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4,853 results

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Page 1
Phage therapy: From biological mechanisms to future directions.
Strathdee SA, Hatfull GF, Mutalik VK, Schooley RT. Strathdee SA, et al. Cell. 2023 Jan 5;186(1):17-31. doi: 10.1016/j.cell.2022.11.017. Cell. 2023. PMID: 36608652 Free PMC article. Review.
Increasing antimicrobial resistance rates have revitalized bacteriophage (phage) research, the natural predators of bacteria discovered over 100 years ago. ...Developing therapeutic phages takes a coordinated effort of multiple stakeholders. Herein, we review …
Increasing antimicrobial resistance rates have revitalized bacteriophage (phage) research, the natural predators of bacteria d …
Formulation, stabilisation and encapsulation of bacteriophage for phage therapy.
Malik DJ, Sokolov IJ, Vinner GK, Mancuso F, Cinquerrui S, Vladisavljevic GT, Clokie MRJ, Garton NJ, Stapley AGF, Kirpichnikova A. Malik DJ, et al. Adv Colloid Interface Sci. 2017 Nov;249:100-133. doi: 10.1016/j.cis.2017.05.014. Epub 2017 May 14. Adv Colloid Interface Sci. 2017. PMID: 28688779 Free article. Review.
Against a backdrop of global antibiotic resistance and increasing awareness of the importance of the human microbiota, there has been resurgent interest in the potential use of bacteriophages for therapeutic purposes, known as phage therapy. A number of ph …
Against a backdrop of global antibiotic resistance and increasing awareness of the importance of the human microbiota, there has been resurg …
Bacteriophage therapy for drug-resistant Staphylococcus aureus infections.
Liu K, Wang C, Zhou X, Guo X, Yang Y, Liu W, Zhao R, Song H. Liu K, et al. Front Cell Infect Microbiol. 2024 Jan 31;14:1336821. doi: 10.3389/fcimb.2024.1336821. eCollection 2024. Front Cell Infect Microbiol. 2024. PMID: 38357445 Free PMC article. Review.
This article provides a comprehensive overview of phage biology, animal models, diverse clinical case treatments, and clinical trials in the context of drug-resistant S. aureus phage therapy. It also assesses the strengths and limitations of phage t …
This article provides a comprehensive overview of phage biology, animal models, diverse clinical case treatments, and clinical trials …
Standardized bacteriophage purification for personalized phage therapy.
Luong T, Salabarria AC, Edwards RA, Roach DR. Luong T, et al. Nat Protoc. 2020 Sep;15(9):2867-2890. doi: 10.1038/s41596-020-0346-0. Epub 2020 Jul 24. Nat Protoc. 2020. PMID: 32709990
The world is on the cusp of a post-antibiotic era, but researchers and medical doctors have found a way forward-by looking back at how infections were treated before the advent of antibiotics, namely using phage therapy. Although bacteriophages (phages …
The world is on the cusp of a post-antibiotic era, but researchers and medical doctors have found a way forward-by looking back at how infec …
Phage Therapy: Going Temperate?
Monteiro R, Pires DP, Costa AR, Azeredo J. Monteiro R, et al. Trends Microbiol. 2019 Apr;27(4):368-378. doi: 10.1016/j.tim.2018.10.008. Epub 2018 Nov 19. Trends Microbiol. 2019. PMID: 30466900 Review.
Strictly lytic phages have been consensually preferred for phage therapy purposes. In contrast, temperate phages have been avoided due to an inherent capacity to mediate transfer of genes between bacteria by specialized transduction - an event that may …
Strictly lytic phages have been consensually preferred for phage therapy purposes. In contrast, temperate phages …
Bacteriophage host range and bacterial resistance.
Hyman P, Abedon ST. Hyman P, et al. Adv Appl Microbiol. 2010;70:217-48. doi: 10.1016/S0065-2164(10)70007-1. Epub 2010 Mar 6. Adv Appl Microbiol. 2010. PMID: 20359459 Review.
We consider these adaptations as they occur among bacteriophages (phages) and their bacterial hosts, since they are significant to phage use as antibacterials (phage therapy) or to protection of industrial ferments from phage attack. ...S …
We consider these adaptations as they occur among bacteriophages (phages) and their bacterial hosts, since they are significan …
Bacteriophage protein Dap1 regulates evasion of antiphage immunity and Pseudomonas aeruginosa virulence impacting phage therapy in mice.
Le S, Wei L, Wang J, Tian F, Yang Q, Zhao J, Zhong Z, Liu J, He X, Zhong Q, Lu S, Liang H. Le S, et al. Nat Microbiol. 2024 Jul;9(7):1828-1841. doi: 10.1038/s41564-024-01719-5. Epub 2024 Jun 17. Nat Microbiol. 2024. PMID: 38886583
Here we identify a phage protein named Dap1 from Pseudomonas aeruginosa phage PaoP5 that both modulates bacterial host behaviour and contributes to phage fitness. ...Moreover, PaoP5deltadap1 fails to rescue P. aeruginosa-infected mice, implying the significan …
Here we identify a phage protein named Dap1 from Pseudomonas aeruginosa phage PaoP5 that both modulates bacterial host behavio …
Bacteriophage-Host Interactions and the Therapeutic Potential of Bacteriophages.
Dicks LMT, Vermeulen W. Dicks LMT, et al. Viruses. 2024 Mar 20;16(3):478. doi: 10.3390/v16030478. Viruses. 2024. PMID: 38543843 Free PMC article. Review.
This review discusses the attachment of phages to bacterial cells, the penetration of bacterial cells, the use of phages in the treatment of bacterial infections, and the limitations of phage therapy. The therapeutic potential of phage-derived p …
This review discusses the attachment of phages to bacterial cells, the penetration of bacterial cells, the use of phages in th …
Targeting Pseudomonas aeruginosa biofilm with an evolutionary trained bacteriophage cocktail exploiting phage resistance trade-offs.
Kunisch F, Campobasso C, Wagemans J, Yildirim S, Chan BK, Schaudinn C, Lavigne R, Turner PE, Raschke MJ, Trampuz A, Gonzalez Moreno M. Kunisch F, et al. Nat Commun. 2024 Oct 3;15(1):8572. doi: 10.1038/s41467-024-52595-w. Nat Commun. 2024. PMID: 39362854 Free PMC article.
However, while up to 80% of human microbial infections are biofilm-associated, research towards targeted improvement of bacteriophages' ability to combat biofilms remains scarce. This study aims at an in vitro biofilm evolution assay to improve multiple bacteriophage …
However, while up to 80% of human microbial infections are biofilm-associated, research towards targeted improvement of bacteriophages …
A Klebsiella-phage cocktail to broaden the host range and delay bacteriophage resistance both in vitro and in vivo.
Chen H, Liu H, Gong Y, Dunstan RA, Ma Z, Zhou C, Zhao D, Tang M, Lithgow T, Zhou T. Chen H, et al. NPJ Biofilms Microbiomes. 2024 Nov 14;10(1):127. doi: 10.1038/s41522-024-00603-8. NPJ Biofilms Microbiomes. 2024. PMID: 39543151 Free PMC article.
Bacteriophages (phages), viruses capable of infecting and lysing bacteria, are a promising alternative for treating infections from hypervirulent, antibiotic-resistant pathogens like Klebsiella pneumoniae, though narrow host range and phage resistance remain …
Bacteriophages (phages), viruses capable of infecting and lysing bacteria, are a promising alternative for treating infections …
4,853 results