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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1947 1
1949 1
1953 1
1955 2
1957 1
1958 2
1959 3
1960 1
1961 2
1962 4
1963 2
1964 3
1965 1
1966 1
1972 2
1973 8
1974 71
1975 129
1976 71
1977 68
1978 69
1979 87
1980 81
1981 95
1982 105
1983 101
1984 125
1985 121
1986 150
1987 142
1988 125
1989 151
1990 179
1991 152
1992 175
1993 167
1994 154
1995 148
1996 150
1997 155
1998 202
1999 180
2000 235
2001 212
2002 218
2003 197
2004 239
2005 246
2006 245
2007 262
2008 264
2009 262
2010 254
2011 269
2012 290
2013 305
2014 241
2015 291
2016 287
2017 258
2018 225
2019 100
2020 3
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7,746 results
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Page 1
Phosphatidylserine: A cancer cell targeting biomarker.
Sharma B and Kanwar SS. Semin Cancer Biol 2018 - Review. PMID 28870843
Phosphatidylserine (PS) is an essential component in all human cells which is present on the inner leaflet of the cell membrane. ...
Phosphatidylserine (PS) is an essential component in all human cells which is present on the inner leaflet of the cell membrane. ...
Necroptotic cell death in anti-cancer therapy
Krysko O, et al. Immunol Rev 2017 - Review. PMID 29027225
Next, we discuss the molecular mechanisms of phosphatidylserine exposure during necroptosis and its role in the recognition of necroptotic cells. ...
Next, we discuss the molecular mechanisms of phosphatidylserine exposure during necroptosis and its role in the recognition of necrop …
Phosphatidylserine Is the Signal for TAM Receptors and Their Ligands.
Lemke G. Trends Biochem Sci 2017 - Review. PMID 28734578 Free PMC article.
A series of recent studies now consolidates the view that phosphatidylserine (PtdSer), a common phospholipid constituent of membrane bilayers, is similarly repurposed for use as a signal between cells and that the ligands and receptors of the Tyro3/Axl/Mer (TAM) family of receptor tyrosine kinases (RTKs) are prominent transducers of this signal....
A series of recent studies now consolidates the view that phosphatidylserine (PtdSer), a common phospholipid constituent of membrane …
Dietary supplements for cognitive impairment
Olivera-Pueyo J and Pelegrín-Valero C. Actas Esp Psiquiatr 2017. PMID 29171642 Free article.
Cerebral aging is associated with changes in the lipid composition of neuronal membranes, so it has been suggested that treatment with phospholipids like phosphatidylcholine and phosphatidylserine could favor cognitive improvement. ...
Cerebral aging is associated with changes in the lipid composition of neuronal membranes, so it has been suggested that treatment with phosp …
Resolvins suppress tumor growth and enhance cancer therapy
Sulciner ML, et al. J Exp Med 2018. PMID 29191914 Free PMC article.
In this study, we show that tumor cells killed by chemotherapy or targeted therapy ("tumor cell debris") stimulate primary tumor growth when coinjected with a subthreshold (nontumorigenic) inoculum of tumor cells by triggering macrophage proinflammatory cytokine release after phosphatidylserine exposure. ...
In this study, we show that tumor cells killed by chemotherapy or targeted therapy ("tumor cell debris") stimulate primary tumor growth when …
ESCRT-III Acts Downstream of MLKL to Regulate Necroptotic Cell Death and Its Consequences
Gong YN, et al. Cell 2017. PMID 28388412 Free PMC article.
Here, we show that, during necroptosis, MLKL-dependent calcium (Ca(2+)) influx and phosphatidylserine (PS) exposure on the outer leaflet of the plasma membrane preceded loss of PM integrity. ...
Here, we show that, during necroptosis, MLKL-dependent calcium (Ca(2+)) influx and phosphatidylserine (PS) exposure on the outer leaf …
Herpes simplex viruses activate phospholipid scramblase to redistribute phosphatidylserines and Akt to the outer leaflet of the plasma membrane and promote viral entry.
Cheshenko N, et al. PLoS Pathog 2018. PMID 29293671 Free PMC article.
We hypothesized that phospholipid scramblase-1 (PLSCR1), a calcium responsive enzyme that flips phosphatidylserines between membrane leaflets, might redistribute Akt to the outside during entry. Confocal imaging, biotinylation of membrane proteins and flow cytometric analysis demonstrated that HSV activates PLSCR1 and flips phosphatidylserines and Akt to the outside shortly following HSV-1 or HSV-2 exposure. ...
We hypothesized that phospholipid scramblase-1 (PLSCR1), a calcium responsive enzyme that flips phosphatidylserines between membrane …
Structure and autoregulation of a P4-ATPase lipid flippase
Timcenko M, et al. Nature 2019. PMID 31243363
Here we describe the cryo-electron microscopy structure of the P4-ATPase Drs2p-Cdc50p, a Saccharomyces cerevisiae lipid flippase that is specific to phosphatidylserine and phosphatidylethanolamine. Drs2p-Cdc50p is autoinhibited by the C-terminal tail of Drs2p, and activated by the lipid phosphatidylinositol-4-phosphate (PtdIns4P or PI4P). ...
Here we describe the cryo-electron microscopy structure of the P4-ATPase Drs2p-Cdc50p, a Saccharomyces cerevisiae lipid flippase that is spe …
The role of PS 18:0/18:1 in membrane function
Skotland T and Sandvig K. Nat Commun 2019 - Review. PMID 31227693 Free PMC article.
While the molecular mechanism underlying interleaflet coupling remains to be fully understood, recent results suggest interactions between the very-long-chain sphingolipids in the outer leaflet, and phosphatidylserine PS18:0/18:1 in the inner leaflet, and an important role for cholesterol for these interactions. Here we review the evidence that cross-linking of sphingolipids may result in clustering of phosphatidylserine and transfer of signals to the cytosol. ...
While the molecular mechanism underlying interleaflet coupling remains to be fully understood, recent results suggest interactions between t …
7,746 results
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