p53 expression in pleomorphic adenoma of salivary glands: A systematic review and meta-analysis

Nader Ahmed Alaizari; Bassel Tarakji; Sadeq Ali Al-Maweri; Hashem Motahir Al-Shamiri; Shourouk Darwish; Feras Baba

doi:10.1016/j.archoralbio.2015.06.019

p53 expression in pleomorphic adenoma of salivary glands: A systematic review and meta-analysis

Arch Oral Biol. 2015 Sep;60(9):1437-41. doi: 10.1016/j.archoralbio.2015.06.019. Epub 2015 Jun 23.

Authors

Nader Ahmed Alaizari¹, Bassel Tarakji², Sadeq Ali Al-Maweri³, Hashem Motahir Al-Shamiri², Shourouk Darwish², Feras Baba⁴

Affiliations

¹ Department of Oral Maxillofacial Sciences, Al-Farabi College of Dentistry and Nursing, Riyadh, Saudi Arabia; Department of Oral Medicine and Pathology, Faculty of Dentistry, Sana'a University, Yemen. Electronic address: dr2007nader@yahoo.com.
² Department of Oral Maxillofacial Sciences, Al-Farabi College of Dentistry and Nursing, Riyadh, Saudi Arabia.
³ Department of Oral Maxillofacial Sciences, Al-Farabi College of Dentistry and Nursing, Riyadh, Saudi Arabia; Department of Oral Medicine and Pathology, Faculty of Dentistry, Sana'a University, Yemen.
⁴ Aleppo University, Faculty of Dentistry, Syria.

PMID: 26163983
DOI: 10.1016/j.archoralbio.2015.06.019

Abstract

Objective: There are conflicting data regarding immunohistochemical expression of p53 in pleomorphic adenoma. This systematic review and meta-analysis aimed to examine whether p53 expression has a role in the pathogenesis of pleomorphic adenoma.

Design: A comprehensive literature search for relevant studies published from 2000 up to end of 2014 was performed using PubMed, EMBASE and the Cochrane Library Databases. Only articles in which p53 detected by immunohistochemical staining were included. The meta-analysis was done using Comprehensive Meta-Analysis software.

Results: Eighteen eligible studies were included in this meta-analysis. Heterogeneity measures showed a statistically significant Cochrane Q value (P-value<0.001). The random effects model showed an effect size of 0.254 with a 95% CI (0.139-0.417). The overall p53 positivity is 25.4%.

Conclusion: Mutant p53 has to be detected by more precise techniques to emphasize on its role in development of pleomorphic adenoma of salivary gland.

Keywords: Immunohistochemical; Meta-analysis; Pleomorphic adenoma; Systemic review; p53.

Publication types

Meta-Analysis
Research Support, Non-U.S. Gov't
Review
Systematic Review

MeSH terms

Adenoma, Pleomorphic / metabolism*
Biomarkers, Tumor / metabolism
Humans
Immunohistochemistry
Salivary Gland Neoplasms / metabolism*
Tumor Suppressor Protein p53 / metabolism*

Substances

Biomarkers, Tumor
Tumor Suppressor Protein p53