jia G. Zhang L, et al. J Cachexia Sarcopenia Muscle. 2024 Dec;15(6):2869-2870. doi: 10.1002/jcsm.13590. Epub 2024 Sep 28. J Cachexia Sarcopenia Muscle. 2024. PMID: 39340323 Free PMC article. No abstract available.

150

Deep Learning for Automatic Knee Osteoarthritis Severity Grading and Classification.

Kinger S. Kinger S. Indian J Orthop. 2024 Sep 11;58(10):1458-1473. doi: 10.1007/s43465-024-01259-4. eCollection 2024 Oct. Indian J Orthop. 2024. PMID: 39324090 Free PMC article.

This study aims to address these challenges by developing a deep learning-based method to predict the likelihood of knee replacement and the Kellgren-Lawrence (KL) grade of knee OA from X-ray images. METHODOLOGY: We employed the Osteoarthritis Initiative (OAI) datas …

This study aims to address these challenges by developing a deep learning-based method to predict the likelihood of knee replacement and the …

151

Weight, height, waist circumference: association with knee osteoarthritis findings from the osteoarthritis initiative.

Antoine LH, Watts KA, Rumble DD, Buchanan T, Sims A, Goodin BR. Antoine LH, et al. Pain Rep. 2024 Sep 20;9(5):e1187. doi: 10.1097/PR9.0000000000001187. eCollection 2024 Oct. Pain Rep. 2024. PMID: 39315116 Free PMC article.

METHODS: Using 4,602 participants (45-79 years) from the Osteoarthritis Initiative, we analyzed the association between knee osteoarthritis and anthropometry collectively and by sex. ...

METHODS: Using 4,602 participants (45-79 years) from the Osteoarthritis Initiative, we analyzed the association between knee o …

152

Strength Training is Associated With Less Knee Osteoarthritis: Data From the Osteoarthritis Initiative: Comment on the Article by Lo et al.

Bai Y, Wang G, Wu Y. Bai Y, et al. Arthritis Rheumatol. 2025 Feb;77(2):239. doi: 10.1002/art.42995. Epub 2024 Sep 30. Arthritis Rheumatol. 2025. PMID: 39300599 No abstract available.

153

Navigating the Global Landscape of Exercise Interventions for Knee Osteoarthritis: Exploring Evolving Trends and Emerging Frontiers From a Bibliometric and Visualization Analysis Perspective (2011-2022).

Chen Q, Cai K, Li S, Du X, Wang F, Yang Y, Cai M. Chen Q, et al. J Am Med Dir Assoc. 2024 Nov;25(11):105269. doi: 10.1016/j.jamda.2024.105269. Epub 2024 Sep 16. J Am Med Dir Assoc. 2024. PMID: 39299293 Review.

The keyword clustering map highlighted an evolution in the field of exercise interventions for KOA, emphasizing 8 key research themes spanning knee osteoarthritis, serum cartilage, osteoarthritis initiative, patellofemoral pain, total knee arthroplasty, exercise-ind …

The keyword clustering map highlighted an evolution in the field of exercise interventions for KOA, emphasizing 8 key research themes spanni …

154

Progression of Bone Marrow Lesions and the Development of Knee Osteoarthritis: Osteoarthritis Initiative Data.

Moradi K, Mohammadi S, Roemer FW, Momtazmanesh S, Hathaway Q, Ibad HA, Hunter DJ, Guermazi A, Demehri S. Moradi K, et al. Radiology. 2024 Sep;312(3):e240470. doi: 10.1148/radiol.240470. Radiology. 2024. PMID: 39287521 Free PMC article.

Materials and Methods This retrospective study included knee MRI scans from the Osteoarthritis Initiative prospective cohort (February 2004-October 2015). The DL model, developed between August and October 2023, segmented the tibiofemoral joint into 10 subregions an …

Materials and Methods This retrospective study included knee MRI scans from the Osteoarthritis Initiative prospective cohort ( …

155

Association between folate intake and radiographic progression, pain function scores in subjects with radiographic knee osteoarthritis: Data from the osteoarthritis initiative.

Luo H, Zheng Z, Xiong Y, Xu H, Xue Q, Sun C. Luo H, et al. Int J Rheum Dis. 2024 Sep;27(9):e15333. doi: 10.1111/1756-185X.15333. Int J Rheum Dis. 2024. PMID: 39246020

METHODOLOGY: Our population-based cohort was extracted from the osteoarthritis initiative (OAI), focusing on individuals with prevalent radiographic knee OA (with a Kellgren-Lawrence score 2). ...

METHODOLOGY: Our population-based cohort was extracted from the osteoarthritis initiative (OAI), focusing on individuals with …

156

Investigating the relationship between radiographic joint space width loss and deep learning-derived magnetic resonance imaging-based cartilage thickness loss in the medial weight-bearing region of the tibiofemoral joint.

Minnig MCC, Arbeeva L, Niethammer M, Nissman D, Lund JL, Marron JS, Golightly YM, Nelson AE. Minnig MCC, et al. Osteoarthr Cartil Open. 2024 Aug 3;6(3):100508. doi: 10.1016/j.ocarto.2024.100508. eCollection 2024 Sep. Osteoarthr Cartil Open. 2024. PMID: 39238657 Free PMC article.

