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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1980 1
1983 1
1985 1
1989 4
1990 9
1991 18
1992 18
1993 40
1994 81
1995 83
1996 85
1997 59
1998 41
1999 46
2000 51
2001 50
2002 44
2003 51
2004 46
2005 62
2006 55
2007 75
2008 79
2009 92
2010 99
2011 102
2012 76
2013 90
2014 77
2015 76
2016 60
2017 52
2018 51
2019 23
2020 0
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1,684 results
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Page 1
The Use of Titanium Dioxide for Selective Enrichment of Phosphorylated Peptides
Thingholm TE and Larsen MR. Methods Mol Biol 2016. PMID 26584923
Titanium dioxide (TiO2) has very high affinity for phosphopeptides and in recent years it has become one of the most popular methods for phosphopeptide enrichment from complex biological samples. ...Here we describe a batch mode protocol for phosphopeptide enrichment using TiO2 chromatographic material followed by desalting and concentration of the sample by reversed phase micro-columns prior to downstream MS and LC-MS/MS analysis....
Titanium dioxide (TiO2) has very high affinity for phosphopeptides and in recent years it has become one of the most popular methods …
Development of Protacs to target cancer-promoting proteins for ubiquitination and degradation
Sakamoto KM, et al. Mol Cell Proteomics 2003. PMID 14525958 Free article.
This Protac consisted of an SCF(beta-TRCP)-binding phosphopeptide derived from IkappaBalpha linked to ovalicin, which covalently binds MetAP-2. ...
This Protac consisted of an SCF(beta-TRCP)-binding phosphopeptide derived from IkappaBalpha linked to ovalicin, which covalently bind …
Metal-organic frameworks in proteomics/peptidomics-A review
Peng J and Wu R. Anal Chim Acta 2018 - Review. PMID 29866274
Based on some specific interactions, MOFs could be employed as solid adsorbents to capture peptides (such as endogenous peptides, glycopeptides, and phosphopeptides) and to selectively detect peptides, and also could be applied as matrix for peptide ionization in mass spectrometry. ...
Based on some specific interactions, MOFs could be employed as solid adsorbents to capture peptides (such as endogenous peptides, glycopepti …
FHA domains: Phosphopeptide binding and beyond.
Almawi AW, et al. Prog Biophys Mol Biol 2017 - Review. PMID 27939759
Forkhead-associated (FHA) domains are small phosphopeptide recognition modules found in eubacterial and eukaryotic, but not archeal, genomes. ...
Forkhead-associated (FHA) domains are small phosphopeptide recognition modules found in eubacterial and eukaryotic, but not archeal, …
Perovskite for the highly selective enrichment of phosphopeptides.
Li XS, et al. J Chromatogr A 2015. PMID 25542702
Selective and effective enrichment of phosphopeptides from complex samples is essential in phosphoproteome study by mass spectrometry (MS). ...It was found here that perovskites exhibited higher selectivity towards phosphopeptides than commonly used ZrO2 and TiO2, even though they all have high affinity to phosphopeptides. ...
Selective and effective enrichment of phosphopeptides from complex samples is essential in phosphoproteome study by mass spectrometry …
Developing Workflow for Simultaneous Analyses of Phosphopeptides and Glycopeptides.
Cho KC, et al. ACS Chem Biol 2019. PMID 30525447 Free PMC article.
We have recently observed and reported a large number of IGPs from phosphoproteomic analysis using IMAC-based phosphopeptides enrichment procedure. To determine whether phosphorylated peptides could be specifically isolated from coenriched IGPs in IMAC experiments with different pH, IMAC procedures were performed at different pH conditions, and we found that the enrichment of phosphopeptides at pH 2.0 was the optimal condition for having the highest number of phosphopeptide identifications; however, coenrichment of phosphopeptides and glycopeptides was inevitable in the entire pH range. ...
We have recently observed and reported a large number of IGPs from phosphoproteomic analysis using IMAC-based phosphopeptides enrichm …
Why phosphoproteomics is still a challenge
Solari FA, et al. Mol Biosyst 2015. PMID 25800119
Despite continuous improvements phosphoproteomics still faces challenges that are often neglected, e.g. partially poor recovery of phosphopeptide enrichment, assessment of phosphorylation stoichiometry, label-free quantification, poor behavior during chromatography, and general limitations of peptide-centric proteomics. ...
Despite continuous improvements phosphoproteomics still faces challenges that are often neglected, e.g. partially poor recovery of phosph
Preparation of TiO(2)/Bi/Fe/Zr nanocomposite for the highly selective enrichment of phosphopeptides.
Zhu B, et al. Talanta 2019. PMID 30609618
It is necessary to effectively absorb trace phosphopeptides/proteins from complex phosphopeptide-containing samples for mass spectrometry (MS)-based phosphoproteomics. ...The results demonstrated that, compared with commercial titanium dioxide for phosphopeptides enrichment, this proposed TiO(2)/Bi/Fe/Zr nanocomposite has a lower detection limit (4 × 10(-10) M) and higher selectivity at a low weight ratio of phosphopeptides/nonphosphopeptides (1:1000). ...
It is necessary to effectively absorb trace phosphopeptides/proteins from complex phosphopeptide-containing samples for mass s …
Facile synthesis of Fe3O4@PDA core-shell microspheres functionalized with various metal ions: A systematic comparison of commonly-used metal ions for IMAC enrichment
Jiang J, et al. Talanta 2018. PMID 29136869
Metal ions differed greatly in affinity towards phosphopeptides, and thus it is essential to systematically compare the phosphopeptides enrichment ability of different metal ions usually used in the IMAC techniques. ...After characterization, the resultant Fe(3)O(4)@PDA-M(n+) microspheres were applied to phosphopeptides enrichment based on the binding affinity between metal ions and phosphopeptides. ...
Metal ions differed greatly in affinity towards phosphopeptides, and thus it is essential to systematically compare the phosphopep
Core-shell structured magnetic metal-organic framework composites for highly selective enrichment of endogenous N-linked glycopeptides and phosphopeptides.
Wu Y, et al. Talanta 2018. PMID 30172513
The as-prepared material exhibited outstanding sensitivity (0.1 fmol/μL), good selectivity (1:20 and 1:50 respectively), excellent ability of size-exclusion (1: 500), fine reusability (six cycles) and great stability (two months) in enriching N-linked glycopeptides and phosphopeptides from tryptic digests of standard proteins by combining HILIC and IMAC. Moreover, it was applied into the enrichment of endogenous N-linked glycopeptides and phosphopeptides in human saliva and achieved great results (43 phosphopeptides and 39 N-linked glycopeptides), revealing its promising potential in enrichment of low-abundance endogenous N-linked glycopeptides and phosphopeptides in practical samples....
The as-prepared material exhibited outstanding sensitivity (0.1 fmol/μL), good selectivity (1:20 and 1:50 respectively), excellent ability o …
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