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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 4
1946 11
1947 14
1948 12
1949 5
1950 17
1951 24
1952 16
1953 17
1954 37
1955 38
1956 36
1957 29
1958 28
1959 44
1960 44
1961 40
1962 58
1963 114
1964 159
1965 128
1966 156
1967 206
1968 273
1969 270
1970 304
1971 327
1972 363
1973 300
1974 342
1975 250
1976 223
1977 195
1978 152
1979 151
1980 183
1981 173
1982 140
1983 160
1984 188
1985 174
1986 176
1987 134
1988 125
1989 149
1990 150
1991 174
1992 136
1993 111
1994 92
1995 105
1996 90
1997 81
1998 76
1999 79
2000 80
2001 84
2002 79
2003 77
2004 101
2005 88
2006 73
2007 109
2008 97
2009 70
2010 94
2011 98
2012 117
2013 106
2014 108
2015 127
2016 130
2017 114
2018 123
2019 63
2020 4
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8,792 results
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Page 1
Pepsin in Saliva as a Diagnostic Marker for Gastroesophageal Reflux Disease: A Meta-Analysis.
Guo Z, et al. Med Sci Monit 2018. PMID 30596632 Free PMC article.
Salivary pepsin detection has previously been considered as a method for GERD diagnosis. We performed a meta-analysis to investigate the utility of salivary pepsin assay as a diagnostic tool of GERD. ...CONCLUSIONS The meta-analysis showed that pepsin in saliva has moderate diagnostic value for GERD, and is not as helpful as previously thought....
Salivary pepsin detection has previously been considered as a method for GERD diagnosis. We performed a meta-analysis to investigate …
Is Pepsin a Reliable Marker of Laryngopharyngeal Reflux? A Systematic Review.
Calvo-Henríquez C, et al. Otolaryngol Head Neck Surg 2017 - Review. PMID 28585488
Review Methods The outcome assessed was the presence of pepsin in LPR patients. We included articles in which pepsin was studied in LPR patients (clinically suspected or with confirmed diagnosis). ...Conclusion Pepsin might be a reliable marker in LPR patients, although questions remain about optimal timing, location, nature, and threshold values for pepsin testing. ...
Review Methods The outcome assessed was the presence of pepsin in LPR patients. We included articles in which pepsin was studi …
Pepsin in saliva as a diagnostic biomarker in laryngopharyngeal reflux: a meta-analysis.
Wang J, et al. Eur Arch Otorhinolaryngol 2018 - Review. PMID 29238875
We assessed the diagnostic value of pepsin in saliva for LPR. METHODS: PubMed, Embase, and Web of Science were searched for studies in English that evaluated the utility of pepsin in saliva in the diagnosis of LPR, published up to 15 March 2017. ...Therefore, further investigations are required to find the optimal method to detect salivary pepsin in diagnosing LPR....
We assessed the diagnostic value of pepsin in saliva for LPR. METHODS: PubMed, Embase, and Web of Science were searched for studies i …
Pepsin as a biomarker for laryngopharyngeal reflux in children with laryngomalacia.
Luebke K, et al. Laryngoscope 2017. PMID 28224634
Pepsin was detected in lavages of laryngomalacia patients (8/10) but absent in controls (0/5; P = .007). Pepsin was observed more frequently in lavages (8/10) than biopsies (4/10; P = .046) of laryngomalacia subjects. Higher median pepsin concentration was observed in laryngomalacia than control lavages (P = .025). CONCLUSIONS: Pepsin in supraglottic specimens demonstrated an association with laryngomalacia, supporting a role for refluxed pepsin in laryngomalacia. ...
Pepsin was detected in lavages of laryngomalacia patients (8/10) but absent in controls (0/5; P = .007). Pepsin was observed m
Effects of pepsin A on heat shock protein 70 response in laryngopharyngeal reflux patients with chronic rhinosinusitis.
Wang J, et al. Acta Otolaryngol 2017. PMID 28784015
RESULTS: Pepsin A levels in nasal secretions were significantly higher in CRSwNP/CRSsNP patients than in controls. HSP70 levels were significantly increased in pepsin A-positive turbinate mucosa compared to controls (p < .001). Similarly, HSP70 levels were significantly increased in pepsin A-positive polyp tissues than in pepsin A-negative polyp tissues (p = .016). ...
RESULTS: Pepsin A levels in nasal secretions were significantly higher in CRSwNP/CRSsNP patients than in controls. HSP70 levels were …
The diagnostic value of pepsin detection in saliva for gastro-esophageal reflux disease: a preliminary study from China.
Du X, et al. BMC Gastroenterol 2017. PMID 29041918 Free PMC article.
Pepsin in saliva has been proposed as a promising diagnostic biomarker for gastro-esophageal reflux. We aimed to determine the diagnostic value of salivary pepsin detection for GERD. ...RESULTS: Patients with GERD had a higher prevalence of pepsin in saliva and higher pepsin concentration than patients with non-GERD and healthy controls (P < 0.001 for all). ...
Pepsin in saliva has been proposed as a promising diagnostic biomarker for gastro-esophageal reflux. We aimed to determine the diagno
A non-interventional, observational study of a fixed combination of pepsin and amino acid hydrochloride in patients with functional dyspepsia.
Forssmann K, et al. BMC Gastroenterol 2017 - Clinical Trial. PMID 29178842 Free PMC article.
Enzynorm®f is a pharmaceutical preparation comprising fixed amounts of pepsin of biological origin and organically bound acid in the form of amino acid hydrochloride. ...CONCLUSION: The results of this study support the efficacy of a fixed combination of pepsin and amino acid hydrochloride for the treatment of patients with FD and also suggest good to moderate treatment tolerability. ...
Enzynorm®f is a pharmaceutical preparation comprising fixed amounts of pepsin of biological origin and organically bound acid in the …
The Intrinsic Pepsin Resistance of Interleukin-8 Can Be Explained from a Combined Bioinformatical and Experimental Approach.
Anders G, et al. IEEE/ACM Trans Comput Biol Bioinform 2018. PMID 28113517
Such similarity could play a key role in understanding IL-8 resistance to the protease pepsin. To support this hypothesis, we applied pepsin assays confirming that intact IL-8 is not degraded by pepsin in comparison to IL-8 in a denaturated state. ...The results obtained in this work contribute to the understanding of the resistance of IL-8 to pepsin proteolysis in terms of its structural properties....
Such similarity could play a key role in understanding IL-8 resistance to the protease pepsin. To support this hypothesis, we applied …
8,792 results
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