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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1976 1
1979 1
1982 2
1985 2
1987 1
1988 1
1989 2
1990 1
1991 3
1992 4
1993 2
1994 9
1995 5
1996 6
1997 5
1998 20
1999 18
2000 16
2001 18
2002 20
2003 12
2004 9
2005 16
2006 22
2007 19
2008 17
2009 18
2010 20
2011 13
2012 16
2013 13
2014 11
2015 9
2016 14
2017 14
2018 10
2019 1
2020 0
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340 results
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Page 1
The Endocannabinoid System and Anxiety.
Lisboa SF, et al. Vitam Horm 2017 - Review. PMID 28061971
Since the discovery and characterization of the endogenous cannabinoid system, several studies have evaluated how cannabinoid compounds and, particularly, how the modulation of the endocannabinoid (eCB) system influences a wide range of functions, from metabolic to mental disorders. ...Finally, data from animal models addressing the mechanisms through which the eCB system modulates anxiety-related behavior dependent on stressful situations, such as the involvement of different receptors, distinct eCBs, modulation of neurotransmitters release, HPA axis and immune system activation, and plastic mechanisms, will also be discussed....
Since the discovery and characterization of the endogenous cannabinoid system, several studies have evaluated how cannabinoid compoun …
How stress contributes to autoimmunity-lessons from Sjögren's syndrome
Skopouli FN and Katsiougiannis S. FEBS Lett 2018 - Review. PMID 29223133 Free article.
In this article, we discuss the effects of stress, not on the immune system but on specific cell populations against which the autoimmune reactivity is directed. ...
In this article, we discuss the effects of stress, not on the immune system but on specific cell populations against which the autoim …
Spinal cord injury-induced immunodeficiency is mediated by a sympathetic-neuroendocrine adrenal reflex.
Prüss H, et al. Nat Neurosci 2017. PMID 28920935
Acute spinal cord injury (SCI) causes systemic immunosuppression and life-threatening infections, thought to result from noradrenergic overactivation and excess glucocorticoid release via hypothalamus-pituitary-adrenal axis stimulation. Instead of consecutive hypothalamus-pituitary-adrenal axis activation, we report that acute SCI in mice induced suppression of serum norepinephrine and concomitant increase in cortisol, despite suppressed adrenocorticotropic hormone, indicating primary (adrenal) hypercortisolism. ...
Acute spinal cord injury (SCI) causes systemic immunosuppression and life-threatening infections, thought to result from noradrenergic overa …
Stress, depression, the immune system, and cancer.
Reiche EM, et al. Lancet Oncol 2004 - Review. PMID 15465465
The persistent activation of the hypothalamic-pituitary-adrenal (HPA) axis in the chronic stress response and in depression probably impairs the immune response and contributes to the development and progression of some types of cancer. ...
The persistent activation of the hypothalamic-pituitary-adrenal (HPA) axis in the chronic stress response and in depression pr …
Gut-brain actions underlying comorbid anxiety and depression associated with inflammatory bowel disease
Abautret-Daly Á, et al. Acta Neuropsychiatr 2018 - Review. PMID 28270247
Evidence is provided for a number of interacting factors including activation of the inflammatory response system in the brain, the hypothalamic-pituitary-adrenal axis, and brain areas implicated in altered behaviours, changes in blood brain barrier integrity, and an emerging role for gut microbiota and response to probiotics in IBD.DiscussionThe impact of psychological stress in models of IBD remains somewhat conflicted, however, it is weighted in favour of stress or early stressful life events as risk factors in the development of IBD, stress-induced exacerbation of inflammation and relapse. ...
Evidence is provided for a number of interacting factors including activation of the inflammatory response system in the brain, the h …
A new theory of depression based on the serotonin/kynurenine relationship and the hypothalamicpituitary- adrenal axis.
Ramírez LA, et al. Biomedica 2018 - Review. PMID 30335249 Free article.
Quinolinic acid activates NMDA receptors in the central nervous system and stimulates the secretion of interleukins IL-6 and 1L-1β, among others, promoting hyper-activity of the HPA axis and reinforcing a bias of the tryptophan metabolism to produce quinolinic acid, and interleukins by the innate immune system, further reducing the synthesis of serotonin and consolidating the depressive process. We discuss the evidence showing that this process can be initiated by either interleukin stimulated by an infection or some vaccines or excessive psychological stress that activates the HPA axis together with said innate immune response, causing a process of aseptic inflammation in the central nervous system....
Quinolinic acid activates NMDA receptors in the central nervous system and stimulates the secretion of interleukins IL-6 and 1L-1β, a …
Immune and Neuroendocrine Mechanisms of Stress Vulnerability and Resilience
Ménard C, et al. Neuropsychopharmacology 2017 - Review. PMID 27291462 Free PMC article.
Together, these clinical findings suggest a role for the immune system in vulnerability to stress-related psychiatric illness. ...We specifically focus on the roles of pro-inflammatory cytokine signaling, peripheral monocyte infiltration, microglial activation, and hypothalamic-pituitary-adrenal axis hyperactivity in stress vulnerability. ...
Together, these clinical findings suggest a role for the immune system in vulnerability to stress-related psychiatric illness. ...We …
Developmental programming of aging trajectory
Vaiserman A, et al. Ageing Res Rev 2018 - Review. PMID 30059788
Main mechanisms linking developmental conditions to later-life health outcomes include persistent changes in epigenetic regulation, (re)programming of major endocrine axes such as growth hormone/insulin-like growth factor axis and hypothalamic-pituitary-adrenal axis and also early-life immune maturation. ...
Main mechanisms linking developmental conditions to later-life health outcomes include persistent changes in epigenetic regulation, (re)prog …
Inflammation, depression and cardiovascular disease in women: the role of the immune system across critical reproductive events.
Mattina GF, et al. Ther Adv Cardiovasc Dis 2019 - Review. PMID 31144599 Free PMC article.
Immune-system activity has been implicated in the etiology of both depression and CVD, but it is unclear how inflammation contributes to sex differences in this comorbidity. ...Recent research provides evidence of pro-inflammatory states and sex differences associated with alterations in the hypothalamic-pituitary-adrenal axis, the renin-angiotensin-aldosterone system and the serotonin/kynurenine pathway, that likely contribute to the development of depression and CVD. ...
Immune-system activity has been implicated in the etiology of both depression and CVD, but it is unclear how inflammation contributes …
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