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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 2
1994 119
1995 369
1996 440
1997 564
1998 652
1999 831
2000 1015
2001 1150
2002 1351
2003 1568
2004 1954
2005 2363
2006 2647
2007 3012
2008 3272
2009 3485
2010 3794
2011 3967
2012 4453
2013 4590
2014 4553
2015 4842
2016 4899
2017 4844
2018 4813
2019 2467
2020 59
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59,035 results
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Page 1
Nutrient Sensing and the Oxidative Stress Response.
Luo H, et al. Trends Endocrinol Metab 2017 - Review. PMID 28314502 Free PMC article.
Recent advances in nutrient sensing have provided molecular insights into the oxidative stress response and suggest that CR triggers an active defense program involving a cascade of molecular regulators to reduce oxidative stress. Physiological studies have provided strong support for oxidative stress in the development of aging-associated conditions and diseases but have also revealed the surprising requirement for oxidative stress to support normal physiological functions and, in some contexts, even slow aging and prevent the progression of cancer. ...
Recent advances in nutrient sensing have provided molecular insights into the oxidative stress response and suggest that CR tr …
Oxidative stress and autophagy: the clash between damage and metabolic needs.
Filomeni G, et al. Cell Death Differ 2015 - Review. PMID 25257172 Free PMC article.
The role of oxidative and nitrosative stress in autophagy is also discussed in the light of its being harmful for both cellular biomolecules and signal mediator through reversible posttranslational modifications of thiol-containing proteins. The redox-independent relationship between autophagy and antioxidant response, occurring through the p62/Keap1/Nrf2 pathway, is also addressed in order to provide a wide perspective upon the interconnection between autophagy and oxidative stress. ...
The role of oxidative and nitrosative stress in autophagy is also discussed in the light of its being harmful for both cellula …
Oxidative stress and diabetic complications.
Giacco F and Brownlee M. Circ Res 2010 - Review. PMID 21030723 Free PMC article.
Oxidative stress plays a pivotal role in the development of diabetes complications, both microvascular and cardiovascular. The metabolic abnormalities of diabetes cause mitochondrial superoxide overproduction in endothelial cells of both large and small vessels, as well as in the myocardium. ...
Oxidative stress plays a pivotal role in the development of diabetes complications, both microvascular and cardiovascular. The
Nutrients and Oxidative Stress: Friend or Foe?
Tan BL, et al. Oxid Med Cell Longev 2018 - Review. PMID 29643982 Free PMC article.
There are different types of nutritionally mediated oxidative stress sources that trigger inflammation. Much information indicates that high intakes of macronutrients can promote oxidative stress and subsequently contribute to inflammation via nuclear factor-kappa B- (NF-κB-) mediated cell signaling pathways. ...However, the molecular mechanisms of nutritionally mediated oxidative stress are complex and poorly understood. Therefore, this review aimed to explore how dietary choices exacerbate or dampen the oxidative stress and inflammation. ...
There are different types of nutritionally mediated oxidative stress sources that trigger inflammation. Much information indic …
Oxidative Stress: Major Threat in Traumatic Brain Injury.
Khatri N, et al. CNS Neurol Disord Drug Targets 2018 - Review. PMID 29952272
This leads to the generation of oxidative stress which further leads to mitochondrial dysfunction, lipid peroxidation and oxidation of proteins and DNA. ...CONCLUSION: In the present review we provide extensive overview of the role of reactive oxygen species (ROS)-induced oxidative stress and its fatal effects on brain after TBI....
This leads to the generation of oxidative stress which further leads to mitochondrial dysfunction, lipid peroxidation and oxid …
Sepsis and Oxidative Stress in the Newborn: From Pathogenesis to Novel Therapeutic Targets.
Poggi C and Dani C. Oxid Med Cell Longev 2018 - Review. PMID 30174784 Free PMC article.
Together with inflammation, oxidative stress is involved in detrimental pathways activated during neonatal sepsis, eventually leading to organ dysfunction and death. ...Despite antioxidant systems are induced during neonatal sepsis, as an adaptive response to an increased oxidative burden, a condition of redox imbalance favoring oxidative pathways occurs, resulting in increased markers of oxidative stress damage. ...
Together with inflammation, oxidative stress is involved in detrimental pathways activated during neonatal sepsis, eventually …
Oxidative stress.
Burton GJ and Jauniaux E. Best Pract Res Clin Obstet Gynaecol 2011 - Review. PMID 21130690 Free PMC article.
Considerable evidence implicates oxidative stress in the pathophysiology of many complications of human pregnancy, and this topic has now become a major focus of both clinical and basic science research. Oxidative stress arises when the production of reactive oxygen species overwhelms the intrinsic anti-oxidant defences. Reactive oxygen species play important roles as second messengers in many intracellular signalling cascades aimed at maintaining the cell in homeostasis with its immediate environment. ...
Considerable evidence implicates oxidative stress in the pathophysiology of many complications of human pregnancy, and this to …
Oxidative Stress in Retinal Diseases.
Nishimura Y, et al. Oxid Med Cell Longev 2017. PMID 28424744 Free PMC article.
The role of oxidative stress during inflammatory processes.
Lugrin J, et al. Biol Chem 2014 - Review. PMID 24127541
Abstract The production of various reactive oxidant species in excess of endogenous antioxidant defense mechanisms promotes the development of a state of oxidative stress, with significant biological consequences. In recent years, evidence has emerged that oxidative stress plays a crucial role in the development and perpetuation of inflammation, and thus contributes to the pathophysiology of a number of debilitating illnesses, such as cardiovascular diseases, diabetes, cancer, or neurodegenerative processes. ...
Abstract The production of various reactive oxidant species in excess of endogenous antioxidant defense mechanisms promotes the development …
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