DESIGN: We analyzed a subset of knees (n = 256) from the Osteoarthritis Initiative (OAI) likely in early stage OA based on joint space narrowing (JSN) measurements. ...

DESIGN: We analyzed a subset of knees (n = 256) from the Osteoarthritis Initiative (OAI) likely in early stage OA based on j …

157

Evaluation of an automated laminar cartilage T2 relaxation time analysis method in an early osteoarthritis model.

Wirth W, Maschek S, Wisser A, Eder J, Baumgartner CF, Chaudhari A, Berenbaum F, Eckstein F; OA-BIO Consortium. Wirth W, et al. Skeletal Radiol. 2025 Mar;54(3):571-584. doi: 10.1007/s00256-024-04786-1. Epub 2024 Sep 4. Skeletal Radiol. 2025. PMID: 39230576 Free PMC article.

MATERIALS AND METHODS: 2D U-Nets were trained from manually segmented femorotibial cartilages (n = 72) from all 7 echoes (All(E)), or from the 1st echo only (1(st)(E)) of multi-echo-spin-echo (MESE) MRIs acquired by the Osteoarthritis Initiative (OAI). Because of it …

MATERIALS AND METHODS: 2D U-Nets were trained from manually segmented femorotibial cartilages (n = 72) from all 7 echoes (All(E)), or from t …

158

Do Existing Magnetic Resonance Imaging Definitions of Knee Osteoarthritis Identify Knees That Will Develop Clinically Significant Disease Over Up To 11 Years of Follow-Up?

Chang AH, Roemer FW, Guermazi A, Almagor O, Lee JJ, Chmiel JS, Muhammad LN, Song J, Sharma L. Chang AH, et al. Arthritis Rheumatol. 2025 Feb;77(2):140-150. doi: 10.1002/art.42982. Epub 2024 Oct 17. Arthritis Rheumatol. 2025. PMID: 39229747 Free PMC article.

OBJECTIVE: In individuals without radiographic knee osteoarthritis (OA), we investigated whether magnetic resonance imaging (MRI)-defined knee OA at baseline was associated with incident radiographic and symptomatic disease during up to 11 years of follow-up. METHODS: Osteoart …

OBJECTIVE: In individuals without radiographic knee osteoarthritis (OA), we investigated whether magnetic resonance imaging (MRI)-defined kn …

159

Multisite Musculoskeletal Pain Is Associated with Long-Term Declined Physical Quality of Life and Knee-Related Quality of Life in Older Adults with or at Risk of Knee Osteoarthritis.

Alqahtani BA, Alenazi AM. Alqahtani BA, et al. Medicina (Kaunas). 2024 Aug 12;60(8):1305. doi: 10.3390/medicina60081305. Medicina (Kaunas). 2024. PMID: 39202586 Free PMC article.

Data from 4796 participants aged between 45 and 79 years were acquired from the Osteoarthritis Initiative. Based on self-reported physician-diagnosed osteoarthritis and grade 2 in either knee using Kellgren and Lawrence grade at baseline, individuals at risk were c …

Data from 4796 participants aged between 45 and 79 years were acquired from the Osteoarthritis Initiative. Based on self-repor …

160

Assessing the Value of Imaging Data in Machine Learning Models to Predict Patient-Reported Outcome Measures in Knee Osteoarthritis Patients.

Nair A, Alagha MA, Cobb J, Jones G. Nair A, et al. Bioengineering (Basel). 2024 Aug 12;11(8):824. doi: 10.3390/bioengineering11080824. Bioengineering (Basel). 2024. PMID: 39199782 Free PMC article.

We included 2408 patients from the Osteoarthritis Initiative (OAI) database, with 629 patients from the Multicenter Osteoarthritis Study (MOST) database. ...

We included 2408 patients from the Osteoarthritis Initiative (OAI) database, with 629 patients from the Multicenter Osteoarthr …

161

The natural history of marginal erosions in hands with and without osteoarthritis.

Sharma HA, McAlindon TE, Roberts MB, Haugen IK, Lo GH, Duryea J, Schaefer LF, Smith SE, Eaton CB, Driban JB. Sharma HA, et al. Clin Rheumatol. 2024 Oct;43(10):3239-3248. doi: 10.1007/s10067-024-07116-x. Epub 2024 Aug 22. Clin Rheumatol. 2024. PMID: 39172292 Free PMC article.

DESIGN: We studied participants from the Osteoarthritis Initiative with baseline and 48-month hand radiographs. A radiologist and rheumatologist evaluated the radiographs for disease severity (Kellgren-Lawrence grades) and erosions (central or marginal), respectivel …

DESIGN: We studied participants from the Osteoarthritis Initiative with baseline and 48-month hand radiographs. A radiologist …

162

The role of the World Guidelines for Falls Prevention and Management's risk stratification algorithm in predicting falls: a retrospective analysis of the Osteoarthritis Initiative.

Ragusa FS, Di Bella G, Dominguez LJ, Veronese N, Smith L, Barbagallo M. Ragusa FS, et al. Age Ageing. 2024 Aug 6;53(8):afae187. doi: 10.1093/ageing/afae187. Age Ageing. 2024. PMID: 39171386 Free PMC article.

