Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

MyNCBI Filters
Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1964 1
1980 3
1981 22
1982 34
1983 37
1984 28
1985 44
1986 49
1987 50
1988 59
1989 98
1990 114
1991 191
1992 232
1993 315
1994 394
1995 470
1996 453
1997 384
1998 324
1999 324
2000 302
2001 293
2002 236
2003 194
2004 177
2005 214
2006 193
2007 213
2008 183
2009 147
2010 108
2011 108
2012 100
2013 111
2014 62
2015 80
2016 76
2017 80
2018 49
2019 25
2020 0
Text availability
Article attribute
Article type
Publication date

Search Results

6,331 results
Results by year
Filters applied: . Clear all
Page 1
Phosphotyrosine-Mediated Regulation of Enterohemorrhagic Escherichia coli Virulence.
Robertson CD, et al. mBio 2018. PMID 29487233 Free PMC article.
Our recent phosphotyrosine profiling study of E. coli identified 342 phosphorylated proteins, indicating that phosphotyrosine modifications in bacteria are more prevalent than previously anticipated. ...We demonstrate that EHEC utilizes a previously uncharacterized phosphotyrosine signaling pathway through Cra to fine-tune the expression of virulence-associated genes to effectively control T3SS production. ...
Our recent phosphotyrosine profiling study of E. coli identified 342 phosphorylated proteins, indicating that phosphotyrosine
Protein Clusters in Phosphotyrosine Signal Transduction.
Mayer BJ and Yu J. J Mol Biol 2018 - Review. PMID 29870724 Free PMC article.
It has long been observed that the cooperative association of the receptors and effectors produces higher-order protein assemblies (clusters) following signal activation in virtually all phosphotyrosine signal transduction systems. ...
It has long been observed that the cooperative association of the receptors and effectors produces higher-order protein assemblies (clusters …
Ultra-deep tyrosine phosphoproteomics enabled by a phosphotyrosine superbinder.
Bian Y, et al. Nat Chem Biol 2016. PMID 27642862
We identified ∼20,000 distinct phosphotyrosyl peptides and >10,000 pTyr sites, of which 36% were 'novel', from nine human cell lines using the superbinder approach. Tyrosine kinases, SH2 domains and phosphotyrosine phosphatases were preferably phosphorylated, suggesting that the toolkit of kinase signaling is subject to intensive regulation by phosphorylation. ...
We identified ∼20,000 distinct phosphotyrosyl peptides and >10,000 pTyr sites, of which 36% were 'novel', from nine human cell lin …
Reverse Binding Mode of Phosphotyrosine Peptides with SH2 Protein.
Wang R, et al. Biochemistry 2018. PMID 30091902
Here we apply site-specific cysteine-α-chloroacetyl cross-linking to scrutinize the binding between the Src homology 2 (SH2) domain and phosphotyrosine (pY) peptides, a highly dynamic interaction that is a key to cellular signal transduction. ...
Here we apply site-specific cysteine-α-chloroacetyl cross-linking to scrutinize the binding between the Src homology 2 (SH2) domain and p
Cell regulation by phosphotyrosine-targeted ubiquitin ligases.
Cooper JA, et al. Mol Cell Biol 2015 - Review. PMID 25776560 Free PMC article.
Three classes of E3 ubiquitin ligases, members of the Cbl, Hakai, and SOCS-Cul5-RING ligase families, stimulate the ubiquitination of phosphotyrosine-containing proteins, including receptor and nonreceptor tyrosine kinases and their phosphorylated substrates. ...Here we review relevant literature and then focus on more-recent developments in understanding the structures, substrates, and pathways through which the phosphotyrosine-specific ubiquitin ligases regulate diverse aspects of cell biology....
Three classes of E3 ubiquitin ligases, members of the Cbl, Hakai, and SOCS-Cul5-RING ligase families, stimulate the ubiquitination of pho
Site-specific incorporation of phosphotyrosine using an expanded genetic code.
Hoppmann C, et al. Nat Chem Biol 2017. PMID 28604697 Free PMC article.
Here we report an efficient method to generate pure, active phosphotyrosine-containing proteins by genetically encoding a stable phosphotyrosine analog that is convertible to native phosphotyrosine. We demonstrate its general compatibility with proteins of various sizes, phosphotyrosine sites and functions, and reveal a possible role of tyrosine phosphorylation in negative regulation of ubiquitination....
Here we report an efficient method to generate pure, active phosphotyrosine-containing proteins by genetically encoding a stable p
Distinguishing Sulfotyrosine Containing Peptides from their Phosphotyrosine Counterparts Using Mass Spectrometry.
Chen G, et al. J Am Soc Mass Spectrom 2018. PMID 29313205
In contrast, phosphotyrosine is stable during fragmentation using all these methods. This differential stability provides a mechanism to distinguish sulfopeptides from phosphopeptides. Based on the rigorous characterization presented herein, this work serves as a model for accurate identification of phosphotyrosine and, more challenging, sulfotyrosine, in complex proteomic samples. ...
In contrast, phosphotyrosine is stable during fragmentation using all these methods. This differential stability provides a mechanism …
Phosphotyrosine signalling and the origin of animal multicellularity.
Tong K, et al. Proc Biol Sci 2017. PMID 28768887 Free PMC article.
Historically, given its indispensable functions in intercellular communication and exclusive presence in metazoans, phosphotyrosine (pTyr) signalling was considered a metazoan-specific evolutionary innovation that might have contributed to the origin of metazoan multicellularity. ...
Historically, given its indispensable functions in intercellular communication and exclusive presence in metazoans, phosphotyrosine ( …
Genetically encoding phosphotyrosine and its nonhydrolyzable analog in bacteria.
Luo X, et al. Nat Chem Biol 2017. PMID 28604693 Free PMC article.
Using a propeptide strategy to increase cellular uptake of O-phosphotyrosine (pTyr) and its nonhydrolyzable analog 4-phosphomethyl-L-phenylalanine (Pmp), we identified an orthogonal aminoacyl-tRNA synthetase-tRNA pair that allows site-specific incorporation of both pTyr and Pmp into recombinant proteins in response to the amber stop codon in Escherichia coli in good yields. ...
Using a propeptide strategy to increase cellular uptake of O-phosphotyrosine (pTyr) and its nonhydrolyzable analog 4-phosphomethyl-L- …
iPhosY-PseAAC: identify phosphotyrosine sites by incorporating sequence statistical moments into PseAAC.
Khan YD, et al. Mol Biol Rep 2018. PMID 30311130
Here, we present a more accurate and efficient sequence-based computational method for prediction of phosphotyrosine (PhosY) sites by incorporation of statistical moments into PseAAC. ...
Here, we present a more accurate and efficient sequence-based computational method for prediction of phosphotyrosine (PhosY) sites by …
6,331 results
Jump to page
Feedback