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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1959 1
1965 4
1966 2
1967 2
1968 4
1969 11
1970 5
1971 8
1972 10
1973 8
1974 15
1975 15
1976 13
1977 12
1978 24
1979 24
1980 28
1981 25
1982 32
1983 25
1984 23
1985 49
1986 45
1987 47
1988 48
1989 55
1990 38
1991 69
1992 67
1993 90
1994 110
1995 91
1996 98
1997 86
1998 93
1999 98
2000 110
2001 121
2002 94
2003 86
2004 77
2005 110
2006 115
2007 112
2008 143
2009 130
2010 128
2011 129
2012 104
2013 101
2014 112
2015 119
2016 114
2017 88
2018 93
2019 46
2020 0
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3,315 results
Results by year
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Page 1
An oncogene-induced DNA damage model for cancer development
Halazonetis TD, et al. Science 2008 - Review. PMID 18323444
Yet recent experimental findings suggest that, in both precancerous lesions and cancers, activated oncogenes induce stalling and collapse of DNA replication forks, which in turn leads to formation of DNA DSBs. ...In addition, in precancerous lesions, these DNA DSBs activate p53, which, by inducing apoptosis or senescence, raises a barrier to tumor progression. ...
Yet recent experimental findings suggest that, in both precancerous lesions and cancers, activated oncogenes induce stalling and coll …
Overexpression of immunomodulatory mediators in oral precancerous lesions.
Gonçalves AS, et al. Hum Immunol 2017. PMID 28941745
We investigated the expression of these immunomodulatory mediators in oral precancerous lesions (oral leukoplakia-OL; n=80) and whether these molecules were related to the risk of malignant transformation. ...
We investigated the expression of these immunomodulatory mediators in oral precancerous lesions (oral leukoplakia-OL; n=80) and wheth …
Genome-wide DNA methylation profiles in precancerous conditions and cancers.
Kanai Y. Cancer Sci 2010 - Review. PMID 19891661 Free article.
Genome-wide analysis of DNA methylation status has revealed that the DNA methylation profile at the precancerous stage is basically inherited by the corresponding cancers developing in individual patients. DNA methylation status is not simply altered at the precancerous stage; rather, DNA methylation alterations at the precancerous stage may confer vulnerability to further genetic and epigenetic alterations, generate more malignant cancers, and thus determine patient outcome. ...
Genome-wide analysis of DNA methylation status has revealed that the DNA methylation profile at the precancerous stage is basically i …
Proposed Terminology and Classification of Pre-Malignant Neoplastic Conditions: A Consensus Proposal.
Valent P, et al. EBioMedicine 2017 - Review. PMID 29203377 Free PMC article.
Although some pre-malignant stages of a malignancy have been characterized, no global system to define and to classify these conditions is available. ...The outcomes of this conference are summarized herein and include a basic proposal for a nomenclature and classification of pre-malignant conditions. ...
Although some pre-malignant stages of a malignancy have been characterized, no global system to define and to classify these conditions
3,315 results
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