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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1979 3
1980 8
1981 7
1982 4
1983 5
1984 13
1985 6
1986 8
1987 6
1988 7
1989 7
1990 15
1991 13
1992 8
1993 15
1994 18
1995 16
1996 15
1997 12
1998 21
1999 16
2000 13
2001 23
2002 28
2003 44
2004 77
2005 125
2006 338
2007 586
2008 649
2009 755
2010 1005
2011 1035
2012 1075
2013 1198
2014 1112
2015 1166
2016 1071
2017 1214
2018 1104
2019 361
2020 5
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11,897 results
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Page 1
Epigenetic foundations of pluripotent stem cells that recapitulate in vivo pluripotency.
Yagi M, et al. Lab Invest 2017 - Review. PMID 28869587 Free article.
Pluripotent stem cells, such as embryonic stem cells and induced pluripotent stem cells, have been derived and maintained in vitro under culture conditions that include stimulators and inhibitors of extrinsic signaling. Recent advances in stem cell cultivation have opened the possibility of capturing naive pluripotency, which is reminiscent of the pluripotency of inner cell mass cells, in vitro. ...
Pluripotent stem cells, such as embryonic stem cells and induced pluripotent stem cells, have been derived and maintained in v
Pluripotent Stem Cells from Domesticated Mammals.
Ezashi T, et al. Annu Rev Anim Biosci 2016 - Review. PMID 26566158
Whereas the derivation of fully pluripotent ESC from these species has proved slow, reprogramming of somatic cells to iPSC has been more straightforward. ...Based on work in humans and rodents, achievement of full pluripotency will likely require fine adjustments in the growth factors and signaling inhibitors provided to the cells. ...
Whereas the derivation of fully pluripotent ESC from these species has proved slow, reprogramming of somatic cells to iPSC has been m …
Epigenetic aberrations in human pluripotent stem cells.
Bar S and Benvenisty N. EMBO J 2019 - Review. PMID 31088843 Free PMC article.
Human pluripotent stem cells (hPSCs) are being increasingly utilized worldwide in investigating human development, and modeling and discovering therapies for a wide range of diseases as well as a source for cellular therapy. Yet, since the first isolation of human embryonic stem cells (hESCs) 20 years ago, followed by the successful reprogramming of human-induced pluripotent stem cells (hiPSCs) 10 years later, various studies shed light on abnormalities that sometimes accumulate in these cells in vitro Whereas genetic aberrations are well documented, epigenetic alterations are not as thoroughly discussed. ...
Human pluripotent stem cells (hPSCs) are being increasingly utilized worldwide in investigating human development, and modeling and d …
Identifying Human Naïve Pluripotent Stem Cells - Evaluating State-Specific Reporter Lines and Cell-Surface Markers.
Collier AJ and Rugg-Gunn PJ. Bioessays 2018 - Review. PMID 29574793
Recent reports that human pluripotent stem cells can be captured in a spectrum of states with variable properties has prompted a re-evaluation of how pluripotency is acquired and stabilised. ...Here, several transcriptional and epigenetic hallmarks of human pluripotent states in the recently described cell lines are reviewed and evaluated. ...
Recent reports that human pluripotent stem cells can be captured in a spectrum of states with variable properties has prompted a re-e …
Clinical potentials of human pluripotent stem cells.
Mora C, et al. Cell Biol Toxicol 2017 - Review. PMID 28176010
To pursue these goals, the discipline is taking advantage of pluripotent stem cells (PSCs), a peculiar type of cell possessing the ability to differentiate into every cell type of the body. ...However, since 2006, it is possible to restore in an adult cell a pluripotent ESC-like condition by forcing the expression of four transcription factors with the rejuvenating reprogramming technology invented by Yamanaka. ...
To pursue these goals, the discipline is taking advantage of pluripotent stem cells (PSCs), a peculiar type of cell possessing the ab …
iPSC technology-based regenerative therapy for diabetes
Kondo Y, et al. J Diabetes Investig 2018 - Review. PMID 28609558 Free PMC article.
The directed differentiation of human pluripotent stem cells, such as embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs), into pancreatic endocrine lineages has been vigorously examined by reproducing the in vivo developmental processes of the pancreas. ...
The directed differentiation of human pluripotent stem cells, such as embryonic stem cells (hESCs) and induced pluripotent ste …
Derivation of pluripotent stem cells from nascent undifferentiated teratoma.
An Y, et al. Dev Biol 2019. PMID 30529251 Free article.
Teratomas are tumors consisting of components of the three germ layers that differentiate from pluripotent stem cells derived from germ cells. ...The expression levels of pluripotency genes and global transcriptomes in CDGCs as well as these cells' adaption to culture conditions for primed pluripotency suggested that their pluripotent status is intermediate between naïve and primed pluripotency. ...
Teratomas are tumors consisting of components of the three germ layers that differentiate from pluripotent stem cells derived from ge …
Pluripotent stem cells.
Verfaillie C. Transfus Clin Biol 2009 - Review. PMID 19442552
The cloning of "Dolly" in 1997, more than 40 years after the first frogs were cloned, combined with the very fast progress made in our understanding of the molecular processes that govern the pluripotency of ESC has lead to the ability of scientists to recreate a pluripotent state in fibroblasts and other cells from mouse, rat and man, named induced pluripotent stem cells (iPSC). ...In addition, the ability to generate custom made pluripotent stem cells will no doubt lead to the development of protein or small molecule drugs that can induce differentiation not only of iPSC or ESC to mature tissue cells, but also endogenous tissue stem cells. ...
The cloning of "Dolly" in 1997, more than 40 years after the first frogs were cloned, combined with the very fast progress made in our under …
Deconstructing transcriptional heterogeneity in pluripotent stem cells.
Kumar RM, et al. Nature 2014. PMID 25471879 Free PMC article.
Pluripotent stem cells (PSCs) are capable of dynamic interconversion between distinct substates; however, the regulatory circuits specifying these states and enabling transitions between them are not well understood. ...Notably, either removal of mature microRNAs or pharmacological blockage of signalling pathways drives PSCs into a low-noise ground state characterized by a reconfigured pluripotency network, enhanced self-renewal and a distinct chromatin state, an effect mediated by opposing microRNA families acting on the Myc/Lin28/let-7 axis. ...
Pluripotent stem cells (PSCs) are capable of dynamic interconversion between distinct substates; however, the regulatory circuits spe
Can pluripotent stem cells be used in cell-based therapy?
Picanço-Castro V, et al. Cell Reprogram 2014 - Review. PMID 24606201 Free PMC article.
Pluripotent stem cells, both embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), have the ability to differentiate into several cell types that can be used in drug testing and also in the study and treatment of diseases. ...In this review, we address the pluripotent cell types, how to obtain and characterize these cells, and differentiation assays. ...
Pluripotent stem cells, both embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), have the ability to diffe
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