The aim of the present study was to verify sensitivity, specificity and accuracy of World Guidelines for Falls Prevention and Management (WGFPM) falls risk stratification algorithm using data from the Osteoarthritis Initiative (OAI). METHODS: Participants aged betwe …

The aim of the present study was to verify sensitivity, specificity and accuracy of World Guidelines for Falls Prevention and Management (WG …

163

Accurate, automated classification of radiographic knee osteoarthritis severity using a novel method of deep learning: Plug-in modules.

Lee DW, Song DS, Han HS, Ro DH. Lee DW, et al. Knee Surg Relat Res. 2024 Aug 13;36(1):24. doi: 10.1186/s43019-024-00228-3. Knee Surg Relat Res. 2024. PMID: 39138550 Free PMC article.

The model was trained and developed using the Osteoarthritis Initiative dataset and was subsequently tested on an independent dataset, the Multicenter Osteoarthritis Study (test set size: 17,040). ...

The model was trained and developed using the Osteoarthritis Initiative dataset and was subsequently tested on an independent …

164

A Preliminary Study of Quantitative MRI Cartilage Loss Fraction and Its Association With Future Arthroplasty Using the Osteoarthritis Initiative Database.

Jo S, Sebro RA, Zhang L, Wang Z, Chang L, Hochberg MC, Mitchell BD. Jo S, et al. Cureus. 2024 Jul 10;16(7):e64279. doi: 10.7759/cureus.64279. eCollection 2024 Jul. Cureus. 2024. PMID: 39130899 Free PMC article.

Materials and methods Publicly available knee MRIs from the Osteoarthritis Initiative were used. A total of 38 participants with Kellgren-Lawrence (K-L) grade >1 and 38 participants with K-L grade 1 at enrollment were matched in age, sex, race, and BMI, and ass …

Materials and methods Publicly available knee MRIs from the Osteoarthritis Initiative were used. A total of 38 participants wi …

165

Predicting incident radiographic knee osteoarthritis through quantitative meniscal lesion parameters: data from the osteoarthritis initiative.

Bo K, Xie X, Liu X, Ou J, Zhang Y, Wang X, Yang S, Zhang W, Zhang L, Chang J. Bo K, et al. BMC Musculoskelet Disord. 2024 Aug 6;25(1):626. doi: 10.1186/s12891-024-07706-5. BMC Musculoskelet Disord. 2024. PMID: 39107768 Free PMC article.

BACKGROUND: This study investigates the potential of novel meniscal parameters as predictive factors for incident radiographic knee osteoarthritis (ROA) over a span of four years, as part of the Osteoarthritis Initiative (OAI) study. OBJECTIVES: Quantitative measure …

BACKGROUND: This study investigates the potential of novel meniscal parameters as predictive factors for incident radiographic knee osteoart …

166

Infrapatellar fat pad size and subcutaneous fat in knee osteoarthritis radiographic progression: data from the osteoarthritis initiative.

Lee K, Banuls-Mirete M, Lombardi AF, Posis AIB, Chang EY, Lane NE, Guma M. Lee K, et al. Arthritis Res Ther. 2024 Jul 30;26(1):145. doi: 10.1186/s13075-024-03367-w. Arthritis Res Ther. 2024. PMID: 39080699 Free PMC article.

METHODS: This case-control study used data from the Osteoarthritis Initiative (OAI) and included 315 cases (all the right knees with a minimum of Kellgren-Lawrence score (KL) of 0 and an increase of 1 KL from baseline to 48 months) and 315 controls matched by age, …

METHODS: This case-control study used data from the Osteoarthritis Initiative (OAI) and included 315 cases (all the right knee …

167

Bisphosphonates show no association with preventing, slowing, or delaying radiographic changes and pain in hip osteoarthritis: A 4-year study in female adults using data from the Osteoarthritis Initiative Study.

Salis Z. Salis Z. Int J Rheum Dis. 2024 Aug;27(8):e15279. doi: 10.1111/1756-185X.15279. Int J Rheum Dis. 2024. PMID: 39078051

METHODS: This study examined data from the Osteoarthritis Initiative (OAI), which included 4088 hips from 2057 participants. Bisphosphonate users were identified as those who reported usage at least three times, including at baseline and during the subsequent 1, 2, …

METHODS: This study examined data from the Osteoarthritis Initiative (OAI), which included 4088 hips from 2057 participants. B …

168

Diagnosing the Severity of Knee Osteoarthritis Using Regression Scores From Artificial Intelligence Convolution Neural Networks.

Fei M, Lu S, Chung JH, Hassan S, Elsissy J, Schneiderman BA. Fei M, et al. Orthopedics. 2024 Sep-Oct;47(5):e247-e254. doi: 10.3928/01477447-20240718-02. Epub 2024 Jul 29. Orthopedics. 2024. PMID: 39073041 Free article.

MATERIALS AND METHODS: This study used 8260 radiographic images from The Osteoarthritis Initiative to develop and assess four neural network models (VGG16, EfficientNetV2 small, ResNet34, and DenseNet196). ...

MATERIALS AND METHODS: This study used 8260 radiographic images from The Osteoarthritis Initiative to develop and assess four …

169

Association of physical activity trajectories over 8 years and risk of knee replacement: data from the osteoarthritis initiative.

