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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1966 2
1967 1
1968 2
1970 1
1971 2
1972 2
1973 4
1974 5
1975 6
1976 10
1977 7
1978 9
1979 5
1980 8
1981 4
1982 11
1983 10
1984 11
1985 9
1986 18
1987 21
1988 21
1989 31
1990 40
1991 40
1992 40
1993 46
1994 62
1995 67
1996 61
1997 90
1998 85
1999 104
2000 114
2001 107
2002 135
2003 156
2004 239
2005 296
2006 252
2007 325
2008 339
2009 377
2010 413
2011 380
2012 452
2013 455
2014 421
2015 344
2016 323
2017 271
2018 270
2019 91
2020 1
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5,836 results
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Page 1
The amazing osteocyte
Bonewald LF. J Bone Miner Res 2011 - Review. PMID 21254230 Free PMC article.
Far from being the "passive placeholder in bone," this cell has been found to have numerous functions, such as acting as an orchestrator of bone remodeling through regulation of both osteoclast and osteoblast activity and also functioning as an endocrine cell. ...
Far from being the "passive placeholder in bone," this cell has been found to have numerous functions, such as acting as an orchestrator of …
Regulation of Proliferation, Differentiation and Functions of Osteoblasts by Runx2.
Komori T. Int J Mol Sci 2019 - Review. PMID 30987410 Free PMC article.
Runx2 is essential for osteoblast differentiation and chondrocyte maturation. During osteoblast differentiation, Runx2 is weakly expressed in uncommitted mesenchymal cells, and its expression is upregulated in preosteoblasts, reaches the maximal level in immature osteoblasts, and is down-regulated in mature osteoblasts. ...Runx2 regulates the proliferation of osteoblast progenitors and their differentiation into osteoblasts via reciprocal regulation with hedgehog, Fgf, Wnt, and Pthlh signaling molecules, and transcription factors, including Dlx5 and Sp7. ...
Runx2 is essential for osteoblast differentiation and chondrocyte maturation. During osteoblast differentiation, Runx2 is weak …
Molecular signaling in bone cells: Regulation of cell differentiation and survival
Plotkin LI and Bruzzaniti A. Adv Protein Chem Struct Biol 2019 - Review. PMID 31036293
The differentiation and activity of osteoblasts and osteoclasts are regulated by molecules produced by matrix-embedded osteocytes, as well as by cross talk between osteoblasts and osteoclasts through secreted factors. ...We have summarized here the current knowledge on selected intracellular signal pathways activated in osteoblasts, osteocytes, and osteoclasts....
The differentiation and activity of osteoblasts and osteoclasts are regulated by molecules produced by matrix-embedded osteocytes, as …
In Vitro Co-culture Model of Primary Human Osteoblasts and Osteocytes in Collagen Gels.
Skottke J, et al. Int J Mol Sci 2019. PMID 31018582 Free PMC article.
Co-cultivation of mature osteoblasts with osteocytes, derived from the three different approaches was performed in a transwell system, with osteocytes, embedded in collagen gels at the apical side and osteoblasts on the basal side of a porous membrane, which allowed the separate gene expression analysis for osteocytes and osteoblasts. ...Expression of osteocyte markers was not significantly changed in the presence of osteoblasts. In contrast, osteocalcin gene expression of osteoblasts was significantly upregulated in all examined co-cultures with differentiated osteocytes. ...
Co-cultivation of mature osteoblasts with osteocytes, derived from the three different approaches was performed in a transwell system …
Hypertrophic chondrocytes can become osteoblasts and osteocytes in endochondral bone formation.
Yang L, et al. Proc Natl Acad Sci U S A 2014. PMID 25092332 Free PMC article.
Osteoblasts, accompanying vascular invasion, lay down endochondral bone to replace cartilage. However, whether an HC can become an osteoblast and contribute to the full osteogenic lineage has been the subject of a century-long debate. ...This discovery of a chondrocyte-to-osteoblast lineage continuum revises concepts of the ontogeny of osteoblasts, with implications for the control of bone homeostasis and the interpretation of the underlying pathological bases of bone disorders....
Osteoblasts, accompanying vascular invasion, lay down endochondral bone to replace cartilage. However, whether an HC can become an
The cellular effects of Pulsed Electromagnetic Fields on osteoblasts: A review.
Galli C, et al. Bioelectromagnetics 2019 - Review. PMID 30908726
The present review has compared in vitro studies on PEMFs on different osteoblast models, which elucidate potential mechanisms of action for PEMFs, up to the most recent insights into the role of primary cilia, and highlight the critical issues underlying at least some of the inconsistent results in the available literature. ...
The present review has compared in vitro studies on PEMFs on different osteoblast models, which elucidate potential mechanisms of act …
Buried alive: how osteoblasts become osteocytes.
Franz-Odendaal TA, et al. Dev Dyn 2006 - Review. PMID 16258960 Free article.
During osteogenesis, osteoblasts lay down osteoid and transform into osteocytes embedded in mineralized bone matrix. Despite the fact that osteocytes are the most abundant cellular component of bone, little is known about the process of osteoblast-to-osteocyte transformation. ...Those osteoblasts on the bone surface that are destined for burial and destined to become osteocytes slow down matrix production compared to neighbouring osteoblasts, which continue to produce bone matrix. ...
During osteogenesis, osteoblasts lay down osteoid and transform into osteocytes embedded in mineralized bone matrix. Despite the fact …
The osteocyte
Knothe Tate ML, et al. Int J Biochem Cell Biol 2004 - Review. PMID 14592527
Differentiation of osteoblasts and osteocytes from mesenchymal stem cells.
Heino TJ and Hentunen TA. Curr Stem Cell Res Ther 2008 - Review. PMID 18473879
MSCs possess an extensive potential to proliferate and differentiate e.g. into osteoblasts, osteocytes, adipocytes and chondrocytes. ...We also shortly introduce the characteristics and function of bone-forming osteoblasts and their role in angiogenesis. MSCs are of interest in clinical applications, since they can be easily isolated from bone marrow aspirates and expanded in vitro. ...
MSCs possess an extensive potential to proliferate and differentiate e.g. into osteoblasts, osteocytes, adipocytes and chondrocytes. …
[Recent advances in nephronectin]
Qian GQ, et al. Sheng Li Xue Bao 2019 - Review. PMID 31646334 Chinese. Free article.
NPNT is involved in the process of kidney development and acute kidney injury, regulates proliferation and differentiation of osteoblast, and induces the vasculogenesis in vitro. ...
NPNT is involved in the process of kidney development and acute kidney injury, regulates proliferation and differentiation of osteoblast
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