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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1996 10
1997 18
1998 35
1999 49
2000 36
2001 50
2002 55
2003 60
2004 56
2005 63
2006 88
2007 70
2008 86
2009 107
2010 87
2011 122
2012 103
2013 83
2014 106
2015 87
2016 70
2017 70
2018 86
2019 36
2020 0
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1,483 results
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Page 1
Structures of human Patched and its complex with native palmitoylated sonic hedgehog.
Qi X, et al. Nature 2018. PMID 29995851 Free PMC article.
N-terminally palmitoylated HH releases the repression of Patched to the oncoprotein smoothened (SMO); however, the mechanism by which HH recognizes Patched is unclear. ...The palmitoylated N terminus of SHH-N inserts into a cavity between the extracellular domains of PTCH1 and dominates the PTCH1-SHH-N interface, which is distinct from that reported for SHH-N co-receptors(8). ...
N-terminally palmitoylated HH releases the repression of Patched to the oncoprotein smoothened (SMO); however, the mechanism by which …
Structural Basis for Cholesterol Transport-like Activity of the Hedgehog Receptor Patched.
Zhang Y, et al. Cell 2018. PMID 30415841 Free PMC article.
Loss of Patched function, the most common cause of basal cell carcinoma, permits unregulated activation of Smoothened and of the Hedgehog pathway. A cryo-EM structure of the Patched protein reveals striking transmembrane domain similarities to prokaryotic RND transporters. ...
Loss of Patched function, the most common cause of basal cell carcinoma, permits unregulated activation of Smoothened and of the Hedg …
Patched Receptors Sense, Interpret, and Establish an Epidermal Hedgehog Signaling Gradient.
Adolphe C, et al. J Invest Dermatol 2017. PMID 27498049 Free article.
To explore the contribution of Hedgehog receptors Ptch1 and Ptch2 in establishing the epidermal signaling gradient, we quantitated the level of pathway activity generated in Ptch1- and Ptch1;Ptch2-deficient skin and defined the contribution of each receptor to regulation of the levels of Hedgehog signaling identified in wild-type skin. ...
To explore the contribution of Hedgehog receptors Ptch1 and Ptch2 in establishing the epidermal signaling gradient, we quantitated th …
Structural basis for the recognition of Sonic Hedgehog by human Patched1
Gong X, et al. Science 2018. PMID 29954986
The Hedgehog (Hh) pathway involved in development and regeneration is activated by the extracellular binding of Hh to the membrane receptor Patched (Ptch). ...
The Hedgehog (Hh) pathway involved in development and regeneration is activated by the extracellular binding of Hh to the membrane receptor …
New mutations and an updated database for the patched-1 (PTCH1) gene.
Reinders MG, et al. Mol Genet Genomic Med 2018. PMID 29575684 Free PMC article.
BCNS most commonly is caused by a germline mutation in the patched-1 (PTCH1) gene. PTCH1 mutations are also described in patients with holoprosencephaly. ...
BCNS most commonly is caused by a germline mutation in the patched-1 (PTCH1) gene. PTCH1 mutations are also described in patients wit …
sm"FISH"ing for Hedgehog
Drummond ML and Atwood SX. J Invest Dermatol 2017 - Review. PMID 28010757 Free article.
Patched (Ptch) receptors are critical negative regulators of Hedgehog signaling, where Ptch1 loss causes basal cell carcinoma and Ptch1;Ptch2 loss disrupts skin and hair follicle development. Adolphe et al. use single molecule fluorescent in situ hybridization to show quantitatively that Ptch receptors create a Hedgehog signaling gradient that may specify hair follicle development....
Patched (Ptch) receptors are critical negative regulators of Hedgehog signaling, where Ptch1 loss causes basal cell carcinoma
Two Patched molecules engage distinct sites on Hedgehog yielding a signaling-competent complex.
Qi X, et al. Science 2018. PMID 30139912 Free PMC article.
N-terminally palmitoylated HH initiates signaling by binding its receptor Patched-1 (PTCH1). A recent 1:1 PTCH1-HH complex structure visualized a palmitate-mediated binding site on HH, which was inconsistent with previous studies that implied a distinct, calcium-mediated binding site for PTCH1 and HH co-receptors. Our 3.5-angstrom resolution cryo-electron microscopy structure of native Sonic Hedgehog (SHH-N) in complex with PTCH1 at a physiological calcium concentration reconciles these disparate findings and demonstrates that one SHH-N molecule engages both epitopes to bind two PTCH1 receptors in an asymmetric manner. ...
N-terminally palmitoylated HH initiates signaling by binding its receptor Patched-1 (PTCH1). A recent 1:1 PTCH1-HH complex structure …
Human receptors patched and smoothened partially transduce hedgehog signal when expressed in Drosophila cells.
De Rivoyre M, et al. J Biol Chem 2006. PMID 16867986 Free article.
In humans, dysfunctions of the Hedgehog receptors Patched and Smoothened are responsible for numerous pathologies. However, signaling mechanisms involving these receptors are less well characterized in mammals than in Drosophila. To obtain structure-function relationship information on human Patched and Smoothened, we expressed these human receptors in Drosophila Schneider 2 cells. ...
In humans, dysfunctions of the Hedgehog receptors Patched and Smoothened are responsible for numerous pathologies. However, si …
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