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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1997 11
1998 50
1999 73
2000 67
2001 63
2002 75
2003 97
2004 96
2005 135
2006 198
2007 218
2008 275
2009 331
2010 389
2011 475
2012 584
2013 745
2014 786
2015 822
2016 788
2017 812
2018 742
2019 385
2020 8
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7,251 results
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Page 1
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
Engelman JA, et al. Nat Rev Genet 2006 - Review. PMID 16847462
Phosphatidylinositol 3-kinases (PI3Ks) evolved from a single enzyme that regulates vesicle trafficking in unicellular eukaryotes into a family of enzymes that regulate cellular metabolism and growth in multicellular organisms. ...
Phosphatidylinositol 3-kinases (PI3Ks) evolved from a single enzyme that regulates vesicle trafficking in unicellular e
Phosphoinositide 3-kinase pathways and autophagy require phosphatidylinositol phosphate kinases.
Choi S, et al. Adv Biol Regul 2018 - Review. PMID 29472147 Free PMC article.
Phosphatidylinositol phosphate kinases (PIPKs) generate a lipid messenger phosphatidylinositol 4,5-bisphosphate (PI4,5P(2)) that controls essentially all aspects of cellular functions. ...A focus will be on the roles of PIPKs in control of the phosphoinositide 3-kinase pathway and autophagy....
Phosphatidylinositol phosphate kinases (PIPKs) generate a lipid messenger phosphatidylinositol 4,5-bisphosphate (PI4,5P
PIK3CA-related overgrowth spectrum (PROS): diagnostic and testing eligibility criteria, differential diagnosis, and evaluation
Keppler-Noreuil KM, et al. Am J Med Genet A 2015. PMID 25557259 Free PMC article.
Somatic activating mutations in the phosphatidylinositol-3-kinase/AKT/mTOR pathway underlie heterogeneous segmental overgrowth phenotypes. ...
Somatic activating mutations in the phosphatidylinositol-3-kinase/AKT/mTOR pathway underlie heterogeneous segmental overgrowth …
The PTEN⁻PI3K Axis in Cancer
Papa A and Pandolfi PP. Biomolecules 2019 - Review. PMID 30999672 Free PMC article.
Fine-tuning of the phosphatidylinositol 3-kinase (PI3K) pathway signaling output is essential for the maintenance of tissue homeostasis and uncontrolled activation of this cascade leads to a number of human pathologies including cancer. ...
Fine-tuning of the phosphatidylinositol 3-kinase (PI3K) pathway signaling output is essential for the maintenance of tissue ho …
Synthetically Lethal Interactions of ATM, ATR, and DNA-PKcs
Kantidze OL, et al. Trends Cancer 2018 - Review. PMID 30352678
These kinases are appropriate for synthetic lethal therapies because their genes are frequently mutated in cancer, and specific inhibitors are currently in clinical trials. ...
These kinases are appropriate for synthetic lethal therapies because their genes are frequently mutated in cancer, and specific inhib …
The emerging mechanisms of isoform-specific PI3K signalling
Vanhaesebroeck B, et al. Nat Rev Mol Cell Biol 2010 - Review. PMID 20379207
Phosphoinositide 3-kinases (PI3Ks) function early in intracellular signal transduction pathways and affect many biological functions. ...
Phosphoinositide 3-kinases (PI3Ks) function early in intracellular signal transduction pathways and affect many biological fun …
Phosphatidylinositol-3,4,5-trisphosphate: tool of choice for class I PI 3-kinases.
Salamon RS and Backer JM. Bioessays 2013 - Review. PMID 23765576 Free PMC article.
Class I PI 3-kinases signal by producing the signaling lipid phosphatidylinositol(3,4,5) trisphosphate, which in turn acts by recruiting downstream effectors that contain specific lipid-binding domains. The class I PI 3-kinases comprise four distinct catalytic subunits linked to one of seven different regulatory subunits. All the class I PI 3-kinases produce the same signaling lipid, PIP3, and the different isoforms have overlapping expression patterns and are coupled to overlapping sets of upstream activators. ...
Class I PI 3-kinases signal by producing the signaling lipid phosphatidylinositol(3,4,5) trisphosphate, which in …
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