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Glucocerebrosidase Mutations and Motor Reserve in Parkinson's Disease.
Chung SJ, Lee PH, Sohn YH, Kim YJ. Chung SJ, et al. J Parkinsons Dis. 2021 Aug 26. doi: 10.3233/JPD-212758. Online ahead of print. J Parkinsons Dis. 2021. PMID: 34459414
BACKGROUND: The concept of motor reserve explains the individual differences in motor deficits despite similar degrees of nigrostriatal dopamine depletion in Parkinson's disease (PD). OBJECTIVE: To investigate glucocerebrosidase (GBA) variants as potential determina …
BACKGROUND: The concept of motor reserve explains the individual differences in motor deficits despite similar degrees of nigrostriatal dopa …
Predicting Neuropsychiatric Symptoms of Parkinson's Disease with Measures of Striatal Dopaminergic Deficiency.
Bishnoi R, Badir MC, Surya S, Youssef NA. Bishnoi R, et al. Curr Alzheimer Res. 2021 Aug 27. doi: 10.2174/1567205018666210827122133. Online ahead of print. Curr Alzheimer Res. 2021. PMID: 34455969
BACKGROUND: The role of nigrostriatal dopaminergic neurons degeneration is well established in the pathophysiology of Parkinson's disease. However, it is unclear if and how the degeneration of the dopamine pathways affects the manifestation of the neuropsychiatric s …
BACKGROUND: The role of nigrostriatal dopaminergic neurons degeneration is well established in the pathophysiology of Parkinson's
A bidirectional relationship between anxiety, depression and gastrointestinal symptoms in Parkinson's disease.
Jones JD, Dominguez B, Bunch J, Uribe C, Valenzuela Y, Jacobs JP. Jones JD, et al. Clin Park Relat Disord. 2021 Aug 10;5:100104. doi: 10.1016/j.prdoa.2021.100104. eCollection 2021. Clin Park Relat Disord. 2021. PMID: 34430845 Free PMC article.
INTRODUCTION: Anxiety, depression and gastrointestinal (GI) symptoms are common non-motor symptoms in Parkinson's disease (PD). Past studies provide evidence of a disrupted microbiome-gut-brain axis in PD, which is associated with certain motor and non-motor symptom …
INTRODUCTION: Anxiety, depression and gastrointestinal (GI) symptoms are common non-motor symptoms in Parkinson's disease (PD) …
Apathy: An underestimated feature in GBA and LRRK2 non-manifesting mutation carriers.
Pachi I, Koros C, Simitsi AM, Papadimitriou D, Bougea A, Prentakis A, Papagiannakis N, Bozi M, Antonelou R, Angelopoulou E, Beratis I, Stamelou M, Trapali XG, Papageorgiou SG, Stefanis L. Pachi I, et al. Parkinsonism Relat Disord. 2021 Aug 18;91:1-8. doi: 10.1016/j.parkreldis.2021.08.008. Online ahead of print. Parkinsonism Relat Disord. 2021. PMID: 34425330
INTRODUCTION: Higher prevalence of motor and non-motor features has been observed in non-manifesting mutation carriers of Parkinson's Disease (PD) compared to Healthy Controls (HC). The aim was to detect the differences between GBA and LRRK2 mutation carriers withou …
INTRODUCTION: Higher prevalence of motor and non-motor features has been observed in non-manifesting mutation carriers of Parkinson' …
An individualized prediction of time to cognitive impairment in Parkinson's disease: A combined multi-predictor study.
Tang C, Zhao X, Wu W, Zhong W, Wu X. Tang C, et al. Neurosci Lett. 2021 Sep 25;762:136149. doi: 10.1016/j.neulet.2021.136149. Epub 2021 Aug 2. Neurosci Lett. 2021. PMID: 34352339
BACKGROUND: Cognitive impairment (CI) is important for the prognosis of Parkinson's disease (PD). Early prediction whether and when cognitive decline from normal cognition (NC) will occur is crucial for preventing or delaying the progression timely. The curre …
BACKGROUND: Cognitive impairment (CI) is important for the prognosis of Parkinson's disease (PD). Early prediction whether and …
Olfaction, cholinergic basal forebrain degeneration, and cognition in early Parkinson disease.