Wang Y, Shen Z, Xing X, Ge L, Pan F, Cai G. Wang Y, et al. BMC Musculoskelet Disord. 2024 Jul 26;25(1):586. doi: 10.1186/s12891-024-07710-9. BMC Musculoskelet Disord. 2024. PMID: 39061027 Free PMC article.

METHODS: This study used data from the Osteoarthritis Initiative. The Physical Activity Scale for the Elderly and the KR were assessed annually from baseline to 9 years. ...

METHODS: This study used data from the Osteoarthritis Initiative. The Physical Activity Scale for the Elderly and the KR were …

170

Fully and Weakly Supervised Deep Learning for Meniscal Injury Classification, and Location Based on MRI.

Jiang K, Xie Y, Zhang X, Zhang X, Zhou B, Li M, Chen Y, Hu J, Zhang Z, Chen S, Yu K, Qiu C, Zhang X. Jiang K, et al. J Imaging Inform Med. 2025 Feb;38(1):191-202. doi: 10.1007/s10278-024-01198-4. Epub 2024 Jul 17. J Imaging Inform Med. 2025. PMID: 39020156 Free PMC article.

In this retrospective study, data were from the osteoarthritis initiative (OAI). The MR images were reconstructed using a sagittal intermediate-weighted fat-suppressed turbo spin-echo sequence. (1) We used 130 knees from the OAI to develop the LGSA-UNet model which …

In this retrospective study, data were from the osteoarthritis initiative (OAI). The MR images were reconstructed using a sagi …

171

Blood pressure is associated with knee pain severity in middle-aged and elderly individuals with or at risks for osteoarthritis: data from the Osteoarthritis Initiative.

Liu Y, Du G. Liu Y, et al. BMC Musculoskelet Disord. 2024 Jul 12;25(1):536. doi: 10.1186/s12891-024-07657-x. BMC Musculoskelet Disord. 2024. PMID: 38997710 Free PMC article.

METHODS: Our sample consisted of 2598 subjects (60.7% female, aged 45-79 years) collected from the Osteoarthritis Initiative. Blood pressure parameters included blood pressure stage, systolic blood pressure (SBP), diastolic blood pressure (DBP) and pulse pressure (P …

METHODS: Our sample consisted of 2598 subjects (60.7% female, aged 45-79 years) collected from the Osteoarthritis Initiative. …

172

Radiographic Findings Associated With Mild Hip Dysplasia in 3869 Patients Using a Deep Learning Measurement Tool.

Jang SJ, Driscoll DA, Anderson CG, Sokrab R, Flevas DA, Mayman DJ, Vigdorchik JM, Jerabek SA, Sculco PK. Jang SJ, et al. Arthroplast Today. 2024 Jun 18;28:101398. doi: 10.1016/j.artd.2024.101398. eCollection 2024 Aug. Arthroplast Today. 2024. PMID: 38993836 Free PMC article.

We validated a deep learning (DL) algorithm to measure angles relevant to hip dysplasia and applied this algorithm to determine the prevalence of dysplasia in a large population based on incremental radiographic cutoffs. METHODS: Patients from the Osteoarthritis Initiat …

We validated a deep learning (DL) algorithm to measure angles relevant to hip dysplasia and applied this algorithm to determine the prevalen …

173

Femorotibial angle scan-rescan reproducibility: A high-precision calculation on a large cohort.

Hall TAG, Jones GG, van Arkel RJ. Hall TAG, et al. Knee Surg Sports Traumatol Arthrosc. 2024 Dec;32(12):3133-3140. doi: 10.1002/ksa.12352. Epub 2024 Jul 10. Knee Surg Sports Traumatol Arthrosc. 2024. PMID: 38984897 Free PMC article.

METHODS: In this study, 4589 FTA measurement pairs from 2586 subjects acquired a year apart were used to estimate FTA scan-rescan reproducibility using data from the Osteoarthritis Initiative. Subjects with radiographic progression of osteoarthritis or other conditi …

METHODS: In this study, 4589 FTA measurement pairs from 2586 subjects acquired a year apart were used to estimate FTA scan-rescan reproducib …

174

Two-Stage Classification of Future Knee Osteoarthritis Severity After 8 Years Using MRI: Data from the Osteoarthritis Initiative.

Nurmirinta TAT, Turunen MJ, Korhonen RK, Tohka J, Liukkonen MK, Mononen ME. Nurmirinta TAT, et al. Ann Biomed Eng. 2024 Dec;52(12):3172-3183. doi: 10.1007/s10439-024-03578-x. Epub 2024 Jul 9. Ann Biomed Eng. 2024. PMID: 38980544 Free PMC article.

Our training dataset comprised longitudinal 8-year follow-up data of 1213 knees from the Osteoarthritis Initiative. Through extensive experimentation with various feature combinations, we identified KL baseline and weight as the most essential features, while gender …

Our training dataset comprised longitudinal 8-year follow-up data of 1213 knees from the Osteoarthritis Initiative. Through ex …

175

Development and validation of a frailty index for use in the osteoarthritis initiative.

O'Brien MW, Maxwell SP, Moyer R, Rockwood K, Theou O. O'Brien MW, et al. Age Ageing. 2024 Jun 1;53(6):afae125. doi: 10.1093/ageing/afae125. Age Ageing. 2024. PMID: 38935532 Free PMC article.

