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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1966 1
1967 1
1969 1
1971 1
1972 1
1974 5
1975 4
1976 9
1977 11
1978 10
1979 13
1980 7
1981 8
1982 15
1983 17
1984 23
1985 21
1986 16
1987 15
1988 15
1989 15
1990 37
1991 35
1992 29
1993 27
1994 38
1995 44
1996 43
1997 44
1998 44
1999 41
2000 53
2001 61
2002 69
2003 81
2004 81
2005 123
2006 129
2007 106
2008 134
2009 156
2010 180
2011 199
2012 199
2013 226
2014 251
2015 229
2016 217
2017 185
2018 186
2019 61
2020 0
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3,124 results
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Page 1
The Great Beauty of the osteoclast.
Cappariello A, et al. Arch Biochem Biophys 2014 - Review. PMID 24976175
Much has been written recently on osteoclast biology, but this cell type still astonishes scientists with its multifaceted functions and unique properties. ...All these facets will be discussed in this review article, with the aim of underscoring The Great Beauty of the osteoclast....
Much has been written recently on osteoclast biology, but this cell type still astonishes scientists with its multifaceted functions …
Osteoclast function and bone-resorbing activity: An overview.
Soysa NS and Alles N. Biochem Biophys Res Commun 2016 - Review. PMID 27157135
Therefore, understanding the fundamentals of osteoclast-induced bone resorption and the cytokines and other substances that modulate the osteoclast activity unequivocally provide insights into the development of drugs to ameliorate pathological bone diseases with enhanced bone resorption. The aim of this review is to examine the literature on osteoclast function and bone-resorbing activity....
Therefore, understanding the fundamentals of osteoclast-induced bone resorption and the cytokines and other substances that modulate …
Apical External Root Resorption and Repair in Orthodontic Tooth Movement: Biological Events
Feller L, et al. Biomed Res Int 2016 - Review. PMID 27119080 Free PMC article.
Resorption of cementum is regulated by mechanisms similar to those controlling osteoclastogenesis and bone resorption. Following root resorption there is repair by cellular cementum, but factors mediating the transition from resorption to repair are not clear. ...
Resorption of cementum is regulated by mechanisms similar to those controlling osteoclastogenesis and bone resorption. Following root …
Osteoblasts and osteoclasts in bone remodeling and inflammation.
Tanaka Y, et al. Curr Drug Targets Inflamm Allergy 2005 - Review. PMID 16101541
Bone homeostasis is maintained by a balance between bone resorption by osteoclasts and bone formation by osteoblasts. Osteoblasts not only play a central role in bone formation by synthesizing multiple bone matrix proteins, but regulate osteoclast maturation by soluble factors and cognate interaction, resulting in bone resorption. Osteoclast maturation requires stimulation by RANKL expressed on osteoblasts, and the cognate interaction is mediated by firm adhesion via ICAM-1. ...
Bone homeostasis is maintained by a balance between bone resorption by osteoclasts and bone formation by osteoblasts. Osteoblasts not …
Hyperactivation of Nrf2 leads to hypoplasia of bone in vivo
Yoshida E, et al. Genes Cells 2018. PMID 29542224 Free article.
Experiments with primary culture cells derived from Keap1-null mice showed that differentiation of both osteoclasts and osteoblasts was attenuated, showing that impaired differentiation of osteoblasts rather than osteoclasts is responsible for bone hypoplasia caused by Nrf2 hyperactivation. ...
Experiments with primary culture cells derived from Keap1-null mice showed that differentiation of both osteoclasts and osteoblasts w …
Pathologic conditions of hard tissue: role of osteoclasts in osteolytic lesion.
Kitazawa R, et al. Histochem Cell Biol 2018 - Review. PMID 29356963
In tumor-related local osteolysis, tumor-derived osteoclast-activating factors induce bone resorption not by directly acting on osteoclasts but by indirectly upregulating receptor activator of NFκB ligand (RANKL) on osteoblastic cells. Similarly, synovial tissue in the autoimmune arthritis model does overexpress RANKL and contains numerous osteoclast precursors, and like a landing craft, when it comes in contact with eroded bone surfaces, osteoclast precursors are immediately polarized to become mature osteoclasts, inducing rapidly progressive bone destruction at a late stage of the disease. ...
In tumor-related local osteolysis, tumor-derived osteoclast-activating factors induce bone resorption not by directly acting on os
[Imaging of bone and joint destruction]
Kikuta J and Ishii M. Nihon Rinsho Meneki Gakkai Kaishi 2017 - Review. PMID 29238016 Japanese. Free article.
  Osteoclasts are bone-resorbing giant polykaryons that differentiate from mononuclear macrophage/monocyte-lineage hematopoietic precursors. ...We also developed pH-sensing chemical fluorescent probes to detect localized acidification by bone-resorbing osteoclasts on the bone surface in vivo, and identified two distinct functional states of differentiated osteoclasts, 'bone-resorptive' and 'non-resorptive'. ...
Osteoclasts are bone-resorbing giant polykaryons that differentiate from mononuclear macrophage/monocyte-lineage hematopoietic prec
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