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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1952 1
1953 3
1959 2
1960 5
1961 7
1962 5
1965 6
1966 3
1967 9
1968 17
1969 12
1970 10
1971 20
1972 14
1973 15
1974 9
1975 5
1976 13
1977 11
1978 10
1979 14
1980 13
1981 11
1982 11
1983 26
1984 22
1985 26
1986 34
1987 56
1988 50
1989 53
1990 64
1991 69
1992 80
1993 92
1994 86
1995 86
1996 107
1997 135
1998 138
1999 125
2000 149
2001 143
2002 163
2003 197
2004 174
2005 225
2006 290
2007 362
2008 408
2009 425
2010 458
2011 517
2012 550
2013 553
2014 562
2015 535
2016 593
2017 585
2018 578
2019 210
2020 0
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8,169 results
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Page 1
Parkinson's disease: a review.
Beitz JM. Front Biosci (Schol Ed) 2014 - Review. PMID 24389262
Parkinson's Disease is the second most common progressive neurodegenerative disorder affecting older American adults and is predicted to increase in prevalence as the United States population ages. Resulting from a pathophysiologic loss or degeneration of dopaminergic neurons in the substantia nigra of the midbrain and the development of neuronal Lewy Bodies, idiopathic Parkinson's Disease is associated with risk factors including aging, family history, pesticide exposure and environmental chemicals (e.g., synthetic heroin use). ...
Parkinson's Disease is the second most common progressive neurodegenerative disorder affecting older American adults and is pr
Parkinson disease.
Kim SD, et al. Handb Clin Neurol 2018 - Review. PMID 30482313
Parkinson disease (PD) is a complex, multisystem disorder with both neurologic and systemic nonmotor manifestations. It is neurodegenerative in nature in which disordered balance, gait, and falls are universal problems that can be present at initial diagnosis, and which progress over time. Freezing of gait is a particularly debilitating feature of PD that becomes more prevalent over time with disease progression, being present in approximately 7% after 2 years of disease and 28% after 5 years. ...
Parkinson disease (PD) is a complex, multisystem disorder with both neurologic and systemic nonmotor manifestations. It is neu
Neuropathology of Parkinson disease.
Dickson DW. Parkinsonism Relat Disord 2018 - Review. PMID 28780180 Free PMC article.
INTRODUCTION: Parkinson's disease (PD) is characterized by bradykinesia, rigidity, postural instability and tremor. Several pathologic processes can produce this syndrome, but neurodegeneration accompanied by neuronal inclusions composed of α-synuclein (Lewy bodies) is considered the typical pathologic correlate of PD. ...Molecular pathology of PD is summarized from cell biological and animal studies. RESULTS: The pathologic feature that correlates with signs and symptoms of PD is neuronal loss in the substantia nigra with dopaminergic denervation of the striatum. ...
INTRODUCTION: Parkinson's disease (PD) is characterized by bradykinesia, rigidity, postural instability and tremor. Several pa …
Parkinson's disease.
Samii A, et al. Lancet 2004 - Review. PMID 15172778
Parkinson's disease is the most common serious movement disorder in the world, affecting about 1% of adults older than 60 years. ...Symptoms of Parkinson's disease respond in varying degrees to drugs, and surgery offers hope for patients no longer adequately controlled in this manner. ...
Parkinson's disease is the most common serious movement disorder in the world, affecting about 1% of adults older than 60 year
Stages in the development of Parkinson's disease-related pathology.
Braak H, et al. Cell Tissue Res 2004 - Review. PMID 15338272
The synucleinopathy, idiopathic Parkinson's disease, is a multisystem disorder that involves only a few predisposed nerve cell types in specific regions of the human nervous system. ...As the disease progresses, components of the autonomic, limbic, and somatomotor systems become particularly badly damaged. During presymptomatic stages 1-2, inclusion body pathology is confined to the medulla oblongata/pontine tegmentum and olfactory bulb/anterior olfactory nucleus. ...