BACKGROUND: The Osteoarthritis Initiative (OAI) evaluates the development and progression of osteoarthritis. ...

176

Identifying significant structural factors associated with knee pain severity in patients with osteoarthritis using machine learning.

Zhao Z, Zhao M, Yang T, Li J, Qin C, Wang B, Wang L, Li B, Liu J. Zhao Z, et al. Sci Rep. 2024 Jun 26;14(1):14705. doi: 10.1038/s41598-024-65613-0. Sci Rep. 2024. PMID: 38926487 Free PMC article.

The data of semi-quantitative assessments of knee radiographs, semi-quantitative assessments of knee magnetic resonance imaging (MRI), and MRI images from 567 individuals in the Osteoarthritis Initiative (OAI) were utilized to train a series of machine learning mode …

The data of semi-quantitative assessments of knee radiographs, semi-quantitative assessments of knee magnetic resonance imaging (MRI), and M …

177

Cachexia in preclinical rheumatoid arthritis: Longitudinal observational study of thigh magnetic resonance imaging from osteoarthritis initiative cohort.

Moradi K, Mohajer B, Guermazi A, Kwoh CK, Bingham CO, Mohammadi S, Cao X, Wan M, Roemer FW, Demehri S. Moradi K, et al. J Cachexia Sarcopenia Muscle. 2024 Oct;15(5):1823-1833. doi: 10.1002/jcsm.13533. Epub 2024 Jun 24. J Cachexia Sarcopenia Muscle. 2024. PMID: 38923846 Free PMC article.

METHODS: In this observational cohort study, the Osteoarthritis Initiative (OAI) participants were categorized into Pre-RA and propensity score (PS)-matched control groups. ...

METHODS: In this observational cohort study, the Osteoarthritis Initiative (OAI) participants were categorized into Pre-RA and …

178

Shoulder Symptom Trajectories Over Four Years: Data From a Longitudinal Study on Osteoarthritis.

Tran G, Dube B, Kingsbury SR, Conaghan PG. Tran G, et al. Arthritis Care Res (Hoboken). 2024 Oct;76(10):1436-1443. doi: 10.1002/acr.25383. Epub 2024 Jul 14. Arthritis Care Res (Hoboken). 2024. PMID: 38923320 Free article.

We aimed to describe longitudinal patterns of shoulder symptoms and determine risk factors for incidence and persistence. METHODS: Data from Osteoarthritis Initiative participants observed annually for four years were used to describe shoulder symptom (yes/no, side) …

We aimed to describe longitudinal patterns of shoulder symptoms and determine risk factors for incidence and persistence. METHODS: Data from …

179

The mediation effects of malalignment on the relation of sex to the risk of incidence tibiofemoral osteoarthritis.

Xin H, Li X, Zhang Y, Zeng C, Lei G, Yang T, Wei J. Xin H, et al. Osteoarthritis Cartilage. 2024 Sep;32(9):1134-1140. doi: 10.1016/j.joca.2024.06.006. Epub 2024 Jun 14. Osteoarthritis Cartilage. 2024. PMID: 38880429 Free article.

DESIGN: Using data from Multicenter Osteoarthritis Study (MOST) and Osteoarthritis Initiative (OAI), we examined the relation of sex to the incident medial and lateral TFROA and performed mediation analyses to assess to what extent varus and valgus malalignments acc …

DESIGN: Using data from Multicenter Osteoarthritis Study (MOST) and Osteoarthritis Initiative (OAI), we examined the relation …

180

Thigh muscle composition changes in knee osteoarthritis patients during weight loss: Sex-specific analysis using data from osteoarthritis initiative.

Moradi K, Mohajer B, Mohammadi S, Guermazi A, Ibad HA, Roemer FW, Cao X, Link TM, Demehri S. Moradi K, et al. Osteoarthritis Cartilage. 2024 Sep;32(9):1154-1162. doi: 10.1016/j.joca.2024.05.013. Epub 2024 Jun 6. Osteoarthritis Cartilage. 2024. PMID: 38851527 Free PMC article.

We investigated longitudinal sex-based changes in thigh muscle quality during weight loss in participants with KOA. METHODS: Using Osteoarthritis Initiative (OAI) cohort data, we included females and males with baseline radiographic KOA who experienced > 5 % redu …

We investigated longitudinal sex-based changes in thigh muscle quality during weight loss in participants with KOA. METHODS: Using Osteoa …

181

Knee-Loading Predictions with Neural Networks Improve Finite Element Modeling Classifications of Knee Osteoarthritis: Data from the Osteoarthritis Initiative.

Paz A, Lavikainen J, Turunen MJ, García JJ, Korhonen RK, Mononen ME. Paz A, et al. Ann Biomed Eng. 2024 Sep;52(9):2569-2583. doi: 10.1007/s10439-024-03549-2. Epub 2024 Jun 6. Ann Biomed Eng. 2024. PMID: 38842728 Free PMC article.

182

The mediating role of synovitis in meniscus pathology and knee osteoarthritis radiographic progression.

Deng H, Chen Z, Kang J, Liu J, Chen S, Li M, Tao J. Deng H, et al. Sci Rep. 2024 May 29;14(1):12335. doi: 10.1038/s41598-024-63291-6. Sci Rep. 2024. PMID: 38811752 Free PMC article.

