Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

MyNCBI Filters
Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1996 5
1997 10
1998 14
1999 29
2000 21
2001 28
2002 30
2003 36
2004 36
2005 41
2006 64
2007 45
2008 59
2009 76
2010 55
2011 85
2012 77
2013 64
2014 79
2015 59
2016 55
2017 64
2018 72
2019 30
2020 0
Text availability
Article attribute
Article type
Publication date

Search Results

1,026 results
Results by year
Filters applied: . Clear all
Page 1
Structural Basis for Cholesterol Transport-like Activity of the Hedgehog Receptor Patched.
Zhang Y, et al. Cell 2018. PMID 30415841 Free PMC article.
Hedgehog protein signals mediate tissue patterning and maintenance by binding to and inactivating their common receptor Patched, a 12-transmembrane protein that otherwise would suppress the activity of the 7-transmembrane protein Smoothened. ...A cryo-EM structure of the Patched protein reveals striking transmembrane domain similarities to prokaryotic RND transporters. ...
Hedgehog protein signals mediate tissue patterning and maintenance by binding to and inactivating their common receptor Patched
Patched-2 functions to limit Patched-1 deficient skin cancer growth.
Veenstra VL, et al. Cell Oncol (Dordr) 2018. PMID 29869097 Free PMC article.
The Hh pathway is regulated by interactions between the Patched-1 (Ptch1) and Smoothened (Smo) receptors. Smo is an activating receptor and is subject to inhibition by Ptch1. ...This receptor interaction is pivotal to restraining uncontrolled cellular growth. Both receptors have been found to be frequently mutated in BCCs. ...
The Hh pathway is regulated by interactions between the Patched-1 (Ptch1) and Smoothened (Smo) receptors. Smo is an activating …
New mutations and an updated database for the patched-1 (PTCH1) gene.
Reinders MG, et al. Mol Genet Genomic Med 2018. PMID 29575684 Free PMC article.
BCNS most commonly is caused by a germline mutation in the patched-1 (PTCH1) gene. PTCH1 mutations are also described in patients with holoprosencephaly. ...
BCNS most commonly is caused by a germline mutation in the patched-1 (PTCH1) gene. PTCH1 mutations are also described in patie …
Structures of human Patched and its complex with native palmitoylated sonic hedgehog.
Qi X, et al. Nature 2018. PMID 29995851 Free PMC article.
N-terminally palmitoylated HH releases the repression of Patched to the oncoprotein smoothened (SMO); however, the mechanism by which HH recognizes Patched is unclear. Here we report cryo-electron microscopy structures of human patched 1 (PTCH1) alone and in complex with the N-terminal domain of 'native' sonic hedgehog (native SHH-N has both a C-terminal cholesterol and an N-terminal fatty-acid modification), at resolutions of 3.5 Å and 3.8 Å, respectively. ...
N-terminally palmitoylated HH releases the repression of Patched to the oncoprotein smoothened (SMO); however, the mechanism by which …
Structural basis for the recognition of Sonic Hedgehog by human Patched1
Gong X, et al. Science 2018. PMID 29954986
The Hedgehog (Hh) pathway involved in development and regeneration is activated by the extracellular binding of Hh to the membrane receptor Patched (Ptch). ...
The Hedgehog (Hh) pathway involved in development and regeneration is activated by the extracellular binding of Hh to the membrane recept
Cholesterol Modification of Smoothened Is Required for Hedgehog Signaling
Xiao X, et al. Mol Cell 2017. PMID 28344083 Free article.
This modification was inhibited by Patched-1 (Ptch1) but enhanced by Hh. The SMO(D95N) mutation, which could not be cholesterol modified, was refractory to Hh-stimulated ciliary localization and failed to activate downstream signaling. ...
This modification was inhibited by Patched-1 (Ptch1) but enhanced by Hh. The SMO(D95N) mutation, which could not be cholestero …
Cryo-EM structure of oxysterol-bound human Smoothened coupled to a heterotrimeric Gi
Qi X, et al. Nature 2019. PMID 31168089 Free PMC article.
The oncoprotein Smoothened (SMO), a G-protein-coupled receptor (GPCR) of the Frizzled-class (class-F), transduces the Hedgehog signal from the tumour suppressor Patched-1 (PTCH1) to the glioma-associated-oncogene (GLI) transcription factors, which activates the Hedgehog signalling pathway(1,2). ...
The oncoprotein Smoothened (SMO), a G-protein-coupled receptor (GPCR) of the Frizzled-class (class-F), transduces the Hedgehog signal …
Smoothened stimulation by membrane sterols drives Hedgehog pathway activity
Deshpande I, et al. Nature 2019. PMID 31263273 Free PMC article.
Hedgehog signalling is fundamental to embryonic development and postnatal tissue regeneration(1). Aberrant postnatal Hedgehog signalling leads to several malignancies, including basal cell carcinoma and paediatric medulloblastoma(2). Hedgehog proteins bind to and inhibit the transmembrane cholesterol transporter Patched-1 (PTCH1), which permits activation of the seven-transmembrane transducer Smoothened (SMO) via a mechanism that is poorly understood. ...
Hedgehog signalling is fundamental to embryonic development and postnatal tissue regeneration(1). Aberrant postnatal Hedgehog signall …
The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism.
Rudolf AF, et al. Nat Chem Biol 2019. PMID 31548691 Free PMC article.
While the palmitoyl group binds and inactivates Patched 1 (PTCH1), the main receptor for HH ligands, the function of the cholesterol modification has remained mysterious. ...
While the palmitoyl group binds and inactivates Patched 1 (PTCH1), the main receptor for HH ligands, the function of th …
Morphogen gradient reconstitution reveals Hedgehog pathway design principles
Li P, et al. Science 2018. PMID 29622726 Free PMC article.
We found that the combination of double-negative regulatory logic and negative feedback through the PTCH receptor accelerates gradient formation and improves robustness to variation in the morphogen production rate compared with alternative designs. ...
We found that the combination of double-negative regulatory logic and negative feedback through the PTCH receptor accelerates gradien …
1,026 results
Jump to page
Feedback