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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1961 3
1962 1
1968 2
1969 3
1971 2
1972 6
1973 4
1974 2
1975 3
1976 8
1977 6
1978 4
1979 4
1980 7
1981 5
1982 6
1983 6
1984 5
1985 11
1986 14
1987 19
1988 21
1989 35
1990 42
1991 52
1992 53
1993 72
1994 106
1995 97
1996 118
1997 115
1998 168
1999 198
2000 194
2001 224
2002 219
2003 222
2004 239
2005 272
2006 301
2007 303
2008 324
2009 431
2010 427
2011 570
2012 582
2013 611
2014 743
2015 838
2016 819
2017 792
2018 779
2019 400
2020 8
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9,570 results
Results by year
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Page 1
Genetics of Pancreatic Neoplasms and Role of Screening.
Katabathina VS, et al. Magn Reson Imaging Clin N Am 2018 - Review. PMID 30376976
There is a wide spectrum of pancreatic neoplasms with characteristic genetic abnormalities, tumor pathways, and histopathology that primarily determine tumor biology, treatment response, and prognosis. Although most pancreatic tumors are sporadic, 10% of neoplasms occur in the setting of distinct hereditary syndromes. Detailed studies of these rare syndromes have allowed researchers to identify a myriad of specific genetic signatures of pancreatic tumors. ...
There is a wide spectrum of pancreatic neoplasms with characteristic genetic abnormalities, tumor pathways, and histopathology …
Pancreatic cancer.
Vincent A, et al. Lancet 2011 - Review. PMID 21620466 Free PMC article.
Furthermore, pancreatic cancer responds poorly to most chemotherapeutic agents. Hence, we need to understand the biological mechanisms that contribute to development and progression of pancreatic tumours. In this Seminar we will discuss the most common and deadly form of pancreatic cancer, pancreatic ductal adenocarcinoma....
Furthermore, pancreatic cancer responds poorly to most chemotherapeutic agents. Hence, we need to understand the biological mechanism …
Pancreatic Cancer Genetics.
Amundadottir LT. Int J Biol Sci 2016 - Review. PMID 26929738 Free PMC article.
Although relatively rare, pancreatic tumors are highly lethal [1]. In the United States, an estimated 48,960 individuals will be diagnosed with pancreatic cancer and 40,560 will die from this disease in 2015 [1]. ...Tumors arising in the endocrine pancreas (pancreatic neuroendocrine tumors) represent less than 5% of all pancreatic tumors [5]. ...
Although relatively rare, pancreatic tumors are highly lethal [1]. In the United States, an estimated 48,960 individuals will be diag …
Genetics and biology of pancreatic ductal adenocarcinoma.
Hezel AF, et al. Genes Dev 2006 - Review. PMID 16702400 Free article.
Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer death in the United States with a median survival of <6 mo and a dismal 5-yr survival rate of 3%-5%. ...Recent advances include insights into the cancer's cellular origins, high-resolution genomic profiles pointing to potential new therapeutic targets, and refined mouse models reflecting both the genetics and histopathologic evolution of human PDAC. ...
Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer death in the United States with a median survival of &l
Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer.
Klein AP, et al. Nat Commun 2018. PMID 29422604 Free PMC article.
In 2020, 146,063 deaths due to pancreatic cancer are estimated to occur in Europe and the United States combined. To identify common susceptibility alleles, we performed the largest pancreatic cancer GWAS to date, including 9040 patients and 12,496 controls of European ancestry from the Pancreatic Cancer Cohort Consortium (PanScan) and the Pancreatic Cancer Case-Control Consortium (PanC4). ...Expression quantitative trait locus analysis in three independent pancreatic data sets provides molecular support of NOC2L as a pancreatic cancer susceptibility gene....
In 2020, 146,063 deaths due to pancreatic cancer are estimated to occur in Europe and the United States combined. To identify common …
Emerging strategies in BRCA-positive pancreatic cancer.
Kowalewski A, et al. J Cancer Res Clin Oncol 2018 - Review. PMID 29777302 Free PMC article.
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest diseases in the United States and Europe. BRCA1 and BRCA2 are among the most common of the known genetic mutations involved in familial PDAC. ...METHODS: We conducted a review of the literature for data on possible therapies in BRCA-positive and BRCA-negative pancreatic cancer. ...
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest diseases in the United States and Europe. BRCA1 and BRCA2 are among t
Genetics of Pancreatic Cancer and Its Implications on Therapy.
Tatarian T and Winter JM. Surg Clin North Am 2016 - Review. PMID 27865273
Over the past decade, emerging technologies have provided new insights into the genomic landscape of pancreatic ductal adenocarcinoma (PDA). ...This article provides a report on the current landscape of pancreas cancer genetics and targeted therapeutics....
Over the past decade, emerging technologies have provided new insights into the genomic landscape of pancreatic ductal adenocarcinoma …
Association Between Inherited Germline Mutations in Cancer Predisposition Genes and Risk of Pancreatic Cancer.
Hu C, et al. JAMA 2018. PMID 29922827 Free PMC article.
IMPORTANCE: Individuals genetically predisposed to pancreatic cancer may benefit from early detection. Genes that predispose to pancreatic cancer and the risks of pancreatic cancer associated with mutations in these genes are not well defined. ...CONCLUSIONS AND RELEVANCE: In this case-control study, mutations in 6 genes associated with pancreatic cancer were found in 5.5% of all pancreatic cancer patients, including 7.9% of patients with a family history of pancreatic cancer and 5.2% of patients without a family history of pancreatic cancer. ...
IMPORTANCE: Individuals genetically predisposed to pancreatic cancer may benefit from early detection. Genes that predispose to pa
Pathological and molecular evaluation of pancreatic neoplasms.
Rishi A, et al. Semin Oncol 2015 - Review. PMID 25726050 Free PMC article.
Pancreatic neoplasms are morphologically and genetically heterogeneous and include a wide variety of tumors ranging from benign to malignant with an extremely poor clinical outcome. ...Here we review the pathological classification of pancreatic neoplasms from the molecular and genetic perspectives....
Pancreatic neoplasms are morphologically and genetically heterogeneous and include a wide variety of tumors ranging from benig
Organoid models for translational pancreatic cancer research.
Tiriac H, et al. Curr Opin Genet Dev 2019 - Review. PMID 30844513 Free PMC article.
Despite recent advances in the treatment of cancer, pancreatic ductal adenocarcinoma (PDAC) still retains the worst survival rate of common malignancies. ...Organoids models have been applied to pancreatic cancer research and offer a promising platform for precision medicine approaches....
Despite recent advances in the treatment of cancer, pancreatic ductal adenocarcinoma (PDAC) still retains the worst survival rate of …
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