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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1946 1
1952 2
1954 1
1955 5
1956 5
1957 1
1958 1
1959 8
1960 12
1961 9
1962 10
1965 4
1966 17
1967 24
1968 41
1969 47
1970 43
1971 40
1972 29
1973 35
1974 40
1975 51
1976 44
1977 37
1978 37
1979 28
1980 32
1981 37
1982 30
1983 29
1984 40
1985 27
1986 33
1987 27
1988 34
1989 27
1990 29
1991 36
1992 33
1993 18
1994 9
1995 23
1996 18
1997 6
1998 11
1999 12
2000 11
2001 10
2002 7
2003 6
2004 19
2005 20
2006 10
2007 15
2008 14
2009 8
2010 12
2011 15
2012 17
2013 18
2014 19
2015 32
2016 33
2017 19
2018 22
2019 8
2020 1
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1,353 results
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Page 1
Salivary Pepsin Lacks Sensitivity as a Diagnostic Tool to Evaluate Extraesophageal Reflux Disease.
Dy F, et al. J Pediatr 2016. PMID 27453366 Free PMC article.
RESULTS: Twenty-one of the 50 patients (42%) were salivary pepsin-positive, with a median salivary pepsin concentration of 10 ng/mL (IQR, 10-55 ng/mL). There was no significant difference in the distributions of acid, nonacid, total reflux episodes, full column reflux, or any other reflux variable in patients who were pepsin-positive compared with those who were pepsin-negative (P > .50). ...
RESULTS: Twenty-one of the 50 patients (42%) were salivary pepsin-positive, with a median salivary pepsin concentration of 10 …
Gastric Acid and Pepsin Work Together in Simulated Gastric Acid Inhalation Leading to Pulmonary Fibrosis in Rats.
Chen S, et al. Med Sci Monit 2019. PMID 31419218 Free PMC article.
The bleomycin group was administered a one-time intratracheal injection of bleomycin, whereas the 3 simulated aspiration groups were treated either with an intratracheal instillation of gastric fluid combined with pepsin, with pepsin alone, or with hydrochloric acid, all twice a week, and the negative control group was administered normal saline twice a week. ...CONCLUSIONS The study demonstrates that aspiration of gastric contents can cause pulmonary fibrosis, and mixed aspiration of pepsin and gastric fluid can accelerate this process. ...
The bleomycin group was administered a one-time intratracheal injection of bleomycin, whereas the 3 simulated aspiration groups were treated …
A novel catalysis by porcine pepsin in debranching guar galactomannan.
Shobha MS, et al. Carbohydr Polym 2014. PMID 24507326
BACKGROUND: Pepsin (porcine stomach mucosa, E.C. 3.4.23.1), an acid protease catalyzes the hydrolysis (debranching) of guar galactomannan (GG), a co-polymer of mannose and galactose residues thereby showing its non-specific catalysis towards glycosidic substrates. ...GENERAL SIGNIFICANCE: Here we show a novel mode of catalysis (other than proteolysis) by porcine pepsin with a different active site residue....
BACKGROUND: Pepsin (porcine stomach mucosa, E.C. 3.4.23.1), an acid protease catalyzes the hydrolysis (debranching) of guar galactoma …
Thiol-ene Monolithic Pepsin Microreactor with a 3D-Printed Interface for Efficient UPLC-MS Peptide Mapping Analyses.
Jönsson A, et al. Anal Chem 2017. PMID 28322047 Free article.
Off-stoichiometric thiol-ene is utilized as both bulk material and as a monolithic stationary phase for immobilization of the proteolytic enzyme pepsin. The digestion efficiency of the, thiol-ene based, immobilized enzyme reactor (IMER) is compared to that of a conventional, agarose packed bed, pepsin IMER column commonly used in LC-MS based protein analyses. ...