We conducted an observational study in the Osteoarthritis Initiative (OAI) cohort, with a 48-month follow-up. Meniscus pathology and synovitis were measured by MRI osteoarthritis knee score (MOAKS) at baseline and 24 months, and a comprehensive synovitis score was c …

We conducted an observational study in the Osteoarthritis Initiative (OAI) cohort, with a 48-month follow-up. Meniscus patholo …

183

Head-to-head comparison of appropriate use criteria for knee arthroplasty: A multicenter cohort study.

Riddle DL, Dumenci L. Riddle DL, et al. Osteoarthr Cartil Open. 2024 May 9;6(3):100482. doi: 10.1016/j.ocarto.2024.100482. eCollection 2024 Sep. Osteoarthr Cartil Open. 2024. PMID: 38800824 Free PMC article.

DESIGN: Longitudinal data from the Osteoarthritis Initiative (OAI) and the Multicenter Osteoarthritis Study (MOST) were combined to produce a dataset of 922 persons with knee arthroplasty, 602 of which had adequate data for RAND classification and had their surgery …

DESIGN: Longitudinal data from the Osteoarthritis Initiative (OAI) and the Multicenter Osteoarthritis Study (MOST) were combin …

184

Interactions of cumulative load with biomarkers of cartilage turnover predict knee cartilage change over 2 years: data from the osteoarthritis initiative.

Ivanochko NK, Gatti AA, Stratford PW, Maly MR. Ivanochko NK, et al. Clin Rheumatol. 2024 Jul;43(7):2317-2327. doi: 10.1007/s10067-024-07014-2. Epub 2024 May 24. Clin Rheumatol. 2024. PMID: 38787477

Among participants enrolled in the Osteoarthritis Initiative Biomarkers Consortium Project, a representation of cumulative load exposure and its interaction with cartilage turnover biomarkers were weakly related with 2-year change in knee cartilage. ...

Among participants enrolled in the Osteoarthritis Initiative Biomarkers Consortium Project, a representation of cumulative loa …

185

MedKnee: A New Deep Learning-Based Software for Automated Prediction of Radiographic Knee Osteoarthritis.

Touahema S, Zaimi I, Zrira N, Ngote MN, Doulhousne H, Aouial M. Touahema S, et al. Diagnostics (Basel). 2024 May 10;14(10):993. doi: 10.3390/diagnostics14100993. Diagnostics (Basel). 2024. PMID: 38786291 Free PMC article.

To accomplish this task, 5000 knee X-ray images obtained from the Osteoarthritis Initiative public dataset (OAI) were divided into train, valid, and test datasets in a ratio of 7:1:2 with a balanced distribution across each KL grade. ...

To accomplish this task, 5000 knee X-ray images obtained from the Osteoarthritis Initiative public dataset (OAI) were divided …

186

Characterization of clinical data for patient stratification in moderate osteoarthritis with support vector machines, regulatory network models, and verification against osteoarthritis Initiative data.

Segarra-Queralt M, Galofré M, Tio L, Monfort J, Monllau JC, Piella G, Noailly J. Segarra-Queralt M, et al. Sci Rep. 2024 May 23;14(1):11797. doi: 10.1038/s41598-024-62212-x. Sci Rep. 2024. PMID: 38782951 Free PMC article.

Thresholds are tested against patient stratification according to baseline WOMAC data from the Osteoarthritis Initiative, and the mean accuracy is 0.97. For our cohort, the data used as SVM inputs are knee OA descriptors, synovial fluid proteomic measurements (n = 2 …

Thresholds are tested against patient stratification according to baseline WOMAC data from the Osteoarthritis Initiative, and …

187

Gender and age differences in the associations between cortical thickness and hand osteoarthritis severity: data from the Osteoarthritis Initiative.

Smith SE, Driban JB, Eaton CB, Schaefer LF, Miao QR, Roberts MB, Cauley JA, McAlindon TE, Duryea J. Smith SE, et al. Osteoarthritis Cartilage. 2024 Sep;32(9):1141-1148. doi: 10.1016/j.joca.2024.05.002. Epub 2024 May 18. Osteoarthritis Cartilage. 2024. PMID: 38768803 Free PMC article.

METHOD: Hand radiographs of 3575 participants (2039 F/1536 M) from the Osteoarthritis Initiative were assessed at baseline and 48 months. A reader used a semi-automated software tool to calculate T(cort), a measurement of the cortical thickness, for metacarpals 2-4. …

METHOD: Hand radiographs of 3575 participants (2039 F/1536 M) from the Osteoarthritis Initiative were assessed at baseline and …

188

Inadequate Classification of Poor Response After Total Knee Arthroplasty: A Comparative Analysis of 15 Definitions Using Data From the Dutch Arthroplasty Register and the Osteoarthritis Initiative Database.

Te Molder MEM, Dowsey MM, Smolders JMH, van Steenbergen LN, van den Ende CHM, Heesterbeek PJC. Te Molder MEM, et al. J Arthroplasty. 2024 Oct;39(10):2483-2489. doi: 10.1016/j.arth.2024.05.032. Epub 2024 May 15. J Arthroplasty. 2024. PMID: 38759818 Free article.

