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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1997 106
1998 389
1999 535
2000 666
2001 846
2002 924
2003 1073
2004 1189
2005 1289
2006 1291
2007 1412
2008 1498
2009 1604
2010 1679
2011 1692
2012 1948
2013 2104
2014 2099
2015 2150
2016 2060
2017 2044
2018 2153
2019 1116
2020 15
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28,282 results
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Page 1
The PI3K Pathway in Human Disease
Fruman DA, et al. Cell 2017 - Review. PMID 28802037 Free PMC article.
Phosphoinositide 3-kinase (PI3K) activity is stimulated by diverse oncogenes and growth factor receptors, and elevated PI3K signaling is considered a hallmark of cancer. ...Here we provide a perspective on the roles of class I PI3Ks in the regulation of cellular metabolism and in immune system functions, two topics closely intertwined with cancer biology. ...
Phosphoinositide 3-kinase (PI3K) activity is stimulated by diverse oncogenes and growth factor receptors, and elevated PI3K signaling …
PI3K signaling in cancer: beyond AKT
Lien EC, et al. Curr Opin Cell Biol 2017 - Review. PMID 28343126 Free PMC article.
Although PI3K and its lipid product phosphatidylinositol-3,4,5-trisphosphate (PIP(3)) have been shown to activate multiple downstream signaling proteins, the vast majority of studies have focused on the protein kinase AKT as the dominant effector of PI3K signaling. ...Second, Rac signaling mediates the reorganization of the actin cytoskeleton to regulate cancer cell migration, invasion, and metabolism. ...
Although PI3K and its lipid product phosphatidylinositol-3,4,5-trisphosphate (PIP(3)) have been shown to activate multi …
The biology of cancer: metabolic reprogramming fuels cell growth and proliferation
DeBerardinis RJ, et al. Cell Metab 2008 - Review. PMID 18177721 Free article.
We also consider regulation of these fluxes by cellular mediators of signal transduction and gene expression, including the phosphatidylinositol 3-kinase (PI3K)/Akt/mTOR system, hypoxia-inducible factor 1 (HIF-1), and Myc, during physiologic cell proliferation and tumorigenesis....
We also consider regulation of these fluxes by cellular mediators of signal transduction and gene expression, including the phosphatidyli
Phosphoinositide 3-kinase pathways and autophagy require phosphatidylinositol phosphate kinases.
Choi S, et al. Adv Biol Regul 2018 - Review. PMID 29472147 Free PMC article.
Phosphatidylinositol phosphate kinases (PIPKs) generate a lipid messenger phosphatidylinositol 4,5-bisphosphate (PI4,5P(2)) that controls essentially all aspects of cellular functions. ...A focus will be on the roles of PIPKs in control of the phosphoinositide 3-kinase pathway and autophagy....
Phosphatidylinositol phosphate kinases (PIPKs) generate a lipid messenger phosphatidylinositol 4,5-bisphosphate (PI4,5P
PIK3CA-related overgrowth spectrum (PROS): diagnostic and testing eligibility criteria, differential diagnosis, and evaluation
Keppler-Noreuil KM, et al. Am J Med Genet A 2015. PMID 25557259 Free PMC article.
Somatic activating mutations in the phosphatidylinositol-3-kinase/AKT/mTOR pathway underlie heterogeneous segmental overgrowth phenotypes. ...
Somatic activating mutations in the phosphatidylinositol-3-kinase/AKT/mTOR pathway underlie heterogeneous segmental overgrowth …
Mechanisms of ATM Activation
Paull TT. Annu Rev Biochem 2015 - Review. PMID 25580527
I highlight functional similarities between the activation mechanisms of ATM, phosphatidylinositol 3-kinases (PI3Ks), and the other PI3K-like kinases, as well as recent structural insights into their regulation....
I highlight functional similarities between the activation mechanisms of ATM, phosphatidylinositol 3-kinases (PI3Ks), a …
Oncogenic Roles of the PI3K/AKT/mTOR Axis
Aoki M and Fujishita T. Curr Top Microbiol Immunol 2017 - Review. PMID 28550454
Genetic evidences also indicate their roles in malignancies induced by activation of the upstream oncoproteins including receptor tyrosine kinases and RAS and those induced by the loss of the negative regulators of the PI3K/AKT/mTOR pathway such as PTEN, TSC1/2, LKB1, and PIPP. ...
Genetic evidences also indicate their roles in malignancies induced by activation of the upstream oncoproteins including receptor tyrosine …
The Beclin 1 network regulates autophagy and apoptosis
Kang R, et al. Cell Death Differ 2011 - Review. PMID 21311563 Free PMC article.
It interacts with several cofactors (Atg14L, UVRAG, Bif-1, Rubicon, Ambra1, HMGB1, nPIST, VMP1, SLAM, IP(3)R, PINK and survivin) to regulate the lipid kinase Vps-34 protein and promote formation of Beclin 1-Vps34-Vps15 core complexes, thereby inducing autophagy. ...
It interacts with several cofactors (Atg14L, UVRAG, Bif-1, Rubicon, Ambra1, HMGB1, nPIST, VMP1, SLAM, IP(3)R, PINK and survivin) to r …
Isoform-specific activities of the regulatory subunits of phosphatidylinositol 3-kinases - potentially novel therapeutic targets.
Ito Y, et al. Expert Opin Ther Targets 2018 - Review. PMID 30205700 Free PMC article.
The main regulatory subunits of Class IA phosphatidylinositol 3-kinase (PI3K), p85α and p85β, initiate diverse cellular activities independent of binding to the catalytic subunit p110. ...
The main regulatory subunits of Class IA phosphatidylinositol 3-kinase (PI3K), p85α and p85β, initiate diverse cellular activi …
Emerging evidence of signalling roles for PI(3,4)P2 in Class I and II PI3K-regulated pathways.
Hawkins PT and Stephens LR. Biochem Soc Trans 2016 - Review. PMID 26862220
There are eight members of the phosphoinositide family of phospholipids in eukaryotes; PI, PI3P, PI4P, PI5P, PI(4,5)P2, PI(3,4)P2, PI(3,5)P2 and PI(3,4,5)P3. ...PI(3,4,5)P3 can be dephosphorylated by both 3- and 5-phosphatases, producing PI(4,5)P2 and PI(3,4)P2, respectively. There is now strong evidence that PI(3,4)P2 generated by this route does not merely represent another pathway for removal of PI(3,4,5)P3, but can act as a signalling molecule in its own right, regulating macropinocytosis, fast endophilin-mediated endocytosis (FEME), membrane ruffling, lamellipodia and invadopodia. ...
There are eight members of the phosphoinositide family of phospholipids in eukaryotes; PI, PI3P, PI4P, PI5P, PI(4,5)P2, PI(3,4)P2, PI …
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