Off-stoichiometric thiol-ene is utilized as both bulk material and as a monolithic stationary phase for immobilization of the proteolytic en …
Pepsin and Its Importance for Functional Dyspepsia: Relic, Regulator or Remedy?
Petersen KU. Dig Dis 2018 - Review. PMID 28982106
Historical treatment attempts with pepsin products were shrugged off, as a simple calculation shows that quantitative substitution is pointless. ...Key Message: As functional dyspepsia represents a heterogeneous disorder, it may be intriguing to view pepsin as a potential (although still to be proven) treatment modality, distinguished by a diversity of pro-digestive effects....
Historical treatment attempts with pepsin products were shrugged off, as a simple calculation shows that quantitative substitution is …
Association between Pepsin in Bronchoalveolar Lavage Fluid and Prognosis of Chronic Fibrosing Interstitial Lung Disease.
Kim Y, et al. Tohoku J Exp Med 2018. PMID 30405002 Free article.
We measured pepsin, a marker of gastric aspiration, in bronchoalveolar lavage (BAL) fluid of chronic fibrosing ILD patients to evaluate the association between BAL fluid pepsin and prognosis of chronic fibrosing ILDs. ...BAL fluid pepsin may be used as a prognostic marker for predicting mortality in chronic fibrosing ILD patients....
We measured pepsin, a marker of gastric aspiration, in bronchoalveolar lavage (BAL) fluid of chronic fibrosing ILD patients to evalua …
Detection of Pepsin in Oral Secretions of Infants with and without Laryngomalacia.
Klimara MJ, et al. Ann Otol Rhinol Laryngol 2020. PMID 31631681
Although pepsin in operative supraglottic lavage specimens is associated with severe laryngomalacia, detection of pepsin in oral secretions has not been demonstrated in an outpatient setting. ...CONCLUSION: Pepsin in saliva appears to be associated with laryngomalacia, suggesting a role for salivary pepsin as a noninvasive marker of LPR in patients with laryngomalacia. ...
Although pepsin in operative supraglottic lavage specimens is associated with severe laryngomalacia, detection of pepsin in or …
Characterization of pepsin from rabbit gastric extract, its action on β-casein and the effects of lipids on proteolysis.
Sams L, et al. Food Funct 2018. PMID 30379166
While its gastric lipase activity has been characterized and compared to other lipases, its pepsin activity has not been studied. We measured pepsin activity in RGE using both hemoglobin and azocoll as substrates, and identified the protein separated by SDS-PAGE as a type II-4 mature pepsin of 328 amino acid residues using Edman sequencing, LC-MS/MS analysis and intact mass measurement. ...
While its gastric lipase activity has been characterized and compared to other lipases, its pepsin activity has not been studied. We …
Revisiting the enzymatic kinetics of pepsin using isothermal titration calorimetry.
Luo Q, et al. Food Chem 2018. PMID 30064809 Free article.
To better understand the role of pepsin in protein digestion, we used isothermal titration calorimetry to study the enzymatic kinetics of pepsin with bovine serum albumin as the substrate. We found that pepsin has a higher catalytic rate at lower pH, while its affinity to substrate is lower. At the same pH, pepsin has lower activity and affinity at higher ionic strengths. ...
To better understand the role of pepsin in protein digestion, we used isothermal titration calorimetry to study the enzymatic kinetic …
Differences in the P1' substrate specificities of pepsin A and chymosin.
Kageyama H, et al. J Biochem 2010. PMID 19819898
Porcine pepsin A and bovine chymosin are typical models of aspartic proteinases. The hydrolytic specificities of these proteinases, along with those of human pepsin A and monkey chymosin, were investigated with 29 peptide substrates that included various P1' variants of seven parent peptides. ...Porcine and human pepsin A showed similar hydrolytic specificities, strongly preferring a hydrophobic/aromatic residue at P1' of any type of peptide. ...
Porcine pepsin A and bovine chymosin are typical models of aspartic proteinases. The hydrolytic specificities of these proteinases, a …
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