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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1964 1
1980 3
1981 22
1982 34
1983 37
1984 28
1985 44
1986 49
1987 50
1988 59
1989 98
1990 114
1991 191
1992 232
1993 315
1994 394
1995 470
1996 453
1997 384
1998 324
1999 324
2000 302
2001 293
2002 236
2003 194
2004 177
2005 214
2006 193
2007 213
2008 183
2009 147
2010 108
2011 108
2012 100
2013 111
2014 62
2015 80
2016 76
2017 80
2018 49
2019 25
2020 1
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6,332 results
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Page 1
A phosphotyrosine switch regulates organic cation transporters.
Sprowl JA, et al. Nat Commun 2016. PMID 26979622 Free PMC article.
Here we report a unique phosphorylation-dependent interaction between drug transporters and tyrosine kinase inhibitors (TKIs), which has uncovered widespread phosphotyrosine-mediated regulation of drug transporters. ...
Here we report a unique phosphorylation-dependent interaction between drug transporters and tyrosine kinase inhibitors (TKIs), which has unc …
Precise RNA editing by recruiting endogenous ADARs with antisense oligonucleotides
Merkle T, et al. Nat Biotechnol 2019. PMID 30692694
We successfully applied RESTORE to a panel of standard human cell lines and human primary cells and demonstrated repair of the clinically relevant PiZZ mutation, which causes α1-antitrypsin deficiency, and editing of phosphotyrosine 701 in STAT1, the activity switch of the signaling factor. ...
We successfully applied RESTORE to a panel of standard human cell lines and human primary cells and demonstrated repair of the clinically re …
Phosphotyrosine-Mediated Regulation of Enterohemorrhagic Escherichia coli Virulence.
Robertson CD, et al. mBio 2018. PMID 29487233 Free PMC article.
Our recent phosphotyrosine profiling study of E. coli identified 342 phosphorylated proteins, indicating that phosphotyrosine modifications in bacteria are more prevalent than previously anticipated. ...We demonstrate that EHEC utilizes a previously uncharacterized phosphotyrosine signaling pathway through Cra to fine-tune the expression of virulence-associated genes to effectively control T3SS production. ...
Our recent phosphotyrosine profiling study of E. coli identified 342 phosphorylated proteins, indicating that phosphotyrosine
Protein Clusters in Phosphotyrosine Signal Transduction.
Mayer BJ and Yu J. J Mol Biol 2018 - Review. PMID 29870724 Free PMC article.
It has long been observed that the cooperative association of the receptors and effectors produces higher-order protein assemblies (clusters) following signal activation in virtually all phosphotyrosine signal transduction systems. ...
It has long been observed that the cooperative association of the receptors and effectors produces higher-order protein assemblies (clusters …
Ultra-deep tyrosine phosphoproteomics enabled by a phosphotyrosine superbinder.
Bian Y, et al. Nat Chem Biol 2016. PMID 27642862
We identified ∼20,000 distinct phosphotyrosyl peptides and >10,000 pTyr sites, of which 36% were 'novel', from nine human cell lines using the superbinder approach. Tyrosine kinases, SH2 domains and phosphotyrosine phosphatases were preferably phosphorylated, suggesting that the toolkit of kinase signaling is subject to intensive regulation by phosphorylation. ...
We identified ∼20,000 distinct phosphotyrosyl peptides and >10,000 pTyr sites, of which 36% were 'novel', from nine human cell lin …
Large-Scale Phosphoproteomics Reveals Shp-2 Phosphatase-Dependent Regulators of Pdgf Receptor Signaling
Batth TS, et al. Cell Rep 2018. PMID 29514104 Free article.
Despite its low cellular abundance, phosphotyrosine (pTyr) regulates numerous cell signaling pathways in health and disease. We applied comprehensive phosphoproteomics to unravel differential regulators of receptor tyrosine kinase (RTK)-initiated signaling networks upon activation by Pdgf-ββ, Fgf-2, or Igf-1 and identified more than 40,000 phosphorylation sites, including many phosphotyrosine sites without additional enrichment. ...
Despite its low cellular abundance, phosphotyrosine (pTyr) regulates numerous cell signaling pathways in health and disease. We appli …
A molecular assembly phase transition and kinetic proofreading modulate Ras activation by SOS
Huang WYC, et al. Science 2019. PMID 30846600 Free PMC article.
We further demonstrate that this kinetic proofreading is modulated by the LAT (linker for activation of T cells)-Grb2-SOS phosphotyrosine-driven phase transition at the membrane....
We further demonstrate that this kinetic proofreading is modulated by the LAT (linker for activation of T cells)-Grb2-SOS phosphotyrosine
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