Barrett MJ, Murphy JM, Zhang J, Blair JC, Flanigan JL, Nawaz H, Dalrymple WA, Sperling SA, Patrie J, Druzgal TJ. Barrett MJ, et al. Parkinsonism Relat Disord. 2021 Jul 27;90:27-32. doi: 10.1016/j.parkreldis.2021.07.024. Online ahead of print. Parkinsonism Relat Disord. 2021. PMID: 34348192
INTRODUCTION: Impaired olfaction and reduced cholinergic nucleus 4 (Ch4) volume both predict greater cognitive decline in Parkinson's disease (PD). We examined the relationship between olfaction, longitudinal change in cholinergic basal forebrain nuclei and their ta …
INTRODUCTION: Impaired olfaction and reduced cholinergic nucleus 4 (Ch4) volume both predict greater cognitive decline in Parkinson' …
Discovery of Parkinson's disease states and disease progression modelling: a longitudinal data study using machine learning.
Severson KA, Chahine LM, Smolensky LA, Dhuliawala M, Frasier M, Ng K, Ghosh S, Hu J. Severson KA, et al. Lancet Digit Health. 2021 Sep;3(9):e555-e564. doi: 10.1016/S2589-7500(21)00101-1. Epub 2021 Jul 29. Lancet Digit Health. 2021. PMID: 34334334 Free article.
BACKGROUND: Parkinson's disease is heterogeneous in symptom presentation and progression. ...METHODS: In this longitudinal data study, data were collected for up to 7-years on 423 patients with early Parkinson's disease and 196 healthy controls …
BACKGROUND: Parkinson's disease is heterogeneous in symptom presentation and progression. ...METHODS: In this longitudi …
Development and Validation of a Prognostic Model for Cognitive Impairment in Parkinson's Disease With REM Sleep Behavior Disorder.
Chen F, Li Y, Ye G, Zhou L, Bian X, Liu J. Chen F, et al. Front Aging Neurosci. 2021 Jul 12;13:703158. doi: 10.3389/fnagi.2021.703158. eCollection 2021. Front Aging Neurosci. 2021. PMID: 34322014 Free PMC article.
The presentation and progression of Parkinson's disease (PD) are not uniform, but the presence of rapid eye movement sleep behavior disorder (RBD) in PD patients may indicate a worse prognosis than isolated PD. ...This study aimed to develop a prognostic mode …
The presentation and progression of Parkinson's disease (PD) are not uniform, but the presence of rapid eye movement sl …
No effect of Parkinson's disease-polygenic load on striatal density of dopaminergic neuron in healthy subjects.
Pak K, Lee MJ, Kim K, Kim IJ. Pak K, et al. Ann Nucl Med. 2021 Jul 21. doi: 10.1007/s12149-021-01657-w. Online ahead of print. Ann Nucl Med. 2021. PMID: 34287783
OBJECTIVE: There has been increasing evidence to support the role of genetic factors in Parkinson's disease (PD). (123)I-FP-CIT single-photon emission computed tomography (SPECT) enables in vivo visualization of the striatal density of dopaminergic neuron. ...Data u …
OBJECTIVE: There has been increasing evidence to support the role of genetic factors in Parkinson's disease (PD). (123)I-FP-CI …
Temporal trajectory of biofluid markers in Parkinson's disease.
Baek MS, Lee MJ, Kim HK, Lyoo CH. Baek MS, et al. Sci Rep. 2021 Jul 20;11(1):14820. doi: 10.1038/s41598-021-94345-8. Sci Rep. 2021. PMID: 34285331 Free PMC article.
Full dynamics of biofluid biomarkers have been unknown in patients with Parkinson's disease (PD). Using data from 396 PD patients and 182 controls in the Parkinson's Progression Markers Initiative (PPMI) database, we estimated long …
Full dynamics of biofluid biomarkers have been unknown in patients with Parkinson's disease (PD). Using data from 396 PD patie …
288 results
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