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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1947 1
1948 1
1963 3
1964 5
1965 98
1966 234
1967 362
1968 324
1969 385
1970 414
1971 381
1972 396
1973 461
1974 449
1975 443
1976 425
1977 390
1978 486
1979 566
1980 668
1981 676
1982 835
1983 790
1984 869
1985 954
1986 956
1987 903
1988 897
1989 1031
1990 1008
1991 1054
1992 1014
1993 1002
1994 1011
1995 1019
1996 1185
1997 1270
1998 1307
1999 1351
2000 1577
2001 1645
2002 1692
2003 2023
2004 2149
2005 2336
2006 2335
2007 2634
2008 2618
2009 2811
2010 3070
2011 3226
2012 3237
2013 3404
2014 3715
2015 3588
2016 3546
2017 3480
2018 3447
2019 1734
2020 29
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74,624 results
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Page 1
Noninvasive Treatments for Acute, Subacute, and Chronic Low Back Pain: A Clinical Practice Guideline From the American College of Physicians.
Qaseem A, et al. Ann Intern Med 2017. PMID 28192789
RECOMMENDATION 2: For patients with chronic low back pain, clinicians and patients should initially select nonpharmacologic treatment with exercise, multidisciplinary rehabilitation, acupuncture, mindfulness-based stress reduction (moderate-quality evidence), tai chi, yoga, motor control exercise, progressive relaxation, electromyography biofeedback, low-level laser therapy, operant therapy, cognitive behavioral therapy, or spinal manipulation (low-quality evidence). ...RECOMMENDATION 3: In patients with chronic low back pain who have had an inadequate response to nonpharmacologic therapy, clinicians and patients should consider pharmacologic treatment with nonsteroidal anti-inflammatory drugs as first-line therapy, or tramadol or duloxetine as second-line therapy. ...
RECOMMENDATION 2: For patients with chronic low back pain, clinicians and patients should initially select nonpharmacologic treatment …
Medical Cannabis for Neuropathic Pain.
Lee G, et al. Curr Pain Headache Rep 2018 - Review. PMID 29388063
Neuropathic pain is a complicated condition that is challenging to treat with our current medications. Recent scientific discovery has elucidated the intricate role of the endocannabinoid system in the pathophysiology of neuropathic pain. As societal perceptions change, and legislation on medical cannabis relaxes, there is growing interest in the use of medical cannabis for neuropathic pain. ...
Neuropathic pain is a complicated condition that is challenging to treat with our current medications. Recent scientific discovery ha …
The Effects of Cannabis Among Adults With Chronic Pain and an Overview of General Harms: A Systematic Review.
Nugent SM, et al. Ann Intern Med 2017 - Review. PMID 28806817
BACKGROUND: Cannabis is increasingly available for the treatment of chronic pain, yet its efficacy remains uncertain. PURPOSE: To review the benefits of plant-based cannabis preparations for treating chronic pain in adults and the harms of cannabis use in chronic pain and general adult populations. ...DATA SYNTHESIS: From 27 chronic pain trials, there is low-strength evidence that cannabis alleviates neuropathic pain but insufficient evidence in other pain populations. ...
BACKGROUND: Cannabis is increasingly available for the treatment of chronic pain, yet its efficacy remains uncertain. PURPOSE: To rev …
Clinicians' Guide to Cannabidiol and Hemp Oils
VanDolah HJ, et al. Mayo Clin Proc 2019 - Review. PMID 31447137 Free article.
Patients report relief for a variety of conditions, particularly pain, without the intoxicating adverse effects of medical marijuana. In June 2018, the first CBD-based drug, Epidiolex, was approved by the US Food and Drug Administration for treatment of rare, severe epilepsy, further putting the spotlight on CBD and hemp oils. ...
Patients report relief for a variety of conditions, particularly pain, without the intoxicating adverse effects of medical marijuana. …
Nonopioid versus opioid agents for chronic neuropathic pain, rheumatoid arthritis pain, cancer pain and low back pain.
Noori SA, et al. Pain Manag 2019 - Review. PMID 30681031
Chronic pain continues to be a major health issue throughout the world and a huge economic burden for nations around the world. ...This review explores and compares the efficacy and safety of opioid and nonopioid agents for the following commonly encountered chronic pain conditions: neuropathic pain, rheumatoid arthritis joint pain, cancer pain and low back pain. ...
Chronic pain continues to be a major health issue throughout the world and a huge economic burden for nations around the world. ...Th …
Neuropathic low back pain in clinical practice.
Baron R, et al. Eur J Pain 2016 - Review. PMID 26935254 Free PMC article.
DATABASES AND DATA TREATMENT: Literature searches were performed in PubMed, key pain congresses and ProQuest Dialog to identify published evidence on neuropathic back pain and its management. ...Neuropathic pain (NP) is challenging to manage. Many patients with chronic LBP have pain that is refractory to existing treatments. ...
DATABASES AND DATA TREATMENT: Literature searches were performed in PubMed, key pain congresses and ProQuest Dialog to identify publi …
Chronification of Pain: Mechanisms, Current Understanding, and Clinical Implications.
Pak DJ, et al. Curr Pain Headache Rep 2018 - Review. PMID 29404791
PURPOSE OF REVIEW: The development of acute to chronic pain involves distinct pathophysiological changes in the peripheral and central nervous systems. ...Regional anesthetic techniques and preemptive analgesia should also be utilized when appropriate to reduce the intensity and duration of acute post-operative pain, which has been correlated with higher incidences of chronic pain....
PURPOSE OF REVIEW: The development of acute to chronic pain involves distinct pathophysiological changes in the peripheral and centra …
Multimodal Analgesia, Current Concepts, and Acute Pain Considerations.
Helander EM, et al. Curr Pain Headache Rep 2017 - Review. PMID 28132136
In addition to opioids, drugs with differing mechanisms of actions target pain pathways resulting in additive and/or synergistic effects. ...Overall, a multimodal analgesic approach should be used when treating postoperative pain, as it can potentially reduce side effects and provide the benefit of treating pain through different cellular pathways....
In addition to opioids, drugs with differing mechanisms of actions target pain pathways resulting in additive and/or synergistic effe …
[Differential indications of opioids in pain therapy].
Heyn J and Azad SC. Anaesthesist 2017 - Review. PMID 28971215 German.
Due to their strong analgesic potency opioids are highly effective in the therapy of acute and particularly cancer-induced chronic pain; however, the individual opioids differ considerably with respect to their pharmacokinetic and physicochemical properties and may therefore not be equally applicable for every patient. ...This process can be substantially influenced by genetic polymorphisms or drug interactions. Knowledge of all these factors for individual opioids, which influence the efficacy and side effects, is therefore crucial. ...
Due to their strong analgesic potency opioids are highly effective in the therapy of acute and particularly cancer-induced chronic …
Opioid-free anesthesia: a different regard to anesthesia practice
Lavand'homme P and Estebe JP. Curr Opin Anaesthesiol 2018 - Review. PMID 29994942
PURPOSE OF REVIEW: In the past two decades, opioids have been prescribed increasingly for the treatment of various chronic pain conditions and during the perioperative period. ...
PURPOSE OF REVIEW: In the past two decades, opioids have been prescribed increasingly for the treatment of various chronic pain condi …
74,624 results
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