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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1997 35
1998 174
1999 204
2000 278
2001 368
2002 352
2003 383
2004 402
2005 427
2006 478
2007 499
2008 503
2009 531
2010 573
2011 581
2012 690
2013 696
2014 667
2015 586
2016 494
2017 447
2018 384
2019 285
2020 233
2021 233
2022 161
2023 96
2024 34

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9,596 results

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Page 1
PI3K inhibitors are finally coming of age.
Vanhaesebroeck B, Perry MWD, Brown JR, André F, Okkenhaug K. Vanhaesebroeck B, et al. Nat Rev Drug Discov. 2021 Oct;20(10):741-769. doi: 10.1038/s41573-021-00209-1. Epub 2021 Jun 14. Nat Rev Drug Discov. 2021. PMID: 34127844 Free PMC article. Review.
Targeting PI3K/Akt signal transduction for cancer therapy.
He Y, Sun MM, Zhang GG, Yang J, Chen KS, Xu WW, Li B. He Y, et al. Signal Transduct Target Ther. 2021 Dec 16;6(1):425. doi: 10.1038/s41392-021-00828-5. Signal Transduct Target Ther. 2021. PMID: 34916492 Free PMC article. Review.
Discovery of GDC-0077 (Inavolisib), a Highly Selective Inhibitor and Degrader of Mutant PI3Kα.
Hanan EJ, Braun MG, Heald RA, MacLeod C, Chan C, Clausen S, Edgar KA, Eigenbrot C, Elliott R, Endres N, Friedman LS, Gogol E, Gu XH, Thibodeau RH, Jackson PS, Kiefer JR, Knight JD, Nannini M, Narukulla R, Pace A, Pang J, Purkey HE, Salphati L, Sampath D, Schmidt S, Sideris S, Song K, Sujatha-Bhaskar S, Ultsch M, Wallweber H, Xin J, Yeap S, Young A, Zhong Y, Staben ST. Hanan EJ, et al. J Med Chem. 2022 Dec 22;65(24):16589-16621. doi: 10.1021/acs.jmedchem.2c01422. Epub 2022 Dec 1. J Med Chem. 2022. PMID: 36455032
9,596 results