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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1962 1
1965 6
1966 10
1967 16
1968 12
1969 16
1970 17
1971 14
1972 27
1973 18
1974 24
1975 28
1976 46
1977 40
1978 37
1979 49
1980 39
1981 44
1982 48
1983 50
1984 60
1985 57
1986 64
1987 85
1988 70
1989 55
1990 81
1991 77
1992 81
1993 82
1994 96
1995 89
1996 81
1997 99
1998 98
1999 112
2000 120
2001 128
2002 154
2003 173
2004 174
2005 196
2006 190
2007 250
2008 262
2009 279
2010 308
2011 388
2012 452
2013 468
2014 515
2015 506
2016 515
2017 462
2018 429
2019 213
2020 4
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7,389 results
Results by year
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Page 1
Employing Metabolism to Improve the Diagnosis and Treatment of Pancreatic Cancer.
Halbrook CJ and Lyssiotis CA. Cancer Cell 2017 - Review. PMID 28073003 Free article.
Pancreatic cancer cells have extensively reprogrammed metabolism, which is driven by oncogene-mediated cell-autonomous pathways, the unique physiology of the tumor microenvironment, and interactions with non-cancer cells. In this review, we discuss how recent efforts delineating rewired metabolic networks in pancreatic cancer have revealed new in-roads to develop detection and treatment strategies for this dreadful disease....
Pancreatic cancer cells have extensively reprogrammed metabolism, which is driven by oncogene-mediated cell-autonomous pathway
Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion.
Sousa CM, et al. Nature 2016. PMID 27509858 Free PMC article.
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease characterized by an intense fibrotic stromal response and deregulated metabolism. ...Here we show that stroma-associated pancreatic stellate cells (PSCs) are critical for PDAC metabolism through the secretion of non-essential amino acids (NEAA). ...
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease characterized by an intense fibrotic stromal response and deregulate
The plasticity of pancreatic cancer metabolism in tumor progression and therapeutic resistance.
Biancur DE and Kimmelman AC. Biochim Biophys Acta Rev Cancer 2018 - Review. PMID 29702208 Free PMC article.
Pancreatic ductal adenocarcinoma (PDA) is an aggressive cancer that is highly refractory to the current standards of care. The difficulty in treating this disease is due to a number of different factors, including altered metabolism. ...
Pancreatic ductal adenocarcinoma (PDA) is an aggressive cancer that is highly refractory to the current standards of care. The diffic
Tumor microenvironment participates in metastasis of pancreatic cancer.
Ren B, et al. Mol Cancer 2018 - Review. PMID 30060755 Free PMC article.
Pancreatic cancer is a deadly disease with high mortality due to difficulties in its early diagnosis and metastasis. The tumor microenvironment induced by interactions between pancreatic epithelial/cancer cells and stromal cells is critical for pancreatic cancer progression and has been implicated in the failure of chemotherapy, radiation therapy and immunotherapy. Microenvironment formation requires interactions between pancreatic cancer cells and stromal cells. Components of the pancreatic cancer microenvironment that contribute to desmoplasia and immunosuppression are associated with poor patient prognosis. ...
Pancreatic cancer is a deadly disease with high mortality due to difficulties in its early diagnosis and metastasis. The tumor microe
Pancreatic Cancer Metabolism: Breaking It Down to Build It Back Up.
Perera RM and Bardeesy N. Cancer Discov 2015 - Review. PMID 26534901 Free PMC article.
Pancreatic ductal adenocarcinoma (PDA) is the quintessential aggressive malignancy that thrives in nutrient-poor, hypoxic environments. ...SIGNIFICANCE: Alterations in tumor cell and systemic metabolism are central to the biology of pancreatic cancer. Further investigation of these processes will provide important insights into how these tumors develop and grow, and suggest new approaches for its detection, prevention, and treatment....
Pancreatic ductal adenocarcinoma (PDA) is the quintessential aggressive malignancy that thrives in nutrient-poor, hypoxic environment
The Intricate Metabolism of Pancreatic Cancers.
Camelo F and Le A. Adv Exp Med Biol 2018 - Review. PMID 29946776
Currently, approximately 95% of pancreatic cancers are pancreatic ductal adenocarcinoma (PDAC), which is the most aggressive form and the fourth leading cause of cancer death with extremely poor prognosis [1]. ...This chapter will discuss the complexity of metabolic features in pancreatic cancers. To be able to fully comprehend the heterogeneous nature of cancer metabolism, we need to take into account the close relationship between cancer metabolism and genetics. ...
Currently, approximately 95% of pancreatic cancers are pancreatic ductal adenocarcinoma (PDAC), which is the most aggressive f …
An overview of polyamine metabolism in pancreatic ductal adenocarcinoma.
Phanstiel O. Int J Cancer 2018 - Review. PMID 29134652 Free article.
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest major cancers, with a five year survival rate of less than 8%. ...This review seeks to fill this void by describing what is currently known about polyamine metabolism in PDAC and identifies new targets and opportunities to treat this disease. ...
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest major cancers, with a five year survival rate of less than 8%. ...Thi
Advancement of NF-κB Signaling Pathway: A Novel Target in Pancreatic Cancer.
Pramanik KC, et al. Int J Mol Sci 2018 - Review. PMID 30563089 Free PMC article.
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers and is the third highest among cancer related deaths. Despite modest success with therapy such as gemcitabine, pancreatic cancer incidence remains virtually unchanged in the past 25 years. ...
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers and is the third highest among cancer related deaths. Despite
Signaling Networks That Control Cellular Plasticity in Pancreatic Tumorigenesis, Progression, and Metastasis.
Crawford HC, et al. Gastroenterology 2019 - Review. PMID 30716326 Free PMC article.
Pancreatic ductal adenocarcinoma is one of the deadliest cancers, and its incidence on the rise. The major challenges in overcoming the poor prognosis with this disease include late detection and the aggressive biology of the disease. Intratumoral heterogeneity; presence of a robust, reactive, and desmoplastic stroma; and the crosstalk between the different tumor components require complete understanding of the pancreatic tumor biology to better understand the therapeutic challenges posed by this disease. ...
Pancreatic ductal adenocarcinoma is one of the deadliest cancers, and its incidence on the rise. The major challenges in overcoming t
Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein.
Kamphorst JJ, et al. Cancer Res 2015. PMID 25644265 Free PMC article.
In this study, we examined the metabolism of pancreatic ductal adenocarcinoma (PDAC), a poorly vascularized lethal KRAS-driven malignancy. ...
In this study, we examined the metabolism of pancreatic ductal adenocarcinoma (PDAC), a poorly vascularized lethal KRAS-driven …
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