The synucleinopathy, idiopathic Parkinson's disease, is a multisystem disorder that involves only a few predisposed nerve cell …
Selective neuronal vulnerability in Parkinson disease.
Surmeier DJ, et al. Nat Rev Neurosci 2017 - Review. PMID 28104909 Free PMC article.
Intracellular α-synuclein (α-syn)-rich protein aggregates called Lewy pathology (LP) and neuronal death are commonly found in the brains of patients with clinical Parkinson disease (cPD). It is widely believed that LP appears early in the disease and spreads in synaptically coupled brain networks, driving neuronal dysfunction and death. ...
Intracellular α-synuclein (α-syn)-rich protein aggregates called Lewy pathology (LP) and neuronal death are commonly found in the bra …
Neuropathological Staging of Brain Pathology in Sporadic Parkinson's disease: Separating the Wheat from the Chaff.
Braak H and Del Tredici K. J Parkinsons Dis 2017 - Review. PMID 28282810 Free PMC article.
A relatively small number of especially susceptible nerve cell types within multiple neurotransmitter systems of the human central, peripheral, and enteric nervous systems (CNS, PNS, ENS) become involved in the degenerative process underlying sporadic Parkinson's disease (sPD). ...The PD staging system not only caused controversy but contributed a framework for (1) assessing pathology in the spinal cord, ENS, and PNS in relationship to that evolving in the brain, (2) defining prodromal disease and cohorts of at-risk individuals, (3) developing potential prognostic biomarkers for very early disease, (4) testing novel hypotheses and experimental models of α-synuclein propagation and disease progression, and (5) finding causally-oriented therapies that intervene before the substantia nigra becomes involved. ...
A relatively small number of especially susceptible nerve cell types within multiple neurotransmitter systems of the human central, peripher …
Parkinson's: a syndrome rather than a disease?
Titova N, et al. J Neural Transm (Vienna) 2017 - Review. PMID 28028643 Free PMC article.
Emerging concepts suggest that a multitude of pathology ranging from misfolding of alpha-synuclein to neuroinflammation, mitochondrial dysfunction, and neurotransmitter driven alteration of brain neuronal networks lead to a syndrome that is commonly known as Parkinson's disease. The complex underlying pathology which may involve degeneration of non-dopaminergic pathways leads to the expression of a range of non-motor symptoms from the prodromal stage of Parkinson's to the palliative stage. ...
Emerging concepts suggest that a multitude of pathology ranging from misfolding of alpha-synuclein to neuroinflammation, mitochondria …
The Phenomenology of Parkinson's Disease.
Hess CW and Hallett M. Semin Neurol 2017 - Review. PMID 28511251 Free PMC article.
The motor symptoms of Parkinson's disease are not limited to the cardinal symptoms of bradykinesia, rigidity, and resting tremor, but also include a variety of interrelated motor phenomena such as deficits in spatiotemporal planning and movement sequencing, scaling and timing of movements, and intermuscular coordination that can be clinically observed. Although many of these phenomena overlap, a review of the full breadth of the motor phenomenon can aid in the diagnosis and monitoring of disease progression....
The motor symptoms of Parkinson's disease are not limited to the cardinal symptoms of bradykinesia, rigidity, and resting trem …
The hallmarks of Parkinson's disease.
Antony PM, et al. FEBS J 2013 - Review. PMID 23663200 Free article.
Since the discovery of dopamine as a neurotransmitter in the 1950s, Parkinson's disease (PD) research has generated a rich and complex body of knowledge, revealing PD to be an age-related multifactorial disease, influenced by both genetic and environmental factors. The tremendous complexity of the disease is increased by a nonlinear progression of the pathogenesis between molecular, cellular and organic systems. ...
Since the discovery of dopamine as a neurotransmitter in the 1950s, Parkinson's disease (PD) research has generated a rich and …
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