METHODS: Data of patients one year after primary TKA from the Dutch Arthroplasty Register (n = 12,275) and the Osteoarthritis Initiative database (n = 204) were used to examine the prevalence, overlap (estimated by Cohen's kappa), and discriminative accuracy (sensit …

METHODS: Data of patients one year after primary TKA from the Dutch Arthroplasty Register (n = 12,275) and the Osteoarthritis Init …

189

Integrating Radiomics and Neural Networks for Knee Osteoarthritis Incidence Prediction.

Li S, Cao P, Li J, Chen T, Luo P, Ruan G, Zhang Y, Wang X, Han W, Zhu Z, Dang Q, Wang Q, Zhang M, Bai Q, Chai Z, Yang H, Chen H, Tang M, Akbar A, Tack A, Hunter DJ, Ding C. Li S, et al. Arthritis Rheumatol. 2024 Sep;76(9):1377-1386. doi: 10.1002/art.42915. Epub 2024 Jul 8. Arthritis Rheumatol. 2024. PMID: 38751101

We aimed to develop and test a magnetic resonance imaging (MRI)-based joint space (JS) radiomic model (RM) to predict radiographic KOA incidence through neural networks by integrating meniscus and femorotibial cartilage radiomic features. METHODS: In the Osteoarthritis …

We aimed to develop and test a magnetic resonance imaging (MRI)-based joint space (JS) radiomic model (RM) to predict radiographic KOA incid …

190

Radiomic features of the medial meniscus predicts incident destabilizing meniscal tears: Data from the osteoarthritis initiative.

Villagran M, Driban JB, Lu B, MacKay JW, McAlindon TE, Harkey MS. Villagran M, et al. J Orthop Res. 2024 Sep;42(9):2080-2087. doi: 10.1002/jor.25851. Epub 2024 May 15. J Orthop Res. 2024. PMID: 38747030 Free PMC article.

We used magnetic resonance (MR) images from an existing case-control study that includes images from the first 4 years of the Osteoarthritis Initiative (OAI). For this exploratory analysis (n = 215), we limited our study sample to people with (1) intact menisci at t …

We used magnetic resonance (MR) images from an existing case-control study that includes images from the first 4 years of the Osteoarthri …

191

One-stop detection of anterior cruciate ligament injuries on magnetic resonance imaging using deep learning with multicenter validation.

Wang M, Yu C, Li M, Zhang X, Jiang K, Zhang Z, Zhang X. Wang M, et al. Quant Imaging Med Surg. 2024 May 1;14(5):3405-3416. doi: 10.21037/qims-23-1539. Epub 2024 Apr 10. Quant Imaging Med Surg. 2024. PMID: 38720839 Free PMC article.

METHODS: A retrospective study was performed extracting data from the Osteoarthritis Initiative (OAI). A total of 1,589 knees (comprising 1,443 intact, 90 with partial tears, and 56 with full tears) were enrolled to construct the classification model. ...

METHODS: A retrospective study was performed extracting data from the Osteoarthritis Initiative (OAI). A total of 1,589 knees …

192

Gender differences in patterns of cartilage loss: Data from the Osteoarthritis Initiative.

Amesbury R, Ragati-Haghi H, Mathiessen A, Laffaye T, Stein RI, Collins JE, Kent Kwoh C, Duryea J. Amesbury R, et al. Osteoarthritis Cartilage. 2024 Sep;32(9):1149-1153. doi: 10.1016/j.joca.2024.04.010. Epub 2024 Apr 29. Osteoarthritis Cartilage. 2024. PMID: 38692504 Free PMC article.

METHODS: We measured cartilage volume change in the indexed knee of 700 subjects with Kellgren-Lawrence 1, 2, or 3 from the Osteoarthritis Initiative for four follow-up periods (baseline [BL] to 24 mo, BL to 48 mo, BL to 72 mo, and BL to 96 mo) using the local area …

METHODS: We measured cartilage volume change in the indexed knee of 700 subjects with Kellgren-Lawrence 1, 2, or 3 from the Osteoarthriti …

193

Relationship Between 2 Years of Muscle Strength Decrease and Volume Loss of Menisci and Cartilage According to Knee Pain in Mild and Moderate Knee Osteoarthritis.

Zhang H, Shuai T, Wang J, Li K, Nie Y. Zhang H, et al. Am J Phys Med Rehabil. 2024 Jan 1;104(1):1-7. doi: 10.1097/PHM.0000000000002507. Epub 2024 Apr 30. Am J Phys Med Rehabil. 2024. PMID: 38686814

DESIGN: Two hundred seventy-nine participants were retrospectively obtained from the Osteoarthritis Initiative. Western Ontario McMaster University and Knee Injury and Osteoarthritis Outcome Score were used to assess pain and function. ...

DESIGN: Two hundred seventy-nine participants were retrospectively obtained from the Osteoarthritis Initiative. Western Ontari …

194

X-ray with finite element analysis is a viable alternative for MRI to predict knee osteoarthritis: Data from the Osteoarthritis Initiative.

Mononen ME, Liukkonen MK, Turunen MJ. Mononen ME, et al. J Orthop Res. 2024 Sep;42(9):1964-1973. doi: 10.1002/jor.25861. Epub 2024 Apr 22. J Orthop Res. 2024. PMID: 38650428 Free article.

