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Quoted phrase not found in phrase index: "Osteocalcin increased"
Page 1
Functions of Osteocalcin in Bone, Pancreas, Testis, and Muscle.
Komori T. Komori T. Int J Mol Sci. 2020 Oct 12;21(20):7513. doi: 10.3390/ijms21207513. Int J Mol Sci. 2020. PMID: 33053789 Free PMC article. Review.
Osteocalcin (Ocn), which is specifically produced by osteoblasts, and is the most abundant non-collagenous protein in bone, was demonstrated to inhibit bone formation and function as a hormone, which regulates glucose metabolism in the pancreas, testosterone synthesis in t …
Osteocalcin (Ocn), which is specifically produced by osteoblasts, and is the most abundant non-collagenous protein in bone, was demon …
The Endocrine Function of Osteocalcin Regulated by Bone Resorption: A Lesson from Reduced and Increased Bone Mass Diseases.
Rossi M, Battafarano G, Pepe J, Minisola S, Del Fattore A. Rossi M, et al. Int J Mol Sci. 2019 Sep 11;20(18):4502. doi: 10.3390/ijms20184502. Int J Mol Sci. 2019. PMID: 31514440 Free PMC article. Review.
The study of bone diseases characterized by increased or reduced bone mass due to osteoclast alterations has been essential to understand the great role played by osteocalcin in the endocrine functions of the skeleton. The ability of osteoclasts to regulate the deca …
The study of bone diseases characterized by increased or reduced bone mass due to osteoclast alterations has been essential to unders …
Osteocalcin and its endocrine functions.
Mizokami A, Kawakubo-Yasukochi T, Hirata M. Mizokami A, et al. Biochem Pharmacol. 2017 May 15;132:1-8. doi: 10.1016/j.bcp.2017.02.001. Epub 2017 Feb 9. Biochem Pharmacol. 2017. PMID: 28189726 Review.
However, evidence has been accumulated in the past decade showing that bone also functions as an endocrine organ that regulates systemic glucose and energy metabolism. Osteocalcin, an osteoblast-specific secreted protein, acts as a hormone by stimulating insulin production …
However, evidence has been accumulated in the past decade showing that bone also functions as an endocrine organ that regulates systemic glu …
An overview of osteocalcin progress.
Li J, Zhang H, Yang C, Li Y, Dai Z. Li J, et al. J Bone Miner Metab. 2016 Jul;34(4):367-79. doi: 10.1007/s00774-015-0734-7. Epub 2016 Jan 8. J Bone Miner Metab. 2016. PMID: 26747614 Review.
An increasing amount of data indicate that osteocalcin is an endocrine hormone which regulates energy metabolism, male fertility and brain development. ...Moreover, the extensive expression of osteocalcin and its putative receptor GPRC6A imply that there are …
An increasing amount of data indicate that osteocalcin is an endocrine hormone which regulates energy metabolism, male fertili …
Increased trabecular bone and improved biomechanics in an osteocalcin-null rat model created by CRISPR/Cas9 technology.
Lambert LJ, Challa AK, Niu A, Zhou L, Tucholski J, Johnson MS, Nagy TR, Eberhardt AW, Estep PN, Kesterson RA, Grams JM. Lambert LJ, et al. Dis Model Mech. 2016 Oct 1;9(10):1169-1179. doi: 10.1242/dmm.025247. Epub 2016 Jul 28. Dis Model Mech. 2016. PMID: 27483347 Free PMC article.
The rat osteocalcin (Bglap) gene locus shares greater synteny with that of humans. To further examine the role of osteocalcin in disease, we created a rat model with complete loss of osteocalcin using the CRISPR/Cas9 system. ...Cortical bone volume and densit …
The rat osteocalcin (Bglap) gene locus shares greater synteny with that of humans. To further examine the role of osteocalcin …
New insights into the biology of osteocalcin.
Zoch ML, Clemens TL, Riddle RC. Zoch ML, et al. Bone. 2016 Jan;82:42-9. doi: 10.1016/j.bone.2015.05.046. Epub 2015 Jun 6. Bone. 2016. PMID: 26055108 Free PMC article. Review.
Circulating undercarboxylated osteocalcin, which is regulated by insulin, acts in a feed-forward loop to increase beta-cell proliferation as well as insulin production and secretion, while skeletal muscle and adipose tissue respond to osteocalcin by increa …
Circulating undercarboxylated osteocalcin, which is regulated by insulin, acts in a feed-forward loop to increase beta-cell pr …
Osteocalcin inhibits myocyte aging through promotion of starvation-induced autophagy via IL-6/STAT3 signaling.
Gu P, Tao D, Xu Y, Yang Q, Bai T, Hu S, Yang X. Gu P, et al. Exp Gerontol. 2023 Mar;173:112082. doi: 10.1016/j.exger.2023.112082. Epub 2023 Jan 5. Exp Gerontol. 2023. PMID: 36621698 Free article.
Osteocalcin injection in mice also resulted in increased relative LC3-II/LC3-I protein expression and autophagosome numbers. Osteocalcin treatment significantly increased the secretion of IL-6 in muscle cells and tissue, and activated STAT3 signaling. …
Osteocalcin injection in mice also resulted in increased relative LC3-II/LC3-I protein expression and autophagosome numbers. …
Exercise ameliorates anxious behavior and promotes neuroprotection through osteocalcin in VCD-induced menopausal mice.
Kang Y, Yao J, Gao X, Zhong H, Song Y, Di X, Feng Z, Xie L, Zhang J. Kang Y, et al. CNS Neurosci Ther. 2023 Dec;29(12):3980-3994. doi: 10.1111/cns.14324. Epub 2023 Jul 4. CNS Neurosci Ther. 2023. PMID: 37402694 Free PMC article.
RESULTS: The VCD mice showed obvious anxiety-like behaviors and 10 weeks of treadmill exercise significantly ameliorated the anxiety and increased circulating osteocalcin in VCD mice. Exercise increased the number of BRDU and NEUN co-localization cells in hip …
RESULTS: The VCD mice showed obvious anxiety-like behaviors and 10 weeks of treadmill exercise significantly ameliorated the anxiety and …
Osteocalcin and vascular function: is there a cross-talk?
Tacey A, Hayes A, Zulli A, Levinger I. Tacey A, et al. Mol Metab. 2021 Jul;49:101205. doi: 10.1016/j.molmet.2021.101205. Epub 2021 Mar 6. Mol Metab. 2021. PMID: 33684607 Free PMC article. Review.
BACKGROUND: The bone-derived protein osteocalcin (OC), in its undercarboxylated (ucOC) form, has a beneficial effect on energy metabolism and may be a future therapeutic target for metabolic diseases. Increasing evidence suggests a link between ucOC and cardiovascul …
BACKGROUND: The bone-derived protein osteocalcin (OC), in its undercarboxylated (ucOC) form, has a beneficial effect on energy metabo …
Increased bone formation in osteocalcin-deficient mice.
Ducy P, Desbois C, Boyce B, Pinero G, Story B, Dunstan C, Smith E, Bonadio J, Goldstein S, Gundberg C, Bradley A, Karsenty G. Ducy P, et al. Nature. 1996 Aug 1;382(6590):448-52. doi: 10.1038/382448a0. Nature. 1996. PMID: 8684484 Free article.
A few molecular determinants of bone remodelling that affect osteoclast activity have been characterized, but the molecular determinants of osteoblast activity are unknown. To investigate the role of osteocalcin, the most abundant osteoblast-specific non-collagenous protei …
A few molecular determinants of bone remodelling that affect osteoclast activity have been characterized, but the molecular determinants of …
11,985 results
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