Enantioselective Flow Synthesis of Rolipram Enabled by a Telescoped Asymmetric Conjugate Addition-Oxidative Aldehyde Esterification Sequence Using in Situ-Generated Persulfuric Acid as Oxidant.
Org Lett. 2022 Feb 4;24(4):1066-1071. doi: 10.1021/acs.orglett.1c04300. Epub 2022 Jan 20.
Org Lett. 2022.
PMID: 35050638
Free PMC article.
The telescoped process takes advantage of a polystyrene-supported chiral organocatalyst along with in situ-generated persulfuric acid as a robust and scalable oxidant for direct aldehyde esterification. ...
The telescoped process takes advantage of a polystyrene-supported chiral organocatalyst along with in situ-generated persulfuric a …