195

Diabetes is associated with longitudinal declined physical performance measures in persons with or at risk of knee osteoarthritis: data from the Osteoarthritis Initiative.

Alenazi AM, Alqahtani BA. Alenazi AM, et al. Eur J Phys Rehabil Med. 2024 Jun;60(3):496-504. doi: 10.23736/S1973-9087.24.08034-1. Epub 2024 Apr 22. Eur J Phys Rehabil Med. 2024. PMID: 38647532 Free PMC article.

POPULATION: This study included participants with or at risk of knee OA aged from 45 to 79 years from the Osteoarthritis Initiative from baseline to 96 months follow-up. METHODS: The participants performed physical performance measures using a 20 m Walk Test for Gai …

POPULATION: This study included participants with or at risk of knee OA aged from 45 to 79 years from the Osteoarthritis Initiativ …

196

Effect of weight loss on knee joint synovitis over 48 months and mediation by subcutaneous fat around the knee: data from the Osteoarthritis Initiative.

Löffler MT, Ngarmsrikam C, Giesler P, Joseph GB, Akkaya Z, Lynch JA, Lane NE, Nevitt M, McCulloch CE, Link TM. Löffler MT, et al. BMC Musculoskelet Disord. 2024 Apr 17;25(1):300. doi: 10.1186/s12891-024-07397-y. BMC Musculoskelet Disord. 2024. PMID: 38627635 Free PMC article.

METHODS: We included 234 overweight and obese participants (body mass index [BMI] 25 kg/m(2)) from the Osteoarthritis Initiative (OAI) with > 10% weight loss (n = 117) or stable overweight (< 3% change, n = 117) over 48 months matched for age and sex. ...

METHODS: We included 234 overweight and obese participants (body mass index [BMI] 25 kg/m(2)) from the Osteoarthritis Initiative …

197

Bicycling over a Lifetime Is Associated with Less Symptomatic Knee Osteoarthritis: Data from the Osteoarthritis Initiative.

Lo GH, Richard MJ, Kriska AM, McAlindon TE, Harkey M, Rockette-Wagner B, Eaton CB, Hochberg MC, Kwoh CK, Nevitt MC, Bhakta PB, McLaughlin CP, Driban JB. Lo GH, et al. Med Sci Sports Exerc. 2024 Sep 1;56(9):1678-1684. doi: 10.1249/MSS.0000000000003449. Epub 2024 Apr 11. Med Sci Sports Exerc. 2024. PMID: 38600648 Free PMC article.

METHODS: This was a retrospective, cross-sectional study within the Osteoarthritis Initiative (OAI), where we investigated OAI participants with complete data on bicycling, knee pain, and radiographic evidence of knee OA. ...

METHODS: This was a retrospective, cross-sectional study within the Osteoarthritis Initiative (OAI), where we investigated OAI …

198

Considerations beyond spine pain: do different co-occurring lower body joint pains differentially influence physical function and quality of life ratings?

McGargill S, Sein M, Sibille KT, Thompson Z, Brownstein M, Vincent HK. McGargill S, et al. BMC Musculoskelet Disord. 2024 Apr 8;25(1):269. doi: 10.1186/s12891-024-07393-2. BMC Musculoskelet Disord. 2024. PMID: 38589851 Free PMC article.

The purpose of this study was to determine the differences in functional outcomes and QOL among individuals with back pain who have concurrent additional pain sites or no pain sites. METHODS: Data from the Osteoarthritis Initiative (OAI) cohort were used for this cr …

The purpose of this study was to determine the differences in functional outcomes and QOL among individuals with back pain who have concurre …

199

Identification of Severe Grading in Knee OsteoArthritis from MRI using Ensemble Deep Learning.

Alyami J. Alyami J. Curr Med Imaging. 2024;20:e15734056289963. doi: 10.2174/0115734056289963240318040945. Curr Med Imaging. 2024. PMID: 38584509

By utilizing an ensemble technique, the model's accuracy in predicting disease development is enhanced, surpassing the limitations of traditional biomarkers. METHODS: The study used the Osteoarthritis Initiative dataset to develop an ensemble Deep Learning model tha …

By utilizing an ensemble technique, the model's accuracy in predicting disease development is enhanced, surpassing the limitations of tradit …

200

Gardening/yardwork in people with knee osteoarthritis is not associated with symptom or structural progression over 48 months: data from the Osteoarthritis Initiative.

Lo GH, Patarini JC, Richard MJ, McAlindon TE, Kriska AM, Rockette-Wagner B, Eaton CB, Hochberg MC, Kwoh CK, Nevitt MC, Driban JB. Lo GH, et al. Clin Rheumatol. 2024 May;43(5):1755-1762. doi: 10.1007/s10067-024-06912-9. Epub 2024 Apr 1. Clin Rheumatol. 2024. PMID: 38561590

OBJECTIVE: To evaluate the relationship of gardening/yardwork with symptomatic and structural progression in those with pre-existing radiographic knee osteoarthritis (OA) in the Osteoarthritis Initiative (OAI), an observational study designed to evaluate potential a …

OBJECTIVE: To evaluate the relationship of gardening/yardwork with symptomatic and structural progression in those with pre-existing radiogr …

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