A skin colonizer disrupts inflammatory and humoral immune defenses in hidradenitis suppurativa.
Agbogan VA, Bugault F, Guenin-Macé L, Gribonika I, Planchais C, Morel JD, Delaleu J, Pérez-Chaparro PJ, Atlan M, Delage M, Nassif A, Mouquet H, Belkaid Y, Join-Lambert O, Demangel C.
Agbogan VA, et al.
EMBO Mol Med. 2026 May;18(5):1744-1770. doi: 10.1038/s44321-026-00407-7. Epub 2026 Mar 24.
EMBO Mol Med. 2026.
PMID: 41876796
Free PMC article.
Here, we report that HS patients mount IgA and IgG responses against skin colonizers, notably Porphyromonas uenonis (Pu), a rare species selectively enriched in severe disease. In these patients, Pu foci are detected in the epidermis, surrounded by IgA deposits, and …
Here, we report that HS patients mount IgA and IgG responses against skin colonizers, notably Porphyromonas uenonis (Pu), a ra …