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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1947 2
1948 3
1949 3
1950 2
1951 2
1952 5
1953 2
1954 7
1955 1
1956 4
1957 5
1958 4
1959 5
1960 6
1961 9
1962 18
1963 64
1964 85
1965 68
1966 64
1967 82
1968 80
1969 116
1970 87
1971 124
1972 143
1973 143
1974 167
1975 168
1976 122
1977 173
1978 131
1979 165
1980 169
1981 160
1982 222
1983 242
1984 280
1985 305
1986 276
1987 317
1988 356
1989 342
1990 390
1991 417
1992 311
1993 373
1994 380
1995 351
1996 338
1997 362
1998 365
1999 365
2000 326
2001 344
2002 339
2003 296
2004 363
2005 326
2006 350
2007 357
2008 313
2009 278
2010 280
2011 271
2012 258
2013 244
2014 245
2015 242
2016 229
2017 205
2018 183
2019 82
2020 1
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13,293 results
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Page 1
Safety of Phenylephrine Infusion Through Peripheral Intravenous Catheter in the Neurological Intensive Care Unit.
Datar S, et al. J Intensive Care Med 2018. PMID 28569131
The purpose of this study was to evaluate the safety of phenylephrine infusion through peripheral intravenous catheter (PIV) in the neuro ICU. ...The most common indications for phenylephrine use were hemodynamic augmentation (40%) and postoperative hypotension (32%). The most common location of PIV-infusing phenylephrine was proximal upper extremity (50%). ...
The purpose of this study was to evaluate the safety of phenylephrine infusion through peripheral intravenous catheter (PIV) in the n …
The Efficacy and Safety of Norepinephrine and Its Feasibility as a Replacement for Phenylephrine to Manage Maternal Hypotension during Elective Cesarean Delivery under Spinal Anesthesia.
Wang X, et al. Biomed Res Int 2018 - Review. PMID 30687737 Free PMC article.
However, phenylephrine is associated with dose-dependent reflex bradycardia and decreased cardiac output, which can endanger the mother and fetus in certain circumstances. ...Nine reports were found for norepinephrine use either alone or compared to phenylephrine. Results show that norepinephrine efficacy in rescuing maternal hypotension is similar to that of phenylephrine without obvious maternal or neonatal adverse outcomes, and with a lower incidence of bradycardia and greater cardiac output. ...
However, phenylephrine is associated with dose-dependent reflex bradycardia and decreased cardiac output, which can endanger the moth …
Phenylephrine, a common cold remedy active ingredient, suppresses uterine contractions through cAMP signalling.
Chen X, et al. Sci Rep 2018. PMID 30076382 Free PMC article.
Prazosin, an inhibitor of α(1)-adrenoceptor, did not prevent phenylephrine-mediated relaxations. Conversely, ICI118551, an antagonist of β2-adrenoceptors, inhibited phenylephrine relaxation. In the presence of ICI118551, high concentrations (>30 μM) of phenylephrine caused mouse uterine contractions, suggesting that β-adrenoceptor-mediated inhibition interferes with the phenylephrine contractile potential. ...
Prazosin, an inhibitor of α(1)-adrenoceptor, did not prevent phenylephrine-mediated relaxations. Conversely, ICI118551, an antagonist …
The Phenylephrine Test Revisited.
Barsegian A, et al. Ophthalmic Plast Reconstr Surg 2018. PMID 28353471
PURPOSE: To characterize the phenylephrine test in ptotic patients to help clinicians perform the test more efficiently. METHODS: Adults with involutional ptosis (n = 24, 30 eyes) were assessed with digital photographs for response to topical 2.5% phenylephrine drop instillation. ...No patient characteristic studied affected the likelihood of eyelid response to phenylephrine or presence of Hering effect. CONCLUSIONS: Although most ptotic eyelids demonstrate a response to 2.5% phenylephrine within 10 minutes, there is a subset of patients that respond much later. ...
PURPOSE: To characterize the phenylephrine test in ptotic patients to help clinicians perform the test more efficiently. METHODS: Adu …
Phenylephrine increases cardiac output by raising cardiac preload in patients with anesthesia induced hypotension.
Kalmar AF, et al. J Clin Monit Comput 2018 - Clinical Trial. PMID 29569112 Free PMC article.
Induction of general anesthesia frequently induces arterial hypotension, which is often treated with a vasopressor, such as phenylephrine. ...In specific circumstances, however, phenylephrine may also contribute to an increase in venous return and thus cardiac output (CO). ...
Induction of general anesthesia frequently induces arterial hypotension, which is often treated with a vasopressor, such as phenylephrine
Efficacy and safety of norepinephrine versus phenylephrine for the management of maternal hypotension during cesarean delivery with spinal anesthesia: A systematic review and meta-analysis.
Xu S, et al. Medicine (Baltimore) 2019. PMID 30702617 Free PMC article.
BACKGROUND: Phenylephrine is the current "gold standard' vasopressor used to treat maternal hypotension in women undergoing cesarean delivery with spinal anesthesia. ...Accordingly, norepinephrine is a promising alternative to phenylephrine. However, before routine clinical application, more studies are warranted....
BACKGROUND: Phenylephrine is the current "gold standard' vasopressor used to treat maternal hypotension in women undergoing cesarean …
The phenylephrine concentration-response relationship for blood pressure after nasal delivery in children.
Anderson BJ, et al. Paediatr Anaesth 2017. PMID 28868789
There are few data quantifying either absorption pharmacokinetics or phenylephrine concentration effect on blood pressure in children. METHODS: Published observations of plasma concentration and blood pressure changes after phenylephrine nasal administration (0.1 mL kg(-1) , 0.25% or 0.5%) in children (n = 52, 2-12 years, 10-40 kg) were pooled with those in adults (23-81 years) given phenylephrine 2.5% (n = 10) and 10% (n = 10) eyedrops. ...
There are few data quantifying either absorption pharmacokinetics or phenylephrine concentration effect on blood pressure in children …
Phenylephrine vs ephedrine in cesarean delivery under spinal anesthesia: A systematic literature review and meta-analysis.
Xu C, et al. Int J Surg 2018. PMID 30389535
The phenylephrine group also had lower fetal acidosis rate, higher umbilical artery and vein pH values and less base excess in the elective surgery. ...CONCLUSION: Phenylephrine and ephedrine were both effective in maintaining hemodynamic balance. Newborns benefited more from phenylephrine in elective cesarean delivery, but not in emergency cesarean delivery or in parturients with pre-eclampsia. ...
The phenylephrine group also had lower fetal acidosis rate, higher umbilical artery and vein pH values and less base excess in the el …
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